Notes:
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• A final note about document formats: Items noted as (pdf) are Adobe Acrobat documents that require the free Adobe Acrobat reader from Adobe

Digital and Multimedia Anatomy

• Dermatlas; a database of dermatalogic and histalogic images. Johns Hopkins University.
• DermIS; with an exhaustive atlas of images of dermatologic conditions and dermatologic manifestations of systemic conditions. From Friedrich-Alexander-Universität, Erlangen-Nürnberg, Germany.
• Integrated Medical Curriculum; educational series on anatomy, physiology, pharmacology. Free registration required. From Gold Standard Multimedia Inc.
• PediatricRadiology.com; a comprehensive source of pediatric imaging resources
• Lung Anatomy and Pediatric Airway Anatomy from The Virtual Hospital
• Cross Sectional Anatomy from the Visible Human Project at the NLM
• Digital Anatomist at the University of Washington
• A fascinating account of the history of the study of anatomy in Introductory Anatomy, by D.R. Johnson in Human Biology Course Notes, from The Centre for Human Biology, University of Leeds
• Structure and Function of the Lung, by TA Godwin, Cornell University Medical College

Return to Top of Table of Contents

Pulmonary

Respiratory Physiology

• Robert F. Respiratory Physiology. Update in Anaesthesia 2000; 12:11. [full-text]
• Law L, Bukwirwa H. The Physiology of Oxygen Delivery. Update in Anaesthesia 1999; 10:3. [full-text]
• Integrated Medical Curriculum; educational series on anatomy, physiology, pharmacology. Free registration required. From Gold Standard Multimedia Inc.
• ABC of oxygen: Oxygen transport - 1. Basic principles. Treacher DF, Leach RM. Br Med J 1998;317:1302-1306. (full-text)
• Cellular and Molecular Mechanisms of Pulmonary Vascular Remodeling. Stenmark KR, Mecham RP. Annu. Rev. Physiol. 1997; 59: 89-144. (full-text for subscribers)
• Pulmonary Physiology in Clinical Practice. Martin L. A full-text textbook in development. From Mt. Sinai Medical Center, Cleveland OH. Includes:
  • PCO2 and Alveolar Ventilation
  • Oxygen Transfer
  • Acid-Base Balance
• Fundamentals of Acid-Base Balance, Grogano AW. On GasNet
• Acid-Base Tutorial. Grogano AW. Tulane University.
• Ventilation and Perfusion Matching in the Lung, a computer model for teaching pulmonary physiology (requires Netscape 3.0+ and Shockwave), from Academic Computing at New York University

Respiratory Infections

• RSV/Bronchiolitis
  • Davison C, Ventre KM, Luchetti M, Randolph AG. Efficacy of interventions for bronchiolitis in critically ill infants: A systematic review and meta-analysis. Pediatr Crit Care Med. 2004 Sep;5(5):482-489. [abstract]
  • King VJ, Viswanathan M, Bordley WC, et al. Pharmacologic Treatment of Bronchiolitis in Infants and Children: A Systematic Review. Arch Pediatr Adolesc Med 2004;158 127-137 [abstract]
  • Hartling L, Wiebe N, Russell K, Patel H, Klassen TP. A Meta-analysis of Randomized Controlled Trials Evaluating the Efficacy of Epinephrine for the Treatment of Acute Viral Bronchiolitis. Arch Pediatr Adolesc Med 2003;157 957-964 [abstract]; with an accompanying "Evidence-based Journal Club" style review: King TM, Alperovitz-Bichell, Rowe PC, Lehmann HP. Is Epinephrine Efficacious in the Treatment of Bronchiolitis? Arch Pediatr Adolesc Med 2003;157 965-968 [full-text]
  • van Woensel JBM, van Aalderen WMC, Kimpen JLL. Viral lower respiratory tract infection in infants and young children. Br Med J 2003;327 36-40. [abstract]
  • Wainwright C, Altamarino L, Medico-Cirujano et al. A Multicenter, Randomized, Double-Blind, Controlled Trial of Nebulized Epinephrine in Infants with Acute Bronchiolitis. New Engl J Med 2003;349:27-35. [abstract]
    • PedsCCM EB Journal Club Review, by P Prodhan, N Noviski
  • Management of Bronchiolitis in Infants and Children. Evidence Report/Technology Assessment. Agency for Healthcare Research and Quality. [full-text]
  • Patel H, Platt RW, Pekeles GS, Ducharme FM. A randomized, controlled trial of the effectiveness of nebulized therapy with epinephrine compared with albuterol and saline in infants hospitalized for acute viral bronchiolitis. J Pediatr. 2002;141(6):818-24. [abstract]
    • PedsCCM EB Journal Club Review, by R Lambert, R Sanders
  • Martinón-Torres F, Rodríguez-Núñez A, Martinón-Sánchez JM. Heliox Therapy in Infants With Acute Bronchiolitis. Pediatrics 2002; 109:68-73. [abstract; full-text for subscribers/AAP members]
    • PedsCCM EB Journal Club Review, by H Trivedi, K Biagas
  • Luchetti M, Ferrero F, Gallini C et al. Multicenter randomized, controlled study of porcine 6 in severe respiratory syncytial virus-induced respiratory failure. Pediatr Crit Care Med 2002; 3:261-268. [abstract; full-text on Medscape]
    • PedsCCM EB Journal Club Review, by M Wilhelm
  • Numa AH, Williams GD, Dakin CF. The Effect of Nebulized Epinephrine on Respiratory Mechanics and Gas Exchange in Bronchiolitis. Am J Respir Crit Care Med 2001; 164:86-91. [abstract; full-text for subscribers]
  • Tibby SM, Hatherill M, Wright SM et al. Exogenous Surfactant Supplementation in Infants with Respiratory Syncytial Virus Bronchiolitis Am J Respir Crit Care Med 2000; 162: 1251-1256. [Abstract] [Full-text for subscribers]
    • PedsCCM EB Journal Club Review, by S Kache
  • Garrison MM, Christakis DA, Harvey E, Cummings P, Davis RL. Systemic Corticosteroids in Infant Bronchiolitis: A Meta-analysis. Pediatrics. 2000;105:E44. [abstract] [full-text]
    • PedsCCM EB Journal Club Review, by M. Bonnie Dutta
  • Perlstein PH, Kotagal UR, Bolling C, et al. Evaluation of an evidence-based guideline for bronchiolitis. Pediatrics 1999;104:1334-41. [abstract] [full-text for AAP members]
  • Perlstein PH, Kotagal UR, Schoettker PJ, et al. Sustaining the implementation of an evidence-based guideline for bronchiolitis. Arch Pediatr Adolesc Med. 2000;154(10):1001-7.[abstract] [full-text for subscribers]
  • Bülow SM, Nir M, Levin E, et al. Prednisolone Treatment of Respiratory Syncytial Virus Infection: A Randomized Controlled Trial of 147 Infants. Pediatrics 1999; 104: e77. [abstract] [full-text]
    • Review by J. Hageman, B. Markovitz
  • Ribavirin in ventilated respiratory syncytial virus bronchiolitis. A randomized, placebo-controlled trial. Guerguerian AM, Gauthier M, Lebel MH, Farrell CA, Lacroix J. Am J Respir Crit Care Med 1999;160:829-34. [abstract] [full-text for subscribers]
    • PedsCCM EB Journal Club Review by P. Chalikonda
  • Khongphatthanayothin A, Wong PC, Samara Y, et al. Impact of respiratory syncytial virus infection on surgery for 19: postoperative course and outcome. Crit Care Med 1999;27:1974-81. [abstract]
    • PedsCCM EB Journal Club Review, by C. Babbitt, J. Feldman
  • 4 Models For Respiratory Syncytial Virus-Associated Hospitalization. Moler F, Ohmit SE. Am J Respir Crit Care Med 1999; 159: 1234-1240. [abstract] [full-text for subscribers]
  • Bronchiolitis. DiNicola LK, Gayle MO. Jacksonville Medicine September 1998.
  • Prevention of Respiratory Syncytial Virus Infections: Indications for the Use of Palivizumab and Update on the Use of RSV-IGIV. Committee on Infectious Diseases and Committee on Fetus and Newborn. Pediatrics 1998; 102: 1211-1216. (full-text for AAP members) [abstract]
  • Reassessment of the Indications for Ribavirin Therapy in Respiratory Syncytial Virus Infections, from Policy Statements of the American Academy of Pediatrics
  • RSV-IgIV Use, a PedComm AAP Member Alert, from the AAP (only available via the Members Only Channel
  • Heliox therapy for bronchiolitis: Report of a case and discussion
    • by Gideon Paret, MD
  • Meta-analysis of studies assessing ribavirin
    • by Adrienne G. Randolph, MD
  • Ribavirin for Respiratory Syncytial Virus Lower Respiratory Tract Infection: A Systematic Overview. Randolph, A., Wang, E. Arch Pediatr Adolesc Med. 1996;150:942-947. [abstract].
    • PedsCCM EB Journal Club Review, by M. Verive
  • Prevention and Treatment of Respiratory Syncytial Virus - the search for a Cost-Effective Strategy. Buck ML. Pediatric Pharmacotherapy 1997; 3(10). (University of Virginia)
  • Effectiveness of ribavirin in otherwise well infants with respiratory syncytial virus-associated respiratory failure. Pediatric Critical Study Group. Moler FW, Steinhart CM, Ohmit SE, Stidham GL. J Pediatr 1996; 128:422-428 [abstract]
  • Roosevelt G, Sheehan K, Grupp-Phelan J, Tanz RR, Listernick R. Dexamethasone in bronchiolitis: a randomised controlled trial. Lancet 1996; 348:292-295 [abstract]
    • Review, by E. Stiles
  • Efficacy of beta2-Agonists in Bronchiolitis: A Reappraisal and Meta-analysis. Flores G, Horwitz RI. Pediatrics 1997; 100: 233-39. (abstract)
  • Efficacy of Bronchodilator Therapy in Bronchiolitis: A Meta-analysis. Kellner JD, et al. Arch Pediatr Adolesc Med 1996; 150:1166-1172. (abstract).
    • PedsCCM EB Journal Club Review, by M. Reloza-Macias
  • The Use of Albuterol in Hospitalized Infants With Bronchiolitis. Dobson JV, Stephens-Groff SM, McMahon SR, Stemmler MH, Brallier SL, Bay C. Pediatrics 1998; 101: 361-368. (abstract)
    • PedsCCM EB Journal Club Review, by K.Daphtary, K. Meert
  • Does Ribavirin Impact on the Hospital Course of Children With Respiratory Syncytial Virus (RSV) Infection? An Analysis Using the Pediatric Investigators Collaborative Network on Infections in Canada (PICNIC) RSV Database. Law, B.J., Wang, E.L., MacDonald, N., McDonald, J., Dobson, S., Boucher, F., Langley, J., Robinson, J., Mitchell, I., Stephens, D. Pediatrics 1997 99(3): e7. (full-text)
  • Respiratory Syncytial Virus (RSV) Immune Globulin Intravenous Therapy for RSV Lower Respiratory Tract Infection in Infants and Young Children at High Risk for Severe RSV Infections. Rodriguez, W.J., Gruber, W.C., Welliver, R.C., Groothuis, J.R., Simoes, E.A.F., Meissner, H.C., Hemming, V.G., Hall, C.B., Lepow, M.L., Rosas, A.J., Robertsen, C., Kramer, A.A., and for the Respiratory Syncytial Virus Immune Globulin Study Group. Pediatrics 1997 99(3): 454-461. (abstract)
  • Dexamethasone in salbutamol-treated inpatients with acute bronchiolitis: A randomized, controlled trial. Klassen, TP, Sutcliffe, T, Watters, LK, et al. J Pediatr 1997; 130:191-6. [abstract]
    • PedsCCM EB Journal Club Review, by B. Markovitz
  • Helium-oxygen improves clinical 1 scores in children with acute bronchiolitis. Hollman G, Shen G, Zeng L, et al. Crit Care Med 1998;26:1731-1736. [abstract]
    • PedsCCM EB Journal Club Review, by K. Ackerman

• Ventilator-Associated/Nosocomial Pneumonia
  • Gauvin F, Dassa C, Chaibou M, Proulx F, Farrell CA, Lacroix J. Ventilator-associated pneumonia in intubated children: comparison of different diagnostic methods. Pediatr Crit Care Med. 2003 Oct;4(4):437-43. [abstract]
  • Girou E, Schortgen F, Delclaux C, et al. Association of noninvasive ventilation with nosocomial infections and survival in critically ill patients. JAMA. 2000 Nov 8;284(18):2361-7. [abstract]
  • Dodek P, Keenan S, Cook D, et al. Evidence-based clinical practice guideline for the prevention of ventilator-associated pneumonia. Ann Intern Med. 2004 Aug 17;141(4):305-13. [abstract]
  • Kola A, Eckmanns T, Gastmeier P. Efficacy of heat and moisture exchangers in preventing ventilator-associated pneumonia: meta-analysis of randomized controlled trials. Intensive Care Med. 2005 Jan;31(1):5-11 [abstract]
  • Bar-Zohar D, Sivan Y. The Yield of Flexible Fiberoptic Bronchoscopy in Pediatric Intensive Care Patients. Chest. 2004 Oct;126(4):1353-1359. [abstract]
  • Mentec H, May-Michelangeli L, Rabbat A, Varon E, Le Turdu F, Bleichner G. Blind and bronchoscopic sampling methods in suspected ventilator-associated pneumonia: A multicentre prospective study. Intensive Care Med. 2004; 30-1319-1326. [abstract]
    • PedsCCM EB Journal Club Review, by M Weber
  • Elatrous S, Boukef R, Ouanes Besbes L, Marghli S, Nooman S, Nouira S, Abroug F. Diagnosis of ventilator-associated pneumonia: agreement between quantitative cultures of endotracheal aspiration and plugged telescoping catheter. Intensive Care Med. 2004 May;30(5):853-8. [abstract]
  • Shorr AF, Duh MS, Kelly KM, Kollef MH; CRIT Study Group. Red blood cell transfusion and ventilator-associated pneumonia: A potential link? Crit Care Med. 2004 Mar;32(3):666-74. [abstract]
  • Wunderink RG, Rello J, Cammarata SK, Croos-Dabrera RV, Kollef MH. Linezolid vs vancomycin: analysis of two double-blind studies of patients with methicillin-resistant Staphylococcus aureus nosocomial pneumonia. Chest. 2003 Nov;124(5):1789-97. [abstract]
  • Chastre J, Wolff M, Fagon J-Y, et al. Comparison of 8 vs 15 Days of Antibiotic Therapy for Ventilator-Associated Pneumonia in Adults: A Randomized Trial. JAMA 2003;290 2588-2598[abstract]
    • PedsCCM EB Journal Club Review, by J Cortes
  • Sirvent JM, Vidaur L, Gonzalez S, et al. Microscopic examination of intracellular organisms in protected bronchoalveolar mini-lavage fluid for the diagnosis of ventilator-associated pneumonia. Chest. 2003;123(2):518-23 [abstract]
    • PedsCCM EB Journal Club Review, by C Kennedy
  • Johanson WG, Dever LL. Nosocomial pneumonia. Intensive Care Med 2003; 29: 23-29 [abstract]
  • Hoffken G, Niederman MS. Nosocomial Pneumonia: The Importance of a De-escalating Strategy for Antibiotic Treatment of Pneumonia in the ICU. Chest. 2002;122(6):2183-96. [abstract]
  • Rello J, Ollendorf DA, Oster G, Vera-Llonch M, Bellm L, Redman R, Kollef MH. Epidemiology and Outcomes of Ventilator-Associated Pneumonia in a Large US Database. Chest. 2002;122(6):2115-21. [abstract]
  • Zack JE, Garrison T, Trovillion E, Clinkscale D, Coopersmith CM, Fraser VJ, Kollef MH. Effect of an education program aimed at reducing the occurrence of ventilator-associated pneumonia. Crit Care Med. 2002;30(11):2407-12. [abstract]
  • Wu CL, le Yang D, Wang NY, Kuo HT, Chen PZ. Quantitative Culture of Endotracheal Aspirates in the Diagnosis of Ventilator-Associated Pneumonia in Patients With Treatment Failure. Chest 2002;122 662-668. [abstract; full-text for subscribers]
  • Ntoumenopoulos G, Presneill JJ, McElholum M, Cade JF. Chest physiotherapy for the prevention of ventilator-associated pneumonia Intensive Care Med 2002;28: 850-856. [abstract; full-text for subscribers]
    • PedsCCM EB Journal Club Review, by N Hoover, J Stockwell
  • Elward AM, Warren DK, Fraser VJ. Ventilator-Associated Pneumonia in Pediatric Intensive Care Unit Patients: Risk Factors and Outcomes. Pediatrics 2002; 109: 758-764. [abstract; full-text for subscribers/AAP members]
  • Lopriore E, Markhorst DG, Gemke RJBJ. Ventilator-associated pneumonia and upper airway colonisation with Gram negative bacilli: the role of stress ulcer prophylaxis in children. Intensive Care Med 2002; 28: 763-767.[abstract]
    • Review, by D Godorov
  • Adair CG, Gorman SP, Byers LM et al. Eradication of endotracheal tube biofilm by nebulised gentamicin. Intensive Care Med 2002;28: 426-431. [abstract; full-text for subscribers]
  • Chastre J, Fagon JV. Ventilator-associated Pneumonia. Am J Respir Crit Care Med 2002;165 867-903. [abstract; full-text for subscribers]
  • Smulders K, van der Hoeven H, Weers-Pothoff I, Vandenbroucke-Grauls C. A Randomized Clinical Trial of Intermittent Subglottic Secretion Drainage in Patients Receiving 8 Ventilation. Chest 2002;121: 858-862 [abstract; full-text for subscribers]
    • PedsCCM EB Journal Club Review by M Sehgal
  • Rello J, Paiva JA, Baraibar J, et al. International Conference for the Development of Consensus on the Diagnosis and Treatment of Ventilator-Associated Pneumonia. Chest 2001;120 955-970. [abstract; full-text for subscribers]
  • Mayhall CG. Ventilator-Associated Pneumonia or Not? Contemporary Diagnosis. Emerging Infectious Diseases 2001; 7. [full-text]
  • Heyland D. Ventilator-associated pneumonia: Current management strategies. Critical Care Rounds 2000; 1:(1). [full-text pdf]
    • PedsCCM EB Journal Club Review, by N Mehta
  • Ibrahim EH, Ward S, Sherman G, Schaiff R, Fraser VJ, Kollef MH. Experience with a clinical guideline for the treatment of ventilator-associated pneumonia. Crit Care Med. 2001;29(6):1109-15. [abstract]
  • Timsit JF, Cheval C, Gachot B et al. Usefulness of a strategy based on bronchoscopy with direct examination of bronchoalveolar lavage fluid in the initial antibiotic therapy of suspected ventilator-associated pneumonia. Intensive Care Med, 2001; DOI 10.1007/s001340000840 [abstract; full-text for subscribers]
  • Burmester M, Mok Q. How 15 is non-bronchoscopic bronchoalveolar lavage in critically ill mechanically ventilated children? Intensive Care Med, 2001; DOI 10.1007/s001340100904. [abstract; full-text for subscribers]
  • Bergmans DCJJ, Bonten MJM, Gaillard CA et al. Prevention of Ventilator-associated Pneumonia by Oral Decontamination A Prospective, Randomized, Double-blind, Placebo-controlled Study. Am J Respir Crit Care Med 2001; 164:382-388. [abstract; full-text for subscribers]
    • PedsCCM EB Journal Club Review, by P Kamat, J Stockwell
  • Effectiveness and Cost of Selective Decontamination of the Digestive Tract in Critically Ill Intubated Patients. A randomized, double-blind, placebo-controlled, multicenter trial. Sanchez Garcia MS, Cambronero Galache JA, Diaz JL, et al. Am J Respir Crit Care Med 1998;158: 908-916. [abstract] [full-text for subscribers only]
    • PedsCCM EB Journal Club review, by P. Johnson, B. Markovitz
  • van Saene HKF, Petros AJ, Ramsay G, Baxby D. All great truths are iconoclastic: selective decontamination of the digestive tract moves from heresy to level 1 truth. Intensive Care Med 2003; 29: 677-690 [abstract]
  • Singh N, Rogers P, Atwood CW, Wagener MM, Yu VL. Short-course Empiric Antibiotic Therapy for Patients with Pulmonary Infiltrates in the Intensive Care Unit. A proposed solution for indiscriminate antibiotic prescription. Am J Respir Crit Care Med. 2000;162(2):505-511. [abstract] [full-text for subscribers]
  • Combes P, Fauvage B, Oleyer C. Nosocomial pneumonia in mechanically ventilated patients, a prospective randomised evaluation of the Stericath closed suctioning system Intensive Care Med 2000; 26: 878-882. [abstract]
  • Markowicz P, Wolff M, Djedaini K, et al. Multicenter Prospective Study of Ventilator-Associated Pneumonia During Acute Respiratory Distress Syndrome. Incidence, prognosis, and risk factors. Am J Respir Crit Care Med. 2000 Jun 1;161(6):1942-1948.[abstract] [full-text for subscribers]
  • The Attributable Morbidity and Mortality of Ventilator-Associated Pneumonia in the Critically Ill Patient. Heyland DK, Cook DJ, Griffith L, et al. Am J Respir Crit Care Med 1999; 159: 1249-1256. [abstract] [full-text for subscribers]
  • Kollef MH, Skubas NJ, Sundt TM. A Randomized Clinical Trial of Continuous Aspiration of Subglottic Secretions in Cardiac Surgery Patients. Chest 1999 116: 1339-1346. [abstract] [full-text for subscribers]
  • Barret JP, Ramzy PI, Wolf SE, Herndon DN. Sensitivity and Specificity of Bronchoalveolar Lavage and Protected Bronchial Brush in the Diagnosis of Pneumonia in Pediatric Burn Patients. Arch Surg. 1999;134:1243-1247. [abstract]
    • Review, by A Vohra
  • Comparison of Two Methods of Diagnostic Lung Lavage in Ventilated Infants with Lung Disease. Darbaville PA, South M, McDougall PN. Am J Respir Crit Care Med 1999;160: 771-777. [abstract; full-text for subscribers]
  • Labenne M, Poyart C, Rambaud C, et al. Blind protected specimen brush and bronchoalveolar lavage in ventilated children. Crit Care Med. 1999 ;27:2537-43. [abstract]
    • PedsCCM EB Journal Club Review, by R Sanders, AL Graciano
  • Diagnosis of nosocomial pneumonia in mechanically ventilated patients: repeatability of the bronchoalveolar lavage. Gerbeaux P, Ledoray V, Boussuges A, Molenat F, Jean P, Sainty JM Am J Respir Crit Care Med 1998;157(1):76-80. [abstract]
  • Influence of Airway Management on Ventilator-Associated Pneumonia: Evidence From Randomized Trials. Cook D, De Jonghe B, Brochard L, Brun-Buisson C. JAMA 1998;279:781-787. (abstract)
  • Kollef M. Current Concepts: The Prevention of Ventilator-Associated Pneumonia. New Engl J Med 1999; 340:627-634. [citation]
  • A Randomized Clinical Trial of Continuous Aspiration of Subglottic Secretions in Cardiac Surgery Patients. Kollef MH, Skubas NJ, Sundt TF. Chest. 1999;116:1339-1346.[abstract] [full-text for subscribers only]
  • Fagon JY, Chastre J, Wolff M, et al. Invasive and 8 strategies for management of suspected ventilator-associated pneumonia. A randomized trial. Ann Intern Med. 2000;132:621-30. [abstract, full-text]
  • Guideline for Prevention of Nosocomial Pneumonia, Tablan, OC et al., and the Hospital Infection Control Practices Advisory Committee of the Centers for Disease Control
  • A Randomized Study Assessing the Systematic Search for Maxillary Sinusitis in Nasotracheally Mechanically Ventilated Patients. Influence of Nosocomial Maxillary Sinusitis on the Occurrence of Ventilator-associated Pneumonia. Holzapfel L, Chastang C, Demingeon G, et al. Am J Respir Crit Care Med 1999; 159: 695-701. [abstract] [full-text for subscribers]
    • PedsCCM EB Journal Club Review, by K. Daphtary, K. Meert

• Other
  • Keren R, Zaoutis TE, Bridges CB, et al. Neurological and neuromuscular disease as a risk factor for respiratory failure in children hospitalized with influenza infection. JAMA. 2005 Nov 2;294(17):2188-94. [abstract]

The Pediatric Airway

• Gupta VK, Cheifetz IM. Heliox administration in the pediatric intensive care unit: An evidence-based review. Pediatr Crit Care Med. 2005 Mar;6(2):204-11. [abstract]
• Reynolds SF, Heffner J. Airway Management of the Critically Ill Patient: Rapid-Sequence Intubation. Chest 2005;127 1397-1412 [abstract]
• Essouri S, Nicot F, Clement A, Garabedian EN, Roger G, Lofaso F, Fauroux B. Noninvasive positive pressure ventilation in infants with upper airway obstruction: comparison of continuous and bilevel positive pressure. Intensive Care Med. 2005 Apr;31(4):574-80 [abstract]
• Gomes Cordeiro AM, Fernandes JC, Troster EJ. Possible risk factors associated with moderate or severe airway injuries in children who underwent endotracheal intubation. Pediatr Crit Care Med. 2004 Jul;5(4):364-8. [abstract]
  • PedsCCM EB Journal Club Review
• Bar-Zohar D, Sivan Y. The Yield of Flexible Fiberoptic Bronchoscopy in Pediatric Intensive Care Patients. Chest. 2004 Oct;126(4):1353-1359. [abstract]
• Intubation, L Ibsen, Oregon Health Sciences University (teaching file)
• Newth CJ, Rachman B, Patel N, Hammer J. The use of cuffed versus uncuffed endotracheal tubes in pediatric intensive care. J Pediatr. 2004 Mar;144(3):333-7 [abstract]
• Mhanna MJ, Zamel YB, Tichy CM, Super DM. The "air leak" test around the endotracheal tube, as a predictor of postextubation stridor, is age dependent in children. Crit Care Med. 2002;30(12):2639-43. [abstract]
• De Bast Y, De Backer D, Moraine JJ et al. The cuff leak test to predict failure of tracheal extubation for laryngeal edema. Intensive Care Med 2002; 28: 1267-1272. [abstract]
  • PedsCCM EB Journal club Review, by A Wratney, DK Benjamin Jr, I Cheifetz
• Markovitz BP, Randolph AG. Corticosteroids for the Prevention of Reintubation and Postextubation Stridor in Pediatric Patients: A Meta-Analysis. Pediatr Crit Care Med 2002; 3:223-226. [abstract; full-text on Medscape]
  • PedsCCM EB Journal Club Review, by K Brinkman
• Pediatric Airway Obstruction: A Pictorial Review, from the Department of Paediatric Otolaryngology, The Hospital for Sick Children, Toronto, Canada
• Weber JE, Chudnofsky CR, Younger JG et al. A Randomized Comparison of Helium-Oxygen Mixture (Heliox) and Racemic Epinephrine for the Treatment of Moderate to Severe Croup. Pediatrics 2001; 107: e96. [full-text]
  • PedsCCM EB Journal Club Review, by M Cooper
• Jacobs BR, Salman BA, Cotton RT, Lyons K, Brilli RJ. Postoperative management of children after single-stage laryngotracheal reconstruction. Crit Care Med. 2001;29(1):164-168. [abstract]
• The effectiveness of glucocorticoids in treating croup: meta-analysis . Ausejo M, Saenz A, Pham B, et al. Br Med J 1999;319:595-600. (full-text)
  • Reviewed as a Critically Appraised Topic: Glucocorticoids Are Effective in Decreasing Croup Symptoms In Children. Brenner K. University of Michigan Health System's Department of Pediatrics and Communicable Diseases
  • PedsCCM EB Journal Club Review by M. Sanchez-Mendiola
• Effect of Continuous Positive Airway Pressure on Forced Expiratory Flows in Infants with Tracheomalacia. Davis S, Jones M, Kisling J, Angelicchio C, Tepper RS. Am J Respir Crit Care Med 1998; 158:148-152. (full-text for subscribers only; abstract)
• Evaluation of Stridor and Wheezing. Holinger L. The Child's Doctor Spring 1998. From Children's Memorial Hospital and Northwestern University Medical School.
• Head and Neck Emergencies, from University of Wisconsin Dept. of Surgery
• Management of Airway Emergencies; an American Association of Respiratory Care practice guideline
• The LMA Web Page: information about the larnygeal mask airway (not specific to pediatrics)
• From The Electric Airway at The University of Iowa's Virtual Hospital (includes radiographs, sounds, movies, and more)
  • Anatomy
  • Croup Syndromes
  • Subglottic Stenosis
  • Tracheo/Laryngomalacia
  • Epiglottitis
  • Case Studies
• Dexamethasone in the prevention of postextubation stridor in children. Tellez DW, Galvis AG, Storgion SA, Amer HN, Hoseyni M, Deakers TW. J Pediatr 1991;118:289-294. [abstract]
  • PedsCCM EB Journal Club Review, by A. Randolph
• Dexamethasone for the prevention of postextubation airway obstruction: a prospective, randomized, double-blind, placebo-controlled trial. Anene O, Meert KL, Uy H, Simpson P, Sarniak AP. Crit Care Med 1996; 24: 1666-1669. [abstract]
  • PedsCCM EB Journal Club Review, by A. Randolph
• Markovitz BP, Randolph AG. Corticosteroids for the prevention and treatment of post-extubation stridor in neonates, children and adults. Cochrane Database Syst Rev. 2000;(2):CD001000. [abstract]
• Retropharyngeal Abscess, from University of Hawaii Radiology Cases in Pediatric Emergency Medicine
• Supraglottitis, from Baylor Pediatric Otolaryngology

Respiratory Care, Acid-Base, PFT's, Diagnostics

• Cohen S, Springer C, Avital A, et al. Amino-Terminal Pro-Brain-Type Natriuretic Peptide: Heart or Lung Disease in Pediatric Respiratory Distress? Pediatrics 2005;115 1347-1350 [abstract]
• Rumbak MJ, Newton M, Truncale T, Schwartz SW, Adams JW, Hazard PB. A prospective, randomized, study comparing early percutaneous dilational tracheotomy to prolonged translaryngeal intubation (delayed tracheotomy) in critically ill medical patients. Crit Care Med. 2004 Aug;32(8):1689-94. [abstract]
• Main E, Stocks J. The influence of physiotherapy and suction on respiratory deadspace in ventilated children. Intensive Care Med. 2004 Jun;30(6):1152-9. [abstract]
• Main E, Castle R, Newham D, Stocks J. Respiratory physiotherapy vs. suction: the effects on respiratory function in ventilated infants and children. Intensive Care Med. 2004 Jun;30(6):1144-51 [abstract]
• Murray DM, Olhsson V, Fraser JI. Defining acidosis in postoperative cardiac patients using Stewart's method of strong ion difference. Pediatr Crit Care Med. 2004 May;5(3):240-5 [abstract; full-text (356K)]
• Castle RA, Dunne CJ, Mok Q, Wade AM, Stocks J. Accuracy of displayed values of tidal volume in the pediatric intensive care unit. Crit Care Med. 2002;30(11):2566-74. [abstract]
• Main E, Castle R, Stocks J, James I, Hatch D. The influence of endotracheal tube leak on the assessment of respiratory function in ventilated children. Intensive Care Med 2001; 27: 1788-1797. [abstract; full-text for subscribers]
• Stoneman MD, Hill E. Pulse Oximetry. Update in Anaesthesia 2000; 11:4. [full-text]
• Cannon ML, Cornell J, Tripp-Hamel DS, et al. Tidal Volumes For Ventilated Infants Should Be Determined with a Pneumotachometer Placed at the Endotracheal Tube. Am J Respir Crit Care Med 2000; 162: 2109-2112. [abstract] [full-text for subscribers]
• Krause MF, Hoehn T. Chest physiotherapy in mechanically ventilated children: a review. Crit Care Med. 2000 May;28(5):1648-51. [abstract]
• American Thoracic Society/European Respiratory Society. Respiratory Mechanics in Infants: Physiologic Evaluation in Health and Disease. Am Rev Resp Dis 1993; 147: 474-496. [full-text pdf]
• American Thoracic Society. Care of the Child with a Chronic Tracheostomy. Am J Respir Crit Care Med 2000; 161:297-308. [full-text for subscribers]
• Effect of Combined Kinetic Therapy and Percussion Therapy on the Resolution of Atelectasis in Critically Ill Patients. Raoof S, Chowdhrey N, Raoof S, et al. Chest 1999;115:1658-1666. [abstract] [full-text for subscribers only]
• Advances in Respiratory Monitoring During Mechanical Ventilation. Jubran A. Chest. 1999;116:1416-1425. [abstract] [full-text for subscribers only]
• ABC of intensive care: Respiratory support. Shelly MP, Nightingale P. Br Med J 1999;318:1674-1677. (full-text)
• ABC of Oxygen: Acute oxygen therapy. Bateman NT, Leach RM. Br Med J 1998;317:798-801. (full-text)
• ABC of oxygen; Assessing and interpreting arterial blood gases and acid-base balance . Williams AJ. Br Med J 1998;317:1213-1216. (full-text)
• Acid-Base Balance: A Tutorial; an interactive teaching tool by AW Grogano, Anesthesiology Dept., Tulane University Medical Center
• Oxygen Monitoring in Acute Medicine.Sainsbury D. (lecture), from Paediatric Anaesthesia, at South Australia Women's and Children's Hospital, North Adelaide (Internet Explorer users only...)
• Guidelines from the American Association of Respiratory Care
  • Long-Term Invasive Mechanical Ventilation in the Home
  • Capillary Blood Gas Sampling for Neonatal and Pediatric Patients
  • Transport of the Mechanically Ventilated Patient
  • Metabolic Cart determinations
  • Infant Pulmonary Function Testing
  • Capnography/Capnometry
  • Pulse Oximetry
• Keenan SP, Sinuff T, Cook DJ, Hill NS. Does noninvasive positive pressure ventilation improve outcome in acute hypoxemic respiratory failure? A systematic review. Crit Care Med. 2004 Dec;32(12):2516-23. [abstract]
  • PedsCCM EB Journal Club Review, by K Yen
• Park M, Sangean MC, de S Volpe M, et al. Randomized, prospective trial of oxygen, continuous positive airway pressure, and bilevel positive airway pressure by face mask in acute cardiogenic pulmonary edema. Crit Care Med. 2004 Dec;32(12):2407-15. [abstract]
  • PedsCCM EB Journal Club Review, by J Kane
• How Much Oxygen Does the Human Lung Consume? Loer, SA, Scheeren, TWL, Tarnow, J. Anesthesiology 1997; 86:532-7. [abstract]
• Hilbert G, Gruson D, Vargas F et al. Noninvasive ventilation in immunosuppressed patients with pulmonary infiltrates, fever, and acute respiratory failure. N Engl J Med. 2001;344(7):481-7. [abstract]
  • PedsCCM EB Journal Club Review, by J Barron
• Antonelli M, Conti G, Moro ML et al. Predictors of failure of noninvasive positive pressure ventilation in patients with acute hypoxemic respiratory failure: a multi-center study. Intensive Care Med 2001; 27:1718-1728 [abstract, full-text for subscribers]
• Noninvasive ventilation via bilevel positive airway pressure support in pediatric practice. Padman R, Lawless ST, Kettrick RG. Crit Care Med 1998; 26:169-173. [abstract]
• Mehta S, Hill NS. Noninvasive Ventilation. Am J Respir Crit Care Med 201; 163: 540-577. [full-text for subscribers]
• Jaarsma AS, Knoester H, van Rooyen F, Bos AP. Biphasic positive airway pressure ventilation (PeV+) in children. Crit Care. 2001;5(3):174-7. [abstract][full-text in PubMed Central]

