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Evidence-Based Medicine Resources

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TopicCitationLink and Reviewer(s)
Neurologic/Head Trauma/Trauma
DeleriumSilver G, Traube C, Kearney J, Kelly D, Yoon MJ, Nash Moyal W, Gangopadhyay M, Shao H, Ward MJ Detecting pediatric delirium: development of a rapid observational assessment tool.
Intensive Care Med 2012 38(6):1025-31 [abstract]
Review, by Jordana Goldman MD, Baylor College of Medicine and Texas Children's Hospital, Houston, TX
DeleriumJanssen NJ, Tan EY, Staal M, Janssen EP, Leroy PL, Lousberg R, van Os J, Schieveld JN. On the utility of diagnostic instruments for pediatric delirium in critical illness: an evaluation of the Pediatric Anesthesia Emergence Delirium Scale, the Delirium Rating Scale 88, and the Delirium Rating Scale-Revised R-98.
Intensive Care Med 2011 37(8):1331-7 [abstract]
Review, by Sanju Samuel MD, MD Anderson Children's Cancer Hospital, Houston TX
Diagnosis of Cervical Spine InjuryViccellio P, Simon H, Pressman BD, et al. A Prospective Multicenter Study of Cervical Spine Injury in Children
Pediatrics 2001 2001;108 e20 [abstract] [Full-Text]
Review, by K Moynihan Hardart
Diagnosis of Cervical Spine InjuryHoffman JR, Mower WR, Wolfson AB, Todd KH, Zucker MI Validity of a Set of Clinical Criteria to Rule Out Injury to the Cervical Spine in Patients with Blunt Trauma
N Engl J Med 2000 ul 13;343(2):94-99 [abstract]
Review, by A Torres
DKA and Cerebral EdemaGlaser N, Barnett P, McCaslin I, et al., Risk Factors for Cerebral Edema in Children with Diabetic Ketoacidosis
N Engl J Med 2001 344:264-9 [abstract]
Review, by R Rao M Scanlon
DKA and Cerebral EdemaHoorn EJ, Carlotti AP, Costa LA, MacMahon B, Bohn G, Zietse R, Halperin ML, Bohn D. Preventing a drop in effective plasma osmolality to minimize the likelihood of cerebral edema during treatment of children with diabetic ketoacidosis.
J Pediatr 2007 150(5):467-73 [abstract]
Review, by Robert B. Kelly MD and Andranik Madikians, MD, Mattel Children’s Hospital at UCLA, Los Angeles, CA
DKA and Cerebral EdemaMarcin JP, Glaser N, Barnett P, et al., Factors associated with adverse outcomes in children with diabetic ketoacidosis-related cerebral edema
J Pediatr 2002 141(6):793-7 [abstract]
Review, by C Kennedy
Fomepizole Treatment of Methanol PoisoningBrent J, McMartin K, Phillips S, Aaron C, Kulig K Fomepizole for the Treatment of Methanol Poisoning
N Engl J Med 2001 344:424-9 [abstract]
Review, by D. Mackey
Hyperbaric Oxygen for Carbon Monoxide PoisoningWeaver LK, Hopkins RO, Chan KJ , et al., Hyperbaric oxygen for acute carbon monoxide poisoning
N Engl J Med 2002 347:1057-67 [abstract]
Review, by M Fiore
Hypertonic saline and head traumaCooper DJ, Myles PS, McDermott FT, et al. Prehospital hypertonic saline resuscitation of patients with hypotension and severe traumatic brain injury: a randomized controlled trial
JAMA 2004 Mar 17;291(11):1350-7 [abstract]
Review, by G Mander
Hypertonic saline and head traumaSimma B, Burger R, Falk M, Sacher P , Fanconi S A prospective, randomized, and controlled study of fluid management in children with severe head injury: lactated Ringer's solution versus hypertonic saline
Crit Care Med 1998 157: 1483-1488 [abstract] [Full-Text]
Review, by Stephanie Sudikoff, MD
Hypothermia - other usesMourvillier B, Tubach F, van de Beek D, Garot D, Pichon N, Georges H, Lefevre LM, Bollaert PE, Boulain T, Luis D, Cariou A, Girardie P, Chelha R, Megarbane B, Delahaye A, Chalumeau-Lemoine L, Legriel S, Beuret P, Brivet F, Bruel C, Camou F, Chatellier D, Induced Hypothermia in Severe Bacterial Meningitis: A Randomized Clinical Trial
JAMA 2013 310(20):2174-2183 [abstract]
Review, by Neil Brain MbChb, Royal Manchester Children
Hypothermia - other usesMourvillier_B, Tubach F, van de Beek D, Garot D, Pichon N, Georges H, Lefevre LM, Bollaert PE, Boulain T, Luis D, Cariou A, Girardie P, Chelha R, Megarbane B, Delahaye A, Chalumeau-Lemoine L, Legriel S, Beuret P, Brivet F, Bruel C, Camou F, Chatellier D Induced Hypothermia in Severe Bacterial Meningitis: A Randomized Clinical Trial
JAMA 2013 310(20):2174-2183 [abstract]
Review, by Tricia Alleyne MD, University of Tennesse , Le Bonheur Children's Hospital, Memphis TN
Hypothermia after cardiac arrest/hypoxia-ischemiaShankaran S, Laptook AR, Ehrenkranz RA, et al., Whole-body hypothermia for neonates with hypoxic-ischemic encephalopathy.
N Engl J Med 2005 Oct 13;353(15):1574-84 [abstract]
Review, by R Mosalli K Al Faleh
Hypothermia after cardiac arrest/hypoxia-ischemiaHolzer M, Bernard SA, Hachimi-Idrissi S, et al. Hypothermia for neuroprotection after cardiac arrest: systematic review and individual patient data meta-analysis.
Crit Care Med. 2005 Feb;33(2):414-8. [abstract]
Review, by Ivie Doris Esangbedo MD MPH, University of Illiniois at Chicago, Chicago IL
Hypothermia after cardiac arrest/hypoxia-ischemiaThe Hypothermia After Cardiac Arrest Study Group. Mild Therapeutic Hypothermia to Improve the Neurologic Outcome After Cardiac Arrest
N Engl J Med 2002 346:549-56 [abstract]
Review, by S Cooper
Hypothermia after cardiac arrest/hypoxia-ischemiaShah PS, Ohlsson A, Perlman M. Hypothermia to Treat Neonatal Hypoxic Ischemic Encephalopathy: Systematic Review
Arch Pediatr Adolesc Med 2007 161 951-958 [abstract]
Review, by Luis E. Lozada MD, Downing Lu MD, Walter Reed National Military Medical Center, Bethesda, MD
Hypothermia after cardiac arrest/hypoxia-ischemiaJacobs SE, Morley CJ, Inder TE, Stewart MJ, Smith KR, McNamara PJ, Wright IM, Kirpalani HM, Darlow BA, Doyle LW; for the Infant Cooling Evaluation Collaboration. Whole-Body Hypothermia for Term and Near-Term Newborns With Hypoxic-Ischemic Encephalopathy: A Randomized Controlled Trial.
Arch Pediatr Adolesc Med 2011 165(8):692-700 [abstract]
Review, by Rachel Lowdenback DO, Scottie B. Day MD FAAP, Kentucky Children's Hospital, Lexington KY
Hypothermia after cardiac arrest/hypoxia-ischemiaBernard SA, Gray TW, Buist MD, , Treatment of Comatose Survivors of Out-of-Hospital Cardiac Arrest with Induced Hypothermia
N Engl J Med 2002 346:557-63 [abstract]
Review, by M Sehgal
Hypothermia after cardiac arrest/hypoxia-ischemiaFink EL, Clark RS, Kochanek PM, Bell MJ, Watson RS. A tertiary care center's experience with therapeutic hypothermia after pediatric cardiac arrest
Pediatr Crit Care Med. 2010 11(1):66-74 [abstract]
Review, by Giridhar Kaliki Venkata MD, Jai P. Udassi MD, University of Florida College of Medicine, Gainesville, FL
Hypothermia to treat head traumaMarion DW, Penrod LE, Kelsey SF, Obrist WD, Kochanek PM Treatment of traumatic brain injury with moderate hypothermia
N Engl J Med 1997 336: 540-546 [abstract]
Review, by Barry Markovitz, MD
Hypothermia to treat head traumaClifton GL, Miller ER, Choi SC, , Lack of Effect of Induction of Hypothermia after Acute Brain Injury
N Engl J Med 2001 344:556-63 [abstract]
Review, by P Prabhakaran
Hypothermia to treat head traumaHutchison JS, Ward RE, Lacroix J, et al. for the Hypothermia Pediatric Head Injury Trial Investigators andt the Canadian Critical Care Trials Group. Hypothermia Therapy after Traumatic Brain Injury in Children.
N Engl J Med 2008 358; 2447-2456. [abstract]
Review, by Thomas Arnold MD, University of California San Francisco
Hypothermia to treat head traumaAdelson PD, Wisniewski SR, Beca J, Brown SD, Bell M, Muizelaar JP, Okada P, Beers SR, Balasubramani GK, Hirtz D Paediatric Traumatic Brain Injury Consortium. Comparison of hypothermia and normothermia after severe traumatic brain injury in children (Cool Kids): a phase 3, randomised controlled trial
Lancet Neurol 2013 Jun;12(6):546-53 [abstract]
Review, by Catherine Taylor MD, University of Tennesee Health Sciences Center, Memphis TN
Hypothermia to treat head traumaPolderman KH, Joe RTT, Peerdeman SM , et al., Effects of therapeutic hypothermia on intracranial pressure and outcome in patients with severe head injury
Intensive Care Med 2002 28: 1563-1573 [abstract]
Review, by S Thammasitboon S Thammasitboon
Hypothermia to treat head traumaMcIntyre LA, Fergusson DA, Hebert PC, et al., Prolonged Therapeutic Hypothermia After Traumatic Brain Injury in Adults: A Systematic Review
JAMA 2003 289 2992-2999 [abstract]
Review, by N Shafi M Mariscalco
Hypothermia to treat head traumaHenderson WR, Dhingra VK, Chittock DR, et al., Hypothermia in the management of traumatic brain injury. A systematic review and meta-analysis.
Br Med J 2003 Oct;29(10):1637-44 [abstract]
Review, by N Shafi M Mariscalco
Intra-abdominal hypertension managementCheatham ML, Safcsak K Percutaneous Catheter Decompression in the Treatment of Elevated Intra-abdominal Pressure.
Chest 2011 140;1428-1435 [abstract]
Review, by Bao Puente MD, University of Texas Southwestern. Dallas Children’s Medical Center, Dallas TX
Intracranial Pressure Management for Head InjuryKamel H, Navi BB, Nakagawa K, Hemphill JC 3rd, Ko NU. Hypertonic saline versus mannitol for the treatment of elevated intracranial pressure: a meta-analysis of randomized clinical trials.
Crit Care Med 2011 39(3):554-9 [abstract]
Review, by Rekha Solomon MD, Children's Hospital of Michigan, Detroit MI
Intracranial Pressure Management for Head InjuryCooper DJ, Rosenfeld JV, Murray L, Arabi YM, Davies AR, D Decompressive Craniectomy in Diffuse Traumatic Brain Injury
N Engl J Med 2011 364:1493-1502 [abstract]
Review, by Neeraj Srivastava MD, Baylor College of Medicine and Texas Children's Hospital, Houston TX
Intracranial Pressure Management for Head InjuryCremer OL, van Dijk GW, van Wensen E, Brekelmans GJ, Moons KG, Leenen LP, Kalkman CJ. Effect of intracranial pressure monitoring and targeted intensive care on functional outcome after severe head injury.
Crit Care Med. 2005 Oct;33(10):2207-2213. [abstract]
Review, by Meredith Bone MD, Children’s Memorial Hospital, Northwestern University, Chicago, IL
Intracranial Pressure Management for Head InjuryChesnut RM, Temkin N, Carney N, Dikmen S, Rondina C, Videtta W, Petroni G, Lujan S, Pridgeon J, Barber J, Machamer J, Chaddock K, Celix JM, Cherner M, Hendrix T A Trial of Intracranial-Pressure Monitoring in Traumatic Brain Injury.
