Reduction of Cerebral Metabolic Rate: Hypothermia
Metz et al. (1996) Journal of Neurosurgery, 85(4)
- 32.5 C reduced cerebral metabolic rate for oxygen (CMRO2) by 45% without change in CBF
- intracranial pressure decreased significantly (p < 0.01)
Marion et al. (1997) New England Journal of Medicine, 336(8)
- At 12 months, 62% of patients (GCS of 5-7) cooled to 32-33 C have good outcomes vs. 38% of patients in control group