ARDS, Lung Injury, and Mechanical Ventilation

• Honrubia T, Garcia Lopez FJ, Franco N, et al. Noninvasive vs Conventional Mechanical Ventilation in Acute Respiratory Failure: A Multicenter, Randomized Controlled Trial. Chest. 2005 Dec;128(6):3916-24. [abstract]
• Fan E, Needham DM, Stewart TE. Ventilatory management of acute lung injury and acute respiratory distress syndrome. JAMA. 2005 Dec 14;294(22):2889-96. [abstract]
• Sakr Y, Vincent JL, Reinhart K, et al. High tidal volume and positive fluid balance are associated with worse outcome in acute lung injury. Chest. 2005 Nov;128(5):3098-108. [abstract]
• Hager DN, Krishnan JA, Hayden DL, Brower RG. Tidal volume reduction in patients with acute lung injury when plateau pressures are not high. Am J Respir Crit Care Med. 2005 Nov 15;172(10):1241-5. [abstract]
• Martin GS, Moss M, Wheeler AP, Mealer M, Morris JA, Bernard GR. A randomized, controlled trial of furosemide with or without albumin in hypoproteinemic patients with acute lung injury. Crit Care Med. 2005 Aug;33(8):1681-1687. [abstract]
• Stapleton RD, Wang BM, Hudson LD, Rubenfeld GD, Caldwell ES, Steinberg KP. Causes and Timing of Death in Patients With ARDS. Chest. 2005 Aug;128(2):525-32. [abstract]
• Curley MA, Hibberd PL, Fineman LD, et al. Effect of prone positioning on clinical outcomes in children with acute lung injury: a randomized controlled trial. JAMA. 2005 Jul 13;294(2):229-37. [abstract]
• Herridge MS, Cheung AM, Tansey CM, et al. One-year outcomes in survivors of the acute respiratory distress syndrome. N Engl J Med. 2003 Feb 20;348(8):683-93. [abstract]
• Trachsel D, McCrindle BW, Nakagawa S, Bohn DJ. Oxygenation Index Predicts Outcome in Children with Acute Hypoxemic Respiratory Failure. Am J Respir Crit Care Med. 2005; 172:206-211 [abstract]
• Gong MN, Thompson BT, Williams P, et al. Clinical predictors of and mortality in acute respiratory distress syndrome: Potential role of red cell transfusion. Crit Care Med. 2005 Jun;33(6):1191-1198. [abstract]
• An online pediatric mechanical ventilation simulator, from Ken Tegtmeyer, Oregon Health & Science University, and the Media Lab at Doernbecher Children's Hospital, Portland, OR
• Grasso S, Fanelli V, Cafarelli A, Anaclerio R, Amabile M, Ancona G, Fiore T. Effects of High versus Low Positive End-Expiratory Pressures in Acute Respiratory Distress Syndrome. Am J Respir Crit Care Med. 2005 May 1;171(9):1002-8 [abstract]
• Flori HR, Glidden DV, Rutherford GW, Matthay MA. Pediatric Acute Lung Injury: Prospective Evaluation of Risk Factors Associated with Mortality. Am J Respir Crit Care Med. 2005;171 995-1001 [abstract]
• Levy MM, Baylor MS, Bernard GR, et al. Clinical Issues and Research in Respiratory Failure from Severe Acute Respiratory Syndrome. Am J Respir Crit Care Med. 2005;171 518-526 [abstract]
• Moran JL, Bersten AD, Solomon PJ. Meta-analysis of controlled trials of ventilator therapy in acute lung injury and acute respiratory distress syndrome: an alternative perspective. Intensive Care Med. 2005 Feb;31(2):227-35 [abstract]
• Bindl L, Dresbach K, Lentze MJ. Incidence of acute respiratory distress syndrome in German children and adolescents: A population-based study. Crit Care Med. 2005 Jan;33(1):209-312. [abstract] (File Cabinet)
• Keenan SP, Sinuff T, Cook DJ, Hill NS. Does noninvasive positive pressure ventilation improve outcome in acute hypoxemic respiratory failure? A systematic review. Crit Care Med. 2004 Dec;32(12):2516-2523. [abstract]
• Plotz FB, Slutsky AS, Van Vught AJ, Heijnen CJ. Ventilator-induced lung injury and multiple system organ failure: a critical review of facts and hypotheses. Intensive Care Med. 2004; 30:1865-1872. [abstract]
• Gajic O, Dara SI, Mendez JL, et al.Ventilator-associated lung injury in patients without acute lung injury at the onset of mechanical ventilation. Crit Care Med. 2004 Sep;32(9):1817-24 [abstract]
• Mechanical Ventilation, K Tegtmeyer, Oregon Health Sciences University (teaching file)
• Orfanos SE, Mavrommati I, Korovesi I, Roussos C. Pulmonary endothelium in acute lung injury: from basic science to the critically ill. Intensive Care Med 2004; 30:1702-1714. [abstract]
• Sadowski R, Dechert RE, Bandy KP, Juno J, Bhatt-Mehta V, Custer JR, Moler FW, Bratton SL. Continuous Quality Improvement: Reducing Unplanned Extubations in a Pediatric Intensive Care Unit. Pediatrics 2004;114:628Ð632. [abstract]
• NHLBI ARDS Clinical Trials Network. Higher versus Lower Positive End-Expiratory Pressures in Patients with the Acute Respiratory Distress Syndrome. New Engl J Med 2004; 351:327-336. [abstract]
  • PedsCCM EB Journal Club Review, by M White
• Petrucci N, Iacovelli W. Ventilation with Smaller Tidal Volumes: A Quantitative Systematic Review of Randomized Controlled Trials. Anesth Analg 2004;99 193-200. [abstract]
• Farias JA, Frutos F, Esteban A, et al. What is the daily practice of mechanical ventilation in pediatric intensive care units? A multicenter study. Intensive Care Med. 2004 May;30(5):918-25. [abstract]
• Ferrer M, Esquinas A, Leon M, Gonzalez G, Alarcon A, Torres A. Noninvasive ventilation in severe hypoxemic respiratory failure: a randomized clinical trial. Am J Respir Crit Care Med. 2003 Dec 15;168(12):1438-44 [abstract]
  • PedsCCM EB Journal Club Review, by H Sahhar
• Nava S, Carbone G, DiBattista N, et al. Noninvasive ventilation in cardiogenic pulmonary edema: a multicenter randomized trial. Am J Respir Crit Care Med. 2003 Dec 15;168(12):1432-7 [abstract]
  • PedsCCM EB Journal Club Review, by L Thompson
• Anton N, Joffe KM, Joffe AR. Inability to predict outcome of acute respiratory distress syndrome in children when using high frequency oscillation. Intensive Care Med. 2003 Oct;29(10):1763-9 [abstract]
• David M, Weiler N, Heinrichs W, et al. High-frequency oscillatory ventilation in adult acute respiratory distress syndrome. Intensive Care Med. 2003 Oct;29(10):1656-65 [abstract]
  • PedsCCM EB Journal Club Review, by J O'Rourke, N Mehta
• Richard C, Warszawski J, Angurl N, et al. Early Use of the Pulmonary Artery Catheter and Outcomes in Patients With Shock and Acute Respiratory Distress Syndrome: A Randomized Controlled Trial. JAMA 2003;290 2713-2720. [abstract]
  • PedsCCM EB Journal Club Review, by S. Thammasitboon, S. Cortes
• Kurachek SC, Newth CJ, Quasney MW, et al. Extubation failure in pediatric intensive care: A multiple-center study of risk factors and outcomes. Crit Care Med. 2003 Nov;31(11):2657-64. [abstract]
  • PedsCCM EB Journal Club Review, by S Primis, A Wratney, I Cheifetz
• DiCarlo JV, Alexander SR, Agarwal R, Schiffman JD. Continuous veno-venous hemofiltration may improve survival from acute respiratory distress syndrome after bone marrow transplantation or chemotherapy. J Pediatr Hematol Oncol. 2003 Oct;25(10):801-5. [abstract]
  • PedsCCM EB Journal Club Review, by E Cullen
• Flori HR, Ware LB, Glidden D, Matthay MA. Early elevation of plasma soluble intercellular adhesion molecule-1 in pediatric acute lung injury identifies patients at increased risk of death and prolonged mechanical ventilation. Pediatr Crit Care Med. 2003 Jul;4(3):315-321. [abstract]
• Marraro GA. Innovative practices of ventilatory support with pediatric patients. Pediatric Critical Care Medicine 2003; 4(1):8-20. [abstract; full-text pdf 312K]
• Eichacker PQ, Gerstenberger EP, Banks SM, Cui X, Natanson C. Meta-Analysis of Acute Lung Injury and Acute Respiratory Distress Syndrome Trials Testing Low Tidal Volumes. Am J Respir Crit Care Med 2002; 166: 1510-1514. [full-text for subscribers]
• Martin GS, Mangialardi RJ, Wheeler AP, Dupont WD, Morris JA, Bernard GR. Albumin and furosemide therapy in hypoproteinemic patients with acute lung injury. Crit Care Med 2002;30(10):2175-82 [abstract]
  • PedsCCM EB Journal Club Review, by D Godorov
• Derdak S, Mehta S, Stewart TE et al. High-Frequency Oscillatory Ventilation for Acute Respiratory Distress Syndrome in Adults. Am J Resp Crit Care Med 2002; 166:801-808. [abstract]
  • PedsCCM EB Journal Club Review by K Ventre
• Nuckton TJ, Alonso JA, Kallet RH, Daniel BM, Pittet JF, Eisner MD, Matthay MA. Pulmonary dead-space fraction as a risk factor for death in the acute respiratory distress syndrome. N Engl J Med. 2002;346(17):1281-6. [abstract; full-text for subscribers]
  • PedsCCM EB Journal Club Review, by S Kannan, K Meert
• Plötz, Vreugdenhil HAE, Slutsky AS et al. Mechanical ventilation alters the immune response in children without lung pathology. Intensive Care Med 2002; 28: 486-492. [abstract; full-text for subscribers]
• Kopp R, Kuhlen R, Max M, Rossaint R. Evidence-based medicine in the therapy of the acute respiratory distress syndrome. Intensive Care Med 2002; 28: 244-255. [abstract; full-text for subscribers]
• Gattinoni L, Caironi P, Pelosi P, Goodman LR. What Has Computed Tomography Taught Us about the Acute Respiratory Distress. Am J Respir Crit Care Med. 2001;164 1701-1711. [full-text for subscribers]
• Vincent JL, Brase R, Santman F, et al. A multi-centre, double-blind, placebo-controlled study of liposomal prostaglandin E1 (TLC C-53) in patients with acute respiratory distress syndrome. Intensive Care Med 2001; 27: 1578-1583. [abstract; full-text for subscribers]
• Bersten AD, Hunt T, Nicholas TE, Doyle IR. Elevated Plasma Surfactant Protein-B Predicts Development of Acute Respiratory Distress Syndrome in Patients with Acute Respiratory Failure. Am J Respir Crit Care Med 2001;164 648-652. [abstract; full-text for subscribers]
  • Review by S Huntoon Vitali
• Eisner MD, Thompson T, Hudson L et al. Efficacy of Low Tidal Volume Ventilation in Patients with Different Clinical Risk Factors for Acute Lung Injury and the Acute Respiratory Distress Syndrome. Am J Respir Crit Care Med 2001; 164: 231-236. [abstract; full-text for subscribers]
• Granton J. The acute respiratory distress syndrome (ARDS). Critical Care Rounds 2000; 1:(2) [full-text pdf]
• Putensen C, Zech S, Wrigge H, et al. Long-Term Effects of Spontaneous Breathing During Ventilatory Support in Patients with Acute Lung Injury. Am J Respir Crit Care Med 2001; 164:43-49. [abstract; full-text for subscribers]
  • PedsCCM EB Journal Club Review, by S Kache, V Kesavulu
• Crotti S, Mascheroni D, Caironi P, et al. Recruitment and Derecruitment during Acute Respiratory Failure: A Clinical Study. Am J Respir Crit Care Med 2001; 164:131-140. [abstract; full-text for subscribers]
• Edmunds S, Weiss I, Harrison R. Extubation Failure in a Large Pediatric ICU Population. Chest. 2001;119:897-900. [abstract] [full-text for subscribers]
• Dreyfuss D, Saumon G. Pressure-Volume Curves . Searching for the Grail or Laying Patients with Adult Respiratory Distress Syndrome on Procrustes' Bed? Am J Respir Crit Care Med 2001; 163: 2-3. [full-text for subscribers]
• Delclaux C, L'Her E, Alberti C, et al. Treatment of Acute Hypoxemic Nonhypercapnic Respiratory Insufficiency With Continuous Positive Airway Pressure Delivered by a Face Mask: A Randomized Controlled Trial. JAMA. 2000;284(18):2352-2360. [abstract][full-text]
  • PedsCCM EB Journal Club Review, by C. Davison
• McIntyre RC Jr, Pulido EJ, Bensard DD, Shames BD, Abraham E. Thirty years of clinical trials in acute respiratory distress syndrome. Crit Care Med. 2000;28(9):3314-31. [abstract]
• Mangialardi RJ, Martin GS, Bernard GR, et al. Hypoproteinemia predicts acute respiratory distress syndrome development, weight gain, and death in patients with sepsis. Ibuprofen in Sepsis Study Group. Crit Care Med. 2000;28(9):3137-45. [abstract]
  • PedsCCM EB Journal Club Review, by N Faqih
• Evan TW. International Consensus Conferences in Intensive Care Medicine: Non-invasive positive pressure ventilation in acute respiratory failure, Intensive Care Med 2000 DOI 10.1007/s001340000721 [abstract/full-text]
• Antonelli M, Conti G, Bufi M, et al. Noninvasive Ventilation for Treatment of Acute Respiratory Failure in Patients Undergoing Solid Organ Transplantation; A Randomized Trial. AMA. 2000;283:235-241. [abstract] [full-text free for limited time]
  • PedsCCM EB Journal Club Review by P. Prabhakaran, M. Mariscalco
• Arnold JH, Hanson JH, Toro-Figuero LO, Gutierrez J, Berens RJ, Anglin DL. Prospective, randomized comparison of high-frequency oscillatory ventilation and conventional mechanical ventilation in pediatric respiratory failure. Crit Care Med. 1994;22(10):1530-9. [abstract]
  • PedsCCM EB Journal Club Review, by X. Garcia
• Arnold JH, Anas NG, Luckett P, et al. High-frequency oscillatory ventilation in pediatric respiratory failure: a multicenter experience. Crit Care Med. 2000;28(12):3913-9. [abstract]
• Esteban A, Alia I, Gordo F, et al. Prospective Randomized Trial Comparing Pressure-Controlled Ventilation and Volume-Controlled Ventilation in ARDS. Chest. 2000 Jun;117(6):1690-1696. [abstract] [full-text for subscribers]
  • PedsCCM EB Journal Club Review, by A Pelaez
• Practice Guidelines and Consensus Conference Reports from the American College of Chest Physicians
  • Mechanical Ventilation Beyond the Intensive Care Unit. Quick reference guide for clinicians. Adapted from Chest 1998:113(suppl):289S-344S.
• Varpula T, Pettilä, Rintala E, Takkunen O, Valtonen. Late steroid therapy in primary acute lung injury. Intensive Care Med 2000; 26:526-531. [abstract]
  • PedsCCM EB Journal Club Review by U. Narsinghani, M. Heulitt
• The ARDS Network Authors for the ARDS Network. Ketoconazole for Early Treatment of Acute Lung Injury and Acute Respiratory Distress Syndrome: A Randomized Controlled Trial JAMA. 2000;283:1995-2002. [abstract] [full-text for subscribers only]
• Acute Respiratory Distress Syndrome Network. Ventilation with Lower Tidal Volumes as Compared with Traditional Tidal Volumes for Acute Lung Injury and the Acute Respiratory Distress Syndrome. N Engl J Med 2000;342: 1301-1308 [abstract]
  • PedsCCM EB Journal Club Review by S. Cray
• Clark RH, Gerstmann DR, Slutsky AS. Lung Protective Strategies of Ventilation in the Neonate: What Are They? Pediatrics 2000; 105:112-114. [full-text for subscribers/AAP members]
• International Consensus Conferences in Intensive Care Medicine: Ventilator-associated Lung Injury in ARDS. Am J Respir Crit Care Med 1999; 160: 2118-2124. [full-text for subscribers]
• Brower RG, Shanholtz CB, Fessler HE, et al. Prospective, randomized, controlled clinical trial comparing traditional versus reduced tidal volume ventilation in acute respiratory distress syndrome patients. Crit Care Med 1999;27:1492-8. [abstract]
  • PedsCCM EB Journal Club Review, by P. Prabhakaran
• Effect of enteral feeding with eicosapentaenoic acid, gamma-linolenic acid, and antioxidants in patients with acute respiratory distress syndrome. Enteral Nutrition in ARDS Study Group. Gadek JE, DeMichele SJ, Karlstad MD, et al. Crit Care Med 1999;27:1409-20. [abstract]
  • PedsCCM EB Journal Club Review, by S. Bateman
• Jubran A. Advances in Respiratory Monitoring During Mechanical Ventilation. Chest 1999 116: 1416-1425. [abstract] [full-text for subscribers]
• Rossi R, Shemie SD, Calderwood S. Prognosis of pediatric bone marrow transplant recipients requiring mechanical ventilation. Crit Care Med 1999;27:1181-6. [abstract]
  • PedsCCM EB Journal Club Review, by J. Heggen, J. Fortenberry
• Keenan HT, Bratton SL, Martin LD, Crawford SW, Weiss NS. Outcome of children who require mechanical ventilatory support after bone marrow transplantation. Crit Care Med. 2000 Mar;28(3):830-5.[abstract]
  • PedsCCM EB Journal Club Review, by X. Garcia, H. Tcharmtchi
• Ranieri VM, Suter PM, Tortorella C, et al. Effect of Mechanical Ventilation on Inflammatory Mediators in Patients with Acute Respiratory Distress Syndrome: A Randomized Controlled Trial. JAMA 1999; 282:54-61. [abstract; full-text for subscribers]
  • PedsCCM EB Journal Club Review, by S Kache, R Harrison
• Cardiovascular effects of mechanical ventilation. Shekerdemian L, Bohn D. Arch Dis Child 1999; 80: 475-480. [full-text until July, 1999]
• Spontaneous Breathing During Ventilatory Support Improves Ventilation-Perfusion Distributions in Patients with Acute Respiratory Distress Syndrome. Putensen C, Mutz NJ, Putensen-Himmer G, Zinserling J. Am J Respir Crit Care Med 1999; 159: 1241-1248. [abstract] [full-text for subscribers]
• Sigh in Acute Respiratory Distress Syndrome. Pelosi P, Cadringher P, Bottino N, et al. Am J Respir Crit Care Med 1999; 159: 872-880. [abstract] [full-text for subscribers]
• An evidence-based approach to pressure- and volume-limited ventilation strategies. Meade MO. Crit Care Clin 1998; 14:373-85. [abstract]
• Tidal Volume Reduction for Prevention of Ventilator-induced Lung Injury in Acute Respiratory Distress Syndrome. Brochard L, Roudot-Thoraval F, Roupie E et al. Am J Respir Crit Care Med 1998; 158: 1831-1838. [abstract] [full-text for subscribers]
  • PedsCCM EB Journal Club Review, by G. Tse
• Acute Respiratory Failure. Haafiz A, Kissoon N. Jacksonville Medicine September 1998.
• Antonelli M, Conti G, Rocco M, et al. A Comparison of Noninvasive Positive-Pressure Ventilation and Conventional Mechanical Ventilation in Patients with Acute Respiratory Failure. N Engl J Med 1998; 339: 429-435. [abstract]
  • PedsCCM EB Journal Club Review, by G. Deshpande, K. Meert
• Pediatrics, Respiratory Distress Syndrome. Steele D. In Emergency Medicine at Emedicine
• Acute Respiratory Distress Syndrome Caused by Pulmonary and Extrapulmonary Disease: Different Syndromes? Gattinoni L, Pelosi P, Suter PM et al. Am J Respir Crit Care Med 1998; 158:3-11. (full-text for subscribers only; abstract). With an editorial: Respiratory System Mechanics in Adult Respiratory Distress Syndrome: Stretching Our Understanding. Hall J. Am J Respir Crit Care Med 1998; 158: 1-2. (full-text, limited time)
• Varpula T, Pettilä V, Rintala E, Takkunen O, Valtonen V. Late steroid therapy in primary acute lung injury. Intensive Care Med 26 (2000) 5, 526-531. [abstract]
• Effect of Prolonged Methylprednisolone Therapy in Unresolving Acute Respiratory Distress Syndrome - A Randomized Controlled Trial. Meduri GU, Headley AS, Golden E, Carson SJ, Umberger RA, Kelso T, Tolley EA. JAMA 1998; 280:159-165. (abstract)
  • PedsCCM EB Journal Club Review, by M. Kelly, S. Pon
• AutoPEEP and Work of Breathing. Wilson J, Peterson MW. 1997. From the Adult Critical Care Core Curriculum of The Virtual Hospital, University of Iowa.
• Kress JP, O'Connor MF, Schmidt GA. Clinical Examination Reliably Detects Intrinsic Positive End-Expiratory Pressure in Critically Ill, Mechanically Ventilated Patients. Am J Respir Crit Care Med 1999; 159: 290-294. [abstract; full-text for subscribers]
  • PedsCCM EB Journal Club Review, by R. Orellana, M. McPherson
• Peters MJ, Tasker RC, Kiff KM, Yates R, Hatch DJ. Acute hypoxemic respiratory failure in children: case mix and the utility of respiratory severity indices. Intensive Care Med. 1998;24(7):699-705. [abstract]
• Acute lung injury and the acute respiratory distress syndrome. Luce JM. Crit Care Med 1998; 26: 369-376 [abstract]
• Adult Respiratory Distress Syndrome. Rothenhaus T., from Emergency Medicine at Emedicine
• Several articles and an editorial on barotrauma and mechanical ventilation strategies for ARDS in the February 5, 1998 issue of the New England Journal of Medicine:
  • Weg JG, Anzueto A, Balk RA et al. The Relation of Pneumothorax and Other Air Leaks to Mortality in the Acute Respiratory Distress Syndrome. N Engl J Med 1998; 338: 341-6. [abstract]
    • Critical Appraisal of this paper from Critically Appraised Topics at SORAHSN.
  • Amato MBP, Barbas CSV, Medeiros DM, et al. Effect of a Protective-Ventilation Strategy on Mortality in the Acute Respiratory Distress Syndrome. N Engl J Med 1998; 338: 347-354. [abstract]
    • PedsCCM EB Journal Club Review by K. Obata
    • Critical Appraisal of this paper from Critically Appraised Topics at SORAHSN.
  • Stewart TE, Meade MO, Cook DJ, et al. Evaluation of a Ventilation Strategy to Prevent Barotrauma in Patients at High Risk for Acute Respiratory Distress Syndrome. N Engl J Med 1998; 338: 355-361. [abstract]
    • PedsCCM EB Journal Club Review, by M. McPherson, M. Mariscalco
  • With an accompanying full-text editorial: Hudson LD. Protective Ventilation for Patients with Acute Respiratory Distress Syndrome. N Engl J Med 1998; 338: 385-7. [citation]
• Acute Respiratory Failure, diagnosis and management, from Emergency Medicine at The Virtual Hospital, University of Iowa
• Curley MA, Thompson JE, Arnold JH. The effects of early and repeated 8 positioning in pediatric patients with acute lung injury. Chest. 2000 Jul;118(1):156-63. [abstract]
• McAuley DF, Giles S, Fichter H, Perkins GD, Gao F. What is the optimal duration of ventilation in the prone position in acute lung injury and acute respiratory distress syndrome? Intensive Care Med 2002;28: 414-418. [abstract; full-text for subscribers]
• Messerole E, Peine P, Wittkopp S, Marini JJ, Albert RK. The Pragmatics of Prone Positioning. Am J Respir Crit Care Med 2002; 165: 1359-1363. [full-text for subscribers]
• L'Her E, Renault A, Oger E, et al. A prospective survey of early 12-h prone positioning effects in patients with the acute respiratory distress syndrome. Intensive Care Med 2002;28: 570-575. [abstract; full-text for subscribers]
• Gattinoni L, Tognoni G, Pesenti A et al. Effect of Prone Positioning on the Survival of Patients with Acute Respiratory Failure. New Engl J Med 2001; 345:568-573. [abstract; full-text for subscribers]
  • PedsCCM EB Journal Club Review, by P Kamat
• Relvas MS, Silver PC, Sagy M. Prone Positioning of Pediatric Patients With ARDS Results in Improvement in Oxygenation if Maintained > 12 h Daily. Chest. 2003;124(1):269-74. [abstract]
• Effects of the prone position on gas exchange and hemodynamics in severe acute respiratory distress syndrome. Jolliet P, Bulpa P, Chevrolet JC. Crit Care Med 1998;26:1977-85. [abstract]
  • PedsCCM EB Journal Club Review, by V. Gharpure, K. Meert
• Kornecki A, Frndova H, Coates AL, Shemie SD. A Randomized Trial of Prolonged Prone Positioning in Children With Acute Respiratory Failure. Chest 2001 119: 211-218. [Abstract] [Full-text for subscribers]
  • PedsCCM EB Journal Club Review by L Wise-Faberowski
• Hammer GB, Fitzmaurice BG, Brodsky JB. Methods for single-lung ventilation in pediatric patients. Anesth Analg. 1999;89:1426-9. [citation] [full-text for subscribers only]
• Effect of prone and supine positions on functional residual capacity, oxygenation, and respiratory mechanics in ventilated infants and children. Numa AH, Hammer J, Newth CJ. Am J Respir Crit Care Med 1997; 156:1185-1189 [abstract]
• Effects of the Prone Position on Respiratory Mechanics and Gas Exchange during Acute Lung Injury. Pelosi P, Tubiolo D, Mascheroni D, et al. Am J Respir Crit Care Med Volume 1998;157:387-393. [abstract] [full-text for subscribers]
• Effects of ventilation in ventral decubitus position on respiratory mechanics in adult respiratory distress syndrome. Servillo G, Roupie E, De Robertis E, Rossano F, Brochard L, Lemaire F, Tufano R. Intensive Care Med 1997; 23: 1219-1224. (abstract)
• How to use articles about harm: the relationship between high tidal volumes, ventilating pressures, and ventilator-induced lung injury. Meade MO, Cook DJ, Kernerman P, Bernard G. Crit Care Med 1997; 25:1915-1922. [abstract]
• Elective High-frequency Oscillatory Ventilation Versus Conventional Ventilation in Preterm Infants With Pulmonary Dysfunction: Systematic Review and Meta-analyses. Bhuta T, Henderson-Smart DJ. Pediatrics 1997; 100(5): e6 (full-text)
• A Physiologic Approach to Mechanical Ventilation in the Patient with ARDS
  • by Randall Flick, MD
• A Brief Review of Smoke Inhalation Injury
  • by Rob Sheridan
• Adult Respiratory Distress Syndrome: Myths and Controversies, Varon, JV, Wenker, O. The Internet Journal of Anesthesiology; 1997: vol 1, no 1.

Weaning from Mechanical Ventilation

• Nava S, Gregoretti C, Fanfulla F, et al. Noninvasive ventilation to prevent respiratory failure after extubation in high-risk patients. Crit Care Med. 2005 Nov;33(11):2465-2470. [abstract]
• Jubran A, Grant BJ, Laghi F, Parthasarathy S, Tobin MJ. Weaning Prediction: Esophageal Pressure Monitoring Complements Readiness Testing. Am J Respir Crit Care Med. 2005; 171 1252-1259. [abstract]
• Baisch SD, Wheeler WB, Kurachek SC, Cornfield DN. Extubation failure in pediatric intensive care incidence and outcomes. Pediatr Crit Care Med. 2005 May;6(3):312-318 [abstract]
• Marcin JP, Rutan E, Rapetti PM, Brown JP, Rahnamayi R, Pretzlaff RK. Nurse staffing and unplanned extubation in the pediatric intensive care unit. Pediatr Crit Care Med. 2005 May;6(3):254-257. [abstract]
• Fontela PS, Piva JP, Garcia PC, Bered PL, Zilles K. Risk factors for extubation failure in mechanically ventilated pediatric patients. Pediatr Crit Care Med. 2005 Mar;6(2):166-170. [abstract]
• Esteban A, Frutos-Vivar F, Ferguson ND, et al. Noninvasive Positive-Pressure Ventilation for Respiratory Failure after Extubation. New Engl J Med 2004; 350:2452-2460. [abstract]
  • PedsCCM EB Journal Club Review, by T Cholis
• Conti G, Montini L, Pennisi MA, et al. A prospective, blinded evaluation of indexes proposed to predict weaning from mechanical ventilation. Intensive Care Med. 2004 May;30(5):830-6. [abstract]
• Krishnan JA, Moore D, Robeson C, Rand CS, Fessler HE. A Prospective, Controlled Trial of a Protocol-based Strategy to Discontinue Mechanical Ventilation. Am J Respir Crit Care Med 2004;169 673-678 [abstract]
  • PedsCCM EB Journal Club Review, by A Lee, M Nilufer Ozturk
• Ferrer M, Esquinas A, Arancibia F, et al. Non-invasive ventilation during persistent weaning failure. A randomized controlled trial. Am J Respir Crit Care Med. 2003;168(1):70-6 [abstract]
  • PedsCCM EB Journal Club Review by L Smith
• Randolph AG, Wypij D, Venkataraman ST, Hanson JH, Gedeit RG, Meert KL, Luckett PM, Forbes P, Lilley M, Thompson J, Cheifetz IM, Hibberd P, Wetzel R, Cox PN, Arnold JH, for the Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network. Effect of Mechanical Ventilator Weaning Protocols on Respiratory Outcomes in Infants and Children: A Randomized Controlled Trial. JAMA. 2002;288:2561-2568. [abstract]
  • PedsCCM EB Journal Club Review, by M Twite
• Randolph AG, Forbes PW, Gedeit RG, Arnold JH, Wetzel RC, Luckett PM, O'neil ME, Venkataraman ST, Meert KL, Cheifetz IM, Cox PN, Hanson JH; for the Pediatric Acute Lung Injury & Sepsis Investigators (PALISI) Network. Cumulative fluid intake minus output is not associated with ventilator weaning duration or extubation outcomes in children. Pediatr Crit Care Med. 2005 Nov;6(6):642-647 [abstract]
• MacIntyre NR. Evidence-Based Guidelines for Weaning and Discontinuing Ventilatory Support : A Collective Task Force Facilitated by the American College of Chest Physicians; the American Association for Respiratory Care; and the American College of Critical Care Medicine. Chest 2002; 120: 375S-396S. [full-text for subscribers] In: "Evidence-Based Guidelines for Weaning and Discontinuing Ventilatory Support. Supplement to Chest 2001; 120(6). [table of contents]
• Khamiees M, Raju P, DeGirolamo A, Amoateng-Adjepong Y, Manthous CA. Predictors of Extubation Outcome in Patients Who Have Successfully Completed a Spontaneous Breathing Trial. Chest 2001;120 1262-1270. [abstract: full-text for subscribers]
  • PedsCCM EB Journal Club Review, by J Barron
• Smyrnios NA, Connolly A, Wilson MM, et al. Effects of a multifaceted, multidisciplinary, hospital-wide quality improvement program on weaning from mechanical ventilation. Crit Care Med. 2002;30(6):1224-30. [abstract; full-text for subscribers]
  • PedsCCM EB Journal Club Review, by S and S Thammasitboon
• Farias JA, Alía I, Retta A, et al. An evaluation of extubation failure predictors in mechanically ventilated infants and children. Intensive Care Med 2002; 28:752-757. [abstract]
  • PedsCCM EB Journal Club Review, by A Wratney, DK Benjamin, IM Cheifetz
• Farias JA, Retta A, I. Alía, et al. A comparison of two methods to perform a breathing trial before extubation in pediatric intensive care patients. Intensive Care Med 2001; 27:1649-1654. [abstract; full-text for subscribers]. Commentary: Brochard L. Weaning from mechanical ventilation. When paediatric intensive care medicine profits from adult experience and vice-versa. Intensive Care Med 2001; 27:1564-1566L. [full-text for subscribers]
  • PedsCCM EB Journal Club Review, by A Arikan, M McPherson
• Polkey MI, Moxham J. Clinical Aspects of Respiratory Muscle Dysfunction in the Critically Ill. Chest 2001 119: 926-939. [full-text for subscribers]
• Criteria for Weaning from Mechanical Ventilation. Evidence Report/Technology Assessment. From the Evidence-Based Practice Program of the US Agency for Healthcare Research and Quality. [full-text]
• Venkataraman ST, Khan N, Brown A. Validation of predictors of extubation success and failure in mechanically ventilated infants and children. Crit Care Med. 2000;28(8):2991-6. [abstract]
  • PedsCCM EB Journal Club Review, by D. Epstein, R. Bart
• Uusaro A, Chittock DR, Russell JA, Walley KR. Stress test and gastric-arterial PCO2 measurement improve prediction of successful extubation. Crit Care Med. 2000;28(7):2313-9. [abstract]
  • PedsCCM EB Journal Club Review by N Hoover, A Vats
• Marelich GP, Murin S, Battistella F, Inciardi J, Vierra T, Roby M. Protocol Weaning of Mechanical Ventilation in Medical and Surgical Patients by Respiratory Care Practitioners and Nurses : Effect on Weaning Time and Incidence of Ventilator-Associated Pneumonia. Chest. 2000;118(2):459-467. [abstract] [full-text for subscribers]
• Farias JA, Alia I, Esteban A, Golubicki, Olazarri FA. Weaning from mechanical ventilation in pediatric intensive care patients. Intensive Care Med 1998; 24: 1070-1075. [abstract]
  • PedsCCM EB Journal Club Review by P. Jines, A. Madikians
• Jaber S, Carlucci A, Boussarsar M et al. Helium-Oxygen in the Postextubation Period Decreases Inspiratory Effort. Am J Respir Crit Care Med 2001;164 633-637. [abstract; full-text for subscribers]
• Effect of Spontaneous Breathing Trial Duration on Outcome of Attempts to Discontinue Mechanical Ventilation. Esteban A, Alia I, Tobin MJ, et al. Am J Respir Crit Care Med 1999;159:512-518. [abstract]
• Hubble CL, Gentile MA, Tripp DS, Craig DM, Meliones JN, Cheifetz IM. Deadspace to tidal volume ratio predicts successful extubation in infants and children. Crit Care Med. 2000;28(6):2034-40. [abstract]
  • PedsCCM EB Journal Club Review, by A. Torres
• Brochard L, Rauss A, Benito S, et al. Comparison of three methods of gradual withdrawal from ventilatory support during weaning from mechanical ventilation. Am J Respir Crit Care Med 1994; 150:896-903 [abstract]
  • Critical Appraisal of this paper from Critically Appraised Topics at SORAHSN.
• Manczur TI, Greenought A, Pryor D, Rafferty GF. Comparison of predictors of extubation from mechanical ventilation in children. Pediatr Crit Care Med 2000; 1:28-32.
  • PedsCCM EB Journal Club Review, by S. Venkataraman
• Predictors of Successful Extubation in Children. Thiagarajan RR. Bratton SL, Martin LD, Brogan TV, Taylor D. Am J Respir Crit Care Med Volume 1999; 160:1562-1566. [abstract] [full-text for subscribers]
• Baumeister BL, el-Khatib M, Smith PG, Blumer JL. Evaluation of predictors of weaning from mechanical ventilation in pediatric patients. Pediatr Pulmonol. 1997;24:344-52. [abstract]
  • PedsCCM EB Journal Club Review, by S. Venkataraman
• Butler R, Keenan SP, Inman KJ, Sibbald WJ, Block G. Is there a preferred technique for weaning the difficult-to-wean patient? A systematic review of the literature. Crit Care Med. 1999;27:2331-6. [abstract]
  • PedsCCM EB Journal Club Review by A. Torres, J. Wohrley
• A randomized, controlled trial of protocol-directed versus physician-directed weaning from mechanical ventilation. Kollef MH, Shapiro SD, Silver P, et al. Crit Care Med 1997; 25:567-574. [abstract]
  • Critical Appraisal of this paper from Critically Appraised Topics at SORAHSN.