N Engl J Med 2012 367:2471-2481 [abstract]
Review, by Leanna Huard MD, Christopher C. Giza MD, and Robert B. Kelly MD, UCLA Mattel Children's Hospital, Los Angeles, CA
Ketamine sedation issuesWathen JE, Roback MG, Mackenzie T, Bothner JP, Does midazolam alter the clinical effects of intravenous ketamine sedation in children? A double-blind, randomized, controlled, emergency department trial
Ann Emerg Med 2000 36(6):579-588 [abstract]
Review, by J Haizlip
Near Infrared SpectroscopyNagdyman N, Fleck T, Schubert S, et al. Comparison between cerebral tissue oxygenation index measured by near-infrared spectroscopy and venous jugular bulb saturation in children.
Intensive Care Med. 2005 Jun;31(6):846-50 [abstract]
Review, by Carlos Acuna MD, Antonio Cabrera MD, Le Bonheur Children’s Medical Center, University of Tennessee, Memphis, TN
Neurologic/Head Trauma/TraumaMayer SA, Brun NC, Begtrup K, Broderick J, Davis S, Diringer MN, Skolnick BE, Steiner T; Recombinant Activated Factor VII Intracerebral Hemorrhage Trial Investigators. Recombinant activated factor VII for acute intracerebral hemorrhage.
N Engl J Med. 2005 Feb 24;352(8):777-85 [abstract]
Review, by Vikas Shah MD, Cornell University, New York, NY
Neurologic/Head Trauma/TraumaZebrack M, Dandoy C, Hansen K, Scaife E, Mann NC, Bratton SL. Early resuscitation of children with moderate-to-severe traumatic brain injury.
Pediatrics 2009 124(1):56-64. [abstract]
Review, by Mahesh Sharman MD, Olga Zand MD, Aamir Ansari MD, Hurley Medical Center and Michigan State University, Flint MI
Outcomes and head injury managementBennett TD, Riva-Cambrin J, Keenan HT, Korgenski EK, Bratton SL Variation in Intracranial Pressure Monitoring and Outcomes in Pediatric Traumatic Brain InjuryTBI Intracranial Pressure Monitoring and Outcomes.
Arch Pediatr Adolesc Med 2012 166(7):641-7 [abstract]
Review, by Gita Indramohan MD and Robert B. Kelly MD, University of California Los Angeles, Los Angeles CA
Outcomes and head injury managementHenzler D, Cooper DJ, Tremayne AB, Rossaint R, Higgins A. Early modifiable factors associated with fatal outcome in patients with severe traumatic brain injury: a case control study.
Crit Care Med 2007 35(4):1027-31 [abstract]
Review, by S. David McSwain MD MPH, Duke University Medical Center, Durham NC
Paresis in the ICUDe Jonghe B, Sharshar T, Lefaucheur JP, et al., Paresis acquired in the intensive care unit: a prospective multicenter study
JAMA 2002 288(22):2859-67 [abstract]
Review, by J Alten
Paresis in the ICUBanwell BL, Mildner RJ, Hassall AC, et al., Muscle weakness in critically ill children
Neurology 2003 Dec 23;61(12):1779-82 [abstract]
Review, by J Alten M Mariscalco
Postoperative analgesiaLieh-Lai MW, Kauffman RE, Uy HG, Danjin M, Simpson PM. A randomized comparison of ketorolac tromethamine and morphine for postoperative analgesia in critically ill children.
Crit Care Med 1999 27:2782-5 [abstract]
Review, by J. Tuladhar
Prediction Tools for Near-DrowningGraf WD, Cummings P, Quan L, Brutocao D. , Predicting outcome in pediatric submersion victims
Ann Emerg Med 1995 Sep;26(3):312-9 [abstract]
Review, by A Godshall
Prediction Tools for Trauma/Head TraumaQuayle KS, Jaffe DM, Juppermann N, Kaufman BA, Lee BC Diagnostic Testing for Acute Head Injury in Children: When are Head Computed Tomography and Skull Radiographs Indicated?
Pediatrics 1997 340:409-417 [abstract]
Review, by Sahhar, Hanna
Prediction Tools for Trauma/Head TraumaHackbarth RM, Rzeszutko KM, Sturm G, et al. Survival and functional outcome in pediatric traumatic brain injury: a retrospective review and analysis of predictive factors
Crit Care Med 2002 30(7):1630-5 [abstract]
Review, by J Krishnan, W Morrison
Prediction Tools for Trauma/Head TraumaRobinson LR, Micklesen PJ, Tirschwell DL, Lew HL. Predictive value of somatosensory evoked potentials for awakening from coma
Crit Care Med. 2003 Mar;31(3):960-7. [abstract]
Review, by Nadeem Shafi MD, University of Florida, Gainesville FL
Prediction Tools for Trauma/Head TraumaGreenes DS, Schutzman SA., , , Clinical Indicators of Intracranial Injury in Head-injured Infants
Pediatrics 1999 104: 861-867 [abstract] [Full-Text]
Review, by P Tandon S Bateman
Prediction Tools for Trauma/Head TraumaCantais E, Paut O, Giorgi R , , Evaluating the prognosis of multiple, severely traumatized children in the intensive care unit
Intensive Care Med 2001 27: 1511-1517; DOI 10.1007/s001340101039 [abstract]
Review, by A Torres
Prediction Tools for Trauma/Head TraumaHaydel MJ, Preston CA, Mills TJ, , Indications for computed tomography in patients with minor head injury
N Engl J Med 2000 343:100-5 [abstract]
Review, by M Sehgal MM Mariscalco
Prediction Tools for Trauma/Head TraumaTilford JM, Simpson PM, Yeh TS, , Variation in therapy and outcome for pediatric head trauma patients
Crit Care Med 2001 29:1056-1061 [abstract]
Review, by L Faberowski
Prediction Tools for Trauma/Head TraumaWells RG, Vetter C, Laud P, , Intracranial hemorrhage in children younger than 3 years: prediction of intent
Arch Pediatr Adolesc Med 2002 156(3):252-7 [abstract]
Review, by G Capraro S Bateman
Prediction Tools for Trauma/Head TraumaKimberly HH, Shah S, Marill K, Noble V. Correlation of optic nerve sheath diameter with direct measurement of intracranial pressure
Acad Emergency Med 2008 15(2):201-4. [abstract]
Review, by Muzamil Noorani MD, Baylor College of Medicine and Texas Children's Hospital, Houston, TX
Prediction Tools for Trauma/Head TraumaRobertson CMT, Joffe AR, Moore AJ, Watt JM, Neurodevelopmental outcome of young pediatric intensive care survivors of serious brain injury
Pediatric Critical Care Medicine 2002 3(4):345-350 [abstract]
Review, by R Graham
Prediction Tools for Trauma/Head TraumaPerez A, Minces PG, Schnitzler EJ, et al., Jugular venous oxygen saturation or arteriovenous difference of lactate content and outcome in children with severe traumatic brain injury
Pediatric Critical Care Medicine 2003 Jan;4(1):33-8 [abstract]
Review, by J Alten M Mariscalco
Prediction Tools for Trauma/Head TraumaPalchak MJ, Holmes JF, Vance CW, et al., Does an isolated history of loss of consciousness or amnesia predict brain injuries in children after blunt head trauma?
Pediatrics 2004 Jun;113(6):e507-13 [abstract]
Review, by K Typpo
Prediction Tools for Trauma/Head TraumaBechtel K, Stoessel K, Leventhal JM , et al., Characteristics That Distinguish Accidental From Abusive Injury in Hospitalized Young Children With Head Trauma
Pediatrics 2004 114 165-168 [abstract]
Review, by M Winkler
Prediction Tools for Trauma/Head TraumaCarter BG, Butt W., , , A prospective study of outcome predictors after severe brain injury in children
Intensive Care Med 2005 Jun;31(6):840-845 [abstract]
Review, by L Thompson
Secondary injury after head traumaRobertson CS, Valadka AB, Hannay HJ, , Prevention of secondary ischemic insults after severe head injury
Crit Care Med 1999 27:2086-95 [abstract]
Review, by JRM White
Secondary injury after head traumaThe SAFE Study Investigators Saline or Albumin for Fluid Resuscitation in Patients with Traumatic Brain Injury.
N Engl J Med. 2007 357:874-884 [abstract]
Review, by Nicolas Rivera MD and M Michelle Mariscalco MD, Baylor College of Medicine and Texas Children’s Hospital, Houston, TX
Sedation issuesHosokawa K, Shime N, Kato Y, Taniguchi A, Maeda Y, Miyazaki T, Hashimoto S. Dexmedetomidine sedation in children after cardiac surgery.
Pediatr Crit Care Med. 2010 Jan;11(1):39-43. [abstract]
Review, by Kasey Davis MD, University of Alabama at Birmingham, Birmingham AL
Sedation issuesOstermann ME, Keenan SP, Seiferling RA, Sibbald WJ Sedation in the Intensive Care Unit. A Systematic Review
JAMA 2000 283:1451-1459 [abstract] [Full-Text]
Review, by P Jines
Sedation issuesBerens RJ, Meyer MT, Mikhailov TA, et al. A Prospective Evaluation of Opioid Weaning in Opioid-Dependent Pediatric Critical Care Patients.
Anesth Analg 2006 ;102 1045-1050 [abstract]
Review, by Katherine M Pleacher MD, Susan L Bratton MD MPH, University of Utah, Salt Lake City, UT
Sedation issuesBray RJ, , , , Propofol infusion syndrome in children
Paed Anaesth 1998 160:829-34 [abstract] [Full-Text]
Review, by Steven Cray
Sedation issuesKress JP, Pohlman AS, O'Connor MF, Hall JB, Daily Interruption of Sedative Infusions in Critically Ill Patients Undergoing Mechanical Ventilation
N Engl J Med 2000 342:1471-1477 [abstract]
Review, by A. Torres
Sedation issuesPandharipande PP, Pun BT, Herr DL, et al. Effect of sedation with dexmedetomidine vs lorazepam on acute brain dysfunction in mechanically ventilated patients: the MENDS randomized controlled trial.
JAMA 2007 298(22):2644-53. [abstract]
Review, by Nicolas B Rivera MD, Baylor College of Medicine and Texas Children's Hospital, Houston, TX
Seizure treatmentLahat E, Goldman M, Barr J, et al., Comparison of intranasal midazolam with intravenous diazepam for treating febrile seizures in children: prospective randomised study
Br Med J 2000 321:83-86 [Full-Text]
Review, by A Torres
Steroids and head traumaAlderson P, Roberts I. , , , Corticosteroids in acute traumatic brain injury: Systematic review of randomized controlled trials.
Br Med J 1997 314:1855-1859 [abstract]
Review, by Scot Bateman
Subarachnoid hemorrhage managementWestermaier T, Stetter C, Vince GH, Pham M, Tejon JP, Eriskat J, Kunze E, Matthies C, Ernestus RI, Solymosi L, Roosen K. Prophylactic intravenous magnesium sulfate for treatment of aneurysmal subarachnoid hemorrhage: a randomized, placebo-controlled, clinical study.
Crit Care Med 2010 38(5):1284-90. [abstract]
Review, by Kim Ngo MD, Children's Hospital Los Angeles, Los Angeles CA
Tidal volume reduction in ARDS/Prevention of barotraumaMascia L, Zavala E, Bosma K, et al. High tidal volume is associated with the development of acute lung injury after severe brain injury: An international observational study.
Crit Care Med. 2007 35(8):1815-1820. [abstract]
Review, by Timothy Stidham MD, Children's Hospital of Colorado, Denver CO
Systemic/Infectious
Adrenal insufficiency/Steroids in sepsis/septic shockBriegel J, Forst H, Haller M, , Stress doses of hydrocortisone reverse hyperdynamic septic shock: a prospective, randomized, double-blind, single-center study.
