Reduction of Cerebral Metabolic Rate
Goal: Reduce cerebral oxygen requirement
- Anticonvulsants
- To prevent seizure activity
- Pentobarbital ??
- Adverse effects include hypotension and bone marrow dysfunction
- Used only after unsuccessful attempts to control ICP and maximize CPP with other therapies
- Improved outcome not fully supported by research
Traeger et al. (1983) Critical Care Medicine, 11
Ward et al. (1985) Journal of Neurosurgery, 62(3)