Experimental Therapies

• References about Liquivent (perflubron):
  • Partial Liquid Ventilation in Critically Ill Infants Receiving Extracorporeal Life Support. Greenspan, J.S. et al. Pediatrics 1997; 99(1):e2. (full-text)
  • Leach, C. et al. Partial Liquid Ventilation with Perflubron in Premature Infants with Severe Respiratory Distress Syndrome. N Engl J Med 1996; 335: 761-767. [abstract]

    With an full-text editorial: Merritt, T.A., Heldt, G.P. Partial Liquid Ventilation - The Future is Now. N Engl J Med 1996; 814-815. [citation]

• Surfactant
  • Spragg RG, Lewis JF, Walmrath HD, et al. Effect of recombinant surfactant protein C-based surfactant on the acute respiratory distress syndrome. New Engl J Med 2004; 351:884-892. [abstract]
    • PedsCCM EB Journal Club Review, by F Norozian
  • Thomas NJ, Hollenbeak CS, Lucking SE, Willson DF. Cost-effectiveness of exogenous surfactant therapy in pediatric patients with acute hypoxemic respiratory failure. Pediatr Crit Care Med. 2005 Mar;6(2):160-165. [abstract]
  • Willson DF, Thomas NJ, Markovitz BP et al. Effect of Exogenous Surfactant (Calfactant) in Pediatric Acute Lung Injury: A Randomized Controlled Trial. JAMA 2005;293 470-476 [abstract]
    • PedsCCM EB Journal Club Review, by A Shieh Czaja
  • Moller JC, Schaible T, Roll C, et al. Treatment with bovine surfactant in severe acute respiratory distress syndrome in children: a randomized multicenter study. Intensive Care Med. 2003;29(3):437-46. [abstract]
    • Review, by N Mehta
  • Tibby SM, Hatherill M, Wright SM et al. Exogenous Surfactant Supplementation in Infants with Respiratory Syncytial Virus Bronchiolitis Am J Respir Crit Care Med 2000; 162: 1251-1256. [Abstract] [Full-text for subscribers]
  • Inhalational Therapy in Ventilatory Failure. Sainsbury D. (slide presentation 7/1998), from Paediatric Anaesthesia, at South Australia Women's and Children's Hospital, North Adelaide
  • López-Herce J, de Lucas N, Carrillo A, Bustinza A, Moral R. Surfactant treatment for acute respiratory distress syndrome. Arch Dis Child 1999;80:248-252. [abstract]
    • PedsCCM EB Journal Club Review by J. Barron, A. Madikians
  • Instillation of calf lung surfactant extract (calfactant) is beneficial in pediatric acute hypoxemic respiratory failure. Willson DF, Zaritsky A, Bauman LA, et al. Crit Care Med 1999;27:188-95. [abstract]
    • PedsCCM EB Journal Club Review, by P. Srivaths, K. Meert
  • Anzueto, A. et al. Aerosolized Surfactant in Adults with Sepsis-Induced Acute Respiratory Distress Syndrome.N Engl J Med 1996; 334: 1417-1421 [abstract]

    With an accompanying full-text editorial: Matthay M. The Acute Respiratory Distress Syndrome. N Engl J Med 1996; 334: 1469-1470 [citation]

• Nitric Oxide
  • Fioretto JR, De Moraes MA, Bonatto RC, Ricchetti SM, Carpi MF. Acute and sustained effects of early administration of inhaled nitric oxide to children with acute respiratory distress syndrome. Pediatr Crit Care Med. 2004 Sep;5(5):469-74 [abstract; full-text (192K)]
    • PedsCCM EB Journal Club Review, by J Matchey
  • Taylor RW, Zimmerman JL, Dellinger RP, et al. Low-dose inhaled nitric oxide in patients with acute lung injury: a randomized controlled trial. JAMA. 2004 Apr 7;291(13):1603-9 [abstract]
    • PedsCCM EB Journal Club Review, by R Orellana
  • Sokol J, Jacobs SE, Bohn D. Inhaled nitric oxide for acute hypoxemic respiratory failure in children and adults (Cochrane Review). In: The Cochrane Library, Issue 4 2002. Oxford: Update Software. [abstract]
    • Review by S and S Thammasitboon
  • Gerlach H, Keh D, Semmerow A, et al. Dose-Response Characteristics during Long-Term Inhalation of Nitric Oxide in Patients with Severe Acute Respiratory Distress Syndrome: A Prospective, Randomized, Controlled Study. Am J Respir Crit Care Med. 2003;167(7):1008-15. [abstract]
  • Dobyns EL, Anas NG, Fortenberry JD, Deshpande J, Cornfield DN, Tasker RC, Liu P, Eells PL, Griebel J, Kinsella JP, Abman SH. Interactive effects of high-frequency oscillatory ventilation and inhaled nitric oxide in acute hypoxemic respiratory failure in pediatrics. Crit Care Med. 2002;30(11):2425-9. [abstract]
  • Finer NN, Sun JW, Rich W et al. Randomized, Prospective Study of Low-Dose Versus High-Dose Inhaled Nitric Oxide in the Neonate With Hypoxic Respiratory Failure. Pediatrics 2001;108 949-955. [abstract][full-text for subscribers]
  • Miller OI, Tang SF, Keech A, et al. Inhaled nitric oxide and prevention of pulmonary hypertension after 7 heart surgery: a randomised double-blind study. Lancet 2000;356:1464-1469. [abstract]
    • PedsCCM EB Journal Club Review, by K.Daphtary, K. Meert
  • Committee on Fetus and Newborn. Use of Inhaled Nitric Oxide. AAP Policy Statement. Pediatrics 2000;106:344-345. [full-text]
  • Dobyns EL, Cornfield DN, Anas NG, et al. Multicenter randomized controlled trial of the effects of inhaled nitric oxide therapy on gas exchange in children with acute hypoxemic respiratory failure. J Pediatr. 1999;134:406-12. [abstract] [full-text for subscribers]
    • PedsCCM EB Journal Club Review, by A. Torres
    • Review by L. Faberowski (as surrogate endpoint study)
  • The Food and Drug Administration of the US approves iNO for neonatal respiratory failure: Inhaled nitric oxide "in conjunction with ventilatory support and other appropriate agents, is indicated for the treatment of term and near-term (>34 weeks) neonates with hypoxic respiratory failure associated with clinical or echocardiographic evidence of pulmonary hypertension..." [label (pdf)] [letter (pdf)]
  • Inhalational Therapy in Ventilatory Failure. Sainsbury D. (slide presentation 7/1998), from Paediatric Anaesthesia, at South Australia Women's and Children's Hospital, North Adelaide
  • Inhaled Nitric Oxide and Vasoconstrictors in Acute Respiratory Distress Syndrome. Papazian L, Roch A, Bregeon F, et al. Am J Respir Crit Care Med 1999; 160:473-479. [abstract] [full-text for subscribers]
  • Low-dose inhaled nitric oxide improves the oxygenation and ventilation of infants and children with acute, hypoxemic respiratory failure. Ream RS, Hauver JF, Lynch RE, et al. Crit Care Med 1999;27:989-96. [abstract]
    • Review, by R. Sanders
  • Siddon TE, Asif M, Gigenbottam TW. Therapeutic Role of Nitric Oxide in Respiratory Disease. Medscape Pulmonary Medicine 2000; 4(2). [full-text]
  • Randomised trial of three doses of inhaled nitric oxide in acute respiratory distress syndrome. Tang SF, Sherwood MC, Miller OI. Arch Dis Child 1998; 79: 415-418 [full-text until July 1999] [abstract]
  • The efficacy of inhaled nitric oxide in the treatment of acute respiratory distress syndrome. An evidence-based medicine approach. Greene JH, Klinger JR. Crit Care Clin 1998; 14:387-409. [abstract]
  • Intravenous Almitrine Combined with Inhaled Nitric Oxide for Acute Respiratory Distress Syndrome. Gallart L, Lu Q, Puybasset L, et al. Am J Respir Crit Care Med 1998; 158:1770-1777 [abstract] [full-text for subscribers]
    • PedsCCM EB Journal Club Review, by S. Cray
  • Cardiopulmonary Effects of Aerosolized Prostaglandin E1 and Nitric Oxide Inhalation in Patients with Acute Respiratory Distress Syndrome. Putensen C, Hörmann C, Kleinsasser A, Putensen-Himmer G. Am J Respir Crit Care Med 1998; 157: 1743-1747 (full-text for subscribers only)
  • Inhaled Nitric Oxide Versus Conventional Therapy: Effect on Oxygenation in ARDS. Michael JR, Barton RG, Saffle JR, et al. Am J Respir Crit Care Med 1998; 157: 1372-1380. (full-text for subscribers only) With an accompanying editorial: Is Nitric Oxide Inhalation a "Cosmetic" Therapy in Acute Respiratory Distress Syndrome? Payen DM. Am J Respir Crit Care Med 1998; 157: 1361-1362
    • PedsCCM EB Journal Club Review, by G. Reyes
  • Inhaled Nitric Oxide in Acute Respiratory Distress Syndrome: A Pilot Randomized Controlled Study. Troncy E, Collet JP, Shapiro S, et al. Am J Respir Crit Care Med 1998; 157: 1483-1488 (full-text)
  • Effects of inhaled nitric oxide in patients with acute respiratory distress syndrome: results of a randomized phase II trial. Inhaled Nitric Oxide in ARDS Study Group. Dellinger RP, Zimmerman JL, Taylor RW, Straube RC, Hauser DL, Criner GJ, Davis K Jr, Hyers TM, Papadakos P. Crit Care Med 1998; 26: 15-23. [abstract]
    • PedsCCM EB Journal Club Review, by S. Bateman
    • Another Critical Appraisal of this paper by from Critically Appraised Topics at SORAHSN.
  • Improved Oxygenation in a Randomized Trial of Inhaled Nitric Oxide for Persistent Pulmonary Hypertension of the Newborn. Wessel DL, Adatia I, Van Marter LJ, Thompson JE, Kane JW, Stark AR, Kourembanas S. Pediatrics 1997; 100(5): e7. (full-text)
  • Dose response to inhaled nitric oxide in pediatric patients with pulmonary hypertension and acute respiratory distress syndrome. Nakagawa TA, Morris A, Gomez RJ, Johnston SJ, Sharkey T, Zaritsky AL. J Pediatr 1997;131:63-9. (abstract)
  • Inhaled Nitric Oxide and Hypoxic Respiratory Failure in Infants With Congenital Diaphragmatic Hernia. The Neonatal Inhaled Nitric Oxide Study Group (NINOS) Pediatrics 1997; 99: 838-845. [abstract]
    • PedsCCM EB Journal Club Review, by G Ofori-Amanfo
  • The Neonatal Inhaled Nitric Oxide Study Group. Inhaled Nitric Oxide in Full-Term and Nearly Full-Term Infants with Hypoxic Respiratory Failure. N Engl J Med 1997; 336: 597-604. [abstact]
  • PedsCCM EB Journal Club Review, by P. Chhangani, J. Hupert
• The Inhaled Nitric Oxide Study Group. Inhaled Nitric Oxide and Persistent Pulmonary Hypertension of the Newborn. N Engl J Med 1997; 336: 605-610. [abstract]
• Inhaled nitric oxide enhances oxygenation but not survival in infants with alveolar capillary dysplasia. Steinhorn RH, Cox PN, Fineman JR et al. J Pediatr 1997; 130:417-22. (abstract)
• Siddons TE, Asif M, Higenbottam TW. Therapeutic Role of Nitric Oxide in Respiratory Disease. Medscape Respiratory Care 2000; 4(2). [full-text]

Prostacyclin

• Dahlem P, van Aalderen WMC, de Neef M, Dijkgraaf MGW, Bos AP. Randomized controlled trial of aerosolized prostacyclin therapy in children with acute lung injury. Crit Care Med 2004; 32:1055-1060. [abstract]
  • PedsCCM EB Journal Club Review, by AA Arikan
• ECMO...

Asthma

• Kim IK, Phrampus E, Venkataraman S, et al. Helium/oxygen-driven albuterol nebulization in the treatment of children with moderate to severe asthma exacerbations: a randomized, controlled trial. Pediatrics. 2005 Nov;116(5):1127-33. [abstract]
• Wheeler DS, Jacobs BR, Kenreigh CA, Bean JA, Hutson TK, Brilli RJ. Theophylline versus terbutaline in treating critically ill children with status asthmaticus: A prospective, randomized, controlled trial. Pediatr Crit Care Med. 2005 Mar;6(2):142-147 [abstract]
  • PedsCCM EB Journal Club Review, by A Sharangpani, J Natale
• Maffei FA, van der Jagt EW, Powers KS, Standage SW, Connolly HV, Harmon WE, Sullivan JS, Rubenstein JS. Duration of Mechanical Ventilation in Life-Threatening Pediatric Asthma: Description of an Acute Asphyxial Subgroup. Pediatrics 2004;114 762-767. [abstract]
• Soroksky A, Stav D, Shpirer I. A Pilot Prospective, Randomized, Placebo-Controlled Trial of Bilevel Positive Airway Pressure in Acute Asthmatic Attack. Chest 2003;123 1018-1025 [abstract]
  • Review, by K Lewis
• Thill PJ, McGuire JK, Baden HP, Green TP, Checchia PA. Noninvasive positive-pressure ventilation in children with lower airway obstruction. Pediatr Crit Care Med. 2004 Jul;5(4):337-342. [abstract]
  • PedsCCM EB Journal Club Review, by S Rishmawi
• Rodrigo GJ, Rodrigo C, Pollack CV, Rowe B. Use of Helium-Oxygen Mixtures in the Treatment of Acute Asthma: A Systematic Review. Chest 2003;123 891-896 [abstract]
• Ho AMH, Lee A, Karmakar MK et al. Heliox vs Air-Oxygen Mixtures for the Treatment of Patients With Acute Asthma: A Systematic Overview. Chest 2003;123 882-890 [abstract]
  • PedsCCM EB Journal Club Review, by G Wolf
• Qureshi F, Zaritsky A, Poirier MP. Comparative efficacy of oral dexamethasone versus oral prednisone in acute pediatric asthma. J Pediatr. 2001;139(1):20-6. [abstract]
  • PedsCCM EB Journal Club Review, by A Torres
• Roberts JS, Bratton SL, Brogan TV. Acute severe asthma: Differences in therapies and outcomes among pediatric intensive care units. Crit Care Med 2002; 30:581-585. [abstract; full-text for subscribers/SCCM members]
• Adnet F, Dhissi G, Borron S et al. Complication profiles of adult asthmatics requiring paralysis during mechanical ventilation. Intensive Care Med 2001; 27: 1729-1736. [abstract; full-text for subscribers]
• Fitzgerald M. Extracts from "Clinical Evidence": Acute asthma. Br Med J 2001;323 841-845. [full-text]
• Werner HA. Status Asthmaticus in Children : A Review. Chest 2001;119 1913-1929. [abstract; full-text for subscribers]
• Ream RS, Loftis LL, Albers GM et al. Efficacy of IV Theophylline in Children With Severe Status Asthmaticus. Chest 2001;119:1480-1488. [abstract; full-text for subscribers]
  • PedsCCM EB Journal Club Review, by M Chavolla
• Fernández M, Villagrá A, Blanch L, Fernández R. Non-invasive mechanical ventilation in status asthmaticus. Intensive Care Med, 2001; DOI 10.1007/s001340100853 [abstract]
• Craven D, Kercsmar CM, Myers TR, et al. Ipratropium bromide plus nebulized albuterol for the treatment of hospitalized children with acute asthma. J Pediatr. 2001;138(1):51-58. [abstract] [full-text for subscribers]
• Schuh S, Reisman J, Alshehri M, et al. A comparison of inhaled fluticasone and oral prednisone for children with severe acute asthma. N Engl J Med. 2000;343(10):689-94. [abstract]
  • PedsCCM EB Journal Club Review, by A. Torres
• Randomised controlled trial of aminophylline for severe acute asthma. Yung M, South M. Arch Dis Child 1998; 79: 405-410. [full-text until July 1999] [abstract]
  • PedsCCM EB Journal Club Review, by G. Deshpande, K. Meert
• Qureshi F, Pestian J, Davis P, Zaritsky A. Effect of Nebulized Ipratropium on the Hospitalization Rates of Children with Asthma. N Engl J Med 1998;339:1030-5. [abstract]
  • PedsCCM EB Journal Club Review, by A. Torres, K. Bysani
• Should inhaled anticholinergics be added to beta-2 agonists for treating acute childhood and adolescent asthma? A systematic review. Plotnick LH, Ducharme FM. Br Med J 1998;317:971-977. (full-text)
• Asthma. Bremer B., and Pediatrics, Reactive Airway Disease. Chin E., from Emergency Medicine at Emedicine
• Review: Addition of multiple-dose anticholinergics to beta2-agonists improves lung function in children with severe asthma. Plotnick LH, Ducharme FM Evidence-Based Medicine, November/December 1997.
• Intravenous magnesium therapy for moderate to severe pediatric asthma: Results of a randomized, placebo-controlled trial. Ciarallo, L, Sauer, AH, Shannon, MW. J Pediatr 1996; 129: 809-14. [abstract]
  • PedsCCM EB Journal Club Review, by B. Markovitz
• Silverman RA, Osborn H, Runge J, et al. IV magnesium sulfate in the treatment of acute severe asthma: a multicenter randomized controlled trial. Chest 2002;122(2):489-97. [abstract]
• DeNicola L, Blackwelder B. Magnesium sulfate for acute severe asthma; kinetics and clinical response. University of Florida/Jacksonville Powerpoint file (220K)
• Ciarallo L, Brousseau D, Reinert S. Higher-Dose Intravenous Magnesium Therapy for Children With Moderate to Severe Acute Asthma. Arch Pediatr Adolesc Med. 2000;154:979-983. [abstract] [full-text]
  • PedsCCM EB Journal Club Review, by M. Chavolla
• Inhaled helium-oxygen revisited: Effect of inhaled helium-oxygen during the treatment of status asthmaticus in children. Kudukis TM, Manthous CA, Schmidt GA, et al. J Pediatr 1997;130:217-24. (abstract)
• Status Asthmaticus, L Ibsen, Oregon Health Sciences University (teaching file)

Other conditions

• Quiroz R, Kucher N, Zou KH, Kipfmueller F, Costello P, Goldhaber SZ, Schoepf UJ. Clinical Validity of a Negative Computed Tomography Scan in Patients With Suspected Pulmonary Embolism: A Systematic Review. JAMA. 2005 Apr 27;293(16):2012-2017 [abstract]
  • PedsCCM EB Journal Club Review, by S Hanson
• Wan S, Quinlan DJ, Agnelli G, Eikelboom JW. Thrombolysis Compared With Heparin for the Initial Treatment of Pulmonary Embolism: A Meta-Analysis of the Randomized Controlled Trials. Circulation 2004;110 744-749 [abstract]
• Halasa NB, Barr FE, Johnson JE, Edwards KM. Fatal Pulmonary Hypertension Associated With Pertussis in Infants: Does Extracorporeal Membrane Oxygenation Have a Role? Pediatrics 2003;112 1274-1278 [abstract]
• American Thoracic Society. Statement on the Care of the Child with Chronic Lung Disease of Infancy and Childhood. Am J Respir Crit Care Med 2003;168 356-396. [full-text for subscribers]
• Olschewski H, Simmoneau G, Galie N, et al. Inhaled Iloprost for Severe Pulmonary Hypertension. N Engl J Med 2002;347(5):322-9 [abstract]
  • PedsCCM EB Journal Club Review by A Arikan
• Bohn D. Congenital Diaphragmatic Hernia. Am J Respir Crit Care Med 2002; 166:911-915. [full-text for subscribers]
• Kornecki A, Shemie SD. Open lung biopsy in children with respiratory failure. Crit Care Med. 2001;29(6):1247-50. [abstract]
• Thomas KE, Owens CM, Britto J, Nadel S, Habibi P, Nicholson R. Efficacy of Chest CT in a Pediatric ICU : A Prospective Study. Chest. 2000 Jun;117(6):1697-1705. [abstract] [full-text for subscribers]
• Thrombolytic Therapy of Pulmonary Embolism: A Comprehensive Review of Current Evidence. Arcasoy SM, Kreit JW. Chest 1999;115:1695-1707. [abstract] [full-text for subscribers only]
• Primary pulmonary hypertension in childhood. Haworth SG. Arch Dis Child 1998; 79: 452-455. [full-text until July 1999]
• Bronchiolitis Obliterans Organizing Pneumonia (BOOP). Epler G. From Dynamics in Health Care
• Chronic Cough in Children; from Baylor College of Medicine [CME credit available]
• From University of Hawaii Radiology Cases in Pediatric Emergency Medicine
  • Congenital Lobar Emphysema
    • Also see: Congenital Lobar Emphysema, an outline from Neonatology on the Web
  • Pulmonary Hemorrhage with Goodpasture's Syndrome
• Thoracopedia - An Imaging Encyclopedia of Pediatric Thoracic Disease, from The University of Iowa's Virtual Hospital.
• Pulmonary Hemorrhage in Infancy
  • Reports from MMWR (included with ongoing CDC study)
  • Environmental Risk Factors Associated With Pediatric Idiopathic Pulmonary Hemorrhage and Hemosiderosis in a Cleveland Community. Montaña, E. et al. Pediatrics 1997; 99(1):e5. (full-text)
  • Acute Pulmonary Hemorrhage in Infants Associated With Exposure to and Stachybotrysatra Other Fungi. Etzel RA et al. Arch Pediatr Adolesc Med. 1998;152:757-762. (abstract)
  • Idiopathic pulmonary hemorrhage in infancy. Clinical features and management with high frequency ventilation. Pappas MD, Sarnaik AP, Meert KL, Hasan RA, Lieh-Lai MW. Chest 1996; 110: 553-555. [abstract]
• Many others at CHORUS
• Diaphragmatic Paralysis in the Newborn, an outline from Neonatology on the Web

Return to Top of Table of Contents

Ethics

End of life decisions/futility

• Kopelman LM. Are the 21-year-old baby doe rules misunderstood or mistaken? Pediatrics. 2005 Mar;115(3):797-802. [citation]
• Verhagen E, Sauer PJJ. The Groningen Protocol - Euthanasia in Severely Ill Newborns. New Engl J Med 2005; 352:959-962. [extract]
• Carter BS, Howenstein M, Gilmer MJ et al. Circumstances Surrounding the Deaths of Hospitalized Children: Opportunities for Pediatric Palliative Care. Pediatrics 2004;114 e361-e366 [abstract]
• Curtis JR, Engelberg RA, Wenrich MD, et al. Studying communication about end-of-life care during the ICU family conference: development of a framework. J Crit Care. 2002 Sep;17(3):147-60. [abstract]
• Himelstein BP, Hilden JM, Boldt AM, Weissman D. Pediatric Palliative Care. New Engl J Med 2004; 350:1752-1762. [abstract]
• Garros D, Rosychhuk RJ, Cox PN. Circumstances Surrounding End of Life in a Pediatric Intensive Care Unit. Pediatrics 2003;112 371 [abstract]
• Burns JP, Edwards J, Johnson J, Cassem NH, Truog RD. Do-not-resuscitate order after 25 years. Crit Care Med. 2003 May;31(5):1543-50. [abstract]
• Frick S, Uehlinger DE, Zuercher Zenklusen RM. Medical futility: Predicting outcome of intensive care unit patients by nurses and doctors-A prospective comparative study. Crit Care Med. 2003;31(2):456-61. [abstract]
• Interesting case of futility in the PICU: Hill J. Balancing Parental Wishes with Medical Judgment. Virtual Mentor 2003; 5(1). [full-text]
• Way J, Bakc AL, Curtis JR. Withdrawing life support and resolution of conflict with families. Br Med J 2002;325 1342-1345. [full-text]
• Truog RD, Cist AF, Brackett SE, Burns JP, Curley MA, Danis M, DeVita MA, Rosenbaum SH, Rothenberg DM, Sprung CL, Webb SA, Wlody GS, Hurford WE. Recommendations for end-of-life care in the intensive care unit: The Ethics Committee of the Society of Critical Care Medicine. Crit Care Med. 2001;29(12):2332-48. [full-text (pdf) from SCCM Guidelines]
• The Robert Wood Johnson Foundation has issued a Special Report on Pediatric Palliative Care. This in response to the Institute of Medicine's 2002 report: When Children Die: Improving Palliative and End-of-Life Care for Children and Their Families
• Bagatell R, Meyer R, Herron S, Berger A, Villar R. When Children Die: A Seminar Series for Pediatric Residents. Pediatrics 2002;110 348-353. [abstract; full-text for AAP members/subscribers]
• Moynihan Hardart MK, Burns JP, Truog RD. Respiratory Support in Spinal Muscular Atrophy Type I: A Survey of Physician Practices and Attitudes. Pediatrics 2002;110:e24. [abstract, full-text]
• Meyer EC, Burns JP, Griffith JL, Truog RD. Parental perspectives on end-of-life care in the pediatric intensive care unit. Crit Care Med 2002;30:226-231 [abstract; full-text for SCCM members/subscribers]
• Devictor DJ, Nguyen DT. Forgoing life-sustaining treatments: how the decision is made in French pediatric intensive care units. Crit Care Med. 2001;29(7):1356-9. [abstract; full-text for subscribers]
• Street K, Henderson J, Inwald D, Vandyck W, Greig- Midlane H, and Edwards SJL. The distinction between withdrawing life sustaining treatment under the influence of paralysing agents and euthanasia. Br Med J 2001;323:388-391. [full-text]
• Singer PA, Barker G, Bowman KW, et al. Hospital policy on appropriate use of life-sustaining treatment. Crit Care Med. 2001;29(1):187-191. [abstract] Accompanying editorial: Nasraway SA. Unilateral withdrawal of life-sustaining therapy: Is it time? Are we ready? Crit Care Med 2001; 29: 215-217.
• Goh AY, Mok Q. Identifying futility in a paediatric critical care setting: a prospective observational study. Arch Dis Child 2001;84:265-268 [abstract]
• Schneiderman LJ, Gilmer T, Teetzel HD. Impact of ethics consultations in the intensive care setting: a randomized, controlled trial. Crit Care Med. 2000;28(12):3920-4. [abstract]
• Luce JM, Alpers A. Legal Aspects of Withholding and Withdrawing Life Support from Critically Ill Patients in the United States and Providing Palliative Care to Them. Am J Respir Crit Care Med 2000; 162: 2029-2032. [full-text for subscribers]
• Nyman DJ, Sprung CL. End-of-life decision making in the intensive care unit. Intensive Care Med 2000 [DOI] [full-text]
• The November 15, 2000 issue of JAMA focuses on end-of-life issues and decision making. Most pertinent to pediatrics:
  • Wolfe J, Klar, N, Grier HE et al. Understanding of Prognosis Among Parents of Children Who Died of Cancer - Impact on Treatment Goals and Integration of Palliative Care. JAMA. 2000;284:2469-2475. [abstract] [full-text]
  • Rebagliato M, Cuttini M, Broggin L et al. Neonatal End-of-Life Decision Making Physicians' Attitudes and Relationship With Self-reported Practices in 10 European Countries JAMA. 2000;284:2451-2459. [abstract] [full-text]
  • Meisel A, Snyder L, Quill T. Seven Legal Barriers to End-of-Life Care Myths, Realities, and Grains of Truth. JAMA. 2000;284:2495-2501. [abstract] [full-text]
  • Also included is a Resource list on end-of-life care. Quill T.
• Truog RD, Burns JP, Mitchell C, Johnson J, Robinson W. Pharmacologic paralysis and withdrawal of mechanical ventilation at the end of life. New Engl J Med. 2000;342(7):508-11.[abstractabstract]
• Burns JP, Mitchell C, Outwater KM, Geller M, Griffith JL, Todres ID, Truog RD. End-of-life care in the pediatric intensive care unit after the forgoing of life-sustaining treatment. Crit Care Med. 2000;28(8):3060-6. [abstract]
• Committee on Bioethics and Committee on Hospital Care. Palliative Care for Children. AAP Policy Statement. Pediatrics 2000;106:351-357. [full-text]
• Keenan HT, Diekema DS, O'Rourke PP, Cummings P, Woodrum DE. Attitudes toward limitation of support in a pediatric intensive care unit. Crit Care Med. 2000 May;28(5):1590-4. [abstract]
• Doig C, Burgess E. Withholding life-sustaining treatment: Are adolescents competent to make these decisions? Can Med Assoc J 2000;162(11):1585-8. [abstract]
• Pediatric Palliative Care - an issue of Last Acts: Innovations in End-of-Life Care. "An international journal and online forum of leaders in end-of-life care." March-April 2000, Vol. 2, No. 2. From Education Development Center, Inc. (full-text; free registration required)
• Controversies in Medical Ethics: Rhymes JA, McCullough LB, Luchi RJ, et al. Withdrawing Very LowBurden Interventions in Chronically Ill Patients JAMA 2000; 283:1061-1063. (full-text for subscribers only), Pellegrino ED. Decisions to Withdraw Life-Sustaining Treatment. A Moral Algorithm. JAMA 2000; 283: 1065-1067. (full-text for subscribers only)
• Dorr Goold S, Williams B, Arnold RM. Conflicts Regarding Decisions to Limit Treatment: A Differential Diagnosis. JAMA 2000;283:909-914. [abstract] [full-text for subscribers only]
• Kollef MH, Ward S. The influence of access to a private attending physician on the withdrawal of life-sustaining therapies in the intensive care unit. Crit Care Med. 1999;27:2125-32. [abstract]
• Life support in the intensive care unit: a qualitative investigation of technological purposes. Cook DJ, Giacomini M, Johnson N, et al. Can Med Assoc J 1999;161:1109-13. [abstract]
• ABC of intensive care: Withdrawal of treatment. Winter B, Cohen S. Br Med J 1999;319:306-308. (full-text)
• Ethical Dilemma: Discontinuation of ventilation after brain stem death. To whom is our duty of care? Swinburn JMA, Ali SM, Banerjee Dj, Khan ZP. Policy should be balanced with concern for the family. Cranford RE. Brain stem death defines death in law. Jennett B. Br Med J 1999;318:1753-1755. (full-text)
• Can Pediatricians Define and Apply the Concept of Brain Death? Harrison AM, Botkin JR. Pediatrics 1999; 103: e82. [full-text]
• Withdrawal and limitation of life support in paediatric intensive care. Goh AYT, Lum LCS, Chan PWK, et al. Arch Dis Child 1999; 80: 424-428 [abstract] [full-text until July, 1999]
• Treatment decisions for infants and children, from Position Papers of the Canadian Pediatric Society
• Variability in Physician Opinion on Limiting Pediatric Life Support. Randolph AG, Zollo MB, Egger MJ, et al. Pediatrics 1999; 103: e46. (full-text)
• "Doctor, If This Were Your Child, What Would You Do?"Truog RD. Pediatrics 1999; 103: 153-155. [Full-text]
• Coping with loss: The dying child. Black D. Br Med J 1998;316:1376-1378. (full-text)
• Quill TE, Dresser R, Brock DW. The Rule of Double Effect -- A Critique of Its Role in End-of-Life Decision Making. New Engl J Med 1997; 337: 1768-1771 [citation]
• How to ...
  • A protocol for withdrawing life support, by S. Miles
  • Brody, H. et al. Withdrawing Intensive Life-Sustaining Treatment -- Recommendations for Compassionate Clinical Management. N Engl J Med 1997; 336: 652-657. [citation]
• The role of television?
  • Diem, S.J., Lantos, J.D., Tulsky, J.A. 26uscitation on Television -- Miracles and Misinformation. N Engl J Med 1996;334:1578-82. [citation]
• The role of critical care nurses?
  • Asch, D. The Role of Critical Care Nurses in Euthanasia and Assisted Suicide. N Engl J Med 1996;334:1374-9. [abstract]
  • with an accompanying full-text editorial: Scanlon, C. Euthanasia and Nursing Practice -- Right Question, Wrong Answer. N Engl J Med 1996; 334: 1401-1402. [citation]
• Physician-assisted suicide?
  • Angell, M. The Supreme Court and Physician-Assisted Suicide -- The Ultimate Right.N Engl J Med 1997; 336: 50-53. [citation]
  • Orentlicher, D. The Legalization of Physician-Assisted Suicide.N Engl J Med 1996; 335: 663-667. [citation]
  • Annas, G. The Promised End -- Constitutional Aspects of Physician-Assisted Suicide. N Engl J Med 1996; 335; 683-687. [citation]
  • Annas GJ The Bell Tolls for a Constitutional Right to Physician-Assisted Suicide. . N Engl J Med 1997; 337: 1098-1103. [citation]

Organ Transplantation

• Truog RD, Robinson WM. Role of brain death and the dead-donor rule in the ethics of organ transplantation. Crit Care Med. 2003;31(9):2391 [abstract]
• Recommendations for nonheartbeating organ donation. A position paper by the Ethics Committee, American College of Critical Care Medicine, Society of Critical Care Medicine. Crit Care Med. 2001;29(9):1826-31. [citation; full-text for subscribers, SCCM members]
• Wendler D, Dickert N. The Consent Process for Cadaveric Organ Procurement; How Does It Work? How Can It Be Improved? JAMA 2001;285:329-333. [abstract] [full-text for subscribers]
• Issues In Pediatric Organ Donation. D'Agostino CK. Jacksonville Medicine September 1998
• The Potential Benefits of the Pediatric Nonheartbeating Organ Donor. Koogler T, Costarino AT. Pediatrics 1998; 101: 1049-1052. (abstract)
• Transplantation of organs from newborns with anencephaly, Bioethics Committee, Canadian Paediatric Society
• Withdrawing Life Support from Mechanically Ventilated Recipients of Bone Marrow Transplants: A Case for Evidence-Based Guidelines. Rubenfeld, G.D., Crawford, S.W. Ann Intern Med 1996; 125:625-633) (full-text)
• From Bioethics Texts, at MCW's Bioethics Online Service
  • Death to Dust: Organ Donation and Whole Body Donation by K. Iserson

Ethics in Research

• Hulst JM, Peters JW, van den Bos A, et al. Illness severity and parental permission for clinical research in a pediatric ICU population. Intensive Care Med. 2005 Jun;31(6):880-884 [abstract] Accompanying editorial: Truog RD. Increasing the participation of children in clinical research. Intensive Care Med. 2005 Jun;31(6):760-1. [citation]
• Silverman HJ, Luce JM, Lanken PN, Morris AH, Harabin AL, Oldmixon CF, Thompson BT, Bernard GR; for the NHLBI Acute Respiratory Distress Syndrome Clinical Trials Network (ARDSNet). Recommendations for informed consent forms for critical care clinical trials. Crit Care Med. 2005 Apr;33(4):867-882. [abstract]
• Silverman HJ, Miller FG. Control group selection in critical care randomized controlled trials evaluating interventional strategies: An ethical assessment. Crit Care Med. 2004 Mar;32(3):852-7 [abstract]
• Lilford RJ. Ethics of clinical trials from a bayesian and decision analytic perspective: whose equipoise is it anyway? Br Med J 2003;326:980-981. [full-text]
• "Caught in the Middle: Children in Clinical Trials" - Ethical Issues in Pediatric Clinical Research, An Interdisciplinary Symposium. Held at Washington University Medical Center, October 15, 2002. Speakers included Robert Nelson (CHOP) and Rosemary Roberts (FDA). Speaker slides and streaming video available here...
• Ethical issues in clinical research: the April 3, 2003 issue of the New England Journal of Medicine:
  • Was the ARDSnet tidal volume trial ethical? The OHRP has a hold on the ARDSnet trial of fluid management in ARDS. Read: Steinbrook R. How Best to Ventilate? Trial Design and Patient 4 in Studies of the Acute Respiratory Distress Syndrome. N Engl J Med 2003; 384:1393-1401. [full-text for subscribers]
  • Broader questions regarding integration and confusion of clinical research and clinical care: Miller FG, Rosenstein DL. The Therapeutic Orientation to Clinical Trials. N Engl J Med 2003; 384:1383-1386. [full-text for subscribers] and Grunberg SM, Cefalu WT. The Integral Role of Clinical Research in Clinical Care. N Engl J Med 2003; 384:1386-1388. [full-text for subscribers]
  • With an editorial: Drazen JM. Controlling Research Trials. N Engl J Med 2003; 384: 1377-1380. [full-text for subscribers]
• Steinbrook R. Testing Medications in Children. New Engl J Med 2002; 347: 1462-1470. [full-text for subscribers]
• Weil E, Nelson RM, Friedman Ross L. Are Research Ethics Standards Satisfied in Pediatric Journal Publications? Pediatrics 2002;110 364-370. [abstract; full-text for AAP members/subscribers]
• Korn D. Conflicts of interest in biomedical research. JAMA. 2000;284(17):2234-7. [full-text]
• Emanuel EJ, Wendler D, Grady C. What Makes Clinical Research Ethical? JAMA. 2000;283:2701-2711. [abstract] [full-text]
• Morris AD, Zaritsky AL, LeFever G. Evaluation of ethical conflicts associated with randomized, controlled trials in critically ill children. Crit Care Med 2000;28(4):1152-6. [abstract]
• Informed consent in clinical research - a debate in the British Medical Journal:
  • Smith, R. Informed consent: the intricacies. Should the BMJ reject all studies that do not include informed consent?. Br Med J 1997; 314: 1059.
  • Doyal, L. Informed consent in medical research: Journals should not publish research to which patients have not given fully informed consent - with three exceptions. Br Med J 1997; 314: 1107.
  • Tobias, JS. Informed consent in medical research: BMJ's present policy (sometimes approving research in which patients have not given fully informed consent) is wholly correct. Br Med J 1997; 314: 1111.
  • Truog RD, Robinson W, Randolph A, Morris A. Is Informed Consent Always Necessary for Randomized, Controlled Trials? New Engl J Med 1999; 340: 804-807. [citation]
• A discussion about informed consent and publication:
  • Patient Consent for Publication and the Health of the Public. Snider DE. JAMA 1997;278:624-626. (citation)
  • Obtain Informed Consent Before Publishing Information About Patients. Clever LH. JAMA 1997;278:628-629. (citation)
  • And the accompanying editorial: Informed Consent for Publication. Fontanarosa PB, Glass RM. JAMA 1997;278:682-683. [citation]
• World Medical Association Declaration of Helsinki. Ethical Principles for Medical Research Involving Human Subjects. JAMA 2000; 284:3043-3045. [full-text]