Crit Care Med 1999 27:1409-20 [abstract]
Review, by Vaughan David
Adrenal insufficiency/Steroids in sepsis/septic shockCronin L, Cook DJ, Carlet J, Heyland DK, King D Corticosteroids treatment for sepsis: a critical appraisal and meta-analysis of the literature
Crit Care Med 1995 338: 347-354 [abstract]
Review, by Varsha Gharpure, MD Kathleen Meert, MD,
Adrenal insufficiency/Steroids in sepsis/septic shockLefering R, Neugebauer E, , , Steroid controversy in sepsis and septic shock: A meta-analysis.
Crit Care Med 1995 27:188-95 [abstract]
Review, by Cheri Landers, MD,
Adrenal insufficiency/Steroids in sepsis/septic shockOppert M, Schindler R, Husung C, et al., Low-dose hydrocortisone improves shock reversal and reduces cytokine levels in early hyperdynamic septic shock
Crit Care Med 2005 Nov;33(11):2457-64 [abstract]
Review, by S van Schaik
Adrenal insufficiency/Steroids in sepsis/septic shockBollaert PE, Charpentier C, Levy B, Debouverie M, Audibert G Reversal of late septic shock with supraphysiologic doses of hydrocortisone.
Crit Care Med 1998 26:645-650 [abstract]
Review, by Al Torres, MD, MS,
Adrenal insufficiency/Steroids in sepsis/septic shockHebbar KB, Stockwell JA, Leong T, Fortenberry JD. Incidence of adrenal insufficiency and impact of corticosteroid supplementation in critically ill children with systemic inflammatory syndrome and vasopressor-dependent shock
Crit Care Med 2011 39:1145–1150 [abstract]
Review, by Mina Hafzalah MD, Children's Acute Care, Sioux Falls SD
Adrenal insufficiency/Steroids in sepsis/septic shockZimmerman JJ, Williams MD Adjunctive corticosteroid therapy in pediatric severe sepsis: Observations from the RESOLVE study.
Pediatr Crit Care Med. 2011 12(1):2-8. [abstract]
Review, by Joseph Philip MD, Texas Children’s Hospital, Baylor College of Medicine, Houston TX
Adrenal insufficiency/Steroids in sepsis/septic shockSlusher T, Gbadero D, Howard C, Lewison L, Giroir B Randomized, placebo-controlled, double blinded trial of dexamethasone in African children with sepsis
Pediatr Infect Dis J 1996 338: 791-797 [abstract]
Review, by Mignon McCulloch, MD Max Klein, MD
Adrenal insufficiency/Steroids in sepsis/septic shockPayen JF, Dupuis C, Trouve-Buisson T, Vinclair M, Broux C, Bouzat P, Genty C, Monneret D, Faure P, Chabre O, Bosson JL. Corticosteroid after etomidate in critically ill patients: A randomized controlled trial
Crit Care Med 2011 40(1):29-35 [abstract]
Review, by Eugene Chung DO, University of Texas Southwestern, Dallas TX
Adrenal insufficiency/Steroids in sepsis/septic shockAlbert SG, Ariyan S, Rather A. The effect of etomidate on adrenal function in critical illness: a systematic review
Intensive Care Med 2011 37(6):901-10. [abstract]
Review, by Carol Pineda MD, James Lin MD and Robert B. Kelly MD. Mattel Children’s Hospital UCLA, Los Angeles, CA
Adrenal insufficiency/Steroids in sepsis/septic shockCohan P, Wang C, McArthur DL, et al. Acute secondary adrenal insufficiency after traumatic brain injury: A prospective study.
Crit Care Med 2005 Oct;33(10):2358-2366 [abstract]
Review, by A Hoogerland
Adrenal insufficiency/Steroids in sepsis/septic shockSarthi M, Lodha R, Vivekanandhan S, Arora NK. Adrenal status in children with septic shock using low-dose stimulation test
Pediatr Crit Care Med. 2007 8:23-28. [abstract] [Full-Text]
Review, by G Garcia Guerra MD, L Zorzela MD, R Kirsch MD, Stollery Children
Adrenal insufficiency/Steroids in sepsis/septic shockSprung CL, Annane D, Keh D, et al., for the CORTICUS Study Group. Hydrocortisone Therapy for Patients with Septic Shock.
N Engl J Med 2008 358:111-124 [abstract]
Review, by Brian C. Bridges MD, Children
Adrenal insufficiency/Steroids in sepsis/septic shockMarkovitz BP, Goodman DM, Watson RS, Bertoch D, Zimmerman J. A retrospective cohort study of prognostic factors associated with outcome in pediatric severe sepsis: what is the role of steroids?
Pediatr Crit Care Med. 2005 6(3):270-4. [abstract]
Review, by Matthew Borgman MD, Children's Hospital Boston, Boston MA
Adrenal insufficiency/Steroids in sepsis/septic shockAnnane D, Sebille V, Charpentier C, et al., Effect of treatment with low doses of hydrocortisone and fludrocortisone on mortality in patients with septic shock
JAMA 2002 288(7):862-71 [abstract] [Full-Text]
Review, by P Kamat J Fortenberry
Adrenal insufficiency/Steroids in sepsis/septic shockAnnane D, Bellissant E, Bollaert PE, Briegel J, Confalonieri M, De Gaudio R, Keh D, Kupfer Y, Oppert M, Merduri GU. Corticosteroids in the Treatment of Severe Sepsis and Septic Shock in Adults: A Systematic Review
JAMA 2009 301:2362-2375. [abstract]
Review, by Lee Tosi MD, Childrens Hospital Los Angeles, Los Angeles CA
Adrenal insufficiency/Steroids in sepsis/septic shockMarik PE, Zaloga GP, , , Adrenal insufficiency during septic shock
Crit Care Med 2003 31(1):141-5 [abstract]
Review, by P Prabhakaran
Adrenal insufficiency/Steroids in sepsis/septic shockCOIITSS Study Investigators, Annane D, Cariou A, Maxime V, Azoulay E, D Corticosteroid treatment and intensive insulin therapy for septic shock in adults: a randomized controlled trial.
JAMA 2010 27;303(4):341-8 [abstract]
Review, by Fong Lam MD, Baylor College of Medicine, Texas Children's Hospital, Houston TX
Adrenal insufficiency/Steroids in sepsis/septic shockAnnane D, Bellissant E, Bollaert PE, et al., Corticosteroids for severe sepsis and septic shock: a systematic review and meta-analysis
Br Med J 2004 329(7464):480 [abstract]
Review, by M Desai
Adrenal insufficiency/Steroids in sepsis/septic shockMenon K, Ward RE, Lawson ML, Gaboury I, Hutchison JS, HĂ©bert PC, Canadian Critical Care Trials Group. A Prospective Multi-Center Study of Adrenal Function in Critically Ill Children.
Am J Respir Crit Care Med 2010 182:246-251 [abstract]
Review, by Bria M. Coates MD, Eric L Wald MD, Children's Memorial Hospital and Northwestern University, Chicago, IL
Adrenal insufficiency/Steroids in sepsis/septic shockMalerba G, Romana-Girard F, Cravoisy A, et al., Risk factors of relative adrenocortical deficiency in intensive care patients needing mechanical ventilation
Intensive Care Med 2005 31:388-392 [abstract]
Review, by AP Davis
Antimicrobial therapy in sepsisPuskarich MA, Trzeciak S, Shapiro NI, Arnold RC, Horton JM, Studnek JR, Kline JA, Jones AE; on behalf of the Emergency Medicine Shock Research Network (EMSHOCKNET). Association between timing of antibiotic administration and mortality from septic shock in patients treated with a quantitative resuscitation protocol.
Crit Care Med 2011 Sep;39(9):2066-2071 [abstract]
Review, by Asma Razavi MD, Children's Hospital Los Angleles, Los Angeles, CA
Antimicrobial therapy in sepsisBrunkhorst FM, Oppert M, Marx G, Bloos F, Ludewig K, Putensen C, Nierhaus A, Jaschinski U, Meier-Hellmann A, Weyland A, GrĂĽndling M, Moerer O, Riessen R, Seibel A, Ragaller M, BĂĽchler MW, John S, Bach F, Spies C, Reill L, Fritz H, Kiehntopf M, Kuhnt E, Effect of Empirical Treatment With Moxifloxacin and Meropenem vs Meropenem on Sepsis-Related Organ Dysfunction in Patients With Severe Sepsis: A Randomized TrialTreatment for Sepsis-Related Organ Dysfunction.
JAMA 2012 307(22):2390-9. [abstract]
Review, by Leslie Ridall DO, Children's Hospital Colorado, Aurora CO
Antithrombin III in SepsisWiedermann CJ, Hoffmann JN, et al.; for the KyberSept Investigators. High-dose antithrombin III in the treatment of severe sepsis in patients with a high risk of death: Efficacy and safety.
Crit Care Med. 2006 Feb;34(2):285-292. [abstract]
Review, by Nicolas Rivera MD and Mona McPherson MD, Baylor College of Medicine and Texas Children
Antithrombin III in SepsisWarren BL, Eid A, Singer P, et al., High-Dose Antithrombin III in Severe Sepsis: A Randomized Controlled Trial
JAMA 2001 286:1869-1878 [abstract]
Review, by K Hebbar T Petrillo
Beta-blockade for metabolic control after severe burnsHerndon DN, Hart DW, Wolf SE, et al., Reversal of catabolism by beta-blockade after severe burns
N Engl J Med 2001 345: 1223-1229 [abstract]
Review, by M Sharma K Meert
Biomarkers in SepsisFischer JE, Benn A, Harbarth S, Nadal D, Fanconi S. Diagnostic accuracy of G-CSF, IL-8, and IL-1ra in critically ill children with suspected infection
Intensive Care Med 2002 ; 28: 1324-1331. [abstract]
Review, by Margaret Scheffler MD, Baylor College of Medicine and Texas Children's Hospital, Houston TX
Biomarkers in sepsisGibot S, BĂ©nĂ© MC, Noel R, Massin F, Guy J, Cravoisy A, Barraud D, De Carvalho Bittencourt M, Quenot JP, Bollaert PE, Faure G, Charles PE. Combination Biomarkers to Diagnose Sepsis in the Critically Ill Patient.
Am J Respir Crit Care Med 2012 186:65-71 [abstract]
Review, by Mashael F. Alqahtani MBBS, Meredith F. Bone MD, Lurie Children's Hospital and Northwestern University, Chicago IL
Blood transfusionsWhite M, Barron J, Gornbein J, Lin JA. Are red blood cell transfusions associated with nosocomial infections in pediatric intensive care units?
Pediatr Crit Care Med. 2010 Jul;11(4):464-8. [abstract] [Full-Text]
Review, by Kristen Burton MD, Jason McNair MD, Daniel Ripepi MD, Megan Pritt MD, Megan Taylor MD, and Pamela Hilvers MD, West Virginia University School of Medicine, Morgantown WV
Blood transfusionsvan der Wal J, van Heerde M, Markhorst DG, Kneyber MC. Transfusion of leukocyte-depleted red blood cells is not a risk factor for nosocomial infections in critically ill children.
Pediatr Crit Care Med. 2011 Sep;12(5):519-24. [abstract]
Review, by Meredith M Schuldt MD, Downing Lu MD, Walter Reed National Military Medical Center, Bethesda, MD
Blood transfusionsKaram O, Tucci M, Ducruet T, Hume HA, Lacroix J, Gauvin F; for the Canadian Critical Care Trials Group and the PALISI Network. Red blood cell transfusion thresholds in pediatric patients with sepsis
Pediatr Crit Care Med. 2011 Sep;12(5):512-518. [abstract]
Review, by Matthew Bacon MD, Scottie B. Day MD, Kentucky Childrens Hospital, Lexington, KY
Blood transfusionsCarson JL, Carless PA, Hebert PC. Transfusion thresholds and other strategies for guiding allogeneic red blood cell transfusion.
Cochrane Review 2012 4:CD002042. [abstract]
Review, by Madhuradhar Chegondi, MD, Miami Children's Hospital, Miami FL
Blood transfusionsShorr AF, Jackson WL, Kelly KM, Fu M, Kollef MH. Transfusion practice and blood stream infections in critically ill patients.
