Reduction of Cerebral Metabolic Rate: Hypothermia

• Metz et al. (1996) Journal of Neurosurgery, 85(4)

  • 32.5 C reduced cerebral metabolic rate for oxygen (CMRO2) by 45% without change in CBF
  • intracranial pressure decreased significantly (p < 0.01)

• Marion et al. (1997) New England Journal of Medicine, 336(8)

  • At 12 months, 62% of patients (GCS of 5-7) cooled to 32-33 C have good outcomes vs. 38% of patients in control group

Side-effects:

• Potassium flux

• Coagulopathy

• Shivering

• Skin Breakdown

Requires:

• Slow re-warming

• Close monitoring

No pediatric studies!

Previous slide

Next slide

Back to first slide

View graphic version