Other issues

• Wolfson RK, Kahana MD, Nachman JB, Lantos J. Extracorporeal membrane oxygenation after stem cell transplant: Clinical decision-making in the absence of evidence. Pediatr Crit Care Med. 2005 Mar;6(2):200-3. [abstract]
• Kon AA, Ackerson L, Lo B. How pediatricians counsel parents when no "Best-Choice" management exists: lessons to be learned from hypoplastic left heart syndrome. Arch Pediatr Adolesc Med. 2004 May;158(5):436-41. [abstract]
• Studdert DM, Burns JP, Mello MM, et al. Nature of Conflict in the Care of Pediatric Intensive Care Patients With Prolonged Stay. Pediatrics 2003; 112: 553-558 [abstract]
• Davis N, Pohlman A, Gehlbach B et al. Improving the Process of Informed Consent in the Critically Ill. JAMA 2003;289 1963-1968 [abstract]
• Tsai E. Should family members be present during cardiopulmonary resuscitation? New Engl J Med 2002; 346:1019-1021. [full-text for subscribers]
• Hedayat KM, Pirzadeh R. Issues in Islamic Biomedical Ethics: A Primer for the Pediatrician. Pediatrics 2001;108 965-971. [abstract][full-text for AAP members/subscribers]
• Singer PA, Pellegrino ED, Siegler M. Clinical ethics revisited. BMC Medical Ethics 2001 2: 1 [full-text]
• Benatar SR, Bhutta ZA, Daar AS, Hope T, MacRae S, Roberts LW, Sharpe VA. Clinical ethics revisited: responses. BMC Medical Ethics 2001, 2:2 [full-text]
• Lazar NM, Semie S, Webster GC, Dickens BM. Bioethics for clinicians: 24. Brain death. Can Med Assoc J 2001;164(6):833-6. [abstract]
• Singer PA. Recent advances:Medical ethics. Br Med J 2000;321:282-285. [full-text]
• A shared statement of ethical principles for those who shape and give health care: a working draft. The Tavistock Group. Eff Clin Pract. 1999;2(3):141-4.[full-text]
• Managing Disagreements in the Management of Short Bowel and Hypoplastic Left Heart Syndrome. Cooper TR, Garcia-Prats JA, Brody BA. Pediatrics 1999; 104: e48. [abstract] [full-text]
• Shared ethical principles for everybody in health care: a working draft from the Tavistock Group. Tavistock Group. Br Med J 1999;318:248-251. (full-text)
• Annas GJ. Human Rights and Health -- The Universal Declaration of Human Rights at 50. New Engl J Med 1998;339:1777-1781. [citation]
• Child fatalities from religion-motivated medical neglect. Asser SM, Swan R. Pediatrics 1998; 101: 625-629. (abstract)
• Policy Statements from the American Academy of Pediatrics:
  • Ethics and the Care of Critically Ill Infants and Children
  • Guidelines on Forgoing Life Sustaining Medical Treatment
  • Infants with Anencephaly as Organ Sources: Ethical Considerations
  • Informed Consent, Parental Permission, and Assent in Pediatric Practice
• Treatment decisions for infants and children; a bioethics position paper from The Canadian Pediatric Society
• From the Canadian Medical Association Journal series Bioethics for clinicians: (full-text)
  • Harrison C, Kenny NP, Sidarous M, Rowell M. Involving children in medical decisions. Can Med Assoc J 1997;156:825-8 [abstract]
  • McKneally MF, Dickens BM, Meslin EM, Singer PA. Resource allocation. Can Med Assoc J 1997;157:163-7. [abstract]
• Gibson B. Long-term Ventilation for Patients With Duchenne Muscular Dystrophy : Physicians' Beliefs and Practices. Chest 2001 119: 940-946. [abstract] [full-text for subscribers]
• What makes a just healthcare system?. Benatar, S. Br Med J 1996; 313: 1567. (full-text)
• Physician Recommendations and Patient Autonomy: Finding a Balance between Physician Power and Patient Choice. Quill, T.E., Brody, H. Ann Intern Med 1996; 125:763-769. (full-text)

Other Resources in Biomedical Ethics

• The Canadian Medical Association Journal series Bioethics for clinicians
• Bioethics Resources on the Web; a compliation from the National Institutes of Health
• Bioethics for clinicians. A continuing series in the Canadian Medical Association Journal [full-text]
• Bioethics.net; from the University of Pennsylvania Center for Bioethics
• Wisconsin Bioethics Home Page

Return to Top of Table of Contents

Cardiovascular

Physiology/Diagnostics

• Shah MR, Hasselblad V, Stevenson LW, Binanay C, O'Connor CM, Sopko G, Califf RM. Impact of the pulmonary artery catheter in critically ill patients: meta-analysis of randomized clinical trials. JAMA. 2005 Oct 5;294(13):1664-70. [abstract]
• Li J, Hoskote A, Hickey C, et al. Effect of carbon dioxide on systemic oxygenation, oxygen consumption, and blood lactate levels after bidirectional superior cavopulmonary anastomosis. Crit Care Med. 2005 May;33(5):984-989 [abstract]
• Cohen S, Springer C, Avital A, et al. Amino-Terminal Pro-Brain-Type Natriuretic Peptide: Heart or Lung Disease in Pediatric Respiratory Distress? Pediatrics 2005;115 1347-1350 [abstract]
• Levy RL, Chiavacci RM, Nicolson SC et al. An Evaluation of a Noninvasive Cardiac Output Measurement Using Partial Carbon Dioxide Rebreathing in Children. Anesth Analg 2004;99 1642-1647 [abstract]
  • PedsCCM EB Journal Club Review, by M Weber
• Rhodes A, Cusack RJ, Newman PJ, Grounds RM, Bennett ED. A randomised, controlled trial of the pulmonary artery catheter in critically ill patients. Intensive Care Med. 2002 Mar;28(3):256-64 [abstract]
• Tibby SM, Murdoch IA. Monitoring cardiac function in intensive care. Arch Dis Child. 2003 Jan;88(1):46-52. [abstract]
• Pinsky MR. Pulmonary artery occlusion pressure. Intensive Care Med 2003; 29: 19-22. [citation link]
• Boulain T, Achard JM, Teboul JL et al. Changes in BP Induced by Passive Leg Raising Predict Response to Fluid Loading in Critically Ill Patients. Chest 2002;121 1245-1252. [abstract; full-text for subscribers]
• Peters J, Mack GW, Lister G. The importance of the peripheral circulation in critical illnesses Intensive Care Med 2001; 27:1446-1458; DOI 10.1007/s001340101034 [review article; full-text for subscribers]
• Tibby SM, Hatherill M, Durward A, Murdoch IA. Are transoesophageal Doppler parameters a reliable guide to paediatric haemodynamic status and fluid management? Intensive Care Med 2001; 27:201-205. [abstract, full-text for subscribers]
  • PedsCCM EB Journal Club Review, by M Duthie, O Bagshaw
• Interpretation of the pulmonary artery occlusion pressure in mechanically ventilated patients with large respiratory excursions in intrathoracic pressure. Hoyt JD, Leatherman JW. Intensive Care Med 1997; 23: 1125-1131 (abstract) KUMC Cardiology
• Jackson G, Gibbs CR, Davies MK, Lip GYH. ABC of heart failure: Pathopysiology. Br Med J 2000;320:167-170. [full-text]

Dysrhythmias

• Dorian P, Cass D, Schwartz B, et al. Amiodarone as compared with lidocaine for shock-resistant ventricular fibrillation. N Engl J Med. 2002;346(12):884-90. [abstract; full-text for subscribers]
  • PedsCCM EB Journal Club Review, by J Keates Baleeiro, K Meert
• Esberger D, Jones S, Morris F. ABC of clinical electrocardiography: Junctional tachycardias. Br Med J 2002;324 662-665 [full-text]
• Paroxysmal Supraventricular Tachycardia (PSVT) in the Pediatric Patient. interactive presentation with CME credit for nurses, from Health Interactive
• Atrial Flutter. Clark AD. from Emergency Medicine at Emedicine
• Schwartz PJ, Stramba-Badiale M, Segantini A, Austoni P, Bosi G, Giorgetti R, Grancini F, Diego Marni E, Perticone F, Rosti F, Salice P. Prolongation of the QT Interval and the Sudden Infant Death Syndrome. New Engl J Med 1998; 338: 1709-1714. [abstract]
• Pediatrics, Tachycardia. Farah M., from Emergency Medicine at Emedicine
• Pediatric Use of Intravenous Amiodarone: Efficacy and Safety in Critically Ill Patients From a Multicenter Protocol. Perry, J.C., et al. J Am Coll Cardiol 1996; 27: 1246-50. (abstract)

Extracorporeal Life Support (ELSO, ECMO)

• Morris MC, Wernovsky G, Nadkarni VM. Survival outcomes after extracorporeal cardiopulmonary resuscitation instituted during active chest compressions following refractory in-hospital pediatric cardiac arrest. Pediatr Crit Care Med. 2004 Sep;5(5):440-446. [abstract]
  • PedsCCM EB Journal Club Review by M Frazier, A Wratney, I Cheifetz
• Stiller B, Lemmer J, Merkle F, et al. Consumption of blood products during mechanical circulatory support in children: comparison between ECMO and a pulsatile ventricular assist device. Intensive Care Med. 2004; 30:1814-1820. [abstract]
• Halasa NB, Barr FE, Johnson JE, Edwards KM. Fatal Pulmonary Hypertension Associated With Pertussis in Infants: Does Extracorporeal Membrane Oxygenation Have a Role? Pediatrics 2003;112 1274-1278 [abstract]
• Pettignano R, Fortenberry JD, Heard ML, et al. Primary use of the venovenous approach for extracorporeal membrane oxygenation in pediatric acute respiratory failure. Pediatr Crit Care Med 2003;4(3):291-8. [abstract]
  • PedsCCM EB Journal Club Review, by M Sharma
• Hamrick SE, Gremmels DB, Keet CA, et al. Neurodevelopmental outcome of infants supported with extracorporeal membrane oxygenation after cardiac surgery. Pediatrics. 2003 Jun;111(6 Pt 1):e671-5 [full-text]
  • PedsCCM EB Journal Club Review, by S Cooper
• Wilson BJ, Heiman HS, Butler TJ et al. A 16-Year Neonatal/Pediatric Extracorporeal Membrane Oxygenation Transport Experience. Pediatrics 2002;109 189-193. [abstract; full-text for AAP members/subscribers]
• Duncan BW, Bohn DJ, Atz AM, et al. Mechanical circulatory support for the treatment of children with acute fulminant myocarditis. J Thorac Cardiovasc Surg. 2001;122(3):440-448. [abstract]
• O'Neill JM, Schutze GE, Heulitt MJ, Simpson PM, Taylor BJ. Nosocomial infections during extracorporeal membrane oxygenation. Intensive Care Med 2001; 27(8), 1247-1253; [abstract; full-text for subscribers]
• Mamprin F, Pesenti A, Fumagalli R. Extracorporeal circulation for acute respiratory failure. Intensive Care Med 2001; 27:934-936. DOI 10.1007/s001340100867 [full-text for subscribers]
• Montgomery VL, Strotman JM, Ross MP. Impact of multiple organ system dysfunction and nosocomial infections on survival of children treated with extracorporeal membrane oxygenation after heart surgery. Crit Care Med 2000;28:526-31. [abstract]
• Bartlett RH, Roloff DW, Custer JR, et al. Extracorporeal Life Support: The University of Michigan Experience, JAMA 2000;283:904-908. [abstract] [full-text for subscribers only]
• Slides of presentation at 1997 ATS meeting of: ECMO for ARDS; Stopping a RCT. Fackler J, Bohn D, Green T, Heulitt M, Hirsch R, Klein M, Martin L, Newth K, Nichols D, Steinhart C, Ware J. Am J Respir Crit Care 1997; 155: A504. (PowerPoint document, compressed, 52 KB)
• UK collaborative randomised trial of neonatal extracorporeal membrane oxygenation. UK Collaborative ECMO Trial Group. Lancet 1996; 348: 75-82. [abstract]
  • PedsCCM EB Journal Club Review, by A. Randolph
• Extracorporeal Life Support from University of Washington School of Medicine and Children's Hospital Medical Center; an overview, program details, and ELSO statistics
• Extracorporeal Life Support Organization

Shock States

• Sepsis/Septic Shock
  • Oppert M, Schindler R, Husung C, et al. Low-dose hydrocortisone improves shock reversal and reduces cytokine levels in early hyperdynamic septic shock. Crit Care Med. 2005 Nov;33(11):2457-64. [abstract]
  • Levy MM, Macias WL, Vincent JL, Russell JA, Silva E, Trzaskoma B, Williams MD. Early changes in organ function predict eventual survival in severe sepsis. Crit Care Med. 2005 Oct;33(10):2194-2201. [abstract]
  • Abraham E, Laterre PF, Garg R, et al. for the Administration of Drotrecogin Alfa (Activated) in Early Stage Severe Sepsis (ADDRESS) Study Group. Drotrecogin alfa (activated) for adults with severe sepsis and a low risk of death. N Engl J Med. 2005 Sep 29;353(13):1332-41. [abstract]
  • Fiser RT, West NK, Bush AJ, Sillos EM, Schmidt JE, Tamburro RF. Outcome of severe sepsis in pediatric oncology patients. Pediatr Crit Care Med. 2005 Sep;6(5):531-536. [abstract; full-text (pdf 412K)]
  • Varpula M, Tallgren M, Saukkonen K, Voipio-Pulkki LM, Pettila V. Hemodynamic variables related to outcome in septic shock. Intensive Care Med. 2005 Aug;31(8):1066-71. [abstract]
  • 1st International Sepsis Forum on Sepsis in Infants and Children. Pediatr Crit Care Med 2005; S1-S164. [table of contents]
  • Pizarro CF, Troster EJ, Damiani D, Carcillo JA. Absolute and relative adrenal insufficiency in children with septic shock. Crit Care Med. 2005 Apr;33(4):855-859. [abstract]
    • PedsCCM EB Journal Club Review, by A Hsu, MJ Bell, C Corriveau
  • Goldstein B, Giroir B, Randolph A, and Members of the International Consensus Conference on Pediatric Sepsis. International pediatric sepsis consensus conference: Definitions for sepsis and organ dysfunction in pediatrics. Pediatr Crit Care Med. 2005 Jan;6(1):2-8. [abstract; full-text (pdf; 180K)]
  • Surviving sepsis campaign guidelines for the management of severe sepsis and septic shock: Background, recommendations, and discussion from an evidence-based review. Crit Care Med 2004; 32(11): S445-S597. Includes: Parker MM, Hazelzet JA, Carcillo JA. Pediatric considerations. Crit Care Med. 2004 Nov;32(11 Suppl):S591-4. Review [abstract]
  • Fenton KE, Sable CA, Bell MJ, Patel KM, Berger JT. Increases in serum levels of troponin I are associated with cardiac dysfunction and disease severity in pediatric patients with septic shock. Pediatr Crit Care Med. 2004 Nov;5(6):533-538. [abstract; full-text (pdf 192K)]
  • Annane D, Bellissant E, Bollaert PE, Briegel J, Keh D, Kupfer Y. Corticosteroids for severe sepsis and septic shock: a systematic review and meta-analysis. Br Med J 2004 329(7464):480. [abstract]
    • PedsCCM EB Journal Club Review, by M Desai
  • Morelli A, Ricci Z, Bellomo R, et al. Prophylactic fenoldopam for renal protection in sepsis: a randomized, double-blind, placebo-controlled pilot trial. Crit Care Med. 2005 Nov;33(11):2451-6. [abstract]
  • Albanese J, Leone M, Garnier F, et al. Renal Effects of Norepinephrine in Septic and Nonseptic Patients. Chest 2004;126 534-539 [abstract]
  • Schrier RW, Wang W. Acute Renal Failure and Sepsis. N Engl J Med 2004; 351:159-169. [full-text for subscribers]
  • Dellinger RP, Carlet JM, Masur H, et al. Surviving sepsis campaign guidelines for management of severe sepsis and septic shock. Crit Care Med. 2004 Mar;32(3):858-73. [abstract]
  • Warren BL, Eid A, Singer P, et al. High-Dose Antithrombin III in Severe Sepsis: A Randomized Controlled Trial. JAMA 2001;286:1869-1878. [abstract]
    • PedsCCM EB Journal Club Review, by K Hebbar, T Petrillo
  • Richard C, Warszawski J, Angurl N, et al. Early Use of the Pulmonary Artery Catheter and Outcomes in Patients With Shock and Acute Respiratory Distress Syndrome: A Randomized Controlled Trial. JAMA 2003;290 2713-2720. [abstract]
    • PedsCCM EB Journal Club Review, by S. Thammasitboon, S. Cortes
  • Han YY, Carcillo JA, Dragotta MA, et al. Early Reversal of Pediatric-Neonatal Septic Shock by Community Physicians Is Associated With Improved Outcome. Pediatrics 2003;112 793-799. [abstract]. With an accompanying editorial: Kirby A, Goldstein B. Improved Outcomes Associated With Early Resuscitation in Septic Shock: Do We Need to Resuscitate the Patient or the Physician? Pediatrics 2003;112 976-977 [full-text]
    • PedsCCM EB Journal Club Review, by N Faqih
  • Jacobs S, Price Evans DA, Tariq M, Al Omar NF. Fluconazole improves survival in septic shock: A randomized double-blind prospective study. Crit Care Med. 2003 Jul;31(7):1938-46. [abstract]
    • PedsCCM EB Journal Club Review, by P Meaney
  • Kutko MC, Calarco MP, Flaherty MB, Helmrich RF, Ushay HM, Pon S, Greenwald BM. Mortality rates in pediatric septic shock with and without multiple organ system failure. Pediatr Crit Care Med. 2003 Jul;4(3):333-7. [abstract; full-text (pdf 372K]
  • Stegmayr BG, Banga R, Berggren L, Norda R, Rydvall A, Vikerfors T. Plasma exchange as rescue therapy in multiple organ failure including acute renal failure. Crit Care Med. 2003 Jun;31(6):1730-6. [abstract]
  • Marik PE, Zaloga GP. Adrenal insufficiency during septic shock. Crit Care Med. 2003;31(1):141-5. [abstract]
    • PedsCCM EB Journal Club Review, by P Prabhakaran
  • Kern JW, Shoemaker WC. Meta-analysis of hemodynamic optimization in high-risk patients. Crit Care Med. 2002;30(8):1686-92. [abstract]
    • PedsCCM EB Journal Club Review by S and S Thammasitboon
  • Bochu PY, Calandra T. Science, medicine, and the future: Pathogenesis of sepsis: new concepts and implications for future treatment. Br Med J 2003;326 262-266. [full-text]
  • McMaster P, Shann F. The use of extracorporeal techniques to remove humoral factors in sepsis. Pediatric Critical Care Medicine 2003; 4(1):2-7 [abstract]
  • Busund R, Koukline V, Utrobin U, Nedashkovsky E. Plasmapheresis in severe sepsis and septic shock: a prospective, randomised, controlled trial. Intensive Care Med 2002; 28: 1434-1439 [abstract]
    • PedsCCM EB Journal Club Review by J Krishnan, V Vaiyda
  • Annane D, Sebille V, Charpentier C, Bollaert PE, et al. Effect of treatment with low doses of hydrocortisone and fludrocortisone on mortality in patients with septic shock. JAMA. 2002;288(7):862-71. [abstract; full-text for subscribers]
    • PedsCCM EB Journal Club Review, by P Kamat, J Fortenberry
  • Carcillo JA, Fields AI et al. Clinical practice parameters for hemodynamic support of pediatric and neonatal patients in septic shock. Crit Care Med. 2002;30(6):1365-78. [abstract; full-text pdf from the SCCM]
  • Rivers E, Nguyen B, Havstad S, et al. Early Goal-Directed Therapy in the Treatment of Severe Sepsis and Septic Shock. New Engl J Med 2001; 345:1368-77. [abstract; full-text for subscribers]
    • PedsCCM EB Journal Club Review, by S Thammasitboon, M Mcpherson
  • Holmes CL, Patel BM, Russell JA, Walley KR. Physiology of Vasopressin Relevant to Management of Septic Shock. Chest 2001;120 989-1002. [abstract; full-text for subscribers]
  • Bernard GR, Vincent JL, Laterre PF, et al. Efficacy and Safety of Recombinant Human Activated Protein C for Severe Sepsis. N Engl J Med 2001;344:699-709. [Early release full-text] [abstract, full-text for subscribers ]
    • PedsCCM EB Journal Club Review by D Vaughn
    • An editorial: Hinds CJ. Treatment of sepsis with activated protein C; Encouraging news for well selected patients. Br Med J 2001;323:881-882. [full-text]
    • Mackenzie AF. Activated protein C: do more survive? Intensive Care Med. 2005 Oct 15; [Epub ahead of print] [citation]
  • Barton P, Kalil AC, Nadel S, et al. Safety, Pharmacokinetics, and Pharmacodynamics of Drotrecogin Alfa (Activated) in Children With Severe Sepsis. Pediatrics 2004;113 7-17 [abstract]
  • Manns BJ, Lee H, Doig CJ, Johnson D, Donaldson C. An economic evaluation of activated protein C treatment for severe sepsis. N Engl J Med 2002;347:993-1000. [abstract]
    • PedsCCM EB Journal Club Review, by A Arikan
  • Shock, K Tegtmeyer, Oregon Health Sciences University (teaching file)
  • Warren HS, Suffredini AF, Munford RS. Risks and Benefits of Activated Protein C Treatment for Severe SepsisN Engl J Med 2002;347(13):1027-1030. [full-text for subscribers]
  • Siegel JP. Assessing the Use of Activated Protein C in the Treatment of Severe Sepsis. N Engl J Med 2002;347(13):1030-1034. [full-text for subscribers]
  • Angus DC, Linde-Zwirble WT, et al; PROWESS Investigators. Cost-effectiveness of drotrecogin alfa (activated) in the treatment of severe sepsis. Crit Care Med. 2003 Jan;31(1):1-11. [abstract]
    • PedsCCM EB Journal Club Review, by N Mehta
  • Martin C, Viviand X, Leone M, Thirion X. Effect of norepinephrine on the outcome of septic shock. Crit Care Med. 2000;28(8):2758-65. [abstract]
    • PedsCCM EB Journal Club Review, by P. Prabhakaran
  • Angus DC, Birmingham MC, Balk RA, et al. E5 murine monoclonal antiendotoxin antibody in gram-negative sepsis: a randomized controlled trial. E5 Study Investigators. JAMA. 2000;283:1723-30. [abstract] [full-text for subscribers only]
  • Alia I, Esteban A, Gordo F, et al. A randomized and controlled trial of the effect of treatment aimed at maximizing oxygen delivery in patients with severe sepsis or septic shock. Chest 1999;115:453-61. [abstract]
    • PedsCCM EB Journal Club Review by P. Prabhakaran, T. Butler
  • Stress doses of hydrocortisone reverse hyperdynamic septic shock: a prospective, randomized, double-blind, single-center study. Briegel J, Forst H, Haller M, et al. Crit Care Med. 1999;27:723-32. [abstract]
    • PedsCCM EB Journal Club Review, by D. Vaughn
  • Arons MM, Wheller AP, Bernard GR, et al. Effects of ibuprofen on the physiology and survival of hypothermic sepsis. Crit Care Med 1999; 27:699-707. [abstract]
    • PedsCCM EB Journal Club Review, by W Arias
  • Steroid controversy in sepsis and septic shock: a meta-analysis. Lefering R, Neugebauer EA. Crit Care Med 1995;23:1294-303. [abstract]
    • PedsCCM EB Journal Club Review, by C. Landers
  • Corticosteroid treatment for sepsis: a critical appraisal and meta-analysis of the literature. Cronin L, Cook DJ, Carlet J, et al. Crit Care Med 1995; 23: 1430-1439. [abstract]
    • PedsCCM EB Journal Club Review, by V. Gharpure and K. Meert
  • Marik PE, Zaloga GP. Adrenal Insufficiency in the Critically Ill: A New Look at an Old Problem. Chest 2002;122 1784-1796 [abstract]
  • Adrenal insufficiency in septic shock. Hatherill M, Tibby SM, Hilliard T, Turner C, Murdoch IA. Arch Dis Child 1999; 80: 51-55. [full-text until July 1999] [abstract]
  • Hemodynamic Support in Fluid-refractory Pediatric Septic Shock. Ceneviva G, Paschall JA, Maffei F, Carcillo JA. Pediatrics 1998: 102: e19. (full-text)
  • Reversal of late septic shock with supraphysiologic doses of hydrocortisone. Bollaert P, Charpentier C, Levy B, Debouverie M, Audibert G, Larcan A. Crit Care Med 1998;26:645-650 [abstract]
    • PedsCCM EB Journal Club Review, by A. Torres
    • Critical Appraisal of this paper from Critically Appraised Topics at SORAHSN.
  • Norepinephrine or dopamine for the treatment of hyperdynamic septic shock? Martin C. et al. Chest 1993;103:1826-1831. [abstract]
    • Critical Appraisal of this paper from Critically Appraised Topics at SORAHSN.
  • Treatment of Septic Shock with the Tumor Necrosis Factor Receptor:Fc Fusion Protein. Fisher CJ., et al. N Engl J Med 1996; 334: 1697-1702. [abstract]
  • Hemodynamic effects of i.v. milrinone 6 in pediatric patients with septic shock. A prospective, double-blinded, randomized, placebo-controlled, interventional study. Barton P, Garcia J, Kouatli A, Kitchen L, Zorka A, Lindsay C, Lawless S, Giroir B. Chest 1996; 109: 1302-1312. [abstract]
    • PedsCCM EB Journal Club Review, by M. Verive
  • Forsythe SM, Schmidt GA. Sodium Bicarbonate for the Treatment of Lactic Acidosis. Chest 2000 117: 260-267. [abstract] [full-text for subscribers]
• Hatherill M, Waggie Z, Purves L, Reynolds L, Argent A. Mortality and the nature of metabolic acidosis in children with shock. Intensive Care Med. 2003 Feb;29(2):286-91 [abstract]
  • PedsCCM EB Journal Club Review, by R Lambert, A Zaritsky
• Durward A, Mayer A, Skellett S, Taylor D, Hanna S, Tibby SM, Murdoch IA. Hypoalbuminaemia in critically ill children: incidence, prognosis, and influence on the anion gap. Arch Dis Child. 2003 May;88(5):419-22. [abstract]
  • PedsCCM EB Journal Club Review, by R Lambert
• Durward A, Skellett S, Mayer A, Taylor D, Tibby SM, Murdoch IA. The value of the chloride:sodium ratio in differentiating the aetiology of metabolic acidosis. Intensive Care Med 2001;27:828-835. [DOI 10.1007/s001340100915/abstract]
• Choice of fluid for resuscitation:
  • Evidence-based Colloid Use in the Critically Ill: American Thoracic Society Consensus Statement. Am J Respir Crit Care Med 2004;170 1247-1259 [full-text]
  • The SAFE Study Investigators. A comparison of albumin and saline for fluid resuscitation in the Intensive Care Unit. New Engl J Med 2004; 350:2247-2256. [abstract]
    • PedsCCM EB Journal Club Review, by S van Schaik
  • Wilkes MM, Navick RJ. Patient Survival after Human Albumin Administration A Meta-Analysis of Randomized, Controlled Trials. Ann Int Med 2001; 135:149-164. [abstract; full-text for subscribers]
    • PedsCCM EB Journal Club Review, by A Torres
  • Crystalloids vs. 4s in fluid resuscitation: a systematic review. Choi PT, Yip G, Quinonez LG, Cook DJ. Crit Care Med 1999; 27:200-10. [abstract]
    • PedsCCM EB Journal Club review, by M. Sanchez-Mendiola
  • Fluid resuscitation with colloid or crystalloid solutions in critically ill patients: a systematic review of randomised trials. Schierhout G, Roberts I. Br Med J 1998; 316: 961-5. (full-text)
    • PedsCCM EB Journal Club Review, by M. Verive
  • Human albumin administration in critically ill patients: systematic review of randomised controlled trials: Why albumin may not work. Cochrane Injuries Group Albumin Reviewers. Br Med J 1998; 317: 235-240. With an accompanying Editorial. Offringa M. (Br Med J 1998; 317: 223-224), and Science commentary: Why albumin may not work. Berger A. (Br Med J 1998; 317: 240) (all full-text)
    • PedsCCM EB Journal Club Review, by A. Torres
• Annane D, Sébille V, Troché G, et al. A 3-Level Prognostic Classification in Septic Shock Based on Cortisol Levels and Cortisol Response to Corticotropin. JAMA 2000;283:1038-1045. [abstract] [full-text for subscribers only]
  • PedsCCM EB Journal Club Review, by X. Garcia, M. McPherson, M. Mariscalo
• Capillary refill and core-peripheral temperature gap as indicators of haemodynamic status in paediatric intensive care patients. Tibby SM, Hatherill M, Murdoch IA. Arch Dis Child 1999; 80: 163-166. [full-text until July 1999] [abstract]
  • PedsCCM EB Journal Club Review, by S. Cray
• ABC of intensive care: Circulatory support. Hinds CJ, Watson D. Br Med J 1999; 318: 1749-1752. (full-text)
• Deakin CD, Low JL. Accuracy of the advanced trauma life support guidelines for predicting systolic blood pressure using carotid, femoral, and radial pulses: observational study. Br Med J. 2000;321(7262):673-674. [full-text]
• Epstein CD, Peerless JR, Martin JE, Malangoni MA. Comparison of methods of measurements of oxygen consumption in mechanically ventilated patients with multiple trauma: the Fick method versus indirect calorimetry. Crit Care Med. 2000 May;28(5):1363-9. [abstract]

Congenital Heart Disease

• Robin NH, Shprintzen RJ. Defining the clinical spectrum of deletion 22q11.2. J Pediatr. 2005 Jul;147(1):90-6. [citation]
• Li J, Hoskote A, Hickey C, et al. Effect of carbon dioxide on systemic oxygenation, oxygen consumption, and blood lactate levels after bidirectional superior cavopulmonary anastomosis. Crit Care Med. 2005 May;33(5):984-989 [abstract]
• Durward A, Tibby SM, Skellett S, Austin C, Anderson D, Murdoch IA. The strong ion gap predicts mortality in children following cardiopulmonary bypass surgery. Pediatr Crit Care Med. 2005 May;6(3):281-285 [abstract]
• Egan JR, Festa M, Cole AD, Nunn GR, Gillis J, Winlaw DS. Clinical assessment of cardiac performance in infants and children following cardiac surgery. Intensive Care Med. 2005 Apr;31(4):568-573 [abstract]
• Rossi AF, Khan DM, Hannan R, Bolivar J, Zaidenweber M, Burke R. Goal-directed medical therapy and point-of-care testing improve outcomes after congenital heart surgery. Intensive Care Med. 2005 Jan;31(1):98-104. [abstract]
  • PedsCCM EB Journal Club Review, by M Drayer, R Harrison
• Lim DS, Kulik TJ, Kim DW, Charpie JR, Crowley DC, Maher KO. Aminophylline for the prevention of apnea during prostaglandin E1 infusion. Pediatrics. 2003 Jul;112(1 Pt 1):e27-9. [abstract]
  • PedsCCM EB Journal Club Review, by P Alexander
• Schulze-Neick I, Hartenstein P, Li J, et al. Intravenous sildenafil is a potent pulmonary vasodilator in children with congenital heart disease. Circulation. 2003 Sep 9;108 Suppl 1:II167-73. [abstract]
• Charpie JR, Dekeon MK, Goldberg CS, Mosca RS, Bove EL, Kulik TJ. Serial blood lactate measurements predict early outcome after neonatal repair or palliation for complex congenital heart disease. J Thorac Cardiovasc Surg. 2000 Jul;120(1):73-80. [abstract]
  • PedsCCM EB Journal Club Review, by A Gazit
• Murray DM, Olhsson V, Fraser JI. Defining acidosis in postoperative cardiac patients using Stewart's method of strong ion difference. Pediatr Crit Care Med. 2004 May;5(3):240-5 [abstract; full-text (356K)]
• Hoffman GM, Tweddell JS, Ghanayem NS, Mussatto KA, Stuth EA, Jaquis RD, Berger S. Alteration of the critical arteriovenous oxygen saturation relationship by sustained afterload reduction after the norwood procedure. J Thorac Cardiovasc Surg. 2004 Mar;127(3):738-45. [abstract]
  • PedsCCM EB Journal Club Review, by N Lin
• Galli KK, Zimmerman RA, Jarvik GP, Wernovsky G, et al. Periventricular leukomalacia is common after neonatal cardiac surgery. J Thorac Cardiovasc Surg. 2004 Mar;127(3):692-704 [abstract]
• Stocker C, Penny DJ, Brizard CP, Cochrane AD, Soto R, Shekerdemian LS. Intravenous sildenafil and inhaled nitric oxide: a randomised trial in infants after cardiac surgery. Intensive Care Med. 2003 Nov;29(11):1996-200 [abstract]
• Ashburn DA, McCrindle BW, Tchervenkov CI, Jacobs ML, Lofland GK, Bove EL, Spray TL, Williams WG, Blackstone EH. Outcomes after the Norwood operation in neonates with critical aortic stenosis or aortic valve atresia. J Thorac Cardiovasc Surg. 2003 May;125(5):1070-82. [abstract]
• Pizarro C, Malec E, Maher KO, et al. Right Ventricle to Pulmonary Artery Conduit Improves Outcome After Stage I Norwood for Hypoplastic Left Heart Syndrome. Circulation 2003;108 155-160. [abstract]
• Maher KO, Pizarro C, Gidding SS, et al. Hemodynamic Profile After the Norwood Procedure With Right Ventricle to Pulmonary Artery Conduit. Circulation 2003;108 782-784 [abstract]
• Culbert EL, Ashburn DA, Cullen-Dean G, et al. Quality of Life of Children After Repair of Transposition of the Great Arteries. Circulation 2003;108 857-862. [abstract]
  • PedsCCM EB Journal Club Review, by D Stockwell, J Natale
• Abstracts - only on PedsCCM - from The First Asia-Pacific Symposium on Pediatric Cardiac Intensive Care on February 20-22, 2003 at The Phuket Arcadia Resort, Phuket, Thailand.
• Hoffman TM, Wernovsky G, Atz AM, et al. Efficacy and safety of milrinone in preventing low cardiac output syndrome in infants and children after corrective surgery for congenital heart disease. Circulation. 2003 Feb 25;107(7):996-1002. [abstract]
  • PedsCCM EB Journal Club Review, by A Torres
• Clancy RR, McGaurn SA, Wernovsky G, et al. Risk of seizures in survivors of newborn heart surgery using deep hypothermic circulatory arrest. Pediatrics. 2003;111(3):592-601. [abstract]
  • PedsCCM EB Journal Club Review, by G Deshpande, A Torres
• Brown KL, Ridout DA, Goldman AP, Hoskote A, Penny DJ. Risk factors for long intensive care unit stay after cardiopulmonary bypass in children. Crit Care Med. 2003;31(1):28-33. [abstract]
  • PedsCCM EB Journal Club Review, by A Torres
• Ikle L, Hale K, Fashaw L, Boucek M, Rosenberg AA. Developmental outcome of patients with hypoplastic left heart syndrome treated with heart transplantation. J Pediatr. 2003;142(1):20-5. [abstract]
• Bettendorf M, Schmidt KG, Grulich-Henn J, Ulmer HE, Heinrich UE. Tri-iodothyronine treatment in children after cardiac surgery: a double-blind, randomised, placebo-controlled study. Lancet. 2000; 356(9229):529-34. [abstract]
  • PedsCCM EB Journal Club Review, by L Rajagopalan
• Ross OC, Petros A. The sick euthyroid syndrome in paediatric cardiac surgery patients. Intensive Care Med. 2001; 27(7):1124-32 [full-text for subscribers]
• Chang RYR, Chen AY, Klitzner TS. Clinical Management of Infants With Hypoplastic Left Heart Syndrome in the United States, 1988-1997. Pediatrics 2002;110 292-298. [abstract; full-text for AAP members/subscribers]
• Limperopoulos C, Majnemer A, Shevell MI, et al. Predictors of developmental disabilities after open heart surgery in young children with congenital heart defects. J Pediatr. 2002;141(1):51-8. [abstract; full-text for subscribers]
  • PedsCCM EB Journal Club Review by L Elbahlawan
• Chang RKR, Klitzner TS. Can Regionalization Decrease the Number of Deaths for Children Who Undergo Cardiac Surgery? A Theoretical Analysis. Pediatrics 2002; 109:173-181. [abstract; full-text for AAP members/subsribers]
• Spiegelhalter DJ Mortality and volume of cases in paediatric cardiac surgery: retrospective study based on routinely collected data Br Med J 2002;324:261 [full-text]
• Clancy RR, MCGaurn SA, Goin JE, et al. Allopurinol Neurocardiac Protection Trial in Infants Undergoing Heart Surgery Using Deep Hypothermic Circulatory Arrest. Pediatrics 2001;108 61-70. [abstract][full-text for subscribers/AAP members]
  • PedsCCM EB Journal Club Review, by A Shahin
• Miller OI, Tang SF, Keech A, et al. Inhaled nitric oxide and prevention of pulmonary hypertension after congenital heart surgery: a randomised double-blind study. Lancet 2000;356:1464-1469. [abstract]
  • PedsCCM EB Journal Club Review, by K.Daphtary, K. Meert
• Morris K, Beghetti M, Petros A, Adatia I, Bohn D. Comparison of hyperventilation and inhaled nitric oxide for pulmonary hypertension after repair of congenital heart disease. Crit Care Med. 2000;28(8):2974-8. [abstract]
  • PedsCCM EB Journal Club Review, by R Rao, M Scanlon
• Flori HR, Johnson LD, Hanley FL, Fineman JR. Transthoracic intracardiac catheters in pediatric patients recovering from congenital heart defect surgery: associated complications and outcomes. Crit Care Med. 2000;28(8):2997-3001. [abstract]
• Tweddell JS, Hoffman GM, Fedderly RT, et al. Phenoxybenzamine improves systemic oxygen delivery after the Norwood procedure. Ann Thorac Surg. 1999;67(1):161-7. [abstract] [full-text] [discussion on Ann Thoracic Surg website]
• Rossi AF, Seiden HS, Gross RP, Griepp RB. Oxygen transport in critically ill infants after congenital heart operations. Ann Thorac Surg. 1999;67(3):739-44. [abstract] [full-text] [discussion on the Ann Thoracic Surg website]
  • PedsCCM EB Journal Club Review, by A Shahin
• Lequier LL, Nikaidoh H, Leonard SR, Bokovoy JL, White ML, Scannon PJ, Giroir BP. Preoperative and Postoperative Endotoxemia in Children With Congenital Heart Disease. Chest. 2000 Jun;117(6):1706-1712. [abstract] [full-text for subscribers]
• McElhinney DB, Reddy VM, Parry AJ, et al. Management and outcomes of delayed sternal closure after cardiac surgery in neonates and infants. Crit Care Med. 2000;28(4):1180-4. [abstract]
• Bandla HPR, Hopkins RL, Beckerman RC, Gozal D. Pulmonary Risk Factors Compromising Postoperative Recovery After Surgical Repair for Congenital Heart Disease. Chest 1999;116:740-747. [abstract]
  • PedsCCM EB Journal Club Review, by J Geracht, J Barron, D Epstein
• Khongphatthanayothin A, Wong PC, Samara Y, et al. Impact of respiratory syncytial virus infection on surgery for congenital heart disease: postoperative course and outcome. Crit Care Med 1999;27:1974-81. [abstract]
• Early Developmental Outcome After the Norwood Procedure for Hypoplastic Left Heart Syndrom. Kern JH, Hinton VJ, Nereo NE, Hayes CJ, Gersony WM. Pediatrics 1998; 102: 1148-1152. (full-text for AAP members) [abstract]
• Approach To Cyanotic Heart Disease In The First Month Of Life . D'Agostino HJ, Ceithaml EL. Jacksonville Medicine September 1998
• Postoperative Care of the congenital heart surgery patient, from PediHeart. Also with comprehensive information on other General Principles (diagnosis, anesthesia, bypass), Cardiac Anatomy, Cardiac Defects, and Operations.
• Pediatric Cardiac Surgery: The Effect of Hospital and Surgeon Volume on In-hospital Mortality. Hannan EL, Racz M, Kavey RE, Quaegebeur JM, Williams R. Pediatrics 1998;101: 963-969. (abstract) With a review in Evidence Based Medicine 1999; 4. Jan/Feb. Whyte R.
• Congenital Heart Defects, from KUMC Cardiology
• Children's Information Network; many links to CHD resources on the web
• Outlines from CHORUS
• From University of Hawaii Radiology Cases in Pediatric Emergency Medicine
  • Cor Triatriatum
  • Coarctation of the Aorta in Infancy
  • Tetralogy of Fallot
  • DiGeorge Syndrome