Chest. 2005 May;127(5):1722-8. [abstract]
Review, by Sanju Samuel MD, Baylor College of Medicine and Texas Children's Hospital, Houston TX
BNP in septic shockDomico M, Liao P, Anas N, Mink RB. Elevation of brain natriuretic peptide levels in children with septic shock
Pediatr Crit Care Med. 2008 9(5):478-483 [abstract]
Review, by Monika Chauhan M.B;B.S., Children's Hospital of Michigan, Detroit MI
BNP in the diagnosis of heart failurePost F, Weilemann LS, Messow CM, Sinning C, MĂĽnzel T B-type natriuretic peptide as a marker for sepsis-induced myocardial depression in intensive care patients.
Crit Care Med 2008 36(11):3030-3037 [abstract]
Review, by Pooja Kulkarni MD, Columbia University Medical Center, New York NY
Central line infection/complication preventionHind D, Calvert N, McWilliams R, et al., Ultrasonic locating devices for central venous cannulation: meta-analysis
Br Med J 2003 327(7411):361 [abstract]
Review, by E Harry
Central line infection/complication preventionDarouiche RO, Raad II, Heard SO, , A comparison of two antimicrobial-impregnated central venous catheters.
N Engl J Med 1999 158:1770-1777 [abstract] [Full-Text]
Review, by Stephen Schexnayder MD
Central line infection/complication preventionMaki DG, Stolz SM, Wheeler S, , Prevention of Central Venous Catheter-Related Bloodstream Infection by Use of an Antiseptic-Impregnated Catheter.
Ann Intern Med 1997 110: 1025-34 [abstract]
Review, by Stephen Schexnayder,
Central line infection/complication preventionRaad D, Darouiche ER, Dupuis J, , Central venous catheters coated with minocycline and rifampin for the prevention of catheter-related colonization and bloodstream infections.
Ann Intern Med 1997 314:1855-1859 [abstract]
Review, by Stephen Schexnayder
Central line infection/complication preventionZurcher M, Tramer MR, Walder B. Colonization and Bloodstream Infection with Single- Versus Multi-Lumen Central Venous Catheters: A Quantitative Systematic Review
Anesth Analg 2004 ;99 177-182. [abstract]
Review, by by John S Giuliano Jr MD, Derek S Wheeler MD, Cincinnati Children’s Medical Center, Cincinnati OH
Central line infection/complication preventionVeenstra DL, Saint S, Somnath S, Lumley T, Sullivan SD Efficacy of antiseptic-impregnated central venous catheters in preventing catheter-related bloodstream infection. A meta-analysis.
JAMA 1999 281:261-267 [abstract] [Full-Text]
Review, by M. K. Moynihan Hardart
Central line infection/complication preventionVeenstra DL, Saint S, Sullivan SD, , Cost-effectiveness of antiseptic-impregnated central venous catheters for the prevention of catheter-related bloodstream infection.
JAMA 1999 282:554-60 [abstract] [Full-Text]
Review, by M. K. Moynihan Hardart
Central line infection/complication preventionGarland JS, Alex CP, Henrickson KJ, McAuliffe TL, Maki DG. A vancomycin-heparin lock solution for prevention of nosocomial bloodstream infection in critically ill neonates with peripherally inserted central venous catheters: a prospective, randomized trial.
Pediatrics 2005 116(2):e198-205
Review, by Mary G. Gaspers, MD, Baylor College of Medicine, Texas Childrens Hospital
Central line infection/complication preventionPierce CM, Wade A, Mok Q, , Heparin-bonded central venous lines reduce thrombotic and infective complications in critically ill children.
Intensive Care Med 2000 26:967-972 [abstract]
Review, by J. Barron A. Madikians
Central line infection/complication preventionMarik PE, Flemmer M, Harrison W. The risk of catheter-related bloodstream infection with femoral venous catheters as compared to subclavian and internal jugular venous catheters: A systematic review of the literature and meta-analysis
Crit Care Med 2012 40(8):2479-85 [abstract]
Review, by Iris Mandell MD, Children's Hospital Los Angeles, Los Angeles CA
Central line infection/complication preventionFaustino EV, Spinella PC, Li S, Pinto MG, Stoltz P, Tala J, Card ME, Northrup V, Baker KE, Goodman TR, Chen L, Silva CT. Incidence and Acute Complications of Asymptomatic Central Venous Catheter-Related Deep Venous Thrombosis in Critically Ill Children
J Pediatr 2013 162:387-391 [abstract]
Review, by Eric Peters MD, Asher Emanuel MD, Children's Hospital Los Angeles, Los Angeles CA
Central line infection/complication preventionMerrer J, De Jonghe B, Golliot F, , Complications of Femoral and Subclavian Venous Catheterization in Critically Ill Patients: A Randomized Controlled Trial
JAMA 2001 286:700-707 [abstract]
Review, by J Foland T Petrillo
Central line infection/complication preventionParienti JJ, Thirion M, MĂ©garbane B, et al; Members of the Cathedia Study Group. Femoral vs jugular venous catheterization and risk of nosocomial events in adults requiring acute renal replacement therapy: a randomized controlled trial.
JAMA 2008 28;299(20):2413-22. [abstract]
Review, by Srinivas Murthy MD CM, Children's Hospital Boston and Harvard Medical School
Central line infection/complication preventionMarin MG, Lee JC, Skurnick JH, , Prevention of nosocomial bloodstream infections: effectiveness of antimicrobial-impregnated and heparin-bonded central venous catheters
Crit Care Med 2000 Sep;28(9):3332-8 [abstract]
Review, by K Mistry
Central line infection/complication preventionSchmugge M, Risch L, Huber A, Fischer JE, Heparin-Induced Thrombocytopenia-Associated Thrombosis in Pediatric Intensive Care Patients
Pediatrics 2002 109:e10 [abstract]
Review, by K Mistry
Central line infection/complication preventionShah PS, Kalyn A, Satodia P, et al. A Randomized, Controlled Trial of Heparin Versus Placebo Infusion to Prolong the Usability of Peripherally Placed Percutaneous Central Venous Catheters (PCVCs) in Neonates: The HIP (Heparin Infusion for PCVC) Study.
Pediatrics 2007 119(1):e284-91 [abstract]
Review, by Kishore Gadikota MD, Maryrose Valina MD, Ashlee Smith MD, West Virginia University, Morgantown, WV
Central line infection/complication preventionLeon C, Ruiz-Santana S, Rello J, et al., Benefits of minocycline and rifampin-impregnated central venous catheters: A prospective, randomized, double-blind, controlled, multicenter trial
Intensive Care Med 2004 30:1891-1899 [abstract]
Review, by A Jeyapalan
Diabetes ManagementUmpierrez GE, Cuervo R, Karabell A, Latif K, Freire AX, Kitabchi AE Treatment of diabetic ketoacidosis with subcutaneous insulin aspart.
Diabetes Care 2004 27(8):1873-8 [abstract]
Review, by Brian Ely MD, Satid Thammasitboon, MD MHPE, West Virginia University, Morgantown WV
Diagnosis of bacterial infectionsSimon L, Saint-Louis P, Amre DK, Lacroix J, Gauvin F. Procalcitonin and C-reactive protein as markers of bacterial infection in critically ill children at onset of systemic inflammatory response syndrome
Pediatr Crit Care Med. 2008 9:407-413 [abstract]
Review, by Konstantine Xoinis MD, University of California, San Francisco
DIC Score as Prediction ToolKhemani RG, Bart RD, Alonzo TA, Hatzakis G, Hallam D, Newth CJ. Disseminated intravascular coagulation score is associated with mortality for children with shock
Intensive Care Med 2009 35(2):327-33 [abstract]
Review, by Bill Cutrer MD, Baylor College of Medicine and Texas Children's Hospital, Houston TX
Diuretic/renal therapyMorelli A, Ricci Z, Bellomo R, et al. Prophylactic fenoldopam for renal protection in sepsis: a randomized, double-blind, placebo-controlled pilot trial.
Crit Care Med 2005 Nov;33(11):2451-6 [abstract]
Review, by S Wu
DKA and Cerebral EdemaLawrence SE, Cummings EA, Gaboury I, Daneman D. Population-based study of incidence and risk factors for cerebral edema in pediatric diabetic ketoacidosis.
J Pediatr. 2005 May;146(5):688-92. [abstract]
Review, by Girish Deshpande MD, Adelberto Torres MD, University of Illinois, Peoria IL
DKA and Cerebral EdemaJayashree M, Singhi S. Diabetic ketoacidosis: Predictors of outcome in a pediatric intensive care unit of a developing country.
Pediatr Crit Care Med. 2004 Sep;5(5):427-33. [abstract]
Review, by Paul Bauer MD, Medical College of Wisconsin
DKA and Cerebral EdemaGlaser NS, Wootton-Gorges SL, Buonocore MH, Tancredi DJ, Marcin JP, Caltagirone R, Lee Y, Murphy C, Kuppermann N. Subclinical Cerebral Edema in Children With Diabetic Ketoacidosis Randomized to 2 Different Rehydration Protocols
Pediatrics 2012 131;e73 [abstract]
Review, by Amit C. Misra MD, Phoenix Children's Hospital, Phoenix AZ
ECMO for septic shockMaclaren G, Butt W, Best D, Donath S. Central extracorporeal membrane oxygenation for refractory pediatric septic shock
Pediatr Crit Care Med. 2011 12:133–136 [abstract]
Review, by Avind Rampersad MD, Rainbow Babies and Children’s Hospital, Cleveland, OH
Enteral feedingMeert KL, Daphtary KM, Metheny NA, , Gastric vs Small-Bowel Feeding in Critically Ill Children Receiving Mechanical Ventilation: A Randomized Controlled Trial
Chest 2004 126 872-878 [abstract]
Review, by S Rishmawi
Enteral feedingSimpson F, Doig GS. Parenteral vs. enteral nutrition in the critically ill patient: a meta-analysis of trials using the intention to treat principle
Intensive Care Med. 2005 Jan;31(1):12-23 [abstract]
Review, by Autumn M. Richards MD, Kevin M. Creamer MD, Walter Reed Army Medical Center, Washington, D.C. (1)
Enteral feedingNguyen NQ, Chapman MJ, Fraser RJ, Bryant LK, Holloway RH. Erythromycin is more effective than metoclopramide in the treatment of feed intolerance in critical illness.
Crit Care Med 2007 35(2):483-9. [abstract]
Review, by Erin Reade MD, Children's Hospital of Philadelphia
Enteral feedingArtinian V, Krayem H, DiGiovine B. Effects of Early Enteral Feeding on the Outcome of Critically Ill Mechanically Ventilated Medical Patients.
Chest 2006 ;129 960-967 [abstract]
Review, by Brian Tinch MD, David Turner MD, Duke University Medical Center, Durham NC
ErythopoietinLiet JM, Paranon S, Baraton L, Dejode JM, Roze JC. Is a prophylactic treatment by erythropoietin relevant to reduce red blood cell transfusion in the pediatric intensive care unit?
Pediatric Critical Care Medicine 2006 7(6):541-4. [abstract]
Review, by Joel A. Reyes DO, US Air Force and Texas Children’s Hospital/Baylor College of Medicine
Fever control in sepsisSchortgen F, Clabault K, Katsahian S, Devaquet J, Mercat A, Deye N, Dellamonica J, Bouadma L, Cook F, Beji O, Brun-Buisson C, Lemaire F, Brochard L. Fever Control Using External Cooling in Septic Shock: a Randomized Controlled Trial.
Am J Respir Crit Care Med 2012 185:1088-1095 [abstract]
Review, by Margaret Scheffler MD, Baylor College of Medicine and Texas Children's Hospital, Houston TX
Fluconazole in SepsisJacobs S, Price Evans DA, Tariq M, et al., Fluconazole improves survival in septic shock: A randomized double-blind prospective study
Crit Care Med 2003 Jul;31(7):1938-46 [abstract]
Review, by P Meaney
Fluconazole in SepsisPizarro CF, Troster EJ, Damiani D, Carcillo JA., Absolute and relative adrenal insufficiency in children with septic shock.
Crit Care Med 2005 Apr;33(4):855-859 [abstract]
Review, by A Hsu MJ Bell
Goal Directed Therapy in Sepsis Rivers E, Nguyen B, Havstad S, et al. , Early Goal-Directed Therapy in the Treatment of Severe Sepsis and Septic Shock
N Engl J Med 2001 345:1368-77 [abstract]
Review, by S Thammasitboon M Mcpherson
Goal Directed Therapy in SepsisJones AE, Shapiro NI, Trzeciak S, Arnold RC, Claremont HA, Kline JA; Emergency Medicine Shock Research Network (EMShockNet) Investigators Lactate clearance vs central venous oxygen saturation as goals of early sepsis therapy: a randomized clinical trial.
JAMA 2010 303(8):739-46. [abstract]
Review, by Collin Widener MD, University of Alabama, Birmingham, AL
Goal Directed Therapy in SepsisGaieski DF, Mikkelsen ME, Band RA, Pines JM, Massone R, Furia FF, Shofer FS, Goyal M. Impact of time to antibiotics on survival in patients with severe sepsis or septic shock in whom early goal-directed therapy was initiated in the emergency department.
Crit Care Med 2010 38(4):1045-53. [abstract]
Review, by Aaron Spicer MD, Anthony Olivero, MD, Boston Medical Center/Children’s Hospital Boston, Boston University Medical School/Harvard Medical School, Boston, MA
Granulocyte Colony Stimulating Factor in Neonatal SepsisMiura E, Procianoy RS, Bittar C , et al., A Randomized, Double-Masked, Placebo-Controlled Trial of Recombinant Granulocyte Colony-Stimulating Factor Administration to Preterm Infants With the Clinical Diagnosis of Early-Onset Sepsis
Pediatrics 2001 107:30-35 [abstract]
Review, by W Arias
Hemofiltration for sepsisPayen D, Mateo J, Cavaillon JM, Fraisse F, Floriot C, Vicaut E; Hemofiltration and Sepsis Group of the Collège National de RĂ©animation et de MĂ©decine d Impact of continuous venovenous hemofiltration on organ failure during the early phase of severe sepsis: a randomized controlled trial.
Crit Care Med 2009 Mar;37(3):803-10. [abstract]
Review, by Thomas Conlon MD, University of Pittsburgh/Children's Hospital of Pittsburgh, Pittsburgh PA
Hemolytic Uremic SyndromeSafdar N, Said A, Gangnon RE, Maki DG. Risk of Hemolytic Uremic Syndrome After Antibiotic Treatment of Escherichia coli O157:H7 Enteritis. A Meta-analysis
JAMA 2002 ; 288:996-1001. [abstract]
Review, by Jama Sy MD, Texas Children
Hemolytic Uremic SyndromeWong CS, Jelacic S, Habeeb RL, Watkins SL, Tarr PI The risk of the hemolytic-uremic syndrome after antibiotic treatment of Escherichia coli O157:H7 infections
N Engl J Med 2000 342(26):1930-6 [abstract]
Review, by M. Cooper
Hemolytic Uremic SyndromeTrachtman H, Cnaan A, Christen E, et al., Effect of an oral Shiga toxin-binding agent on diarrhea-associated hemolytic uremic syndrome in children: a randomized controlled trial
JAMA 2003 290(10):1337-44 [abstract]
Review, by A Daneshmand R Sanders
Heparin in septic shockZarychanski R, Doucette S, Fergusson D, Roberts D, Houston DS, Sharma S, Gulati H, Kumar A. Early intravenous unfractionated heparin and mortality in septic shock.
Crit Care Med 2008 36(11):2973-2979 [abstract]
Review, by : Alberto Orioles MD, Scott L. Weiss MD, The Children’s Hospital of Philadelphia, Philadelphia, PA
Hyperglycemia/Intensive Insulin TherapyJeschke MG, Kulp GA, Kraft R, Finnerty CC, Mlcak R, Lee JO, Herndon DN. Intensive Insulin Therapy in Severely Burned Pediatric Patients: A Prospective Randomized Trial.
Am J Respir Crit Care Med 2010 182: 351-359. [abstract]
Review, by Mona Karimullah MD, Baylor College of Medicine and Texas Children's Hospital, Houston, TX
Hyperglycemia/Intensive Insulin TherapyWintergerst KA, Buckingham B, Gandrud L, et al. Association of hypoglycemia, hyperglycemia, and glucose variability with morbidity and death in the pediatric intensive care unit
Pediatrics 2006 118(1):173-9 [abstract]
Review, by Shira Gertz MD, Texas Children
Hyperglycemia/Intensive Insulin TherapyVan den Berghe G, Wilmer A, Hermans G, et al. Intensive insulin therapy in the medical ICU.
N Engl J Med 2006 354(5):449-61 [abstract]
Review, by Kourosh Parsapour, MD and James P. Marcin, MD, MPH, UC Davis Childrens Hospital
Hyperglycemia/Intensive Insulin TherapyFaustino EV, Apkon M. Persistent hyperglycemia in critically ill children.
J Pediatr 2005 146(1):30-4 [abstract]
Review, by Michele Kong, MD University of Birmingham at Alabama, AL
Hyperglycemia/Intensive Insulin TherapyKlein GW, Hojsak JM, Schmeidler J, Rapaport R. Hyperglycemia and Outcome in the Pediatric Intensive Care Unit.
J Pediatr 2008 153:379-384 [abstract]
Review, by Sara Aghamohammadi MD, Children's Hospital Los Angeles, Los Angeles, CA
Hyperglycemia/Intensive Insulin TherapyAgus MSD, Steil GM, Wypij D, Costello JM, Laussen PC, Langer M, Alexander JL, Scoppettuolo LA, Pigula FA, Charpie JR, Ohye RG, Gaies MG, for the SPECS Study Investigators Tight Glycemic Control versus Standard Care after Pediatric Cardiac Surgery
N Engl J Med 2012 367: 1208-19 [abstract]
Review, by Alberto Orioles MD, Scott L. Weiss MD, Vijay Srinivasan MD, The Children’s Hospital of Philadelphia, PA
Hyperglycemia/Intensive Insulin TherapyBrunkhorst FM, Engel C, Bloos F, et al., for the German Competence Network Sepsis (SepNet). Intensive Insulin Therapy and Pentastarch Resuscitation in Severe Sepsis.
N Engl J Med 2008 358:125-139. [abstract]
Review, by Tara Neumayr MD, Washington University, St. Louis, MO
Hyperglycemia/Intensive Insulin TherapyYung M, Wilkins B, Norton L, Slater A, for the Paediatric Study Group; Australian and New Zealand Intensive Care Society. Glucose control, organ failure, and mortality in pediatric intensive care
Pediatr Crit Care Med. 2008 9(2):147-152 [abstract] [Full-Text]
Review, by Sunali Goyal MBBS, Punkaj Gupta MBBS and Natan Noviski MD, Massachusetts General Hospital, Boston MA
Hyperglycemia/Intensive Insulin TherapyVan den Berghe G, Wouter P, Weeker F, , Intensive Insulin Therapy in Critically Ill Patients
N Engl J Med 2001 345:1359-67 [abstract]
Review, by N Hoover A Vats
Hyperglycemia/Intensive Insulin TherapyThe NICE-SUGAR Study Investigators. Intensive versus Conventional Glucose Control in Critically Ill Patients
N Engl J Med 2009 360:1283-1297 [abstract]
Review, by Amanda Brooks MD, Northwestern/McGaw Medical Center, Children's Memorial Hospital, Chicago IL
Hyperglycemia/Intensive Insulin TherapyHirshberg E, Larsen G, Van Duker H. Alterations in glucose homeostasis in the pediatric intensive care unit: Hyperglycemia and glucose variability are associated with increased mortality and morbidity
Pediatr Crit Care Med. 2008 9:361-366 [abstract]
Review, by Amanda Johnson MD, University of Massachusetts, Worcester MA
Hyperglycemia/Intensive Insulin TherapyNICE-SUGAR Study Investigators, Finfer S, Liu B, Chittock DR, Norton R, Myburgh JA, McArthur C, Mitchell I, Foster D, Dhingra V, Henderson WR, Ronco JJ, Bellomo R, Cook D, McDonald E, Dodek P, HĂ©bert PC, Heyland DK, Robinson BG. Hypoglycemia and risk of death in critically ill patients.
N Engl J Med 2012 367(12):1108-18 [abstract]
Review, by Manish Bajracharya MD, UTSW Medical Center, Dallas, TX
Hyperglycemia/Intensive Insulin TherapyFinney SJ, Zekveld C, Elia A, Evans TW, Glucose control and mortality in critically ill patients
JAMA 2003 290(15):2041-7 [abstract]
Review, by A Chavez
Hyperglycemia/Intensive Insulin TherapyVlasselaers D, Milants I, Desmet L, Wouters PJ, Vanhorebeek I, van den Heuvel I, Mesotten D, Casaer MP, Meyfroidt G, Ingels C, Muller J, Van Cromphaut S, Schetz M, Van den Berghe G. Intensive insulin therapy for patients in paediatric intensive care: a prospective, randomised controlled study
Lancet 2009 373(9663):547-56. [abstract]
Review, by Kalia P. Ulate MD, Seattle Children's Hospital, Seattle, WA
Hyperglycemia/Intensive Insulin TherapySrinivasan V, Spinella PC, Drott HR, et al., Association of timing, duration, and intensity of hyperglycemia with intensive care unit mortality in critically ill children.
Pediatric Critical Care Medicine 2004 Jul;5(4):329-36 [abstract]
Review, by A Bass
Ibuprofen in Hypothermic SepsisArons MM, Wheller AP, Bernard GR, et al., Effects of ibuprofen on the physiology and survival of hypothermic sepsis
Crit Care Med 1999 27:699-707 [abstract]
Review, by W Arias
Immunoglobulins in sepsisThe INIS Collaborative Group. Treatment of neonatal sepsis with intravenous immune globulin.
N Engl J Med 2011 365(13):1201-11 [abstract]
Review, by Karen Sethi MD, University of Rochester Medical Center, Rochester, NY
Immunoglobulins in sepsisLaupland KB, Kirkpatrick AW, Delaney A. Polyclonal intravenous immunoglobulin for the treatment of severe sepsis and septic shock in critically ill adults: A systematic review and meta-analysis.
Crit Care Med. 2007 35:2686-2692 [abstract]
Review, by Kamal Prasad Sharma MD, Miami Children's Hospital, Miami FL
Immunoglobulins in sepsisKreymann KG, de Heer G, Nierhaus Z, Kluge S. Use of polyclonal immunoglobulins as adjunctive therapy for sepsis or septic shock.
Crit Care Med. 2007 35:2677-2685 [abstract]
Review, by Rahul Bhatia MD, AI duPont Hospital Children, Thomas Jefferson University, Wilmington, DE
Immunonutrition/modulationEnteral Nutrition in ARDS Study Group., Gadek JE, DeMichele SJ, Karlstad MD, Effect of enteral feeding with eicosapentaenoic acid, gamma-linolenic acid, and antioxidants in patients with acute respiratory distress syndrome
Crit Care Med 1999 27:989-96 [abstract]
Review, by Scot Bateman MD,
Immunonutrition/modulationAtkinson S, Sieffert E, Bihari D, GuyŐ Hospital Intensive Care Group, A prospective, randomized, double-blind, controlled clinical trial of enteral immunonutrition in the critically ill
Crit Care Med 1998 2:651-656 [abstract]
Review, by Tom Brazelton, MD, MPH,
Immunonutrition/modulationLauterbach R, Pawlik D, Kowalczych D, , Effect of the immunomodulating agent, pentoxifylline, in the treatment of sepsis in prematurely delivered infants: a placebo-controlled, double-blind trial
Crit Care Med 1999 26:1977-85 [abstract]
Review, by Troy Dominguez MD,
Immunonutrition/modulationHoudijk AP, Rijnsburger ER, Jansen J, et al. Randomised trial of glutamine-enriched enteral nutrition on infectious morbidity in patients with multiple trauma
Lancet. 1998 5;352(9130):772-6. [abstract]
Review, by Jama Sy MD, Texas Children's Hospital and Baylor College of Medicine, Houston TX
Immunonutrition/modulationGarrel D, Patenaude J, Nedelec B, et al. Decreased mortality and infectious morbidity in adult burn patients given enteral glutamine supplements: A prospective, controlled, randomized clinical trial.