Multiple conditions

• Sackner-Bernstein JD, Kowalski M, Fox M, Aaronson K. Short-term risk of death after treatment with nesiritide for decompensated heart failure: a pooled analysis of randomized controlled trials. JAMA. 2005 Apr 20;293(15):1900-5. [abstract]
• Sackner-Bernstein JD, Skopicki HA, Aaronson KD. Risk of worsening renal function with nesiritide in patients with acutely decompensated heart failure. Circulation. 2005 Mar 29;111(12):1487-91 [abstract]
• Yung D, Widlitz AC, Rosenzweig EB, et al. Outcomes in Children With Idiopathic Pulmonary Arterial Hypertension. Circulation 2004;110 660-665 [abstract]
• Nava S, Carbone G, DiBattista N, et al. Noninvasive ventilation in cardiogenic pulmonary edema: a multicenter randomized trial. Am J Respir Crit Care Med. 2003 Dec 15;168(12):1432-7 [abstract]
• Holmes CL, Walley KR. Bad Medicine: Low-Dose Dopamine in the ICU. Chest 2003;123 1266-1275 [abstract]
• Duncan BW, Bohn DJ, Atz AM, et al. Mechanical circulatory support for the treatment of children with acute fulminant myocarditis. J Thorac Cardiovasc Surg. 2001;122(3):440-448. [abstract]
• Hypertensive Emergencies, from the Pediatric Emergency Manual, The Virtual Naval Hospital.
• Bayer AS, Bolger AF, Taubert KA, et al. Diagnosis and Management of Infective Endocarditis and Its Complications. American Heart Association Scientific Statement. Circulation. 1998;98:2936-2948. [full-text]
• Hypertrophic Cardiomyopathy. Zevitz ME, Strafford M. October 1998. In emedicine Pediatrics. From emedicine.
• Pediatrics, Kawasaki's Disease. Parillo S, Parillo CV., from Emergency Medicine at Emedicine
• Myopathies with cardiac involvement, from Neuromuscular Disease Center at Washington University
• VSD and Cardiac Development; interactive presentations with CME credit for nurses, from Health Interactive

Cardiopulmonary Resuscitation

• Ewy GA. Cardiocerebral Resuscitation: The New Cardiopulmonary Resuscitation. Circulation 2005;111 2134-2142 [full-text for subscribers]
• Abella BS, Alvarado JP, Myklebust H, et al. Quality of cardiopulmonary resuscitation during in-hospital cardiac arrest. JAMA. 2005 Jan 19;293(3):305-10. [abstract]
• Pediatric Life Support 2005 Evidence Evaluation Worksheets, from The International Liaison Committee on Resuscitation 2005 Consensus on ECC & CPR Science and Treatment Recommendations. (Current guidelines for Pediatric Advanced Life Support from 2000: Circulation 2000 102 [Suppl I]: I-291 - I-342. [full-text]
• Perondi MBM, Reis AG, Paiva EF, Nadkarni VM, Berg RA. A Comparison of High-Dose and Standard-Dose Epinephrine in Children with Cardiac Arrest. New Engl J Med 2004; 350:1722-1730. [abstract]
  • PedsCCM EB Journal Club Review, by M Sharma
• Wenzel V, Krismer AC, Arntz HR, et al. A Comparison of Vasopressin and Epinephrine for Out-of-Hospital Cardiopulmonary Resuscitation. New Engl J Med 2003; 350:105-113. [abstract]
  • PedsCCM EB Journal Club Review, by K Denev
• Parra DA, Totapally BR, Zahn E, Jacobs J, Aldousany A, Burke RP, Chang AC. Outcome of cardiopulmonary resuscitation in a pediatric cardiac intensive care unit. Crit Care Med. 2000;28(9):3296-300. [abstract]
  • PedsCCM EB Journal Club Review, by KP Mistry
• Shankaran S, Laptook AR, Ehrenkranz RA, et al. Whole-body hypothermia for neonates with hypoxic-ischemic encephalopathy. N Engl J Med. 2005 Oct 13;353(15):1574-84. [abstract]
• Bernard SA, Buist M. Induced hypothermia in critical care medicine: A review. Crit Care Med. 2003 Jul;31(7):2041-51 [abstract]
• Polderman KH. Application of therapeutic hypothermia in the ICU: opportunities and pitfalls of a promising treatment modality. Part 1: Indications and evidence. Intensive Care Med. 2004 Apr;30(4):556-75 [abstract]
• Polderman KH. Application of therapeutic hypothermia in the intensive care unit: Opportunities and pitfalls of a promising treatment modality-Part 2: Practical aspects and side effects. Intensive Care Med. 2004; 30(5):757-769. [abstract]
• Horisberger T, Fischer JE, Fanconi S. One-year survival and neurological outcome after pediatric cardiopulmonary resuscitation. Intensive Care Med 2002; 28: 365-368. [abstract]
  • PedsCCM EB Journal Club Review, by P Prodhan, N Noviski
• Nolan JP, Morley PT, Vanden Hoek TL, et al. ; International Liaison Committee on Resuscitation. Therapeutic hypothermia after cardiac arrest: an advisory statement by the advanced life support task force of the International Liaison Committee on Resuscitation. Circulation. 2003 Jul 8;108(1):118-21 [full-text]
• The Hypothermia After Cardiac Arrest Study Group. Mild Therapeutic Hypothermia to Improve the Neurologic Outcome After Cardiac Arrest. N Engl J Med 2002;346:549-56. [abstract; full-text for subscribers]
• Bernard SA, Gray TW, Buist MD. Treatment of Comatose Survivors of Out-of-Hospital Cardiac Arrest with Induced Hypothermia. N Engl J Med 2002;346:557-63. [abstract; full-text for subscribers]
  • PedsCCM EB Journal Club Review, by M Sehgal
• Reis AG, Nadkarni V, Perondi MB et al. A Prospective Investigation Into the Epidemiology of In-Hospital Pediatric Cardiopulmonary Resuscitation Using the International Utstein Reporting Style, Pediatrics 2002;109 200-209. [abstract; full-text for AAP members/subscribers]
• Code Algorithms, CPR Table, from the Pediatric Emergency Manual, The Virtual Naval Hospital.
• Injuries, Poisoning, and CPR in The Section on Pediatrics of The Merck Manual of Diagnosis and Therapy (full-text)
• An evidence-based evaluation of the use of sodium bicarbonate during cardiopulmonary resuscitation. Levy MM. Crit Care Clin 1998; 14:457-83. [abstract]
• Forsythe SM, Schmidt GA. Sodium Bicarbonate for the Treatment of Lactic Acidosis. Chest 2000 117: 260-267. [abstract] [full-text for subscribers]
• Gueugniaud P-Y, Mols P, Goldstein P, et al., for the European Epinephrine Study Group. A Comparison of Repeated High Doses and Repeated Standard Doses of Epinephrine for Cardiac Arrest outside the Hospital. N Engl J Med 1998;339:1595-601. [abstract]
• ILCOR Advisory Statements: Pediatric Resuscitation. An Advisory Statement From the Pediatric Working Group of the International Liaison Committee on Resuscitation. From Scientific Statements of The American Heart Association.
• Cardiopulmonary resuscitation in pediatric intensive care units. Slonim AD, Patel KM, Ruttimann UE, Pollack MM. Crit Care Med 1997; 25: 1951-1955. [abstract]
• Levine RL, Wayne MA, Miller CC. End-Tidal Carbon Dioxide and Outcome of Out-Of-Hospital Cardiac Arrest. New Engl J Med 1997; 337: 301-6. [abstract]
• Prevalence of Retinal Hemorrhages in Pediatric Patients After In-hospital Cardiopulmonary Resuscitation: A Prospective Study. Odom, A, Christ, E, Kerr, N et al. Pediatrics 1997; 99(6):e3. (full-text) [abstract]]
• High-dose Epinephrine Is Not Superior to Standard-dose Epinephrine in Pediatric In-hospital Cardiopulmonary Arrest. Carpenter, T.C., Stenmark, K.R. Pediatrics 1997 99(3): 403-408. (abstract)
• Additive Impact of In-hospital Cardiac Arrest on the Functioning of Children With Heart Disease. Bloom, A.A., Wright, J.A., Morris, R.D., Campbell, R.M., Krawiecki, N.S. Pediatrics 1997 99(3): 390-398. (abstract)
• Recommended Guidelines for Uniform Reporting of Pediatric Advanced Life Support: The Pediatric Utstein Style, from The American Heart Association (Circulation 1995;92:2006-2020)
• Outcome of Out-of-Hospital Cardiac or Respiratory Arrest in Children. Schindler, M., Bohn, D., Cox, P., McCrindle, B., Jarvis, A., Edmonds, J., Barker, G. N Engl J Med 1996; 335: 1473-1479. [abstract]
  • PedsCCM EB Journal Club Review, by A. Randolph
• 1997 Resuscitation Council (UK) Guidelines: Pediatric Basic Life Support and Pediatric Advanced Life Support
• Paediatric Advanced Life Support: The Australian Resuscitation Council Guidelines, from The Medical Journal of Australia
• PALS simulator, at the Emergency Medicine BBS

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Neurologic/Neuromuscular Disorders

Physiology

• Nagdyman N, Fleck T, Schubert S, et al. Comparison between cerebral tissue oxygenation index measured by near-infrared spectroscopy and venous jugular bulb saturation in children. Intensive Care Med. 2005 Jun;31(6):846-50 [abstract]
• Citerio G, Andrews PJ. Intracranial pressurePart two: Clinical applications and technology. Intensive Care Med. 2004; 30:1882-1885 [citation]
• Walters FJM. Neuropharmacology - Intracranial Pressure and Cerebral Blood Flow. Update in Anaesthesia 1998; 9:7. [full-text]
• Intracranial Pressure and Cerebral Blood Flow. Walters FJM. Update in Anesthesia 1998; 8:4. (full-text)
• Cerebral Blood Flow Determination, from University of Queenland, Brisbane, Australia (server currently not responding)
• Ract C, Vigué. Comparison of the cerebral effects of dopamine and norepinephrine in severely head-injured patients. Intensive Care Med, DOI 10.1007/s001340000754. 5 January 2001 [full-text]
• Cerebral Resusitation and Increased Intracranial Pressure, L Ibsen, Oregon Health Sciences University (teaching file)

CNS Trauma/Head Injury and Near Drowning

• Cohan P, Wang C, McArthur DL, et al. Acute secondary adrenal insufficiency after traumatic brain injury: A prospective study. Crit Care Med. 2005 Oct;33(10):2358-2366. [abstract]
• Cremer OL, van Dijk GW, van Wensen E, Brekelmans GJ, Moons KG, Leenen LP, Kalkman CJ. Effect of intracranial pressure monitoring and targeted intensive care on functional outcome after severe head injury. Crit Care Med. 2005 Oct;33(10):2207-2213. [abstract]
• Tilford JM, Aitken ME, Anand KJ, et al. Hospitalizations for critically ill children with traumatic brain injuries: A longitudinal analysis. Crit Care Med. 2005 Sep;33(9):2074-2081. [abstract]
• Carter BG, Butt W. A prospective study of outcome predictors after severe brain injury in children. Intensive Care Med. 2005 Jun;31(6):840-845. [abstract]
  • PedsCCM EB Journal Club Review, by L Thompson
• Stocchetti N, Maas AI, Chieregato A, van der Plas AA. Hyperventilation in head injury: a review. Chest. 2005 May;127(5):1812-27. [abstract]
• Mayer SA, Brun NC, Begtrup K, Broderick J, Davis S, Diringer MN, Skolnick BE, Steiner T; Recombinant Activated Factor VII Intracerebral Hemorrhage Trial Investigators. Recombinant activated factor VII for acute intracerebral hemorrhage. N Engl J Med. 2005 Feb 24;352(8):777-85 [abstract]
• Graf WD, Cummings P, Quan L, Brutocao D. Predicting outcome in pediatric submersion victims. Ann Emerg Med. 1995 Sep;26(3):312-9 [abstract]
  • PedsCCM EB Journal Club Review, by A Godshall
• Albanese J, Leone M, Garnier F, et al. Renal Effects of Norepinephrine in Septic and Nonseptic Patients. Chest 2004;126 534-539 [abstract]
• Bechtel K, Stoessel K, Leventhal JM et al. Characteristics That Distinguish Accidental From Abusive Injury in Hospitalized Young Children With Head Trauma. Pediatrics 2004;114 165-168 [abstract]
  • PedsCCM EB Journal Club Review, by M Winkler
• Palchak MJ, Holmes JF, Vance CW, et al. Does an isolated history of loss of consciousness or amnesia predict brain injuries in children after blunt head trauma? Pediatrics. 2004 Jun;113(6):e507-13 [abstract]
  • PedsCCM EB Journal Club Review, by K Typpo
• Polderman KH. Application of therapeutic hypothermia in the ICU: opportunities and pitfalls of a promising treatment modality. Part 1: Indications and evidence. Intensive Care Med. 2004 Apr;30(4):556-75 [abstract]
• Polderman KH. Application of therapeutic hypothermia in the intensive care unit: Opportunities and pitfalls of a promising treatment modality-Part 2: Practical aspects and side effects. Intensive Care Med. 2004; 30(5):757-769. [abstract]
• Cooper DJ, Myles PS, McDermott FT, et al. Prehospital hypertonic saline resuscitation of patients with hypotension and severe traumatic brain injury: a randomized controlled trial. JAMA. 2004 Mar 17;291(11):1350-7. [abstract]
  • PedsCCM EB Journal Club Review, by G Mander
• Henderson WR, Dhingra VK, Chittock DR, Fenwick JC, Ronco JJ. Hypothermia in the management of traumatic brain injury. A systematic review and meta-analysis. Intensive Care Med. 2003 Oct;29(10):1637-44. [abstract]
  • PedsCCM EB Journal Club Review, by N Shafi, M Mariscalco
• Harries M. ABC of resuscitation: Near drowning. Br Med J 2003;327:1336-1338[full-text]
• Guidelines for the acute medical management of severe traumatic brain injury in infants, children, and adolescents. Pediatric Critical Care Medicine 2003; 4(3):S1-S75. [full-text]
• McIntyre LA, Fergusson DA, Hebert PC, Moher D, Hutchison JS. Prolonged Therapeutic Hypothermia After Traumatic Brain Injury in Adults: A Systematic Review. JAMA 2003;289 2992-2999[abstract]
  • PedsCCM EB Journal Club Review, by N Shafi, M Mariscalco
• Bernard SA, Buist M. Induced hypothermia in critical care medicine: A review. Crit Care Med. 2003 Jul;31(7):2041-51 [abstract]
• Polderman KH, Joe RTT, Peerdeman SM et al. Effects of therapeutic hypothermia on intracranial pressure and outcome in patients with severe head injury. Intensive Care Med 2002;28: 1563-1573 [abstract]
  • PedsCCM EB Journal Club Review by S and S Thammasitboon
• Perez A, Minces PG, Schnitzler EJ, Agosta GE, Medina SA, Ciraolo CA. Jugular venous oxygen saturation or arteriovenous difference of lactate content and outcome in children with severe traumatic brain injury. Pediatr Crit Care Med. 2003 Jan;4(1):33-8 [abstract]
  • PedsCCM EB Journal Club Review, by J Alten, M Mariscalco
• Biswas AK, Bruce DA, Sklar FH, Bokovoy JL, Sommerauer JF. Treatment of acute traumatic brain injury in children with moderate hypothermia improves intracranial hypertension. Crit Care Med. 2002;30(12):2742-51. [citation]
• Robertson CMT, Joffe AR, Moore AJ, Watt JM. Neurodevelopmental outcome of young pediatric intensive care survivors of serious brain injury. Pediatric Critical Care Medicine 2002; 3(4):345-350. [abstract]
  • PedsCCM EB Journal Club Review, by R Graham
• Bulger EM, Nathens AB, Rivara FP, et al. Management of severe head injury: institutional variations in care and effect on outcome. Crit Care Med 2002;30(8):1870-6. [abstract]
  • PedsCCM EB Journal Club Review, by J Adler
• Hackbarth RM, Rzeszutko KM, Sturm G, et al. Survival and functional outcome in pediatric traumatic brain injury: a retrospective review and analysis of predictive factors. Crit Care Med 2002;30(7):1630-5. [abstract; full-text for subscribers]
  • PedsCCM EB Journal Club Review, by J Krishnan, W Morrison
• Wells RG, Vetter C, Laud P. Intracranial hemorrhage in children younger than 3 years: prediction of intent. Arch Pediatr Adolesc Med. 2002;156(3):252-7. [abstract; full-text for subscribers]
  • PedsCCM EB Journal Club Review, by G Capraro, S Bateman
• Holzer M, Bernard SA, Hachimi-Idrissi S, et al. Hypothermia for neuroprotection after cardiac arrest: systematic review and individual patient data meta-analysis. Crit Care Med. 2005 Feb;33(2):414-8. [abstract]
• The Hypothermia After Cardiac Arrest Study Group. Mild Therapeutic Hypothermia to Improve the Neurologic Outcome After Cardiac Arrest. N Engl J Med 2002;346:549-56. [abstract; full-text for subscribers]
• Bernard SA, Gray TW, Buist MD. Treatment of Comatose Survivors of Out-of-Hospital Cardiac Arrest with Induced Hypothermia. N Engl J Med 2002;346:557-63. [abstract; full-text for subscribers]
• Stancin T, Drotar D, Taylor G et al. Health-Related Quality of Life of Children and Adolescents After Traumatic Brain Injury. Pediatrics 2002; 109: e34. [full-text]
• Guidelines: Management and Prognosis of Severe Traumatic Brain Injury, from the Brain Trauma Foundation.
• Tilford JM, Simpson PM, Yeh TS et al. Variation in therapy and outcome for pediatric head trauma patients. Crit Care Med 2001; 29:1056-1061. [abstract]
  • PedsCCM EB Journal Club Review, by L Faberowski
• Clifton GL, Miller ER, Choi SC, et al. Lack of Effect of Induction of Hypothermia after Acute Brain Injury. N Engl J Med 2001;344:556-63. [abstract]
• Crouchman M, Rossiter L, Colaco T, Forsyth R. A practical outcome scale for paediatric head injury. Arch Dis Child 2001; 84: 120-124. [Abstract] [Full-text for subscribers]
• Qureshi AI, Suarez JI. Use of hypertonic saline solutions in treatment of cerebral edema and intracranial hypertension. Crit Care Med. 2000;28(9):3301-13. [abstract]
• Natale JE, Joseph JG, Helfaer MA, Shaffner DH. Early hyperthermia after traumatic brain injury in children: risk factors, influence on length of stay, and effect on short-term neurologic status. Crit Care Med. 2000;28(7):2608-15. [abstract]
• "Evidence-Based Care of the Child with Traumatic Head Injury"; a Powerpoint presentation by T. Trimarchi. The evidence behind current management recommendations for the head injured patient in the PICU. [original file: head_trauma_research.ppt (668K)] Accompanying file: "ICP management bibliography" - a Word document bibliography for this presentation. [ICP_management_biblio.doc (44K)]
• Haydel MJ, Preston CA, Mills TJ, Luber S, Blaudeau E, DeBlieux PM. Indications for computed tomography in patients with minor head injury. N Engl J Med. 2000 Jul 13;343(2):100-5. [abstract]
  • PedsCCM EB Journal Club Review, by M Sehgal, MM Mariscalco
• Dickinson K, Bunn F, Wentz R, Edwards P, Roberts I. Size and quality of randomised controlled trials in head injury: review of published studies Br Med J 2000;320:1308-1311.[full-text]
• Robertson CS, Valadka AB, Hannay HJ, et al. Prevention of secondary ischemic insults after severe head injury. Crit Care Med. 1999;27:2086-95. [abstract]
  • PedsCCM EB Journal Club Review, by JRM White
• A prospective, randomized, and controlled study of fluid management in children with severe head injury: lactated ringer's solution versus hypertonic saline. Simma B, Burger R, Falk M, Sacher P, Fanconi S. Crit Care Med 1998; 26: 1265-1270. [abstract]
  • PedsCCM EB Journal Club review, by S. Sudikoff
• The Management of Minor Closed Head Injury in Children. Committee on Quality Improvement, American Academy of Pediatrics, Commission on Clinical Policies and Research, American Academy of Family Physicians. Pediatrics 1999;104:1407-1415.
• Management of Children with Head Trauma, from Position Papers of the Canadian Pediatric Society
• Raised Intracranial Pressure in Children, from Guidelines and Statements of the College of Physicians and Surgeons of Manitoba
• An evidence-based approach to management of increased intracranial pressure. Allen CH, Ward JD. Crit Care Clin 1998; 14:485-95. [abstract]
• Subdural haemorrhages in infants: population based study. Jayawant S, Rawlinson A, Gibbon F, Price J, Schulte J, Sharples P, Sibert JR, Kemp AM. Br Med J 1998;317:1558-1561. (full-text)
• Downloadable presentations on head trauma in the picuBOOK
• Neuroimaging, Physical, and Developmental Findings After Inflicted and Noninflicted Traumatic Brain Injury in Young Children. Ewing-Cobbs L, Kramer L, Prasad M. Pediatrics 1998; 102: 300-307. (full-text for AAP members) (abstract)
• Emergency Department Management of Head Injury. Fisher J. 1999. Well referenced outline/review of literature. The Completely Different Pediatric Emergency Medicine Journal.
• Predictors of Death and Neurologic Impairment in Pediatric Submersion Injuries: The Pediatric Risk of Mortality Score. Zuckerman GB, Gregory PM, Santos-Damiani SM. Arch Pediatr Adolesc Med. 1998;152:134-140. (abstract)
• Corticosteroids in acute traumatic brain injury: systematic review of randomised controlled trials. Alderson P, Roberts I. Br Med J 1997; 314:1855-1859. (abstract)
  • PedsCCM EB Journal Club Review, by S. Bateman
• Mechanisms of cerebral protection in cold water drowning. Kallas H (now part of picuBOOK)
• Outcome and acute care hospital costs after warm water near drowning in children. Christensen DW, Jansen P, Perkin RM. Pediatrics 1997; 99:715-721. [abstract]
• Greenes DS, Schutzman SA. Clinical Indicators of Intracranial Injury in Head-injured Infants. Pediatrics 1999; 104: 861-867. [Abstract] [full-text for subscribers, AAP members]
  • PedsCCM EB Journal Club Review, by P Tandon, S Bateman
• Diagnostic Testing for Acute Head Injury in Children: When Are Head Computed Tomography and Skull Radiographs Indicated?. Quayle, KS, Jaffe, DM, Kuppermann, N, Kaufman, B, Lee, BCP, Park, TS, McAlister, WH. Pediatrics 1997; 99(5):e11. (full-text) [abstract]
  • PedsCCM EB Journal Club Review, by H.S. Sahhar
• Coagulopathy in Pediatric Abusive Head Trauma. Hymel, K.P., Abshire, T.C., Luckey, D.W., Jenny, C. Pediatrics 1997 99(3): 371-375. (abstract)
• Treatment of Traumatic Brain Injury with Moderate Hypothermia. Marion, D.W. et al. N Engl J Med 1997; 336: 540-546. (abstract)
  • PedsCCM EB Journal Club Review, by B. Markovitz

Infections

• Bacterial Meningitis (on the web). Lazoff M. From Medical Computing Today
• Dexamethasone as Adjunctive Therapy in Bacterial Meningitis. A Meta-analysis of Randomized Clinical Trials Since 1988. McIntyre PB, Berkey CS, King SM, Schaad UB, Kilpi T, Kanra GY, Odio Perez CM. JAMA 1997;278:925-931. (abstract)
• Tuberculous meningitis from Medscape (registration required)
• Bacterial meningitis in children and adults. Phillips EJ, Simor AE. Postgraduate Medicine 1998; 103: 102.
• Encephalitis. Gutierrez KM, Prober CG. Postgraduate Medicine 1998; 103: 123.

Disease Specific Listings

• Stam J. Thrombosis of the Cerebral Veins and Sinuses. New Engl J Med 2005; 352:1791-1798 [extract]
• Robinson LR, Micklesen PJ, Tirschwell DL, Lew HL. Predictive value of somatosensory evoked potentials for awakening from coma. Crit Care Med. 2003 Mar;31(3):960-7. [abstract]
• Clancy RR, McGaurn SA, Wernovsky G, et al. Risk of seizures in survivors of newborn heart surgery using deep hypothermic circulatory arrest. Pediatrics. 2003;111(3):592-601. [abstract]
  • PedsCCM EB Journal Club Review, by G Deshpande, A Torres
• De Jonghe B, Sharshar T, Lefaucheur JP, et al. Paresis acquired in the intensive care unit: a prospective multicenter study. JAMA. 2002;288(22):2859-67. [abstract]
  • PedsCCM EB Journal Club Review, by J Alten
• deVeber G, Andrew M, Adams C et al. Cerebral Sinovenous Thrombosis in Children. New Engl J Med 2001; 345:417-423. [abstract; full-text for subscribers]
• Guillain-Barre Syndrome. Fanion D, Joyce DM. In Emergency Medicine at Emedicine
• Neuromuscular Complications of Critical Illness, by MW Peterson, in the Critical Care Curriculum at the University of Iowa's Virtual Hospital
• Fortnightly review: the muscular dystrophies. Emery AEH. Br Med J 1998; 317: 991-995 (full-text)
• Neuromuscular and CNS Sydromes, from Neuromuscular Disease Center at Washington University. Includes:
  • Differential diagnosis of Polyneuropathies and Myopathy/Neuromuscular Junction Disorders
  • Myasthenic Syndromes
  • Myoglobinuria/Rhabdomyolysis conditions
  • Myopathies with cardiac involvement
• Offringa M, Moyer VA. Evidence based paediatrics: Evidence based management of seizures associated with fever. Br Med J 2001;323 1111-1114. [full-text]
• Lahat E, Goldman M, Barr J et al. Comparison of intranasal midazolam with intravenous diazepam for treating febrile seizures in children: prospective randomised study. Br Med J 2000;321:83-86.[full-text]
  • PedsCCM EB Journal Club Review, by A Torres
• Midazolam coma for refractory status epilepticus in children. Igartua J, Silver P, Maytal J, Sagy M. Crit Care Med 1999;27:1982-5. [abstract]
• New antiepileptic drugs. Sirven JI, Liporace JD. Postgraduate Medicine 1997; 101: 147.
• Managing Pediatric Epilepsy Syndromes With New Antiepileptic Drugs. Pellock JM. Pediatrics 1999; 104:1106-1116. [full-text for AAP members]
• Management of the paediatric patient with generalized convulsive status epilepticus in the emergency department, from Position Papers of the Canadian Pediatric Society
• Seizure Disorders in Childhood, a review by T. Hoban, from Loyola University Medical Education Network
• Pediatrics, Status Epilepticus. Grace GM. In Emergency Medicine at Emedicine
• From University of Hawaii Radiology Cases in Pediatric Emergency Medicine
  • Strokes in Children
  • Evaluation of the Cervical Spine
• Nervous System Diseases at Karolinska
• DKA and cerebral edema: selected references and abstracts
• Tasker RC, Lutman D, Peters MJ. Hyperventilation in severe diabetic ketoacidosis. Pediatr Crit Care Med. 2005 Jul;6(4):405-411. [abstract; full-text (pdf 400K)]
• Marcin JP, Glaser N, Barnett P, et al. Factors associated with adverse outcomes in children with diabetic ketoacidosis-related cerebral edema. J Pediatr. 2002;141(6):793-7. [abstract]
  • PedsCCM EB Journal Club Review, by C Kennedy
• Glaser NS, Wootton-Gorges SL, Marcin JP, et al. Mechanism of cerebral edema in children with diabetic ketoacidosis. J Pediatr. 2004 Aug;145(2):164-71. [abstract]
• Chiasson J-L, Aris-Jilwan N, Belanger R et al. Diagnosis and treatment of diabetic ketoacidosis and the hyperglycemic hyperosmolar state. Can Med Assoc J 2003;168 859-866. [full-text]

General Topics

• Banwell BL, Mildner RJ, Hassall AC, Becker LE, Vajsar J, Shemie SD. Muscle weakness in critically ill children. Neurology. 2003 Dec 23;61(12):1779-82. [abstract]
  • PedsCCM EB Journal Club Review, by J Alten, M Mariscalco
• ABC of intensive care: Neurological support. Grant IS, Andrews PJD. Br Med J 1999; 319: 110-113. (full-text)
• Neurological Emergencies in the Pediatric ICU. Abram H, Hammond D, Shanks D, Turk W. Jacksonville Medicine September 1998

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Systemic Processes and Other Conditions