Crit Care Med. 2003 Oct;31(10):2444-9. [abstract]
Review, by Jama Sy MD, Texas Children's Hospital and Baylor College of Medicine, Houston TX
Immunonutrition/modulationBeale RJ, Bryg DJ, Bihari DJ, , Immunonutrition in the critically ill: a systematic review of clinical outcome.
Crit Care Med 1999 27:2786-91 [abstract]
Review, by Azzam Maha
Immunonutrition/modulationPittet D, Harbarth S, Suter PM, , Impact of immunomodulating therapy on morbidity in patients with severe sepsis.
Am J Respir Crit Care Me 1999 160:852-7 [abstract] [Full-Text]
Review, by N. Cvijanovich
Immunonutrition/modulationBertolini G, Iapichino G, Radrizzani D, et al. Early enteral immunonutrition in patients with severe sepsis: Results of an interim analysis of a randomized multicentre clinical trial.
Intensive Care Med 2003 29: 834-840. [abstract]
Review, by J Kane MD, Medical College Wisconsin, Milwaukee, WI
Immunonutrition/modulationDouzinas EE, Pitaridis MT, Louris G, , Prevention of infection in multiple trauma patients by high-dose intravenous immunoglobulins.
Crit Care Med 2000 28: 8-15 [abstract]
Review, by S. Bateman
Immunonutrition/modulationAngstwurm MW, Engelmann L, Zimmermann T, et al. Selenium in Intensive Care (SIC) study: Results of a prospective randomized, placebo-controlled, multiple-center study in patients with severe systemic inflammatory response syndrome, sepsis, and septic shock
Crit Care Med 2007 35:118-126 [abstract]
Review, by Marvin Mata MD, Kathleen Meert MD, Children
Immunonutrition/modulationWerdan K, Pilz G, Bujdoso O, et al., for the Score-Based Immunoglobulin Therapy of Sepsis (SBITS) Study Group Score-based immunoglobulin G therapy of patients with sepsis: The SBITS study.
Crit Care Med. 2007 35:2693-2701 [abstract]
Review, by William Cutrer MD, Baylor College of Medicine, Texas Children's Hospital, Houston TX
Immunonutrition/modulationHeyland D, Muscedere J, Wischmeyer PE, Cook D, Jones G, Albert M, Elke G, Berger MM, Day AG; the Canadian Critical Care Trials Group A Randomized Trial of Glutamine and Antioxidants in Critically Ill Patients
N Engl J Med 2013 Apr 18;368(16):1489-1497 [abstract]
Review, by Mohammad Ebraheem MD, Texas Children's Hospital, Houston TX
Immunonutrition/modulationHall JC, Dobb G, Hall J, de Sousa R, Brennan L, McCauley R. A prospective randomized trial of enteral glutamine in critical illness
Intensive Care Med. 2003 Oct;29(10):1710-6 [abstract]
Review, by Ivie Esangbedo MD, Texas Children's Hospital, Baylor College of Medicine, Houston TX
Immunonutrition/modulationHeyland DK, Novak F, Drover JW , et al., Should Immunonutrition Become Routine in Critically Ill Patients? A Systematic Review of the Evidence
JAMA 2001 286:944-953 [abstract]
Review, by N Mehta
Immunonutrition/modulationGalban C, Montejo JC, Mesejo A, et al., An immune-enhancing enteral diet reduces mortality rate and episodes of bacteremia in septic intensive care unit patients
Crit Care Med 2000 28(3):643-8 [abstract]
Review, by R Rastmanesh
Inotropes in ShockRussell JA, Walley KR, Singer J, et al. for the VASST Investigators. Vasopressin versus norepinephrine infusion in patients with septic shock
N Engl J Med. 2008 358:877-87 [abstract]
Review, by Samuel Umaru MD, Nicolas Rivera MD, Baylor College of Medicine and Texas Children
Meningococcal SepsisPeters MJ, Ross-Russell RI, White D , et al, Early severe neutropenia and thrombocytopenia identifies the highest risk cases of severe meningococcal disease
Pediatric Critical Care Medicine 2005 2:225-231 [abstract]
Review, by A Gourishankar
Meningococcal SepsisLevin M, Quint PA, Goldstein B, , Recombinant bactericidal/permeability-increasing protein (rBPI21) as adjunctive treatment for children with severe meningococcal sepsis: a randomised trial.
Lancet 2000 356: 961 - 967 [abstract]
Review, by S. Cray
Meningococcal SepsisCastellanos-Ortega I, Delgado-Rodriguez M, Llorca J, et al., A new prognostic scoring system for meningococcal septic shock in children. Comparison with three other scoring systems.
Intensive Care Med 2002 28: 341-351 [abstract]
Review, by A Vohra
Nosocomial infection preventionSingh-Naz N, Sprague BM, Patel KM, Pollack MM. Risk assessment and standardized nosocomial infection rate in critically ill children
Crit Care Med. 2000 ;28(6):2069-75. [abstract]
Review, by : Joon Suk Choi DO, Downing Lu MD, Walter Reed National Military Medical Center, Washington DC
Nosocomial infection preventionde La Cal MA, Cerda E, Garcia-Hierro P, van Saene HK, Gomez-Santos D, Negro E, Lorente JA. Survival benefit in critically ill burned patients receiving selective decontamination of the digestive tract: a randomized, placebo-controlled, double-blind trial.
Ann Surg. 2005 241(3):424-30 [abstract]
Review, by H Rowlands MD, Birmingham Childrens Hospital, Birmingham UK
Nosocomial infection preventionJack T, Boehne M, Brent BE, Hoy L, Köditz H, Wessel A, Sasse M. In-line filtration reduces severe complications and length of stay on pediatric intensive care unit: a prospective, randomized, controlled trial.
Intensive Care Med 2012 38(6):1008-16 [abstract]
Review, by Alberto Orioles MD, Scott L. Weiss MD, The Children’s Hospital of Philadelphia, Philadelphia, PA
Nosocomial infection preventionJeschke MG, Chinkes DL, Finnerty CC, et al. Blood transfusions are associated with increased risk for development of sepsis in severely burned pediatric patients.
Crit Care Med 2007 35(2):579-83 [abstract]
Review, by Kathryn Young MD, Medical College of Wisconsin, Children
Nosocomial infection preventionCarcillo JA, Dean JM, Holubkov R, Berger J, Meert KL, Anand KJ, Zimmerman J, Newth CJ, Harrison R, Burr J, Willson CC, Nicholson C and the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) Collaborative Pediatric Crit The randomized comparative pediatric critical illness stress-induced immune suppression (CRISIS) prevention trial.
Pediatr Crit Care Med. 2012 13:165–173 [abstract] [Full-Text]
Review, by Elizabeth Rosner DO, Children's Hospital of Michigan, Detroit MI
Nosocomial infection preventionVillatoro E, Bassi C, Larvin M. Antibiotic therapy for prophylaxis against infection of pancreatic necrosis in acute pancreatitis.
Cochrane Review 2006 (4):CD002941 [abstract]
Review, by Edwin Taylor MD, West Virginia University, Morgantown, WV
Nosocomial infection preventionHoneycutt TC, El Khashab M, Wardrop RM 3rd, McNeal-Trice K, Honeycutt AL, Christy CG, Mistry K, Harris BD, Meliones JN, Kocis KC. Probiotic administration and the incidence of nosocomial infection in pediatric intensive care: a randomized placebo-controlled trial.
Pediatr Crit Care Med. 2007 8(5):452-8 [abstract]
Review, by Samantha Gee MD, University of Florida College of Medicine, Shand's Children's Hospital, Gainesville FL
Nosocomial infection preventionVan Houten MA, Uiterwaal CS, Heesen GJ, et al., Does the empiric use of vancomycin in pediatrics increase the risk for Gram-negative bacteremia?
Pediatr Infect Dis J 2001 20(2):171-7 [abstract]
Review, by C Kennedy
Nosocomial infection preventionSlota M, Green M, Farley A, Janosky J, Carcillo J The role of gown and glove isolation and strict handwashing in the reduction of nosocomial infection in children with solid organ transplantation
Crit Care Med 2001 29(2):405-412 [abstract]
Review, by A Lin
Nutritional methodologyPeter JV, Moran JL, Phillips-Hughes J., , A metaanalysis of treatment outcomes of early enteral versus early parenteral nutrition in hospitalized patients.
Crit Care Med 2005 Jan;33(1):213-20 [abstract]
Review, by M Desai
Nutritional methodologyMartin CM, Doig GS, Heyland DK, et al. Multicentre, cluster-randomized clinical trial of algorithms for critical-care enteral and parenteral therapy (ACCEPT)
Can Med Assoc J 2004 ;170 197-204. [abstract]
Review, by Kim Ngo MD, Christopher Babbitt MD, Miller Children's Hospital, Long Beach CA
Nutritional methodologyMehta NM, Bechard LJ, Cahill N, Wang M, Day A, Duggan CP, Heyland DK. Nutritional practices and their relationship to clinical outcomes in critically ill children-An international multicenter cohort study
Crit Care Med 2012 40(7):2204-11 [abstract]
Review, by Alberto Orioles MD, Sharon Y. Irving PhD, CRNP, Vijay Srinivasan MD, The Children’s Hospital of Philadelphia, Philadelphia, PA
Nutritional methodologyLĂłpez-Herce J, Santiago MJ, Sánchez C, MencĂ­a S, Carrillo A, Vigil D. Risk factors for gastrointestinal complications in critically ill children with transpyloric enteral nutrition.
Eur J Clin Nutr 2008 62(3):395-400 [abstract]
Review, by Victoria Sheward MB BS, Tanja Adamovic MD, Royal Brompton Hospital, London, UK
Nutritional methodology Meert KL, Daphtary KM, Metheny NA, , Gastric vs Small-Bowel Feeding in Critically Ill Children Receiving Mechanical Ventilation: A Randomized Controlled Trial
Chest 2004 126 872-878 [abstract]
Review, by D Hsing A Madikians
Outcomes after septic shockCzaja AS, Zimmerman JJ, Nathens AB. Readmission and late mortality after pediatric severe sepsis.
Pediatrics 2009 123(3):849-57 [abstract]
Review, by Jenna MIller MD, Baylor College of Medicine and Texas Children's Hospital, Houston TX
Outcomes after septic shockKnoester H, Sol JJ, Ramsodit P, et al. Cardiac Function in Pediatric Septic Shock Survivors.
Arch Pediatr Adolesc Med 2008 162:1164-1168 [abstract]
Review, by Simon Li MD, Yale University, New Haven CT
Oxygen delivery in shockVallĂ©e F, Vallet B, Mathe O, Parraguette J, Mari A, Silva S, Samii K, Fourcade O, Genestal M. Central venous-to-arterial carbon dioxide difference: an additional target for goal-directed therapy in septic shock?
Intensive Care Med 2008 34(12):2218-2225 [abstract]
Review, by Fong Lam MD, Baylor College of Medicine and Texas Children's Hospital, Houston TX
Plasmafiltration in SepsisReeves JH, Butt WW, Shann F, , Continuous plasmafiltration in sepsis syndrome. Plasmafiltration in Sepsis Study Group.
Crit Care Med 1999 20:17-21 [abstract]
Review, by Steven Cray
Plasmapheresis for sepsisBusund R, Koukline V, Utrobin U, et al., Plasmapheresis in severe sepsis and septic shock: a prospective, randomised, controlled trial
Intensive Care Med 2002 28: 1434-1439 [abstract]
Review, by J Krishnan V Vaiyda
Prediction tool for sepsisAnnane D, S?bille V, Troch? G, , A 3-Level Prognostic Classification in Septic Shock Based on Cortisol Levels and Cortisol Response to Corticotropin.
JAMA 2000 283:1038-1045 [abstract] [Full-Text]
Review, by X. Garcia M. McPherson
Prediction tool for sepsisRey C, Los Arcos M, Concha A, et al. Procalcitonin and C-reactive protein as markers of systemic inflammatory response syndrome severity in critically ill children.
Intensive Care Med 2007 33(3):477-84 [abstract]
Review, by S. David McSwain MD, Duke University, Durham NC
Prediction tool for sepsisRey C, Los Arcos M, Concha A, et al. Procalcitonin and C-reactive protein as markers of systemic inflammatory response syndrome severity in critically ill children.
Intensive Care Med 2007 33(3):477-84 [abstract]
Review, by Punkaj Gupta MD, Massachusetts General Hospital, Boston MA
Prediction tool for sepsisMartin C, Viviand X, Leone M, Thirion X, Effect of norepinephrine on the outcome of septic shock
Crit Care Med 2000 28(8):2758-65 [abstract]
Review, by P. Prabhakaran
Prediction tool for sepsisHowell MD, Donnino M, Clardy P, Talmor D, Shapiro NI. Occult hypoperfusion and mortality in patients with suspected infection.
Intensive Care Med 2007 33(11):1892-9 [abstract]
Review, by Sunali Goyal MBBS (SERI), Punkaj Gupta, MBBS (MGH), Harvard Medical School, Boston
Prediction tool for sepsisKumar A, Roberts D, Wood KE, et al. Duration of hypotension before initiation of effective antimicrobial therapy is the critical determinant of survival in human septic shock.
Crit Care Med 2006 34(6):1589-96 [abstract]
Review, by Thomas Conlon MD, University of Pittsburgh Medical Center/Children’s Hospital of Pittsburgh of UPMC
Prediction tool for sepsisMikkelsen ME, Miltiades AN, Gaieski DF, Goyal M, Fuchs BD, Shah CV, Bellamy SL, Christie JD. Serum lactate is associated with mortality in severe sepsis independent of organ failure and shock
Crit Care Med 2009 37:1670 –1677 [abstract]
Review, by Paul H. Dahm MD, UTHSC Medical School at Houston, Houston TX
Prediction tool for sepsisKim YA, Ha EJ, Jhang WK, Park SJ. Early blood lactate area as a prognostic marker in pediatric septic shock
Intensive Care Med 2013 Oct;39(10):1818-23 [abstract]
Review, by Philip Knight MD, London Deanery, NHS, London, England
Prediction tool for sepsisLevy MM, Macias WL, Vincent JL, Russell JA, Silva E, Trzaskoma B, Williams MD. Early changes in organ function predict eventual survival in severe sepsis.
Crit Care Med. 2005 Oct;33(10):2194-2201. [abstract]
Review, by Ryan Stark MD, Texas Children's Hospital and Baylor College of Medicine, Houston, TX
Prediction tool for sepsisDĂĽnser MW, Takala J, Ulmer H, Mayr VD, Luckner G, Jochberger S, Daudel F, Lepper P, Hasibeder WR, Jakob SM. Arterial blood pressure during early sepsis and outcome.
Intensive Care Med 2009 35(7):1225-33 [abstract]
Review, by Matthe Musick MD, Baylor College of Medicine, Texas Children's Hospital, Houston TX
Prevention of stress ulcerationReveiz L, Guerrero-Lozano R, Camacho A, Yara L, Mosquera PA Stress ulcer, gastritis, and gastrointestinal bleeding prophylaxis in critically ill pediatric patients: A systematic review
Pediatr Crit Care Med. 2010 11(1):124-132 [abstract]
Review, by Courtenay Brook Barlow MD, Melissa Brannen MD, Children's Memorial Hospital, Northwestern University Medical School, Chicago IL
Procalcitonin value in the ICUMatthaiou DK, Ntani G, Kontogiorgi M, Poulakou G, Armaganidis A, Dimopoulos G. An ESICM systematic review and meta-analysis of procalcitonin-guided antibiotic therapy algorithms in adult critically ill patients.
Intensive Care Med 2012 38(6):940-9 [abstract]
Review, by Iris Mandell MD, Children's Hospital Los Angeles, Los Angeles CA
Prognosis Following Bone Marrow TransplantDuncan CN, Lehmann LE, Cheifetz IM, Greathouse K, Haight AE, Hall MW, Herschberger A, Hill KS, Moffet JR, Morrison RR, Norris AL, Petrovic A, Spear DA, Steiner ME, Talano JA, Tamburro RF, Wagner J, McArthur J; for the Pediatric Acute Lung Injury and Sepsi Clinical Outcomes of Children Receiving Intensive Cardiopulmonary Support During Hematopoietic Stem Cell Transplant
Pediatr Crit Care Med. 2013 14(3):261-267 [abstract]
Review, by Mohammad Ebraheem MD, Baylor College of Medicine, Texas Children's Hospital, Houston TX
Recombinant Human Protein C in SepsisNadel S, Goldstein B, Williams MD, Dalton H, Peters M, Macias WL, Abd-Allah SA, Levy H, Angle R, Wang D, Sundin DP, Giroir B REsearching severe Sepsis and Organ dysfunction in children: a gLobal perspective (RESOLVE) study group. Drotrecogin alfa (activated) in children with severe sepsis: a multicentre phase III randomised controlled trial.
Lancet. 2007 369(9564):836-43 [abstract]
Review, by Kimberly Baker MD, American Family Children's Hospital, University of Wisconsin, Madison, WI
Recombinant Human Protein C in SepsisBernard GR, Vincent JL, Laterre PF, , Efficacy and Safety of Recombinant Human Activated Protein C for Severe Sepsis
N Engl J Med 2001 344:699-709 [abstract] [Full-Text]
Review, by D Vaughn
Recombinant Human Protein C in SepsisManns BJ, Lee H, Doig CJ, et al., An economic evaluation of activated protein C treatment for severe sepsis
N Engl J Med 2002 347:993-1000 [abstract]
Review, by A Arikan
Recombinant Human Protein C in SepsisAngus DC, Linde-Zwirble WT, PROWESS Investigators, , Cost-effectiveness of drotrecogin alfa (activated) in the treatment of severe sepsis
Crit Care Med 2003 Jan;31(1):1-11 [abstract]
Review, by N Mehta
Resuscitation FluidsMaitland K, Kiguli S, Opoka RO, Engoru C, Olupot-Olupot P, Akech SO, Nyeko R, Mtove G, Reyburn H, Lang T, Brent B, Evans JA, Tibenderana JK, Crawley J, Russell EC, Levin M, Babiker AG, Gibb DM; the FEAST Trial Group Mortality after Fluid Bolus in African Children with Severe Infection.
N Engl J Med 2011 364:2483-2495 [abstract]
Review, by Shaghig Kouyoumjian MD, Children's Hospital Los Angeles, Los Angeles, CA
Resuscitation FluidsMurphy CV, Schramm GE, Doherty JA, Reichley RM, Gajic O, Afessa B, Micek ST, Kollef MH. The Importance of Fluid Management in Acute Lung Injury Secondary to Septic Shock
Chest 2009 136:102-109 [abstract]
Review, by Michael Sylvia MD, Scot Bateman MD, University of Massachusetts Medical School, Worcester MA
Sedation issuesGupta K, Gupta VK, Jayashree M, Singhi S. Randomized controlled trial of interrupted versus continuous sedative infusions in ventilated children
Pediatr Crit Care Med. 2012 13:131–135 [abstract]
Review, by Keshava Murthy Narayana Gowda MD, Children’s Hospital of Michigan, Detroit MI
Selective Decontamination of the Digestive TractSilvestri L, van Saene HK, Zandstra DF, Marshall JC, Gregori D, Gullo A Impact of selective decontamination of the digestive tract on multiple organ dysfunction syndrome: Systematic review of randomized controlled trials
Crit Care Med 2010 38(5):1370-1376 [abstract]
Review, by William Sasser MD, Stephen Robert MD, University of Alabama at Birmingham, Birmingham AL
SIRS/sepsis predictorsAlberti C, Brun-Buisson C, Chevret S, et al. for the European Sepsis Study Group. Systemic Inflammatory Response and Progression to Severe Sepsis in Critically Ill Infected Patients.
Am J Respir Crit Care Med 2005 ;171 461-468 [abstract]
Review, by by Angela Czaja MD, Seattle Children's Hospital and Regional Medical Center, Seattle, WA
Steroids and traumaRoquilly A, Mahe PJ, Seguin P, Guitton C, Floch H, Tellier AC, Merson L, Renard B, Malledant Y, Flet L, Sebille V, Volteau C, Masson D, Nguyen JM, Lejus C, Asehnoune K. Hydrocortisone therapy for patients with multiple trauma: the randomized controlled HYPOLYTE study.
JAMA 2011 23;305(12):1201-9 [abstract]
Review, by Fernando Beltramo MD, Children's Hospital Los Angeles, Los Angeles CA
Steroids in SepsisCasserly B, Gerlach H, Phillips GS, Lemeshow S, Marshall JC, Osborn TM, Levy MM. Low-dose steroids in adult septic shock: results of the Surviving Sepsis Campaign
Intensive Care Med 2012 Dec;38(12):1946-54 [abstract]
Review, by Cornelius Alfred James MD, Paras Khandhar MD, William Beaumont Hospital- Royal Oak, Royal Oak, MI
Thrombosis issuesReiter PD, Wathen B, Valuck RJ, Dobyns EL. Thrombosis risk factor assessment and implications for prevention in critically ill children
Pediatr Crit Care Med. 2012 13:381–386 [abstract]
Review, by Gokhan Olgun MD, University of Chicago, Chicago IL
Thrombosis issuesFaustino EV, Lawson KA, Northrup V, Higgerson RA. Mortality-adjusted duration of mechanical ventilation in critically ill children with symptomatic central venous line-related deep venous thrombosis.
Crit Care Med 2011 39:1151–1156 [abstract]
Review, by William Bortcosh MD, University of Massachusetts Medical Center, Worcester MA
Thrombosis issuesVincent JL, Ramesh MK, Ernest D, Larosa SP, Pachl J, Aikawa N, Hoste E, Levy H, Hirman J, Levi M, Daga M, Kutsogiannis DJ, Crowther M, Bernard GR, Devriendt J, Puigserver JV, Blanzaco DU, Esmon CT, Parrillo JE, Guzzi L, Henderson SJ, Pothirat C, Mehta P, A Randomized, Double-Blind, Placebo-Controlled, Phase 2b Study to Evaluate the Safety and Efficacy of Recombinant Human Soluble Thrombomodulin, ART-123, in Patients With Sepsis and Suspected Disseminated Intravascular Coagulation
Crit Care Med 2013 41:2070–2079 [abstract]
Review, by Matthew Friedman, MD and Erin Talati Paquette, MD, JD, MBe, Northwestern University/Lurie Children's Hospital, Chicago IL
Toxic Shock Syndrome treatmentShah SS, Hall M, Srivastava R, Subramony A, Levin JE. Intravenous immunoglobulin in children with streptococcal toxic shock syndrome.
Clin Infect Dis 2009 49(9):1369-76 [abstract]
Review, by Jennifer Flint MD, University of Missouri-Kansas City School of Medicine, Kansas City MO
TPA therapy in childrenGupta AA, Leaker M, Andrew M, et al. , Safety and outcomes of thrombolysis with tissue plasminogen activator for treatment of intravascular thrombosis in children
J Pediatr 2001 139(5):682-8 [abstract]
Review, by J Berger
TPA therapy in childrenWang M, Hays T, Balasa V, et al., Low-dose tissue plasminogen activator thrombolysis in children
J Pediatr Hematol Oncol 2003 25(5):379-86 [abstract]
Review, by M Rafay
Vitamin DRippel C, South M, Butt WW, Shekerdemian LS Vitamin D status in critically ill children
Intensive Care Med 2012 Dec;38(12):2055-62 [abstract]
Review, by Ronald Kampanatkosol DO, Catherine Humikowski MD, The University of Chicago, Chicago IL
Cardiovascular/Fluids
Acidosis/Lactate as Mortality PredictorDurward A, Tibby SM, Skellett S, Austin C, Anderson D, Murdoch IA. The strong ion gap predicts mortality in children following cardiopulmonary bypass surgery.