Fluid/Electrolyte Physiology and Derangements

• Uchino S, Kellum JA, Bellomo R, et al. Acute renal failure in critically ill patients: a multinational, multicenter study. JAMA. 2005 Aug 17;294(7):813-8. [abstract]
• Friedrich JO, Adhikari N, Herridge MS, Beyene J. Meta-analysis: low-dose dopamine increases urine output but does not prevent renal dysfunction or death. Ann Intern Med. 2005 Apr 5;142(7):510-24 [abstract]
• Faustino EV, Apkon M. Persistent hyperglycemia in critically ill children. J Pediatr. 2005 Jan;146(1):30-4. [abstract]
• Foland JA, Fortenberry JD, Warshaw BL, et al. Fluid overload before continuous hemofiltration and survival in critically ill children: a retrospective analysis. Crit Care Med. 2004 Aug;32(8):1771-6. [abstract]
  • PedsCCM EB Journal Club Review, by L Thompson
• Srinivasan V, Spinella PC, Drott HR, Roth CL, Helfaer MA, Nadkarni V. Association of timing, duration, and intensity of hyperglycemia with intensive care unit mortality in critically ill children. Pediatr Crit Care Med. 2004 Jul;5(4):329-36. [abstract]
  • PedsCCM EB Journal Club Review, by A Bass
• Murray DM, Olhsson V, Fraser JI. Defining acidosis in postoperative cardiac patients using Stewart's method of strong ion difference. Pediatr Crit Care Med. 2004 May;5(3):240-5 [abstract; full-text (356K)]
• Schrier RW, Wang W. Acute Renal Failure and Sepsis. N Engl J Med 2004; 351:159-169. [full-text for subscribers]
• Fonseca BK, Holdgate A, Craig JC. Enteral vs Intravenous Rehydration Therapy for Children With Gastroenteritis: A Meta-analysis of Randomized Controlled Trials. Arch Pediatr Adolesc Med. 2004 May;158(5):483-90 [abstract]
• Hoorn EJ, Geary D, Robb M, Halperin ML, Bohn D. Acute Hyponatremia Related to Intravenous Fluid Administration in Hospitalized Children: An Observational Study. Pediatrics 2004;113 1279-1284 [abstract]. With an accompanying editorial: Mortiz ML, Ayis JC. Hospital-Acquired Hyponatremia: Why Are There Still Deaths? Pediatrics 2004;113 1395-1396 [full-text]
• Finney SJ, Zekveld C, Elia A, Evans TW. Glucose control and mortality in critically ill patients. JAMA. 2003 Oct 15;290(15):2041-7 [abstract]
  • PedsCCM EB Journal Club Review by A Chavez
• Han YY, Carcillo JA, Dragotta MA, et al. Early Reversal of Pediatric-Neonatal Septic Shock by Community Physicians Is Associated With Improved Outcome. Pediatrics 2003;112 793-799. [abstract]. With an accompanying editorial: Kirby A, Goldstein B. Improved Outcomes Associated With Early Resuscitation in Septic Shock: Do We Need to Resuscitate the Patient or the Physician? Pediatrics 2003;112 976-977 [full-text]
  • PedsCCM EB Journal Club Review, by N Faqih
• Moritz ML, Ayus JC. Prevention of Hospital-Acquired Hyponatremia: A Case for Using Isotonic Saline. Pediatrics 2003;111 227-230 [abstract]; editorial reply: Holliday MA, Segar WE, Friedman A. Reducing Errors in Fluid Therapy Management. Pediatrics 2003;111 424-425 [full-text]
• Coulthard MG, Haycock GB. Distinguishing between salt poisoning and hypernatraemic dehydration in children. Br Med J 2003;326:157-160 [full-text]
• Van den Berghe G, Wouter P, Weeker F, et al. Intensive Insulin Therapy in Critically Ill Patients. New Engl J Med 2001; 345:1359-67. [abstract; full-text for subscribers]
  • PedsCCM EB Journal Club Review, by N Hoover, A Vats
• Van den Berghe G, Wouters PJ, Bouillon R, et al. Outcome benefit of intensive insulin therapy in the critically ill: Insulin dose versus glycemic control. Crit Care Med. 2003 Feb;31(2):359-66. [abstract]
• Schiffl H, Lang SM, Fischer R. Daily hemodialysis and the outcome of acute renal failure. N Engl J Med 2002; 346:305-10. [abstract; full-text for subscribers]
  • PedsCCM EB Journal Club Review, by X Garcia
  • N.B.: An "expression of concern" regarding the scientific conduct in this trial was published in the May 22, 2003 issue of the New England Journal of Medicine..
• Marik P. Low-dose dopamine: a systematic review. Intensive Care Med 2002; 28: 877-883. [abstract; full-text for subscribers]
• Holmes CL, Walley KR. Bad Medicine: Low-Dose Dopamine in the ICU. Chest 2003;123 1266-1275 [abstract]
• Kellum JA, M Decker J. Use of dopamine in acute renal failure: a meta-analysis. Crit Care Med. 2001;29(8):1526-31. [abstract]
  • PedsCCM EB Journal Club Review, by C Davison
• Goldstein SL, Currier H, Graf JM et al. Outcome in Children Receiving Continuous Venovenous Hemofiltration. Pediatrics 2001; 107: 1309-1312.[abstract] [full-text for subscribers/AAP members]
• Phu NH, Hien TT, Mai NTH, et al. Hemofiltration and Peritoneal Dialysis in Infection-Associated Acute Renal Failure in Vietnam. N Engl J Med 2002;347:895-902. [abstract]
• Halberthal M, Halperin ML, Bohn D. Acute hyponatraemia in children admitted to hospital: retrospective analysis of factors contributing to its development and resolution. [full-text]
• Bellomo R, Chapman M, Finfer S, Hickling K, Myburgh J. Low-dose dopamine in patients with early renal dysfunction: a placebo-controlled randomised trial. Australian and New Zealand Intensive Care Society (ANZICS) Clinical Trials Group. Lancet. 2000;356(9248):2139-43. [abstract]
  • PedsCCM EB Journal Club Review, by J Barron, A Madikians
• Murray P, Hall J. Renal Replacement Therapy for Acute Renal Failure, Am J Respir Crit Care Med Volume 2000;162:777-781. [full-text for subscribers]
• A comprehensive website all about pediatric continuous renal replacement therapy: pcrrt.com. Tim Bunchman, DeVos Children's Hospital, Grand Rapids, MI
• Ichai C, Soubielle J, Carles M, Giunti C, Grimaud D. Comparison of the renal effects of low to high doses of dopamine and dobutamine in critically ill patients: a single-blind randomized study.Crit Care Med 2000;28(4):921-8. [abstract]
  • PedsCCM EB Journal Club Review by U. Narsinghani
• Bhalla P, Eaton FE, Coulter JBS, et al. Hyponatraemic seizures and excessive intake of hypotonic fluids in young children. Br Med J 1999;319:1554-1557. [full-text]
• The Changing Pattern of Hypernatremia in Hospitalized Children. Moritz ML, Ayus JC. Pediatrics 1999;104:435-439. [abstract] [full-text for AAP members/subscribers]
• Fluids and Electrolytes in The Section on Pediatrics of The Merck Manual of Diagnosis and Therapy (full-text)
• ABC of intensive care: Renal support. Short A, Cumming A. Br Med J 1999; 319: 41-44. (full-text)
• Physiology of the Kidney. Stewart P. Update in Anesthesia 1998; 6:9. (full-text)
• Ionized magnesium concentrations in critically ill children. Fiser RT, Torres A Jr, Butch AW, Valentine JL. Crit Care Med 1998;26:2048-52. [abstract]
• Noronha JL, Matuschak GM. Magnesium in critical illness: metabolism, assessment, and treatment. Intensive Care Med 2002; 28: 667-679. [abstract; full-text for subscribers]
• Acid-Base Balance; an interactive teaching tool (with Javascript point-and-click nomograms) by AW Grogano, Anesthesiology Dept., Tulane University Medical Center
• Vomiting, Diarrhea, and Dehydration. Martínez-Bianchi V, Rejman-Peterson M, Graber MA. (includes electrolyte composition of body fluids) In Pediatrics: The University of Iowa Family Practice Handbook 1998.
• Abstracts available from The International Conference on Continuous Hemofiltration Therapies, December 5-6, 1996, Paris, France, from Continuous Renal Replacement Therapy and Hemofiltration
• Dehydration and Shock in Pediatric Patients. Fisher JD. 1998. An outline, historical review, and bibliography, in The Completely Different Pediatric Emergency Medicine Journal.
• Diagnosis of Acute Renal Failure, from Emergency Medicine BBS
• Fluids, Electrolytes, and Acid-Base Status in Critical Illness, L Ibsen, Oregon Health Sciences University (teaching file)
• Choice of fluid for resuscitation:
  • The SAFE Study Investigators. A comparison of albumin and saline for fluid resuscitation in the Intensive Care Unit. New Engl J Med 2004; 350:2247-2256. [abstract]
    • PedsCCM EB Journal Club Review, by S van Schaik
  • Crystalloids vs. colloids in fluid resuscitation: a systematic review. Choi PT, Yip G, Quinonez LG, Cook DJ. Crit Care Med 1999; 27:200-10. [abstract]
    • PedsCCM EB Journal Club review, by M. Sanchez-Mendiola
  • Fluid resuscitation with colloid or crystalloid solutions in critically ill patients: a systematic review of randomised trials. Schierhout G, Roberts I. Br Med J 1998; 316: 961-5. (full-text)
    • PedsCCM EB Journal Club Review, by M. Verive
  • Human albumin administration in critically ill patients: systematic review of randomised controlled trials: Why albumin may not work. Cochrane Injuries Group Albumin Reviewers. Br Med J 1998; 317: 235-240. With an accompanying Editorial. Offringa M. (Br Med J 1998; 317: 223-224), and Science commentary: Why albumin may not work. Berger A. (Br Med J 1998; 317: 240) (all full-text)
    • PedsCCM EB Journal Club Review, by A. Torres

Inflammation and Mediators

• ABC of allergies: Anaphylaxis. Ewan PW. Br Med J 1998;316:1442-1445. (full-text)
• ABC of allergies: Adverse reactions to drugs. Vervloet D, Durham S. Br Med J 1998; 316: 1511-1514 (full-text)
• Pediatrics, Anaphylaxis. Linzer J., from Emergency Medicine at Emedicine
• Cytokines in Acute and Chronic Inflammation. Feghali, C., Wright, T. Frontiers in Bioscience 1977; 2: d12-26. (full text)
• Adhesion Molecules - Part I and Adhesion Molecules - Part II: Blood Vessels and Blood Cells, Frenette, P.S., Wagner, D.D. N Engl J Med 1996; 334: 1526-1529 and 1996; 335: 43-45 (citation1; citation2)
• Systemic Vasculitis. Bush TM. Postgraduate Medicine 1998; 103: 68.
• Németh, Boda D. Xanthine oxidase activity and blood glutathione redox ratio in infants and children with septic shock syndrome. Intensive Care Med, DOI 10.1007/s001340000791. 21 December 2000 [full-text]
• Bochu PY, Calandra T. Science, medicine, and the future: Pathogenesis of sepsis: new concepts and implications for future treatment. Br Med J 2003;326 262-266. [full-text]

Systemic Inflammatory Response Syndrome/Multiple Organ Dysfunction

• 1st International Sepsis Forum on Sepsis in Infants and Children. Pediatr Crit Care Med 2005; S1-S164. [table of contents]
• Alberti C, Brun-Buisson C, Chevret S, et al. for the European Sepsis Study Group. Systemic Inflammatory Response and Progression to Severe Sepsis in Critically Ill Infected Patients. Am J Respir Crit Care Med 2005;171 461-468 [abstract]
• ABC of Intensive Care: Organ Dysfunction. Evans TW, Smithies M. Br Med J 1999;318:1606-1609. (full-text)

Hematology/Oncology, Transfusion, Thrombosis

• Armano R, Gauvin F, Ducruet T, Lacroix J. Determinants of red blood cell transfusions in a pediatric critical care unit: a prospective, descriptive epidemiological study. Crit Care Med. 2005 Nov;33(11):2637-44. [abstract]
• Wang M, Hays T, Balasa V, et al. Low-dose tissue plasminogen activator thrombolysis in children. J Pediatr Hematol Oncol. 2003 May;25(5):379-86. [abstract]
  • PedsCCM EB Journal Club Review, by M Rafay
• Schmugge M, Risch L, Huber A, Fischer JE. Heparin-Induced Thrombocytopenia-Associated Thrombosis in Pediatric Intensive Care Patients. Pediatrics 2002; 109:e10. [abstract]
  • PedsCCM EB Journal Club Review, by K Mistry
• Jilma B, Kamath S, Lip GYH. ABC of antithrombotic therapy. Antithrombotic therapy in special circumstances. II---In children, thrombophilia, and miscellaneous conditions. Br Med J 2003; 326:93-96. [full-text]
• Shorr AF, Jackson WL, Kelly KM, Fu M, Kollef MH. Transfusion practice and blood stream infections in critically ill patients. Chest. 2005 May;127(5):1722-8. [abstract]
• Corwin HL, Gettinger A, Pearl RG, Fink MP, Levy MM, Shapiro MJ, Corwin MJ, Colton T. Efficacy of recombinant human erythropoietin in critically ill patients: a randomized controlled trial. JAMA. 2002;288(22):2827-35. [abstract]
  • PedsCCM EB Journal Club Review, by M Cooper
• Laverdière C, Gauvin F, Hébert PC, et al. Survey on transfusion practices of pediatric intensivists. Pediatric Critical Care Medicine 2002; 3(4):335-340. [abstract; featured full-text (pdf)] [see note]
• Taylor RW, Manganaro L, O'Brien J, et al. Impact of allogenic packed red blood cell transfusion on nosocomial infection rates in the critically ill patient. Crit Care Med. 2002;30(10):2249-54. [abstract]
  • PedsCCM EB Journal Club Review, by R Orellana
• Blann AD, Landray MJ, Lip GYH. Clinical review: ABC of antithrombotic therapy. An overview of antithrombotic therapy Br Med J 2002;325:762-765. [full-text]
• Gupta AA, Leaker M, Andrew M, et al. Safety and outcomes of thrombolysis with tissue plasminogen activator for treatment of intravascular thrombosis in children. J Pediatr. 2001;139(5):682-8. [abstract]
  • PedsCCM EB Journal Club Review, by J Berger
• The Thrombosis Interest Group of Canada. With Practical Treatment Guidelines, including several for children:
  • Heparin in Children
  • Thrombolytic Therapy in Children
  • Warfarin in Children
  • Also available for telephone consultation: Canadian Children's Thrombophilia Society: 1-800-NO CLOTS
• Coagulopathies, from the Pediatric Emergency Manual, The Virtual Naval Hospital.
• Wong CS, Jelacic S, Habeeb RL, Watkins SL, Tarr PI. The risk of the hemolytic-uremic syndrome after antibiotic treatment of Escherichia coli O157:H7 infections. N Engl J Med. 2000;342(26):1930-6. [abstract]
  • PedsCCM EB Journal Club Review, by M. Cooper
• Safdar N, Said A, Gangnon RE, Maki DG. Risk of Hemolytic Uremic Syndrome After Antibiotic Treatment of Escherichia coli O157:H7 Enteritis. A Meta-analysis. JAMA 2002; 288:996-1001. [abstract]
• Trachtman H, Cnaan A, Christen E, et al. Effect of an oral Shiga toxin-binding agent on diarrhea-associated hemolytic uremic syndrome in children: a randomized controlled trial. JAMA. 2003;290(10):1337-44. [abstract]
  • PedsCCM EB Journal Club Review, by A Daneshmand, R Sanders
• Pierce CM, Wade A, Mok Q. Heparin-bonded central venous lines reduce thrombotic and infective complications in critically ill children. Intensive Care Medicine 2000; 26:967-972. [abstract]
  • PedsCCM EBJC Review, by J. Barron, A. Madikians
• Polderman KH, Girbes ARJ. Central venous catheter use. Part 1: Mechanical Complications. Intensive Care Med 2002; 28: 1-17. [abstract; full-text for subscribers]
• Andrew M, Michelson AD, Bovill E, Leaker M, Massicotte MP. Guidelines for antithrombotic therapy in pediatric patients. J Pediatr. 1998;132:575-88. [abstract] [full-text for subscribers]
• Dix D, Andrew M, Marzinotto V, et al. The use of low molecular weight heparin in pediatric patients: A prospective cohort study. J Pediatr. 2000;136:439-445. [abstract] [full-text for subscribers] and Manco-Johnson MJ, Nuss R, Hays T, Krupski W, Drose J, Manco-Johnson ML. Combined thrombolytic and anticoagulant therapy for venous thrombosis in children. J Pediatr. 2000;136:446-453. [abstract] [full-text for subscribers] Accompanying editorial: Faix RG. Antithrombotic therapy in pediatrics: Time for higher levels of evidence. J Pediatr. 2000;136:425-42. [full-text]
• Corwin HL, Gettinger A, Rodriguez RM, et al. Efficacy of recombinant human erythropoietin in the critically ill patient: a randomized, double-blind, placebo-controlled trial. Crit Care Med. 1999;27:2346-50. [abstract]
  • PedsCCM EB Journal Club Review by C. Prasad.
• Hebert PC, Wells G, Blajchman MA, et al. A Multicenter, Randomized, Controlled Clinical Trial of Transfusion Requirements in Critical Care. New Engl J Med 1999; 340:409-417. [abstract] With an accompanying editorial: Transfusions in Critically Ill Patients Ely EW. New Engl J Med 1999; 340:467-8. [citation]
  • PedsCCM EB Journal Club Review, by F.H. Levy, B. Markovitz
• From Emergency Medicine at Emedicine
  • Disseminated Intravascular Coagulation. Furlong MA, Furlong BR.
  • Idiopathic Thrombocytopenic Purpura. Silverman MA.
  • Hemolytic Uremic Syndrome. Shapiro W.
• How Rational Is the Crossmatching of Blood in a Pediatric Emergency Department?. Grupp-Phelan, J., Tanz, R. Arch Pediatr Adolesc Med. 1996;150:1140-1144. [abstract]
• Thrombolytic Therapy of Pulmonary Embolism: A Comprehensive Review of Current Evidence. Arcasoy SM, Kreit JW. Chest 1999;115:1695-1707. [abstract] [full-text for subscribers only]
• Wells PS, Anderson DR, Rodger M. Excluding Pulmonary Embolism at the Bedside without Diagnostic Imaging: Management of Patients with Suspected Pulmonary Embolism Presenting to the Emergency Department by Using a Simple Clinical Model and D-dimer. Ann Intern Med. 2001;135:98-107. [abstract][full-text for subscribers]
  • PedsCCM EB Journal Club Review, by D. Mackey
• Late Vascular Occlusion of Central Lines in Pediatric Malignancies. Wilimas JA, Hudson M, Rao B, Luo X, Lott L, Kaste SC. Pediatrics 1998; 101(2): e7. (full-text)

Oncologic Issues

• Lamas A, Otheo E, Ros P et al. Prognosis of child recipients of hematopoietic stem cell transplantation requiring intensive care. Intensive Care Med 2003; 29: 91-96. [abstract]
  • PedsCCM EB Journal Club Review by L Hite
• Paediatric oncology and intensive care treatments: changing trends. Keengwea IN, Stansfielda F, Eden OB. Arch Dis Child 1999;80:553-555. [abstract] [full-text to July 1999]
• Prognosis of pediatric bone marrow transplant recipients requiring mechanical ventilation. Rossi R, Shemie SD, Calderwood S. Crit Care Med 1999;27:1181-6. [abstract]
• Jacobe SJ, Hassan A, Veys P, Mok Q. Outcome of children requiring admission to an intensive care unit after bone marrow transplantation. Crit Care Med. 2003;31(5):1299-305. [abstract]
  • PedsCCM EB Journal Club Review, by E Harry

Gastrointestinal/Nutrition

• Kieft H, Roos AN, van Drunen JD, Bindels AJ, Bindels JG, Hofman Z. Clinical outcome of immunonutrition in a heterogeneous intensive care population. Intensive Care Med. 2005 Apr;31(4):524-532. [abstract]
• Peter JV, Moran JL, Phillips-Hughes J. A metaanalysis of treatment outcomes of early enteral versus early parenteral nutrition in hospitalized patients. Crit Care Med. 2005 Jan;33(1):213-20. [abstract]
• Simpson F, Doig GS. Parenteral vs. enteral nutrition in the critically ill patient: a meta-analysis of trials using the intention to treat principle. Intensive Care Med. 2005 Jan;31(1):12-23 [abstract]
• Meert KL, Daphtary KM, Metheny NA. Gastric vs Small-Bowel Feeding in Critically Ill Children Receiving Mechanical Ventilation: A Randomized Controlled Trial. Chest 2004;126 872-878. [abstract]
  • PedsCCM EB Journal Club Review, by D Hsing, A Madikians
  • Alternate PedsCCM EB Journal Club Review, by S Rishmawi
• Barr J, Hecht M, Flavin KE, Khorana A, Gould MK. Outcomes in critically ill patients before and after the implementation of an evidence-based nutritional management protocol. Chest. 2004 Apr;125(4):1446-57 [abstract]
• Martin CM, Doig GS, Heyland DK, et al. Multicentre, cluster-randomized clinical trial of algorithms for critical-care enteral and parenteral therapy (ACCEPT). Can Med Assoc J 2004;170 197-204. [abstract]
• Hall JC, Dobb G, Hall J, de Sousa R, Brennan L, McCauley R. A prospective randomized trial of enteral glutamine in critical illness. Intensive Care Med. 2003 Oct;29(10):1710-6 [abstract]
• Bhan MK, Bhandari N, Bahl R. Management of the severely malnourished child: perspective from developing countries. Br Med J 2003;326:146-151 [full-text]
• Hoffer LJ. Clinical nutrition: 1. Protein energy malnutrition in the inpatient. Can Med Assoc J 2001;165(10):1345-9. [abstract]
• Messori A, Trippoli S, Vaiani M, Gorini M, Corrado A. Bleeding and pneumonia in intensive care patients given ranitidine and sucralfate for prevention of stress ulcer: meta-analysis of randomised controlled trials. Br Med J. 2000;321(7269):1103-1106. [abstract] [full-text]
  • PedsCCM EB Journal Club Review, by S Cray
• Gharpure V, Meert KL, Sarnaik AP, Metheny NA. Indicators of postpyloric feeding tube placement in children. Crit Care Med. 2000;28(8):2962-6. [abstract]
• Spalding HK, Sullivan KJ, Soremi O, Gonzalez F, Goodwin SR. Bedside placement of transpyloric feeding tubes in the pediatric intensive care unit using gastric insufflation. Crit Care Med. 2000;28(6):2041-4. [abstract]
• Houdijk AP, Rijnsburger ER, Jansen J, et al. Randomised trial of glutamine-enriched enteral nutrition on infectious morbidity in patients with multiple trauma. Lancet. 1998 5;352(9130):772-6. [abstract]
• Garrel D, Patenaude J, Nedelec B, et al. Decreased mortality and infectious morbidity in adult burn patients given enteral glutamine supplements: A prospective, controlled, randomized clinical trial. Crit Care Med. 2003 Oct;31(10):2444-9. [abstract]
• Kamal I. Defusing the intra-abdominal ticking bomb: intestinal malrotation in children. Can Med Assoc J 2000;162:1315-7. [full-text]
• Galban C, Montejo JC, Mesejo A, et al. An immune-enhancing enteral diet reduces mortality rate and episodes of bacteremia in septic intensive care unit patients. Crit Care Med. 2000;28(3):643-8. [abstract]
  • PedsCCM EB Journal Club Review, by R Rastmanesh
• Beale RJ, Bryg DJ, Bihari DJ. Immunonutrition in the critically ill: a systematic review of clinical outcome. Crit Care Med. 1999;27:2799-805. [abstract]
• Heyland DK. Novak F, Drover JW et al. Should Immunonutrition Become Routine in Critically Ill Patients? A Systematic Review of the Evidence . JAMA. 2001;286:944-953. [abstract; full-text for subscribers]
• Bertolini G, Iapichino G, Radrizzani D, et al. Early enteral immunonutrition in patients with severe sepsis: Results of an interim analysis of a randomized multicentre clinical trial. Intensive Care Med (2003) 29: 834-840. [abstract]
• Nutrition Calculator; web-based calculator determines numerous nutrition parameters, e.g., calories/kg/day, mEq of sodium/day, etc., of TPN, IV fluids, and enteral feedings. From Michael Apkon, MD, PhD and The Section of Critical Care and Applied Physiology, Department of Pediatrics, Yale University.
• Total Parenteral Nutrition in the Critically Ill Patient: A Meta-analysis. Heyland DK, MacDonald S, Keefe L, Drover JW. JAMA. 1998;280:2013-2019. [abstract]
• Chaïbou M, Tucci M, Dugas MA, Farrell CA, Proulx F, Lacroix J. Clinically Significant Upper Gastrointestinal Bleeding Acquired in a Pediatric Intensive Care Unit: A Prospective Study. Pediatrics 1998; 102: 933-938. [abstract] [full-text for AAP members/subsribers]
• A randomized controlled study of prophylactic ranitidine in preventing stress-induced gastric mucosal lesions in neonatal intensive care unit patients. Kuusela AL, Ruuska T, Karikoski R, Laippala P, Ikonen S, Janas M, Maki M. Crit Care Med 1997;25:346-351. [abstract]
  • PedsCCM EB Journal Club Review, by G. Deshpande, K. Meert
• Cook D, Guyatt G, Marshall J, et al. A Comparison of Sucralfate and Ranitidine for the Prevention of Upper Gastrointestinal Bleeding in Patients Requiring Mechanical Ventilation. N Engl J Med 1998; 338: 791-7. [abstract]
  • PedsCCM EB Journal Club Review, by S. Bateman
• Pediatrics, Henoch-Scholein-Purpura. Dyne P, Farin H., from Emergency Medicine at Emedicine
• Rahman T, Hodgson H. Clinical management of acute hepatic failure. Intensive Care Med, 2001; DOI 10.1007/s001340100873 [full-text for subscribers]
• The Management of Fulminant Hepatic Failure. Farrell J. The Osler Medical Journal 1997; 2. (full-text)
• Hepatitis A to E, a presentation from Center for Disease Control
• Acute Pancreatitis in Children, from The Pediatric Bulletin
• Ryder SD, Beckingham IJ. ABC of diseases of liver, pancreas, and biliary system: Acute hepatitis. Br Med J 2001;322:151-153. [full-text]

Infectious Diseases

• Bioterrorism
  • From the American Academy of Pediatrics: Children and Disasters: Information from the AAP and Related Resources: includes The Child with Suspected Anthrax Infection
  • CDC Health Advisory: How to Handle Anthrax and Other Biological Agent Threats, October 12, 2001.
  • Archived web broadcast from the CDC: Anthrax: What Every Clinician Should Know. Previous CDC broadcasts are archived here...
  • Also see the October 19, 2001 of MMWR here (pdf)
  • Swartz MN. Current Concepts: Recognition and Management of Anthrax -- An Update. New Engl J Med 2001;345:1621-1626. [full-text]
  • Webcast on demand: "Smallpox: What Every Clinician Should Know." Information is here...
  • Also see the October 19, 2001 of MMWR here (pdf)
  • CDC Health Advisory: How to Handle Anthrax and Other Biological Agent Threats, October 12, 2001.
  • Updated information is always at: CDC's Public Health Emergency Preparedness &and Response
• SARS
  • Levy MM, Baylor MS, Bernard GR, et al. Clinical Issues and Research in Respiratory Failure from Severe Acute Respiratory Syndrome. Am J Respir Crit Care Med. 2005;171 518-526 [abstract]
  • Leung CW, Kwan YW, Ko PW, et al. Severe acute respiratory syndrome among children. Pediatrics. 2004 Jun;113(6):e535-4 [abstract; full-text]
  • Chiu; WK, Cheung; PC, Ng; KL, Ip; PL, Sugunan; VK, Luk; DC, Ma; LC, Chan; BH, Lo; KL, Lai WM. Severe acute respiratory syndrome in children: Experience in a regional hospital in Hong Kong. Pediatr Crit Care Med. 2003 Jul;4(3):279-283. [abstract]
  • Early release articles on SARS from the New England Journal of Medicine:
    • Tsang KW, Ho PL, Ooi GC et al. A Cluster of Cases of Severe Acute Respiratory Syndrome in Hong Kong. New Engl J Med 2003: 10.1056/NEJMoa030666 [abstract]
    • Poutanen SM, Low DE, Henry B. Identification of Severe Acute Respiratory Syndrome in Canada New Engl J Med 2003: 10.1056/NEJMoa030634. [abstract]
    • Drazen JM. Case Clusters of the Severe Acute Respiratory Syndrome New Engl J Med 2003: 10.1056/NEJMe030062 [link]
  • Keep up to date about SARS from the AAP News...
  • Hon KLE, Leung CW, Cheng WTF, et al. Clinical presentations and outcome of severe acute respiratory syndrome in children. Lancet 2003; 61. 1701-3.. [abstract]
  • Lapinsky SE, Hawryluck L. ICU management of severe acute respiratory syndrome. Intensive Care Med. 2003 Jun;29(6):870-5. [abstract]
  • Lew TWK, Kwek T-K, Tai D et al. Acute Respiratory Distress Syndrome in Critically Ill Patients With Severe Acute Respiratory Syndrome. JAMA 2003;290 374-380 [abstract]
  • Fowler RA, Lapinsky SE, Hallett D, et al. Critically Ill Patients With Severe Acute Respiratory Syndrome. JAMA 2003;290 367-373 [abstract]
• General Resources
  • Infectious Disease Position Papers, of the Canadian Pediatric Society
• Prevention/Prophylaxis
  • Garland JS, Alex CP, Henrickson KJ, McAuliffe TL, Maki DG. A vancomycin-heparin lock solution for prevention of nosocomial bloodstream infection in critically ill neonates with peripherally inserted central venous catheters: a prospective, randomized trial. Pediatrics. 2005 Aug;116(2):e198-205. [abstract]
  • Elward AM, Hollenbeak CS, Warren DK, Fraser VJ. Attributable Cost of Nosocomial Primary Bloodstream Infection in Pediatric Intensive Care Unit Patients. Pediatrics 2005;115 868-872 [abstract]
  • Leon C, Ruiz-Santana S, Rello J, et al. Benefits of minocycline and rifampin-impregnated central venous catheters: A prospective, randomized, double-blind, controlled, multicenter trial. Intensive Care Med. 2004; 30:1891-1899 [abstract]
    • PedsCCM EB Journal Club Review, by A Jeyapalan
  • Carrasco MN, Bueno A, De Las Cuevas C, et al. Evaluation of a triple-lumen central venous heparin-coated catheter versus a catheter coated with chlorhexidine and silver sulfadiazine in critically ill patients. Intensive Care Med. 2004 Apr;30(4):633-8 [abstract]
  • Rubinson L, Haponik EF, Wu AW, Diette GB. Internists' Adherence to Guidelines for Prevention of Intravascular Catheter Infections. JAMA 2003;290 2802 [abstract]
  • Dezfulian C, Lavelle J, Nallamothu BK, Kaufman SR, Saint S. Rates of infection for single-lumen versus multilumen central venous catheters: a meta-analysis. Crit Care Med. 2003 Sep;31(9):2385-90. [abstract]
  • McGee DC, Gould MK. Current Concepts: Preventing Complications of Central Venous Catheterization. New Engl J Med 2003; 348:1123-1133. [full-text]
  • Taylor RW, Manganaro L, O'Brien J, et al. Impact of allogenic packed red blood cell transfusion on nosocomial infection rates in the critically ill patient. Crit Care Med. 2002;30(10):2249-54. [abstract]
  • Yogaraj JS, Elward AM, Fraser VJ. Rate, Risk Factors, and Outcomes of Nosocomial Primary Bloodstream Infection in Pediatric Intensive Care Unit Patients. Pediatrics 2002; 110:481-485. [abstract; full-text for AAP members/subscribers]
  • Grohskopf LA, Sinkowitz-Cochran RL, Garrett DO, et al. A national point-prevalence survey of pediatric intensive care unit-acquired infections in the United States. J Pediatr. 2002;140(4):432-8. [abstract; full-text for subscribers]
  • Van Houten MA, Uiterwaal CS, Heesen GJ, Arends JP, Kimpen JL. Does the empiric use of vancomycin in pediatrics increase the risk for Gram-negative bacteremia? Pediatr Infect Dis J 2001;20(2):171-7. [abstract]
    • PedsCCM EB Journal Club Review, by C Kennedy
  • Slota M, Green M, Farley A, Janosky J, Carcillo J. The role of gown and glove isolation and strict handwashing in the reduction of nosocomial infection in children with solid organ transplantation. Crit Care Med. 2001;29(2):405-412. [abstract]
    • PedsCCM EB Journal Club Review, by A Lin
  • Singh-Naz N, Sprague BM, Patel KM, Pollack MM. Risk assessment and standardized nosocomial infection rate in critically ill children. Crit Care Med. 2000;28(6):2069-75. [abstract]
  • Douzinas EE, Pitaridis MT, Louris G et al. Prevention of infection in multiple trauma patients by high-dose intravenous immunoglobulins. Crit Care Med 2000; 28: 8-15. [abstract]
    • PedsCCM EB Journal Club Review, by S Bateman
  • Marin MG, Lee JC, Skurnick JH. Prevention of nosocomial bloodstream infections: effectiveness of antimicrobial-impregnated and heparin-bonded central venous catheters. Crit Care Med. 2000 Sep;28(9):3332-8. [abstract]
    • PedsCCM EB Journal Club Review by K Mistry
  • Pierce CM, Wade A, Mok Q. Heparin-bonded central venous lines reduce thrombotic and infective complications in critically ill children. Intensive Care Medicine 2000; 26:967-972. [abstract]
  • Polderman KH, Girbes ARJ. Central venous catheter use Part 2: Infectious complications. Intensive Care Med 2002; 28: 18-28. [abstract; full-text for subscribers]
  • Acquired immunoparalysis in paediatric intensive care: prospective observational study . Peters M, Petros A, Dixon G, Inwald D, Klein N. Br Med J 1999;319:609-610. (full-text)
  • Factors That Predict Preexisting Colonization With Antibiotic-Resistant Gram-Negative Bacilli in Patients Admitted to a Pediatric Intensive Care Unit. Toltzis P, Hoyen C, Spinner-Block S, et al. Pediatrics 1999; 103: 719-723. [abstract; full-text for AAP members]
  • Veenstra DL, Saint S, Sullivan SD. Cost-effectiveness of antiseptic-impregnated central venous catheters for the prevention of catheter-related bloodstream infection. JAMA. 1999;282:554-60. [abstract] [full-text for subscribers only]
    • PedsCCM EB Journal Club Review, by M. K. Moynihan Hardart
  • Veenstra DL, Saint S, Somnath S, Lumley T, Sullivan SD. Efficacy of antiseptic-impregnated central venous catheters in preventing catheter-related bloodstream infection. A meta-analysis. JAMA;1999;281:261-267. [abstract] [full-text for subscribers only]
    • PedsCCM EB Journal Club Review, by M. K. Moynihan Hardart
  • A Comparison of Two Antimicrobial-Impregnated Central Venous Catheters. Darouiche RO, Raad II, Heard SO et al. N Engl J Med 1999;340:1-8. [abstract]
    • PedsCCM EB Journal Club Review, by S. Schexnayder
  • Effectiveness and Cost of Selective Decontamination of the Digestive Tract in Critically Ill Intubated Patients. A randomized, double-blind, placebo-controlled, multicenter trial. Sanchez Garcia MS, Cambronero Galache JA, Diaz JL, et al. Am J Respir Crit Care Med 1998;158: 908-916. [abstract] [full-text for subscribers only]
    • PedsCCM EB Journal Club review, by P. Johnson, B. Markovitz
  • Krueger WA, Lenhart FP, Neeser G et al. Influence of Combined Intravenous and Topical Antibiotic Prophylaxis on the Incidence of Infections, Organ Dysfunctions, and Mortality in Critically Ill Surgical Patients: A Prospective, Stratified, Randomized, Double-Blind, Placebo-controlled Clinical Trial. Am J Respir Crit Care Med 2002;166 1029-1037 [abstract]
  • van Nieuwenhoven CA, Buskens E, van Tiel FH, Bonten MJM. Relationship Between Methodological Trial Quality and the Effects of Selective Digestive Decontamination on Pneumonia and Mortality in Critically Ill Patients. JAMA. 2001;286:335-340. [abstract; full-text for subscribers]
  • Effectiveness of antibiotic prophylaxis in critically ill adult patients: systematic review of randomised controlled trials. D'Amico R, Pifferi S, Leonetti C, Torri V, Tinazzi A, Liberati A. Br Med J 1998;316:1275-1285. (full-text)
  • The Revised CDC Guidelines for Isolation Precautions in Hospitals: Implications for Pediatrics. Committee on Infectious Diseases and Committee on Hospital Care. Pediatrics 1998; 101: e13. (full-text) [abstract]
  • Guidelines for Isolation Procedures in Hospitals, from The National Center for Infectious Diseases of the Center for Disease Control
  • Recommendations for Preventing the Spread of Vancomycin Resistance, from National Center for Infectious Diseases
• Bacterial Infections/Sepsis
  • 1st International Sepsis Forum on Sepsis in Infants and Children. Pediatr Crit Care Med 2005; S1-S164. [table of contents]
  • Zenz W, Zoehrer B, Levin M, et al. Use of recombinant tissue plasminogen activator in children with meningococcal purpura fulminans: a retrospective study. Crit Care Med. 2004 Aug;32(8):1777-80. [abstract]
  • Han YY, Carcillo JA, Dragotta MA, et al. Early Reversal of Pediatric-Neonatal Septic Shock by Community Physicians Is Associated With Improved Outcome. Pediatrics 2003;112 793-799. [abstract]. With an accompanying editorial: Kirby A, Goldstein B. Improved Outcomes Associated With Early Resuscitation in Septic Shock: Do We Need to Resuscitate the Patient or the Physician? Pediatrics 2003;112 976-977 [full-text]
    • PedsCCM EB Journal Club Review, by N Faqih
  • Watson RS, Carcillo JA, Linde-Zwirble WT, Clermont G, Lidicker J, Angus DC. The epidemiology of severe sepsis in newborns, infants, and children in the U.S. Am J Respir Crit Care Med 2003; 167:695-701. [abstract]
  • Bochu PY, Calandra T. Science, medicine, and the future: Pathogenesis of sepsis: new concepts and implications for future treatment. Br Med J 2003;326 262-266. [full-text]
  • Busund R, Koukline V, Utrobin U, Nedashkovsky E. Plasmapheresis in severe sepsis and septic shock: a prospective, randomised, controlled trial. Intensive Care Med 2002; 28: 1434-1439 [abstract]
    • PedsCCM EB Journal Club Review by J Krishnan, V Vaiyda
  • Fischer JE, Benn A, Harbarth S, Nadal D, Fanconi S. Diagnostic accuracy of G-CSF, IL-8, and IL-1ra in critically ill children with suspected infection. Intensive Care Med 2002; 28: 1324-1331. [abstract]
  • Miura E, Procianoy RS, Bittar C et al. A Randomized, Double-Masked, Placebo-Controlled Trial of Recombinant Granulocyte Colony-Stimulating Factor Administration to Preterm Infants With the Clinical Diagnosis of Early-Onset Sepsis. Pediatrics 2001;107:30-35. [abstract]
    • PedsCCM EB Journal Club Review, by W Arias
  • Bernard GR, Vincent JL, Laterre PF, et al. Efficacy and Safety of Recombinant Human Activated Protein C for Severe Sepsis. N Engl J Med 2001;344:699-709. [abstract] [full-text, for subscribers ]
    • PedsCCM EB Journal Club Review by D Vaughn
    • An editorial: Hinds CJ. Treatment of sepsis with activated protein C; Encouraging news for well selected patients. Br Med J 2001;323:881-882. [full-text]
  • Reeves JH, Butt WW, Shann F, et al. Continuous plasmafiltration in sepsis syndrome. Plasmafiltration in Sepsis Study Group. Crit Care Med. 1999;27:2096-104. [abstract]
    • PedsCCM EB Journal Club Review, by S. Cray
  • Pittet D, Harbarth S, Suter PM, et al.Impact of immunomodulating therapy on morbidity in patients with severe sepsis. Am J Respir Crit Care Med 1999;160:852-7. [abstract] [full-text for subscribers]
    • PedsCCM EB Journal Club Review, by N. Cvijanovich
  • Effect of the immunomodulating agent, pentoxifylline, in the treatment of sepsis in prematurely delivered infants: a placebo-controlled, double-blind trial. Lauterbach R, Pawlik D, Kowalczyk D, et al. Crit Care Med. 1999; 27:807-14. [abstract]
    • PedsCCM EB Journal Club Review, by T. Dominguez
  • Castellanos-Ortega I, Delgado-Rodríguez M, Llorca J, et al. A new prognostic scoring system for meningococcal septic shock in children. Comparison with three other scoring systems. Intensive Care Med 2002; 28: 341-351. [abstract; full-text for subscribers]
    • PedsCCM EB Journal Club Review, by A Vohra
  • Peters MJ, Ross-Russell RI, White D et al. Early severe neutropenia and thrombocytopenia identifies the highest risk cases of severe meningococcal disease. Pediatr Crit Care Med 2001; 2:225-231. [abstract]
    • PedsCCM EB Journal Club Review, by A Gourishankar
  • Briassoulis G, Narlioglou M, Zavras N, Hatzis T. Myocardial injury in meningococcus-induced purpura fulminans in children. Intensive Care Med 2001; 27:1073-1082; DOI 10.1007/s001340100957 [abstract]
  • Nosocomial Infections in Pediatric Intensive Care Units in the United States. Richards MJ, Edwards JR, Culver DH, et al. Pediatrics 1999; 103: e39. (full-text)
  • Emergency management of meningococcal disease. Pollard AJ, Britto J, Nadel S, DeMunter C, Habibi P, Levin M. Arch Dis Child 1999;80:290-296. (full-text until 7/99)
  • White B, Livingstone W, Murphy C, et al. An open-label study of the role of adjuvant hemostatic support with protein C replacement therapy in purpura fulminans-associated meningococcemia. Blood. 2000;96(12):3719-24. [abstract]
  • Levin M, Quint PA, Goldstein B, et al. Recombinant bactericidal/permeability-increasing protein (rBPI₂₁) as adjunctive treatment for children with severe meningococcal sepsis: a randomised trial. Lancet 2000; 356: 961 - 967. [abstract]
    • PedsCCM EB Journal Club Review, by S. Cray
  • Corticosteroid treatment for sepsis: a critical appraisal and meta-analysis of the literature. Cronin L, Cook DJ, Carlet J, et al. Crit Care Med 1995; 23: 1430-1439. [abstract]
    • PedsCCM EB Journal Club Review, by V. Gharpure and K. Meert
  • Phu NH, Hien TT, Mai NTH, et al. Hemofiltration and Peritoneal Dialysis in Infection-Associated Acute Renal Failure in Vietnam. N Engl J Med 2002;347:895-902. [abstract]
  • Steroid controversy in sepsis and septic shock: a meta-analysis. Lefering R, Neugebauer EA. Crit Care Med 1995;23:1294-303. [abstract]
    • PedsCCM EB Journal Club Review, by C. Landers
  • Rivers E, Nguyen B, Havstad S, et al. Early Goal-Directed Therapy in the Treatment of Severe Sepsis and Septic Shock. New Engl J Med 2001; 345:1368-77. [abstract; full-text for subscribers]
    • PedsCCM EB Journal Club Review, by S Thammasitboon, M Mcpherson
  • Adrenal insufficiency in septic shock. Hatherill M, Tibby SM, Hilliard T, Turner C, Murdoch IA. Arch Dis Child 1999; 80: 51-55. [full-text until July 1999] [abstract]
  • Marik PE, Zaloga GP. Adrenal insufficiency during septic shock. Crit Care Med. 2003;31(1):141-5. [abstract]
    • PedsCCM EB Journal Club Review, by P Prabhakaran
  • Fulminant Meningococcemia. Hempel SL. 1997. Case report and discussion. From the Adult Critical Care Core Curriculum of The Virtual Hospital, University of Iowa.
  • Streptococcal Toxic Shock Syndrome, from Emerging Infectious Diseases and the Center for Disease Control
  • Prognostic Factors in Meningococcal Disease. Development of a Bedside Predictive Model and Scoring System. Barquet N, Domingo P, et al. JAMA 1997;278:491-496. (abstract)
  • Randomized, placebo-controlled, double blinded trial of dexamethasone in African children with sepsis. Slusher T, Gbadero D, Howard C, Lewison L, Giroir B, Toro L, Levin D, Holt E, McCracken GH Jr. Pediatr Infect Dis J 1996; 15: 579-583. [abstract]
    • PedsCCM EB Journal Club Review, by M. McCullogh and M. Klein
  • Management/Prevention of Vancomycin-Resistant Enterococci, from Medscape (free registration required)
  • Congenital Infections Koch H, Graber MA. In Pediatrics: The University of Iowa Family Practice Handbook 1998.
• HIV/AIDS
  • Current Concepts: Acute Human Immunodeficiency Virus Type 1 Infection. Kahn JO, Walker BD. N Engl J Med 1998; 339: 33-39. (full-text for subscribers)
  • HIV Infection and AIDS. Dubin J., from Emergency Medicine at Emedicine
  • HIV InSite; a comprehensive HIV resource, including The HIV Drug Database and more
• Other Viral Infections
  West Nile Virus information, from the US Centers for Disease Control and Prevention
  • Ramos MM, Overturf GD, Crowley MR, et al. Infection With Sin Nombre Hantavirus: Clinical Presentation and Outcome in Children and Adolescents. Pediatrics 2001;108 e27 [abstract][full-text]
  • International Herpes Management Forum Library; monographs on management of systemic herpesvirus infections
  • Hantavirus Pulmonary Syndrome. Bacon O. Osler Medical Journal 1998; 4.
  • Hantaviruses: A Global Disease Problem. Schmaljohn C, Hjelle, B. Emerging Infectious Diseases 1997; 3(2):95-104. From MedScape (free registration required)
• Catheter-related infection resources:
  • Safdar N, Maki DG. Risk of catheter-related bloodstream infection with peripherally inserted central venous catheters used in hospitalized patients. Chest. 2005 Aug;128(2):489-95. [abstract]
  • Warren DK, Zack JE, Mayfield JL, et al. The effect of an education program on the incidence of central venous catheter-associated bloodstream infection in a medical ICU. Chest. 2004 Nov;126(5):1612-8. [abstract]
  • Zurcher M, Tramer MR, Walder B. Colonization and Bloodstream Infection with Single- Versus Multi-Lumen Central Venous Catheters: A Quantitative Systematic Review. Anesth Analg 2004;99 177-182. [abstract]
  • Brun-Buisson C, Doyon F, Sollet JP, Cochard JF, Cohen Y, Nitenberg G. Prevention of intravascular catheter-related infection with newer chlorhexidine-silver sulfadiazine-coated catheters: a randomized controlled trial. Intensive Care Med. 2004 May;30(5):837-43 [abstract]
  • Odetola FO, Moler FW, Dechert RE, VanDerElzen K, Chenoweth C. Nosocomial catheter-related bloodstream infections in a pediatric intensive care unit: Risk and rates associated with various intravascular technologies. Pediatr Crit Care Med. 2003 Oct;4(4):432-436. [abstract][full-text; pdf 144K]
  • O'Grady NP, Alexander M, Dellinger EP et al. Guidelines for the Prevention of Intravascular Catheter-Related Infections. Pediatrics 2002;110:e51 [abstract]
  • Garland JS, Henrickson K, Maki DG. The 2002 Hospital Infection Control Practices Advisory Committee Centers for Disease Control and Prevention Guideline for Prevention of Intravascular Device-Related Infection. Pediatrics 2002;110 1009-1013 [full-text for AAP members/subscribers]
  • Polderman KH, Girbes ARJ. Central venous catheter use Part 2: Infectious complications. Intensive Care Med 2002; 28: 18-28. [abstract; full-text for subscribers]
  • Brun-Buisson C. New Technologies and Infection Control Practices to Prevent Intravascular Catheter-related Infections. Am J Respir Crit Care Med. 2001;164 1557-1558 [full-text for subscribers]
  • Merrer J, De Jonghe B, Golliot F et al. Complications of Femoral and Subclavian Venous Catheterization in Critically Ill Patients: A Randomized Controlled Trial. JAMA. 2001;286:700-707. [abstract; full-text for subscribers]
    • Review, by J Foland, T Petrillo
  • An evidence-based approach to central venous catheter management to prevent catheter-related infection in critically ill patients. Randolph AG. Crit Care Clin 1998; 14:411-21. [abstract]
  • Tunneling short-term central venous catheters to prevent catheter-related infection: a meta-analysis of randomized, controlled trials. Randolph AG, Cook DJ, Gonzales CA, Brun-Buisson C. Crit Care Med 1998; 26:1452-1457. [abstract]
  • Central venous catheter replacement strategies: a systematic review of the literature. Cook D, Randolph A, Kernerman P, Cupido C, King D, Soukup C, Brun-Buisson C. Crit Care Med 1997 25:1417-1424. [abstract]
  • Central Venous Catheters Coated with Minocycline and Rifampin for the Prevention of Catheter-Related Colonization and Bloodstream Infections. A Randomized, Double-Blind Trial. Raad I, Darouiche R, Dupuis J et al. Ann Int Med 1997; 127: 267-274. With an associated editorial: Reducing the Risk for Catheter-Related Infections: A New Strategy. Pearson ML, Abrutyn E. Ann Int Med 1997; 127:294-303. (full-text)
    • PedsCCM EB Journal Club review, by S. Schexnayder
  • Prevention of Central Venous Catheter-Related Bloodstream Infection by Use of an Antiseptic-Impregnated Catheter. A Randomized, Controlled Trial. Maki DG, Stolz SM, Wheeler S, Mermel LA. Ann Int Med 1997; 127: 257-266. With an associated editorial: Reducing the Risk for Catheter-Related Infections: A New Strategy. Pearson ML, Abrutyn E. Ann Int Med 1997; 127:294-303.(full-text)
    • PedsCCM EB Journal Club review, by S. Schexnayder
  • Guidelines for the Prevention of Intravascular Catheter-Related Infections, from the National Center for Infectious Diseases and the Center for Disease Control
• Tick-Borne Diseases
  • Pulmonary and Critical Care Update Online, from the American College of Chest Physicians. Lesson 3, Volume 13 - Pulmonary Manifestations of Rickettsial Illnesses. Dorsey G, Jacobs RA. 1998.
  • Human Monocytic Ehrlichiosis in Children. Schutze GE, Jacobs RF. Pediatrics 1997; 100(1): e10. (full-text)
  • ACP Initiative on Lyme Disease, from American College of Physicians Online
  • Lyme Disease; a comprehensive overview, from the Centers for Disease Control
  • European Union of Concerted Action on Lyme Borreliosis: extensive information about Lyme disease
  • Tick Diseases, Lyme. Edlow J. In Emergency Medicine, from emedicine

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Poisoning

Handbooks and Resources

• Poisonings, from the Pediatric Emergency Manual, The Virtual Naval Hospital.
• Evolving Trends and Treatment Advances in Pediatric Poisoning. Liebelt EL, DeAngelis CD. JAMA 1999;282:1113-1115. [full-text]
• Injuries, Poisoning, and CPR in The Section on Pediatrics of The Merck Manual of Diagnosis and Therapy (full-text)
• Toxicology Tutor, from Toxicology and Environmental Health Information Program (TEHIP), at the National Library of Medicine's Specialized Information Services.
• Regional Poison Control Centers in the USA, from The A, B, C's of Health Child Care of The National Center for Infectious Diseases.
• Poison Control Centers in the US, by state, from MedicineNet
• ToxFAQ's, from Agency for Toxic Substances and Disease Registry, Atlanta, GA
  • Includes Case Studies in Environmental Medicine: Lead Toxicity
• Toxidromes, from The Pediatric Bulletin
• Injury and Poisoning Resources at Karolinska

Related topics

• Bernal W, Donaldson N, Wyncoll D, Wendon J. Blood lactate as an early predictor of outcome in paracetamol-induced acute liver failure: a cohort study. Lancet. 2002 Feb 16;359(9306):558-63. [abstract]
  • Review, by P Prodhan, N Noviski
• Chicella M, Jansen P, Parthiban A, Marlowe KF, Bencsath FA, Krueger KP, Boerth R. Propylene glycol accumulation associated with continuous infusion of lorazepam in pediatric intensive care patients. Crit Care Med. 2002;30(12):2752-6. [abstract]
• Brown MJ, Shannon MW, Woolf A, Boyer EW. Childhood Methanol Ingestion Treated With Fomepizole and Hemodialysis. Pediatrics 2001; 108:e77. [abstract][full-text]
• Brent J, McMartin K, Phillips, et al. Fomepizole for the Treatment of Methanol Poisoning. N Engl J Med 2001;344:424-9. [abstract]
  • PedsCCM EB Journal Club Review by D. Mackey
• Casavant MJ. Fomepizole in the Treatment of Poisoning. Pediatrics 2001; 107:170-171. [Full-text for AAP members/subscribers]
• Ethylene glycol poisoning in a child treated with 4-methylpyrazole. Harry P, Jobard E, Briand M, Caubet A, Turcant A. Pediatrics 1998;102: E31. [abstract] [full-text]
• Current Concepts: Carbon Monoxide Poisoning. Ernst A, Zibrak JD. N Engl J Med 1998;339:1603-1608. [full-text for NEJM subscribers]
• Weaver LK, Hopkins RO, Chan KJ et al. Hyperbaric oxygen for acute carbon monoxide poisoning. N Engl J Med 2002; 347:1057-67. [abstract]
  • PedsCCM EB Journal Club Review by M Fiore
• Carbon monoxide poisoning: Is still an underrecognised problem. Walker E, Hay A. Br Med J 1999;319:1082-1083.
• Hyperbaric oxygen in carbon monoxide poisoning. Weaver LK. Br Med J 1999; 319: 1083-1084.
• Varon, J, Marik, PE. Carbon Monoxide Poisoning. Internet Journal of Anesthesiology 1997; V1 N2. http://www.ispub.com/journals/IJEICM/Vol1N2/CO.htm
• Infant Botulism Treatment and Prevention Program, from the Division of Communicable Disease Control, California Department of Health Services. Includes information on obtaining "BabyBIG" (botulism immune globulin)

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Pharmacotherapy

General issues/Original articles

• Krupicka MI, Bratton SL, Sonnenthal K, Goldstein B. Impact of a pediatric clinical pharmacist in the pediatric intensive care unit. Crit Care Med. 2002 Apr;30(4):919-21. [abstract; full-text for subscribers]
• Pretzlaff RK, Vardis RJ, Pollack MM. Aminophylline in the treatment of fluid overload. Crit Care Med. 1999;27:2782-5. [abstract]
  • PedsCCM EB Journal Club Review by P. Jines, R. Harrison
• Pharmacist Participation on Physician Rounds and Adverse Drug Events in the Intensive Care Unit. Leape LL, Cullen DJ, Clapp MD. JAMA. 1999;282:267-270. [abstract].
• van der Vorst MMJ, Ruys-Dudok van Heel I, Kist-van Holthe JE et al. Continuous intravenous furosemide in haemodynamically unstable children after cardiac surgery. Intensive Care Med, 2001; DOI 10.1007/s001340000819 [abstract; full-text for subscribers]
• Singh NC, Kissoon N, Mofada SA, Bennett M, Bohn DJ. Comparison of continuous versus intermittent furosemide administration in postoperative pediatric cardiac patients. Crit Care Med 1992:20:17-21. [abstract]
  • PedsCCM EB Journal Club Review, by P. Jines, J. Feldman

Pediatric therapeutics newsletter

• Pediatric Pharmacotherapy: A Monthly Review for Health Care Professionals (U. of Virginia)
  • Erythema Multiforme, Stevens-Johnson Syndrome, and Toxic Epidermal Necrolysis. Petersen KM. 1998; 4(11).
  • Prevention and Treatment of Respiratory Syncitial Virus - the search for a Cost-Effective Strategy. Buck ML. 1997; 3(10).
  • The Use of 5-HT3 Antagonists in the Prevention of Nausea and Vomiting in Children. Buck ML. 1997; 3(9).
  • Using Low-Molecular-Weight Heparin in Infants and Children
  • Vancomycin controversies
  • Cyclosporin
  • Diuretics

Pharmaceutical Databases and Guidelines

• PRETx: Pediatric Research in Emergency Therapeutics. A database of drugs in emergency medicine and critical illness in children with links to original research and succinct reviews.
• Virtual Library: Pharmacy Databases
• Clinical Pharmacology 2000; an extensive pharmaceutical database, and Integrated Medical Curriculum; educational series on anatomy, physiology, pharmacology. Free registration required. From Gold Standard Multimedia Inc.
• Neonatal medications, from Neonatology on the Web
• FDA MedWatch; The FDA Medical Products Reporting Program, from the U.S. Food and Drug Administration
• Drugs for Pediatric Emergencies Committee on Drugs. Pediatrics 1998; 101(1):e13 (full-text)
• Medscape's First Data Drug Database; search for drug indications, interactions, side effects and more based on generic or brand names, or disease to treat. (free registration required)
• Searchable full-text drug monographs available from:
  • RxMed
• Therapeutics resources, from Diseases, Disorders, and Related Topics at Karolinska
• Antibiotic Guide, from Johns Hopkins University. Searchable by antibiotic, pathogen, or type of infection. Also a downloadable version for PocketPC or PalmOS PDA's.
• Antibiotic guidelines from MCW

Anesthetics, Analgesics, Sedatives, and Muscle Relaxants

• Arroliga A, Frutos-Vivar F, Hall J, Esteban A, Apezteguia C, Soto L, Anzueto A. Use of sedatives and neuromuscular blockers in a cohort of patients receiving mechanical ventilation. Chest. 2005 Aug;128(2):496-506. [abstract]
• Burmester M, Mok Q. Randomised controlled trial comparing cisatracurium and vecuronium infusions in a paediatric intensive care unit. Intensive Care Med. 2005 May;31(5):686-692. [abstract]
• Sedation, L Ibsen, Oregon Health Sciences University (teaching file)
• Vasile B, Rasulo F, Candiani A, Latronico N. The pathophysiology of propofol infusion syndrome: a simple name for a complex syndrome. Intensive Care Med. 2003 Sep;29(9):1417-25 [abstract]
• Courtman SP, Wardurgh A, Petros AJ. Comparison of the bispectral index monitor with the Comfort score in assessing level of sedation of critically ill children. Intensive Care Med. 2003 Dec;29(12):2239-46 [abstract]
• Chicella M, Jansen P, Parthiban A, Marlowe KF, Bencsath FA, Krueger KP, Boerth R. Propylene glycol accumulation associated with continuous infusion of lorazepam in pediatric intensive care patients. Crit Care Med. 2002;30(12):2752-6. [abstract]
• Rigby-Jones AE, Nolan JA, Priston MJ, C Wright PM, Robert Sneyd J, Wolf AR. Pharmacokinetics of Propofol Infusions in Critically Ill Neonates, Infants, and Children in an Intensive Care Unit. Anesthesiology. 2002;97(6):1393-1400. [abstract]
• Cornfield DN, Tegtmeyer K, Nelson MD, Milla CE, Sweeney M. Continuous Propofol Infusion in 142 Critically Ill Children. Pediatrics 2002;110 1177-1181. [abstract]
• Committee on Drugs. Guidelines for Monitoring and Management of Pediatric Patients During and After Sedation for Diagnostic and Therapeutic Procedures: Addendum. Pediatrics 2002; 110: 836-83 [abstract]
• Berde CB, Sethna NF. Drug Therapy: Analgesics for the treatment of pain in children. N Engl J Med 2002; 347(14):1094-1103. [full-text for subscribers]
• Hoffman GM, Nowakowski R, Troshynski TJ et al. Risk Reduction in Pediatric Procedural Sedation by Application of an American Academy of Pediatrics/American Society of Anesthesiologists Process Model. Pediatrics 2002;109 236-243. [abstract; full-text for AAP members/subscribers]
• Sedation, Risk, and Safety: Do We Really Have Data at Last? Polaner DM, Houck CS, Rockoff MA, et al. Pediatrics 2001;108 1006-1008. [full-text for AAP members/subsribers] - an important commentary on: Freeman JM. The risks of sedation for electroencephalograms: data at last. Pediatrics 2001; 108:178 [full-text for AAP members/subscribers]
• Committee on Psychosocial Aspects of Child and Family Health. The Assessment and Management of Acute Pain in Infants, Children, and Adolescents. Pediatrics 2001;108 793-797 [abstract; full-text for AAP members/subscribers]
• Wathen JE, Roback MG, Mackenzie T, Bothner JP. Does midazolam alter the clinical effects of intravenous ketamine sedation in children? A double-blind, randomized, controlled, emergency department trial. Ann Emerg Med. 2000;36(6):579-588. [abstract]
  • PedsCCM EB Journal Club Review, by J Haizlip
• The Committee on Safety of Medicines of the UK's Medicine's Control Agency: "Propofol (Diprivan) infusion: sedation in children aged 16 years or younger contraindicated." In Current Problems in Pharmacovigilance, 2001; 27: 10. [pdf; 384K]
• Wooltorton E. Propofol: contraindicated for sedation of pediatric intensive care patients. Can Med Assoc J 2002; 167:507. [full-text]
• Rainer TH, Jacobs P, Ng YC et al. Cost effectiveness analysis of intravenous ketorolac and morphine for treating pain after limb injury: double blind randomised controlled trial. Br Med J 2000;321:1247-1252. [abstract] [full-text]
  • PedsCCM EB Journal Club Review, by A Torres
• Hertzog JH, Dalton HJ, Anderson BD, et al. Prospective Evaluation of Propofol Anesthesia in the Pediatric Intensive Care Unit for Elective Oncology Procedures in Ambulatory and Hospitalized Children Pediatrics 2000; 106:742-747. [Abstract] [Full-text for subscribers/AAP members]
• De Jonghe B, Cook D, Appere-De-Vecchi C, Guyatt G, Meade M, Outlin H. Using and understanding sedation scoring systems: a systematic review. Intensive Care Med 2000; 26: 275-285. [abstract]
• Tobias JD. Tolerance, withdrawal, and physical dependency after long-term sedation and analgesia of children in the pediatric intensive care unit. Crit Care Med. 2000;28(6):2122-32. [abstract]
• Vernon DD, Witte MK. Effect of neuromuscular blockade on oxygen consumption and energy expenditure in sedated, mechanically ventilated children. Crit Care Med. 2000 May;28(5):1569-71. [abstract]
• Kress JP, Pohlman AS, O'Connor MF, Hall JB. Daily Interruption of Sedative Infusions in Critically Ill Patients Undergoing Mechanical Ventilation. N Engl J Med 2000;342:1471-1477. [abstract]
  • PedsCCM EB Journal Club Review, by A. Torres
• Cote CJ, Notterman DA, Karl HW, Weinberg JA, McCloskey C. Adverse Sedation Events in Pediatrics: A Critical Incident Analysis of Contributing Factors. Pediatrics. 2000;105:805-814. [abstract] [full-text for subscribers/AAP members]
• Ostermann ME, Keenan SP, Seiferling RA, Sibbald WJ. Sedation in the Intensive Care Unit. A Systematic Review. JAMA. 2000;283:1451-1459. [abstract] [full-text for subscribers only]
  • PedsCCM EB Journal Club Review, by P Jines
• Bray RJ. Propofol infusion syndrome in children. Paediatr Anaesth 1998;8:491-9. [abstract]
  • PedsCCM EB Journal Club Review by S. Cray
• Cremer OL, Moons KG, Bouman EA, Kruijswijk JE, de Smet AM, Kalkman CJ. Long-term propofol infusion and cardiac failure in adult head-injured patients. Lancet. 2001;357(9250):117-8. [abstract]
• Perrier ND, Baerga-Varela Y, Murray MJ. Death related to propofol use in an adult patient. Crit Care Med. 2000;28(8):3071-4. [abstract]
• Letter (dated March 26, 2001) from AstraZeneca and the FDA regarding using propofol for sedation of pediatric ICU patients. [pdf]
• Borowitz SM. Propofol Use in Children: Weighing the Benefit and Risk. Pediatric Pharmacotherapy 2000; 6(5). [full-text]
• Slonim AD, Ognibene FP. Amnestic Agents in Pediatric Bronchoscopy. Chest 1999 116: 1802-1808. [abstract] [full-text for subscribers]
• Lawson GR, Bray RJ. Controversy: Sedation of children for magnetic resonance imaging. Arch Dis Child 2000;82:150-153. [full-text for subscribers]
• Clinical uses and controversies of neuromuscular blocking agents in infants and children. Martin LD, Bratton SL, O'Rourke PP. Crit Care Med 1999;27:1358-68. [abstract]
• Ketamine. Tomlinson A. Update in Anesthesia 1994; 4:5. (full-text)
• Propofol Anesthesia for Invasive Procedures in Ambulatory and Hospitalized Children: Experience in the Pediatric Intensive Care Unit. Hertzog JH, Campbell JK, Dalton HJ, J. Hauser GJ. Pediatrics 1999; 103:e30. (full-text)
• The pediatric sedation unit: a mechanism for safe pediatric sedation. Pediatrics 1998;102: e30. (full-text) Also read the responses to this article.
• Comparison of train-of-four and best clinical assessment during continuous paralysis. Strange C, Vaughan L, Franklin C, Johnson J. Am J Respir Crit Care Med 1997;156:1556-1561 [abstract]
• Practice Parameters for Sustained Neuromuscular Blockade in the Adult Critically Ill Patient: An Executive Summary. Shapiro BA, Warren J, Egol AB, et al. Crit Care Med 1995; 23:1601-1605. (pdf) From ACCM/SCCM Guidelines and Practice Parameters.
• Efficacy and Safety of Intravenous Midazolam and Ketamine as Sedation for Therapeutic and Diagnostic Procedures in Children. Parker, R.I., Mahan, R.A., Giugliano, D., Parker, M.M. Pediatrics 1997 99(3): 427-431. (abstract)
• Acute Pain Management in Pediatrics, from The National Library of Medicine Health Services/Technology Assessment Text
• An Opioid calculator; a Java applet to determine opioid equivalents, from Talaria: A Hypermedia Clinical Practice Guidelines for Cancer Pain
• Benzodiazepines and Breathing, in The Virtual Textbook of Anesthesiology
• The Virtual Anesthesia Textbook has more about anesthetics, analgesics, and muscle relaxants

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Syndromes, Metabolic and Genetic Diseases

Inheritable conditions

• Inborn Errors of Metabolism in Infancy: A Guide to Diagnosis. Burton B. Pediatrics 1998; 102: e69. (full-text)
• Pediatrics, Inborn Errors of Metabolism. Weiner DL., from Emergency Medicine at Emedicine
• Malignant Hyperthermia from GASNet's Global Textbook
• Glycogen Storage Diseases; Association for Glycogen Storage Disease (UK)
• OMIM: Online Mendelian Inheritance in Man at the NIH has an excellent search engine!
• GeneClinics: Medical Genetics Knowledge Base

Other disease databases

• Multiple Congenital Anomaly/Mental Retardation Syndromes, by Stanley Jablonski. A searchable database at the US National Library of Medicine.
• Pedbase; a nearly comprehensive database, in a consistent outline structure, of pediatric diseases, from Alan Gandy
• Office of Rare Diseases, NIH
• National Organization of Rare Diseases (NORD) Database

Endocrinopathies

• Lawrence SE, Cummings EA, Gaboury I, Daneman D. Population-based study of incidence and risk factors for cerebral edema in pediatric diabetic ketoacidosis. J Pediatr. 2005 May;146(5):688-92. [abstract]
• Malerba G, Romana-Girard F, Cravoisy A, Dousset B, Nace L, Levy B, Bollaert P. Risk factors of relative adrenocortical deficiency in intensive care patients needing mechanical ventilation. Intensive Care Medicine. 2005;31:388-392. [abstract]
  • PedsCCM EB Journal Club Review, by AP Davis
• Van den Berghe G, Wouter P, Weeker F, et al. Intensive Insulin Therapy in Critically Ill Patients. New Engl J Med 2001; 345:1359-67. [abstract; full-text for subscribers]
• Diabetes Mellitus
  • Jayashree M, Singhi S. Diabetic ketoacidosis: Predictors of outcome in a pediatric intensive care unit of a developing country. Pediatr Crit Care Med. 2004 Sep;5(5):427-33. [abstract]
  • Marcin JP, Glaser N, Barnett P, et al. Factors associated with adverse outcomes in children with diabetic ketoacidosis-related cerebral edema. J Pediatr. 2002;141(6):793-7. [abstract]
  • Lamb WH. Diabetic Ketoacidosis. In eMedicine Pediatrics. 2001.
  • Diabetic Ketoacidosis and Cerebral Edema
    • by Elliot Krane, MD
  • Glaser N, Barnett P, McCaslin I, et al. Risk Factors for Cerebral Edema in Children with Diabetic Ketoacidosis. N Engl J Med 2001;344:264-9. [abstract]
    • PedsCCM EB Journal Club Review by R. Rao, M. Scanlon
  • Diabetic Ketoacidosis, from the Pediatric Emergency Manual, The Virtual Naval Hospital.
  • Pediatrics, Diabetic Ketoacidosis. Young GM. In Emergency Medicine at Emedicine.
  • Variation in the Management of Pediatric Diabetic Ketoacidosis by Specialty Training. Glaser NS, Kuppermann N, Yee CKJ, Schwartz DL, Styne DM. Arch Pediatr Adolesc Med. 1997;151:1125-1132 (abstract)
  • Diabetic Ketoacidosis and Nonketotic Hyperosmolarity, from EMBBS
  • DKA and cerebral edema: selected references and abstracts
  • Also see: Fluid Resuscitation In Diabetic Ketoacidosis- Literature Review. Fisher JD. 1998. The Completely Different Pediatric Emergency Medicine Journal.

Adrenal Insufficiency and Adrenal Crisis. Klauer K., from Emergency Medicine at Emedicine

Return to Top of Table of Contents

Practical Issues and Special Reports

Research in Pediatric Critical Care

• Tobin MJ. Year in Review: Critical Care Medicine. Am J Respir Crit Care Med 2004;169 239-253 [full-text for subscribers]
• Nicholson CE, Gans BM, Change AC, et al. Pediatric critical care medicine: Planning for our research future. Pediatr Crit Care Med 2003; 4(2):196-202. [full-text (pdf 222K)]
• Randolph AG, Lacroix J. Randomized clinical trials in pediatric critical care: Rarely done but desperately needed. Pediatric Critical Care Medicine 2002;3:102-106. [abstract; full-text for subscribers]
• Carcillo JA, Watson S. Is the randomized, controlled trial in children an endangered species? Pediatric Critical Care Medicine 2002;3:197-199. [abstract; full-text for subscribers]
• Randolph AG, Meert KL, O'Neil ME, et al. The Feasibility of Conducting Clinical Trials in Infants and Children with Acute Respiratory Failure. Am J Respir Crit Care Med 2003;167 1334-1340. [abstract]
• "Seeking Support From the NIH for Pediatric Critical Care Research" is an invaluable Powerpoint presentation by Carol Nicholson, MD, MS from the NIH/NICHD/NCMRR to anyone interested in seeking NIH funding. She has presented this at recent meetings and has now graciously made it publicly available. (Powerpoint file, 3.2 MB, or html online version)

Venous and Arterial Access

• Hind D, Calvert N, McWilliams R, et al. Ultrasonic locating devices for central venous cannulation: meta-analysis. Br Med J. 2003;327(7411):361 [abstract]
  • PedsCCM EB Journal Club Review, by E Harry
• Milling TJ Jr, Rose J, Briggs WM, Birkhahn R, Gaeta TJ, Bove JJ, Melniker LA. Randomized, controlled clinical trial of point-of-care limited ultrasonography assistance of central venous cannulation: The Third Sonography Outcomes Assessment Program (SOAP-3) Trial. Crit Care Med. 2005 Aug;33(8):1764-1769. [abstract]
• de Jonge RC, Polderman KH, Gemke RJ. Central venous catheter use in the pediatric patient: Mechanical and infectious complications. Pediatr Crit Care Med. 2005 May;6(3):329-39 [abstract]
• McGee DC, Gould MK. Current Concepts: Preventing Complications of Central Venous Catheterization. New Engl J Med 2003; 348:1123-1133. [full-text]
• Polderman KH, Girbes ARJ. Central venous catheter use. Part 1: Mechanical Complications. Intensive Care Med 2002; 28: 1-17. [abstract; full-text for subscribers]
• Polderman KH, Girbes ARJ. Central venous catheter use Part 2: Infectious complications. Intensive Care Med 2002; 28: 18-28. [abstract; full-text for subscribers]
• Hocking G. Central Venous Access and Monitoring. Update in Anaesthesia 2000; 12:13. [full-text]
• Merrer J, De Jonghe B, Golliot F et al. Complications of Femoral and Subclavian Venous Catheterization in Critically Ill Patients: A Randomized Controlled Trial. JAMA. 2001;286:700-707. [abstract; full-text for subscribers]
• Racadio JM, Doellman DA, Johnson ND. Pediatric Peripherally Inserted Central Catheters: Complication Rates Related to Catheter Tip Location. Pediatrics 2001; e28. [abstract] [full-text]
• Pierce CM, Wade A, Mok Q. Heparin-bonded central venous lines reduce thrombotic and infective complications in critically ill children. Intensive Care Medicine 2000; 26:967-972. [abstract]
  • PedsCCM EBJC Review, by J. Barron, A. Madikians
• Jacobs BR, Barr LL, Brilli RJ, Lyons KA, Wong HR. Intracatheter nitroglycerin infusion fails to prevent catheter-related venous thrombosis: a randomized, controlled trial. Intensive Care Medicine 2000 [DOI] [abstract]
• Flori HR, Johnson LD, Hanley FL, Fineman JR. Transthoracic intracardiac catheters in pediatric patients recovering from congenital heart defect surgery: associated complications and outcomes. Crit Care Med. 2000;28(8):2997-3001. [abstract]
• Teaching Pediatric Procedures: The Vancouver Model for Instructing Seldinger's Technique of Central Venous Access Via the Femoral Vein. Macnab AJ, Macnab M. Pediatrics 1999; 103:e8. (full-text)
• Benefit of heparin in peripheral venous and arterial catheters: systematic review and meta-analysis of randomised controlled trials. Randolph AG, Cook DJ, Gonzales CA, Andrew M. Br Med J 1998; 316: 969 (full-text)
• Ultrasound guidance for placement of central venous catheters: a meta-analysis of the literature. Randolph AG, Cook DJ, Gonzales CA, Pribble CG. Crit Care Med 1996; 24: 2053-2058 [abstract]
• Survey of the Use of Peripherally Inserted Central Venous Catheters in Children. Thiagarajan R, Ramamoorthy C, Gettmann T, Bratton, S. Pediatrics 1997; 99(2): e4. (full-text)
• Femoral venous access is safe in burned children: An analysis of 224 catheters. Goldstein, AM, Weber, JM, Sheridan, RL. J Pediatr 1997; 130:442-6 (abstract)
• Catheter related infection articles: see here

Trauma/Burns/Perioperative Management

• de La Cal MA, Cerda E, Garcia-Hierro P, van Saene HK, Gomez-Santos D, Negro E, Lorente JA. Survival benefit in critically ill burned patients receiving selective decontamination of the digestive tract: a randomized, placebo-controlled, double-blind trial. Ann Surg. 2005 Mar;241(3):424-30. [abstract]
• Evaluation and Management of the Post-Surgical Patient in the PICU: An Overview, L Ibsen, Oregon Health Sciences University (teaching file)
• Ansermino M, Hemsley C. ABC of burns: Intensive care management and control of infection. Br Med J 2004;329:220-223. [full-text]
• Hettiaratchy S, Papini R. ABC of burns: Initial management of a major burn: I overview. Br Med J 2004;328:1555-1557 [full-text]
• Hettiaratchy S, Papini R. ABC of burns: Initial management of a major burn: II--assessment and resuscitation. Br Med J 2004; 329:101-103. [full-text]
• Hettiaratchy S, Dziewulski P. ABC of burns: Pathophysiology and types of burns. Br Med J 2004;328:1427-1429 [full-text]
• Papini R. ABC of burns: Management of burn injuries of various depths. Br Med J 2004;329:158-160 [full-text]
• Curley MA, Quigley SM, Lin M. Pressure ulcers in pediatric intensive care: Incidence and associated factors. Pediatr Crit Care Med. 2003 Jul;4(3):284-290. [abstract]
• Palmieri TL, Jackson W, Greenhalgh DG. Benefits of early tracheostomy in severely burned children. Crit Care Med 2002; 30:922-924. [abstract; full-text for subscribers]
• Herndon DN, Hart DW, Wolf SE, Chinkes DL, Wolfe RR. Reversal of catabolism by beta-blockade after severe burns. New Engl J Med 2001;345: 1223-1229. [abstract; full-text for subscribers]
  • PedsCCM EB Journal Club Review, by M Sharma, K Meert
• Cantais E, Paut O, Giorgi R , Viard L, Camboulives J. Evaluating the prognosis of multiple, severely traumatized children in the intensive care unit. Intensive Care Med 2001; 27: 1511-1517; DOI 10.1007/s001340101039 [abstract; full-text for subscribers]
  • PedsCCM EB Journal Club Review, by A Torres
• Viccellio P, Simon H, Pressman BD, et al. A Prospective Multicenter Study of Cervical Spine Injury in Children. Pediatrics 2001;108 e20 [abstract][full-text]
  • PedsCCM EB Journal Club Review, by K Moynihan Hardart
• Nathens AB, Jurkovich GJ, Maier RV et al. Relationship between trauma center volume and outcomes. JAMA. 2001;285(9):1164-71. [abstract; full-text for subscribers]
  • PedsCCM EB Journal Club Review, by K Hardart
• Trauma, from the Pediatric Emergency Manual, The Virtual Naval Hospital.
• Douzinas EE, Pitaridis MT, Louris G et al. Prevention of infection in multiple trauma patients by high-dose intravenous immunoglobulins. Crit Care Med 2000; 28: 8-15. [abstract]
  • PedsCCM EB Journal Club Review, by S Bateman
• Deakin CD, Low JL. Accuracy of the advanced trauma life support guidelines for predicting systolic blood pressure using carotid, femoral, and radial pulses: observational study. Br Med J. 2000;321(7262):673-674. [full-text]
• American Academy of Pediatrics. Firearm-Related Injuries Affecting the Pediatric Population. Committee on Injury and Poison Prevention. Pediatrics 2000; 105:888-895. [abstract] [full-text]
• Berg MD, Cook L, Corneli HM, Vernon DD, Dean JM. Effect of Seating Position and Restraint Use on Injuries to Children in Motor Vehicle Crashes. Pediatrics. 2000;105:831-835. [abstract] [full-text for subscribers/AAP members]
• Sheridan RL, Remensnyder JP, Schnitzer JJ, et al. Current Expectations for Survival in Pediatric Burns. Arch Pediatr Adolesc Med 2000;154:245-249. [abstract] [full-text for limited time]
• Sheridan RL, Hinson MI, Liang MH, et al. Long-term Outcome of Children Surviving Massive Burns. JAMA 2000;283:69-73. [abstract] [full-text for subscribers]
  • PedsCCM EB Journal Club Review, by R. Graham
• Diaspirin Cross-Linked Hemoglobin (DCLHb) in the Treatment of Severe Traumatic Hemorrhagic Shock: A Randomized Controlled Efficacy Trial. Sloan EP, Koenigsberg M, Gens D, et al. JAMA. 1999;282:1857-1864. [abstract] [full-text for subscribers only]
• Identification of intra-abdominal injuries in children hospitalized following blunt torso trauma. Holmes JF, Sokolove PE, Land C, Kuppermann N. Acad Emerg Med 1999; 6:799-806. [abstract]
• Injuries, Poisoning, and CPR in The Section on Pediatrics of The Merck Manual of Diagnosis and Therapy (full-text)
• Pulmonary Contusion in Children. Allen GS, Cox CS. Southern Med J 1998; 91: 1099-1106.
• Effect of a Pediatric Trauma Response Team on Emergency Department Treatment Time and Mortality of Pediatric Trauma Victims. Vernon DD, Furnival RA, Hansen KW, et al. Pediatrics 1999; 103: 20-24. [abstract, full-text for AAP members)
• Hyperbaric Oxygen Therapy in the Pediatric Patient: The Experience of the Israel Naval Medical Institute. Waisman D, Shupak A, Weisz G, Melamed Y. Pediatrics 1998; 102: e53. (full-text) [abstract]
• ABC of oxygen: Hyperbaric oxygen therapy. Leach RM, Rees PJ, Wilmshurst P. Br Med J 1998;317:1140-1143.
• Initial Management and Stabilization of Pediatric Trauma Patients. Arensman RM, Madonna MB. The Child's Doctor Fall 1997. From Children's Memorial Hospital and Northwestern University Medical School.
• Paediatric Resuscitation Chart and Paediatric Trauma, in the Trauma Handbook from Liverpool Hospital, Sydney, Australia
• Cervical Spine Radiographs in Pediatrics, from Radiology Cases in Pediatric Emergency Medicine, from University of Hawaii, Department of Pediatrics
• Trauma Practice Guidelines, from Eastern Association for the Surgery of Trauma.
  • Practice Management Guidelines for Screening of Blunt Cardiac Injury. EAST Practice Parameter Workgroup for Screening of Blunt Cardiac Injury.
  • Practice Parameters for Identifying Cervical Spine Injuries Following Trauma. EAST Practice Parameter Workgroup for Cervical Spine Clearance.
  • Patient Management Guidelines For the Non-Operative Management Of Blunt Injury to the Liver and Spleen. EAST Practice Parameter Workgroup for Solid Organ Injury Management.
• Hoffman JR, Mower WR, Wolfson AB, Todd KH, Zucker MI. Validity of a Set of Clinical Criteria to Rule Out Injury to the Cervical Spine in Patients with Blunt Trauma. N Engl J Med. 2000 Jul 13;343(2):94-99. [abstract]
  • PedsCCM EB Journal Club Review, by A Torres
• Ryan CM, Schoenfeld DA, Thorpe WP, et al. Objective Estimates of the Probability of Death from Burn Injuries. N Engl J Med 1998; 338: 362-6. [abstract].
• State Gun Safe Storage Laws and Child Mortality Due to Firearms. Cummings P, Grossman DC, Rivara FP, Koepsell TD. JAMA. 1997;278:1084-1086. (abstract)
• Prior Misdemeanor Convictions as a Risk Factor for Later Violent and Firearm-Related Criminal Activity Among Authorized Purchasers of Handguns. Wintemute GJ, Drake CM, Beaumont JJ, Wright MA, Parham CA. JAMA 1998;280:2083-2087. [abstract]
• Teret SP, Webster DW, Vernick JS, et al. Support for New Policies to Regulate Firearms -- Results of Two National Surveys. New Engl J Med 1998; 339: 813-8. [abstract]
  • Hemenway D. Regulation of Firearms. New Engl J Med 1998; 339: 843-5. An editorial. [citation]
• Head and Neck Emergencies, from University of Wisconsin Dept. of Surgery
• Trauma Cases from Southwestern Ontario Regional Academic Health Science Network: interactive CME cases
• Trauma Moulages at Trauma.org: practice interactive trauma resuscitations.
  • Includes a Cervical Spine Moulage with a tutorial on reviewing the Lateral Cervical Spine Radiograph
  • A new, if somewhat irreverant, pediatric moulage
  • Also with a Revised Trauma Score Calculator,
  • As well as independent reviews such as airway management, control of intracranial hypertension, and neuromonitoring
• ABC of Trauma Resuscitation, by P. Cumpston and The Australian and New Zealand Intensive Care Society

Laboratory/Radiologic Studies

• Shojania KG, Burton EC, McDonald KM, Goldman L. Changes in Rates of Autopsy-Detected Diagnostic Errors Over Time: A Systematic Review. JAMA 2003;289 2849-2856 [abstract]
• Coule LW, Truemper EJ, Steinhart CM, Lutin WA. Accuracy and utility of a continuous intra-arterial blood gas monitoring system in pediatric patients. Crit Care Med. 2001;29(2):420-6. [abstract]
  • PedsCCM EB Journal Club Review, by J Tuladhar
• Quasney MW, Goodman DM, Billow M, et al. Routine Chest Radiographs in Pediatric Intensive Care Units. Pediatrics 2001; 107: 241-248. [Abstract] [Full-text for AAP members/subscribers]
• Comparison of simultaneously obtained arterial and capillary blood gases in pediatric intensive care unit patients. Harrison AM, Lynch JM, Dean JM, Witte MK. Crit Care Med 1997; 25: 1904-1908. [abstract]
• Pocket Guide to Diagnostic Tests, Second Edition; some full-text material

Severity of Illness Assessment, Admission/Discharge Issues and Outcomes

• Levy MM, Macias WL, Vincent JL, Russell JA, Silva E, Trzaskoma B, Williams MD. Early changes in organ function predict eventual survival in severe sepsis. Crit Care Med. 2005 Oct;33(10):2194-2201. [abstract]
• Graciano AL, Balko JA, Rahn DS, Ahmad N, Giroir BP. The Pediatric Multiple Organ Dysfunction Score (P-MODS): Development and validation of an objective scale to measure the severity of multiple organ dysfunction in critically ill children. Crit Care Med. 2005 Jul;33(7):1484-1491. [abstract]
• Marcin JP, Song J, Leigh JP. The impact of pediatric intensive care unit volume on mortality: A hierarchical instrumental variable analysis. Pediatr Crit Care Med. 2005 Mar;6(2):136-141 [abstract]
• Leclerc F, Leteurtre S, Duhamel A, et al. Cumulative Influence of Organ Dysfunctions and Septic State on Mortality of Critically Ill Children. Am J Respir Crit Care Med. 2005; 171:348-353. [abstract]
• Slater A, Shann F. The suitability of the Pediatric Index of Mortality (PIM), PIM2, the Pediatric Risk of Mortality (PRISM), and PRISM III for monitoring the quality of pediatric intensive care in Australia and New Zealand. Pediatr Crit Care Med. 2004 Sep;5(5):447-454. [abstract]
• Rees G, Gledhill J, Garralda ME, Nadel S. Psychiatric outcome following paediatric intensive care unit (PICU) admission: a cohort study. Intensive Care Med. 2004; 30:1607-1614. [abstract]
• Leteurtre S, Martinot A, Duhamel A, et al. Validation of the paediatric logistic organ dysfunction (PELOD) score: prospective, observational, multicentre study. Lancet. 2003 Jul 19;362(9379):192-7 [abstract]
• Jaimovich DG, Committee on Hospital Care and Section on Critical Care. Admission and Discharge Guidelines for the Pediatric Patient Requiring Intermediate Care. Pediatrics 2004;113 1430-1433 [abstract]
• Anton N, Joffe KM, Joffe AR. Inability to predict outcome of acute respiratory distress syndrome in children when using high frequency oscillation. Intensive Care Med. 2003 Oct;29(10):1763-9 [abstract]
• Charpie JR, Dekeon MK, Goldberg CS, Mosca RS, Bove EL, Kulik TJ. Serial blood lactate measurements predict early outcome after neonatal repair or palliation for complex congenital heart disease. J Thorac Cardiovasc Surg. 2000 Jul;120(1):73-80. [abstract]
  • PedsCCM EB Journal Club Review, by A Gazit
• Hatherill M, Waggie Z, Purves L, Reynolds L, Argent A. Mortality and the nature of metabolic acidosis in children with shock. Intensive Care Med. 2003 Feb;29(2):286-91 [abstract]
  • PedsCCM EB Journal Club Review, by R Lambert, A Zaritsky
• Taylor A, Butt W, Ciardulli M. The functional outcome and quality of life of children after admission to an intensive care unit. Intensive Care Med 2003; 29: 795-800 [abstract]
• Tenner PA, Dibrell H, Taylor RP. Improved survival with hospitalists in a pediatric intensive care unit Crit Care Med 2003; 31(3):847-852 [abstract]
• Slater A, Shann F, McEniery J. The ANZPIC Registry diagnostic codes: a system for coding reasons for admitting children to intensive care. Intensive Care Med. 2003;29(2):271-7. [abstract]
• Slater A, Shann F, Pearson G. PIM2: a revised version of the Paediatric Index of Mortality. Intensive Care Med. 2003 Feb;29(2):278-85. [abstract]
• Goh AYT, Abdel-Latif MEA, Lum LCS, Abu-Bakar MN. Outcome of children with different accessibility to tertiary pediatric intensive care in a developing country - a prospective cohort study. Intensive Care Med 2003; 29: 97-102. [abstract]
  • PedsCCM EB Journal Club Review, by J Cortes
• McPherson ML, Lairson DR, Smith EO, Brody BA, Jefferson LS. Noncompliance With Medical Follow-up After Pediatric Intensive Care. Pediatrics 2002;109: e94. [full-text]
• Kanter RK. Regional variation in child mortality at hospitals lacking a pediatric intensive care unit. Crit Care Med 2002;30:94-99 [abstract; full-text for SCCM members/subscribers]; accompanying editorial by White JRM, Pollack MM. Easy access to pediatric intensive care unit care: An urban legend? Crit Care Med 2002; 30:256-257. [full-text for SCCM members/subscribers]
• Gemke RJBJ, van Vught AJ. Scoring systems in pediatric intensive care: PRISM III versus PIM. Intensive Care Med 2002; 28: 204-207. [abstract; full-text for subscribers] Accompanied by an editorial: Shann F. Are we doing a good job: PRISM, PIM and all that. Intensive Care Med 2002; 28: 105-107. [abstract; full-text for subscribers]
• Morrison AL, Gillis J, O'Connell AJ et al. Quality of life of survivors of pediatric intensive care. Pediatr Crit Care Med 2002;3:1-5. [abstract; full-text for subscribers]
  • PedsCCM EB Journal Club Review, by K Ventre
• Pearson G, Barry P, Timmins C, Stickley J, Hocking M. Changes in the profile of paediatric intensive care associated with centralisation. Intensive Care Med 2001; 27: 1670-1673. [abstract; full-text for subscribers]
• Anand KJS, Hopkins SE, Wright JA, Ricketts RR, Flanders D. Statistical models to predict the need for postoperative intensive care and hospitalization in pediatric surgical patients Intensive Care Med 2001; 27:873-883. [DOI 10.1007/s001340100929/abstract]
• Tilford JM, Simpson PM, Yeh TS et al. Variation in therapy and outcome for pediatric head trauma patients. Crit Care Med 2001; 29:1056-1061. [abstract]
• Dominguez TE, Chalom R, Costarino AT. The impact of adverse patient occurrences on hospital costs in the pediatric intensive care unit. Crit Care Med. 2001;29(1):169-174. [abstract]
• Goh A, Mok Q. Centralization of paediatric intensive care: are critically ill children appropriately referred to a regional centre? Intensive Care Med 2001; DOI 10.1007/s001340000820. [abstract]
• Pearson GA, Stickley J, Shann F. Calibration of the paediatric index of mortality in UK paediatric intensive care units. Arch Dis Child 2001; 84: 125-128. [Abstract] [Full-text for subscribers] [get PIM here on PedsCCM]
• Crouchman M, Rossiter L, Colaco T, Forsyth R. A practical outcome scale for paediatric head injury. Arch Dis Child 2001; 84: 120-124. [Abstract] [Full-text for subscribers]
• Parra DA, Totapally BR, Zahn E, Jacobs J, Aldousany A, Burke RP, Chang AC. Outcome of cardiopulmonary resuscitation in a pediatric cardiac intensive care unit. Crit Care Med. 2000;28(9):3296-300. [abstract]
  • PedsCCM EB Journal Club Review, by KP Mistry
• Marcin JP, Pollack MM, Patel KM, Ruttimann UE. Combining physician's subjective and physiology-based objective mortality risk predictions. Crit Care Med. 2000;28(8):2984-90. [abstract]
• Fiser DH, Long N, Roberson PK, Hefley G, Zolten K, Brodie-Fowler M. Relationship of pediatric overall performance category and pediatric cerebral performance category scores at pediatric intensive care unit discharge with outcome measures collected at hospital discharge and 1- and 6-month follow-up assessments. Crit Care Med. 2000;28(7):2616-20. [abstract]
• Tilford JM, Simpson PM, Green JW, Lensing S, Fiser DH. Volume-Outcome Relationships in Pediatric Intensive Care Units. Pediatrics. 2000;106(2):289-294. [abstract] [full-text for AAP members/subscribers]
  • PedsCCM EB Journal Club Review, by J. White
• Hatherill M, McIntyre AG, Wattie M, Murdoch IA. Early hyperlactataemia in critically ill children. Intensive Care Med 2000; 26:314-318. [abstract]
  • PedsCCM EB Journal Club Review, by R Graham
• Prognostication and Certainty in the Pediatric Intensive Care Unit. Marcin JP, Pollack MM, Patel KM, et al. Pediatrics 1999; 104: 868-873. [abstract] [full-text for subscribers, AAP members)
• ABC of intensive care: Recovery from intensive care. Griffiths RD, Jones C. Br Med J 1999;319:427-429. (full-text)
• The Pediatric Risk of Mortality (PRISM) Score and Injury Severity Score (ISS) for predicting resource utilization and outcome of intensive care in pediatric trauma. Castello FV, Cassano A, Gregory P, Hammond J. Crit Care Med 1999;27:985-8. [abstract]
• ABC of intensive care: Outcome data and scoring systems. Gunning K, Rowan K. Br Med J 1999; 319: 241-244. (full-text)
• ABC of intensive care: Criteria for admission. Smith G, Nielsen M. Br Med J 1999;318:1544-1547. (full-text)
• Predictors of Death and Neurologic Impairment in Pediatric Submersion Injuries: The Pediatric Risk of Mortality Score. Zuckerman GB, Gregory PM, Santos-Damiani SM. Arch Pediatr Adolesc Med. 1998;152:134-140. (abstract)
• Pediatric critical care training programs have a positive effect on pediatric intensive care mortality. Pollack MM, Patel KM, Ruttimann E. Crit Care Med 1997 Oct;25(10):1637-1642 [abstract]
• Should paediatric intensive care be centralised? Trent versus Victoria. Pearson G, Shann F, Barry P, Vyas J, Thomas D, Powell C, Field D. Lancet 1997; 349:1213-1217. [abstract]
• PRISM III: an updated Pediatric Risk of Mortality score. Pollack MM, Patel KM, Ruttimann UE Crit Care Med 1996; 24:743-752 [abstract]
• Pediatric mortality probability estimated from pre-ICU severity of illness. Kanter RK, Edge WE, Caldwell CR, Nocera MA, Orr RA Pediatrics 1997; 99:59-63 [abstract]
• Poor discriminatory performance of the Pediatric Risk of Mortality (PRISM) score in a South African intensive care unit. Wells M, Riera-Fanego JF, Luyt DK, Dance M, Lipman J Crit Care Med 1996; 24:1507-1513 [abstract]

Patient Safety, Quality Improvement and Guidelines

• Hixson ED, Davis S, Morris S, Harrison AM. Do weekends or evenings matter in a pediatric intensive care unit? Pediatr Crit Care Med. 2005 Sep;6(5):523-530. [abstract]
• Slonim AD, Pollack MM. Integrating the Institute of Medicine's six quality aims into pediatric critical care: Relevance and applications. Pediatr Crit Care Med. 2005 May;6(3):264-269. [abstract; full-text (pdf: 280K)]
• Landrigan CP, Rothschild JM, Cronin JW, et al. Effect of reducing interns' work hours on serious medical errors in intensive care units. N Engl J Med. 2004 Oct 28;351(18):1838-48 [abstract]
  • PedsCCM EB Journal Club Review, by L Huang, J Lajoie
• Rosenberg DI, Moss MM, AAP Section on Critical Care and Committee on Hospital Care. Guidelines and Levels of Care for Pediatric Intensive Care Units. Pediatrics 2004;114 1114-1125. [abstract]
• Sadowski R, Dechert RE, Bandy KP, Juno J, Bhatt-Mehta V, Custer JR, Moler FW, Bratton SL. Continuous Quality Improvement: Reducing Unplanned Extubations in a Pediatric Intensive Care Unit. Pediatrics 2004;114:628Ð632. [abstract]
• Metnitz PG, Reiter A, Jordan B, Lang T. More interventions do not necessarily improve outcome in critically ill patients. Intensive Care Med. 2004; 30: 1586 - 1593 [abstract]
• Tibby SM, Correa-West J, Durward A, Ferguson L, Murdoch IA. Adverse events in a paediatric intensive care unit: relationship to workload, skill mix and staff supervision. Intensive Care Med. 2004 Jun;30(6):1160-6. [abstract]
• Frey B, Argent A. Safe paediatric intensive care. Part 1: Does more medical care lead to improved outcome? Intensive Care Med. 2004 Jun;30(6):1041-6. [abstract]
• Frey B, Argent A. Safe paediatric intensive care Part 2: Workplace organisation, critical incident monitoring and guidelines. Intensive Care Med. 2004; 30:1292-1297. [abstract]
• Auriant I, Reignier J, Pibarot ML et al. Critical incidents related to invasive mechanical ventilation in the ICU: preliminary descriptive study. Intensive Care Med 2002; 28: 452-458. [abstract; full-text for subscribers]
• Evidence-Based Quality Improvement, Principles, and Perspectives, in the January 1999 issue of Pediatrics (full-text for AAP members)
  • Quality Improvement Methods in Clinical Medicine. Plsek PE. Pediatrics 1999; 103; 203-214. [abstract]
  • Evidence-Based Guidelines and Critical Pathways for Quality Improvement. Bergman DA. Pediatrics 1999; 103: 225-232. [abstract]
  • Risk Adjustment for Quality Improvement. Richardson D, Tarnow-Mordi WO, Le SK. Pediatrics 1999; 103: 255-265. [abstract]
• A full-text series on guidelines in the British Medical Journal:
  • Potential benefits, limitations, and harms of clinical guidelines . Woolf SH, Grol R, Hutchinson A, Eccles M, Grimshaw J. Br Med J 1999;318:527-530.
  • Developing guidelines. Shekelle PG, Woolf SH, Eccles M, Grimshaw J. Br Med J 1999;318:593-596.
  • Clinical guidelines: Using clinical guidelines. Feder G, Eccles M, Grol R, Griffiths C, Grimshaw J. Br Med J 1999; 318: 728-730.
  • Clinical guidelines: Legal and political considerations of clinical practice guidelines. Hurwitz B. Br Med J 1999; 318: 661-664.
  • Clinical guidelines - the hidden costs. Haycox A, Bagust A, Walley T. Br Med J 1999; 318: 391-393

Practical PICU Issues and Teaching

Announcing: Pediatric Critical Care Education at picucourse.org.

"The site contains educational material in the form of PowerPoint presentations on topics that form a core curriculum for housetaff (medical students and residents) in the area of Pediatric Critical Care Medicine. These presentations have been authored by members of the Resident Education Committee" of the SCCM.

• Allen HD, Bricker JT, Freed MD, et al. ACC/AHA/AAP recommendations for training in pediatric cardiology. Pediatrics. 2005 Dec;116(6):1574-96. [abstract]
• Nadel FM, Lavelle JM, Fein JA, Giardino AP, Decker JM, Durbin DR. Teaching resuscitation to pediatric residents: the effects of an intervention. Arch Pediatr Adolesc Med. 2000;154(10):1049-54. [abstract] [full-text]
• Playfor S, Thomas D, Choonara I. Recollection of children following intensive care. Arch Dis Child 2000; 83: 445-448. [Abstract] [Full-text for subscribers]
• American Thoracic Society. Care of the Child with a Chronic Tracheostomy. Am J Respir Crit Care Med 2000; 161:297-308. [full-text for subscribers]
• Family presence during invasive procedures in the pediatric intensive care unit: a prospective study. Powers KS, Rubenstein JS. Arch Pediatr Adolesc Med 1999;153:955-8. [full-text for subscribers only] [abstract]
• Pharmacist Participation on Physician Rounds and Adverse Drug Events in the Intensive Care Unit. Leape LL, Cullen DJ, Clapp MD. JAMA. 1999;282:267-270. [abstract] [full-text for subscribers only].
• ABC of intensive care: Other supportive care. Adam S, Sally Forrest S. Br Med J 1999; 319: 175-178. (full-text)
• Use of a computerized advanced cardiac life support simulator improves retention of advanced cardiac life support guidelines better than a textbook review. Schwid HA, Rooke A, Ross BK, Sivaragan M. Crit Care Med. 1999;27:821-4. [abstract]
• ABC of intensive care: Organisation of intensive care. Bennett D, Bion J. Br Med J 1999;318:1468-1470. [full-text]
• Guidelines for Developing Admission and Discharge Policies for the Pediatric Intensive Care Unit. Committee on Hospital Care and Section on Critical Care and Pediatric Section Admission Criteria Task Force. Pediatrics 1999; 103: 840-842. [abstract; full-text for AAP members]
• Guidelines for Intensive Care Unit Design. (pdf) Guidelines/Practice Parameters Committee of the American College of Critical Care Medicine, Society of Critical Care Medicine. Crit Care Med 1995; 23:582-588.
• Performance of Advanced Resuscitation Skills by Pediatric Housestaff. White JR, Shugerman R, Brownlee C, Quan L. Arch Pediatr Adolesc Med. 1998;152:1232-1235 (abstract)
• Medical Calculators with Javascript, including Emergency Medications, Drip Rate-Dose, Body Surface Area, A-a gradient, and Creatinine clearance, from Steve Pon at Cornell University Medical Center's PICU.
• The PICU Resident Syllabus from Children's Hospital Medical Center of Akron, Ohio; a downloadable resource for resident education (now available in pdf!)
• Guidelines and Levels of Care for Pediatric Intensive Care Units, from Policy Statements of the American Academy of Pediatrics
• Evaluation of a pediatric intensive care residency curriculum. Cullen EJ, Lawless ST, Nadkarni VM, McCloskey JJ, Corddry DH, Kettrick RG. Crit Care Med 1997; 25:1898-1903. [abstract]
• Nonradiographic assessment of enteral feeding tube position. Harrison AM, Clay B, Grant MJ, Sanders SV, Webster HF, Reading JC, Dean JM, Witte MK. Crit Care Med 1997; 25: 2055-2059. [abstract]
• Band-Aids and Backboards; chronic illness and hospitalization issues from the patient's perspective
• Where do parents of infants and children in PICU's sleep? Results of a survey on the PICU List
• See our Software page for procedure-tracking software.

Emergency Medical Services for Children/Regional Care/Special Needs

• Honberg L, McPherson M, Strickland B, Gage JC, Newacheck PW. Assuring Adequate Health Insurance: Results of the National Survey of Children With Special Health Care Needs. Pediatrics 2005;115 1233-1239 [abstract]
• Odetola FA, Clark SJ, Freed GL, Bratton SL, Davis MM. A National Survey of Pediatric Critical Care Resources in the United States. Pediatrics 2005;115 e382-e386 [full-text]
• Randolph AG, Gonzales CA, Cortellini L, Yeh TS. Growth of pediatric intensive care units in the United States from 1995 to 2001. J Pediatr. 2004 Jun;144(6):792-8. [abstract]
• White M, Weir PM, Garland L et al. Outcome of critically ill children before and after the establishment of a pediatric retrieval service as a component of a national strategy for pediatric intensive care. Pediatr Crit Care Med 2002; 3:255-260. [abstract]
• Pediatric Emergency Manual, a full-text "pocket" guide to pediatric emergencies, from The Virtual Naval Hospital. Chapters include:
  • Code Algorithms, CPR Table
  • Coagulopathies
  • Diabetic Ketoacidosis
  • Hypertensive Emergencies
  • Poisonings
  • Trauma
• Gausche M, Lewis RJ, Stratton SJ, et al. Effect of Out-of-Hospital Pediatric Endotracheal Intubation on Survival and Neurological Outcome: A Controlled Clinical Trial. JAMA 2000;283:783-790. [abstract] [full-text for subscribers only]
  • PedsCCM EB Journal Club Review, by J. Gregory, K. Tegtmeyer
• American Academy of Pediatrics, American College of Critical Care Medicine/Society of Critical Care Medicine. Consensus Report for Regionalization of Services for Critically Ill or Injured Children (RE9912) Pediatrics 2000;105:152-155 [full-text]
• Emergency Preparedness for Children With Special Health Care Needs. Committee on Pediatric Emergency Medicine. Pediatrics 1999; 104: e53. [full-text]
• Prehospital Advanced Life Support Protocols: Pediatric Emergencies, from Regional Emergency Medical Advisory Committee of New York City Prehospital Life Support Protocols. Examples include Respiratory arrest, Traumatic cardiac arrest, Decompensated shock
• Task Force Report: "From Hospital to Home: Transitioning Children from Acute Care Facilities"
• Provision of intensive care for children. Ratcliffe J. Br Med J 1998; 316: 1547-1548. (full-text editorial)
  • With a series of letters in response and the authors' reply. Br Med J 1998;317:1320.

Technology

• Marcin JP, Nesbitt TS, Kallas HJ, Struve SN, Traugott CA, Dimand RJ. Use of telemedicine to provide pediatric critical care inpatient consultations to underserved rural Northern California. J Pediatr. 2004 Mar;144(3):375-80 [abstract]
• Potts AL, Barr FE, Gregory DF, Wright L, Patel NR. Computerized Physician Order Entry and Medication Errors in a Pediatric Critical Care Unit. Pediatrics 2004;113 59-63 [abstract]
• Hatherill M, Waggie Z, Reynolds L, Argent A. Transport of critically ill children in a resource-limited setting. Intensive Care Med. 2003 Sep;29(9):1547-54 [abstract]
• Apkon M, Singhaviranon P. Impact of an electronic information system on physician workflow and data collection in the intensive care unit Intensive Care Med 2000: DOI 10.1007/s001340000777 [abstract/full-text]
• Imhoff M, Webb A, Goldschmidt A et al. ESICM Statement: Health informatics Intensive Care Med 2000 DOI 10.1007/s001340000747. [abstract/full-text]
• Cook DJ, Giacomini M, Johnson N, et al. Life support in the intensive care unit: a qualitative investigation of technological purposes. Can Med Assoc J 1999;161:1109-13. [abstract]
• Ten Lessons for Evidence-Based Technology Assessment. Eisenberg JM. JAMA 1999; 282:1865-1869. [full-text for subscribers only]
• ABC of intensive care: Cutting edge. Singer M, Little R. Br Med J 1999;319:501-504. (full-text)
• ABC of intensive care: Transport of critically ill patients. Wallace PGM, Ridley SA Br Med J 1999; 319: 368-371. (full-text)
• Clinical Use of Continuous Arterial Blood Gas Monitoring in the Pediatric Intensive Care Unit. Weiss IK, Fink S, Harrison R, et al. Pediatrics 1999; 103: 440-445. [abstract, full-text for AAP members]
• Current status of long term ventilation of children in the United Kingdom: questionnaire survey. Jardine E, O'Toole M, Paton JY, Wallis C. Br Med J 1999;318:295-299. (full-text)
• Telemedicine in Pediatric Transport: A Feasibility Study. Kofos D, Pitetti R, Orr R, Thompson A. Pediatrics 1998; 102: e58. (full-text) [abstract]
• Evaluating information technology in health care: barriers and challenges. Heathfield H, Pitty D, Hanka R. Br Med J 1998;316:1959-1961. (full-text)
• Brenner Children's Home Ventilation Program; an Internet-based electronic medical record for patients receiving home mechanical ventilation, is available for participation by others. Contact: Loren Bauman (lbauman@bgsm.edu).
• Safety of Hospitalized Ventilator-dependent Children Outside of the Intensive Care Unit. Ambrosio IV, Woo MS, Jansen MT, Keens TG. Pediatrics 1998; 101(2): 257-259 (abstract)
• Interactive Communication in High-technology Home Care: Videophones for Pediatric Ventilatory Care. Miyasaka, K. et al. Pediatrics 1997; 99(1):e1. (full-text)

Social/Psychosocial, Legal, Fiscal, Quality and General ICU Issues

• Cimino MA, Kirschbaum MS, Brodsky L, Shaha SH. Assessing medication prescribing errors in pediatric intensive care units. Pediatr Crit Care Med. 2004 Mar;5(2):124-132. [abstract; full-text]
• Mello MM, Burns JP, Truog RD, Studdert DM, Puopolo AL, Brennan TA. Decision making and satisfaction with care in the pediatric intensive care unit: Findings from a controlled clinical trial. Pediatr Crit Care Med. 2004 Jan;5(1):40-47. [abstract; full-text (pdf; 252K)]
• Stott S. Recent advances in intensive care. Br Med J 2000;320:358-361[full-text]
• Hospital costs of pediatric intensive care. Chalom R, Raphaely RC, Costarino AT Crit Care Med 1999 Oct;27(10):2079-85. [abstract]
• Rainer TH, Jacobs P, Ng YC et al. Cost effectiveness analysis of intravenous ketorolac and morphine for treating pain after limb injury: double blind randomised controlled trial. Br Med J 2000;321:1247-1252. [abstract] [full-text]
  • PedsCCM EB Journal Club Review, by A Torres

General Pediatrics Resources

• GPnotebook; an online reference tool with an excellent pediatric section. Oxbridge Solutions, UK.
• eMedicine Pediatrics, a free online textbook of pediatrics. An extensive growing table of contents and a variety of online calculators. From eMedicine.com

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Informatics and Statistics

Courses and Texts

• A New View of Statistics, Will Hopkins, from Sportscience.org
• HyperStat Online, a textbook with extensive contextual links to other resources, from David Lane, Rice University and the Rice Virtual Lab in Statistics;
• Electronic Statistics Textbook, from StatSoft
• An extensive online statistics textbook: SurfStat Australia, from the University of Newcastle.
• Handbook of Medical Informatics Website; van Bemmel JH, Erasmus University, Rotterdam, and Musen MA, Stanford University, Palo Alto, eds.
• Introductory Guide to Statistics, from University of Queenland, Brisbane, Australia (server currently not responding)

Series and Other Resources

• Epidemiology and Biostatistics Resources; an excellent list from Department of Pediatrics, University of Utah School of Medicine
• Statistics on the Web; a large and well organized list. Clay Helberg.
• Statistics for the non-statistician. Greenhalgh T. Br Med J 1977; 315: 364-7. and Statistics for the non-statistician. II: "Significant" relations and their pitfalls. Greenhalgh T. Br Med J 1977; 315: 422-6.
• Web Pages that Perform Statistical Calculations. Pezullo JC. Extensive resource list.
• The Canadian Medical Association Journal series Statistics and Research Methods
• Additional statistics resources on the web listed in: Statistics and Research, J. Loadsman, ed. In The Virtual Anaesthesia Textbook.
• And see the Basic Statistics section of the PedsCCM Evidence-based resource list.

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Evidence-Based Medicine

The EBM resources have been reorganized and relocated to a separate Evidence-Based Medicine Resource List, to better coordinate with the PedsCCM Evidence-Based Journal Club

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Back to File Cabinet Introduction