Pediatr Crit Care Med. 2005 May;6(3):281-285 [abstract]
Review, by Asumthia S Jeyapalan DO, Texas Children's Hospital, Baylor College of Medicine, Houston, TX
Acidosis/Lactate as Mortality PredictorKalyanaraman M, DeCampli WM, Campbell AI, Bhalala U, Harmon TG, Sandiford P, McMahon CK, Shore S, Yeh TS. Serial blood lactate levels as a predictor of mortality in children after cardiopulmonary bypass surgery.
Pediatr Crit Care Med. 2008 9(3):285-8. [abstract]
Review, by Avind Rampersad MD, Florida Hospital for Children, Orlando, FL
Acute Kidney InjuryLi S, Krawczeski CD, Zappitelli M, Devarajan P, Thiessen-Philbrook H, Coca SG, Kim RW, Parikh CR; for the TRIBE-AKI Consortium. Incidence, risk factors, and outcomes of acute kidney injury after pediatric cardiac surgery: A prospective multicenter study
Crit Care Med 2011 39:1493–1499 [abstract]
Review, by Brian Joy MD, Children's Memorial Hospital, Northwestern University, Chicago IL
Acute Kidney InjurySchneider J, Khemani R, Grushkin C, Bart R. Serum creatinine as stratified in the RIFLE score for acute kidney injury is associated with mortality and length of stay for children in the pediatric intensive care unit.
Crit Care Med 2010 2010 Mar;38(3):933-9. [abstract]
Review, by Samuel Umaru MD, Baylor College of Medicine and Texas Children's Hospital, Houston, TX
Adrenal insufficiency/Steroids in sepsis/septic shockCasartelli CH, Garcia PC, Branco RG, Piva JP, Einloft PR, Tasker RC. Adrenal response in children with septic shock.
Intensive Care Med 2007 33(9):1609-13 [abstract]
Review, by Penelope Sandiford MD, Children’s Hospital of Michigan, Detroit MI
Adrenal insufficiency/Steroids in sepsis/septic shockRussell JA, Walley KR, Gordon AC, Cooper DJ, HĂ©bert PC, Singer J, Holmes CL, Mehta S, Granton JT, Storms MM, Cook DJ, Presneill JJ; Dieter Ayers for the Vasopressin and Septic Shock Trial Investigators. Interaction of vasopressin infusion, corticosteroid treatment, and mortality of septic shock.
Crit Care Med 2009 Mar;37(3):811-8. [abstract]
Review, by Danny Castro DO, Baylor College of Medicine, Texas Children's Hospital, Houston TX
Adrenal insufficiency/Steroids in sepsis/septic shockDmello D, Taylor S, O Outcomes of Etomidate in Severe Sepsis and Septic Shock.
Chest 2010 138:1327-1332 [abstract]
Review, by Sanju Susan Samuel MD, Texas Children’s Hospital, Baylor College of Medicine, Houston, TX
Amiodarone for Ventricular FibrillationDorian P, Cass D, Schwartz B, et al., Amiodarone as compared with lidocaine for shock-resistant ventricular fibrillation
N Engl J Med 2002 346(12):884-90 [abstract]
Review, by J Keates Baleeiro K Meert
Anticoagulaton following cardiac surgeryMonagle P, Cochrane A, Roberts R, Manlhiot C, Weintraub R, Szechtman B, Hughes M, Andrew M, McCrindle BW; Fontan Anticoagulation Study Group. A multicenter, randomized trial comparing heparin/warfarin and acetylsalicylic acid as primary thromboprophylaxis for 2 years after the Fontan procedure in children.
J Am Coll Cardiol 2011 2;58(6):645-51 [abstract]
Review, by Anne Camerlingo MD, Children's Hospital Los Angeles, Los Angeles CA
Anticoagulaton following cardiac surgeryWessel DL, Berger F, Li JS, Dähnert I, Rakhit A, Fontecave S, Newburger JW; CLARINET Investigators. Clopidogrel in infants with systemic-to-pulmonary-artery shunts
N Engl J Med 2013 Jun 20;368(25):2377-84 [abstract]
Review, by Rajat Pareek MD, Le Bonheur Children's Hospital, University of Tennessee Health Science Center, Memphis TN
Blood transfusionsCholette J, Rubenstein J, Alfieris G, Powers K, Eaton M, Lerner N. Children with single-ventricle physiology do not benefit from higher hemoglobin levels post cavopulmonary connection: Results of a prospective, randomized, controlled trial of a restrictive versus liberal red-cell transfusion strategy
Pediatr Crit Care Med. 2011 12(1): 39-45 [abstract] [Full-Text]
Review, by Utpal S Bhalala MD, Akira Nishisaki MD, Vijay Srinivasan, MD, Children's Hospital of Philadelphia, University of Pennsylvania, Philadelphia PA
Blood transfusionsKaram O, Tucci M, Ducruet T, Hume HA, Lacroix J, Gauvin F; for the Canadian Critical Care Trials Group and the PALISI Network. Red blood cell transfusion thresholds in pediatric patients with sepsis.
Pediatr Crit Care Med. 2011 12(5): [2010 Nov 4. Epub ahead of print] doi: 10.1097/PCC.0b013e3181fe344b [abstract]
Review, by Chelsea Willie MD, Children's Memorial Hospital, Chicago IL
Blood transfusionsTaylor RW, Manganaro L, O'Brien J, Trottier SJ, Parkar N, Veremakis C. Impact of allogenic packed red blood cell transfusion on nosocomial infection rates in the critically ill patient
Crit Care Med 2002 30(10):2249-54 [abstract]
Review, by R Orellana
Blood transfusionsHebert PC, Wells G, Blajchman MA, Marshall J, A multicenter, randomized, controlled clinical trial of transfusion requirements in critical care.
N Engl J Med 1999 27:200-10 [abstract]
Review, by Fiona H. Levy MD, Barry Markovitz MD,
Blood transfusionsLacroix J, Hebert PC, Hutchison, et al. Transfusion Strategies for Patients in Pediatric Intensive Care Units
N Engl J Med 2007 356:1609-1619 [abstract]
Review, by Eloa S Adams MD, Lucile Packard Children's Hospital, Stanford University School of Medicine, Palo Alto, CA
Blood transfusionsKhan H, Belsher J, Yilmaz M, Afessa B, Moore SB, Hubmayr RD, Gajic O. Fresh frozen plasma and platelet transfusions are associated with development of acute lung injury in critically ill medical patients.
Chest 2007 131:1308-1314 [abstract]
Review, by Robert A. Niebler MD, Medical College of Wisconsin, Milwaukee, WI
Blood transfusionsLeal-Noval SR, Muñoz-GĂłmez M, JimĂ©nez-Sánchez M, Cayuela A, Leal-Romero M, Puppo-Moreno A, Enamorado J, Arellano-Orden V. Red blood cell transfusion in non-bleeding critically ill patients with moderate anemia: is there a benefit?
Intensive Care Med 2013 39(3):445-53 [abstract]
Review, by Marcelo Malakooti MD, Ann & Robert H. Lurie Children’s Hospital of Chicago, at Northwestern University Feinberg School of Medicine, Chicago, IL
Blood transfusionsKneyber MC, Grotenhuis F, Berger RF, Ebels TW, Burgerhof JG, Albers MJ. Transfusion of Leukocyte-Depleted RBCs Is Independently Associated With Increased Morbidity After Pediatric Cardiac Surgery
Pediatr Crit Care Med. 2013 14:298–305 [abstract] [Full-Text]
Review, by Sandeep Arya MD, Children's Mercy Hospital, UMKC, Kansas City, MO
Blood transfusionsCholette JM, Powers KS, Alfieris GM, Angona R, Henrichs KF, Masel D, Swartz MF, Daugherty LE, Belmont K, Blumberg N. Transfusion of Cell Saver Salvaged Blood in Neonates and Infants Undergoing Open Heart Surgery Significantly Reduces RBC and Coagulant Product Transfusions and Donor Exposures: Results of a Prospective, Randomized, Clinical Trial
Pediatr Crit Care Med. 2013 Feb;14(2):137-47. [abstract] [Full-Text]
Review, by Ahmar U. Zaidi, MD and Paras Khandhar, MD, Beaumont Children's Hospital, Royal Oak, MI
Blood transfusionsde Gast-Bakker DH, de Wilde RB, Hazekamp MG, Sojak V, Zwaginga JJ, Wolterbeek R, de Jonge E, Gesink-van der Veer BJ Safety and effects of two red blood cell transfusion strategies in pediatric cardiac surgery patients: a randomized controlled trial
Intensive Care Med 2013 Nov;39(11):2011-9 [abstract]
Review, by Asma Rasavi MD, Children's Hospital Los Angeles, Los Angeles CA
Blood transfusionsKoch CG, Li L, Sessler DI, et al. Duration of Red-Cell Storage and Complications after Cardiac Surgery.
N Engl J Med. 2008 358:1229-1239. [abstract]
Review, by Scott Weiss MD, Feinberg School of Medicine, Northwestern University, Children's Memorial Hospital, Chicago IL
Blood transfusionsNetzer G, Shah C, Iwashyna T, Lanken P, Finkel B, Fuchs B, Guo W, Christie J. Association of Red Cell Transfusion with Mortality in Patients with Acute Lung Injury.
Chest 2007 132:1116-1123. [abstract]
Review, by Anoopindar Ghuman MD, Childrens Hospital Los Angeles, Los Angeles, CA
Blood transfusionsWillems A, Harrington K, Lacroix J, Biarent D, Joffe AR, Wensley D, Ducruet T, HĂ©bert PC, Tucci M; TRIPICU investigators; Canadian Critical Care Trials Group; Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network. Comparison of two red-cell transfusion strategies after pediatric cardiac surgery: a subgroup analysis.
Crit Care Med 2010 38(2):649-56 [abstract]
Review, by Viyeka Sethi MD, University of California San Francisco, San Francisco CA
Blood transfusionsRouette J, Trottier H, Ducruet T, Beaunoyer M, Lacroix J, Tucci M; Canadian Critical Care Trials Group; PALISI Network Red blood cell transfusion threshold in postsurgical pediatric intensive care patients: a randomized clinical trial.
Ann Surg. 2010 251(3):421-7 [abstract]
Review, by Jun Sasaki MD, Miami Children's Hospital, Miami FL
BNP in the diagnosis of heart failureCohen S, Springer C, Avital A, et al., Amino-Terminal Pro-Brain-Type Natriuretic Peptide: Heart or Lung Disease in Pediatric Respiratory Distress?
Pediatrics 2005 115 1347-1350 [abstract]
Review, by R Srinivasan
BNP in the diagnosis of heart failureTissieres P, da Cruz E, Habre W, Aggoun Y, Mensi N, Kalangos A, Beghetti M. Value of brain natriuretic peptide in the perioperative follow-up of children with valvular disease.
Intensive Care Med 2008 34(6):1109-13 [abstract]
Review, by Jagdish Ambwani MD, Newark Beth Israel Medical Center, New Jersey
BNP in the diagnosis of heart failureAuerbach SR, Richmond ME, Lamour JM, Blume ED, Addonizio LJ, Shaddy RE, Mahony L, Pahl E, Hsu DT. BNP levels predict outcome in pediatric heart failure patients: post hoc analysis of the Pediatric Carvedilol Trial.
Circ Heart Fail 2010 Sep 1;3(5):606-11 [abstract]
Review, by Kim Ngo MD, Children's Hospital Los Angeles, Los Angeles CA
Central line infection/complication preventionSchroeder AR, Axelrod DM, Silverman NH, Rubesova E, Merkel E, Roth SJ. A continuous heparin infusion does not prevent catheter-related thrombosis in infants after cardiac surgery.
Pediatr Crit Care Med. 2010 Jul;11(4):489-95. [abstract]
Review, by Amanda Madden DO, Children’s Mercy Hospital, University of Missouri-Kansas City, Kansas City, MO
Chronic Pulmonary Hypertension TherapyOlschewski H, Simmoneau G, Galie N, et al., Inhaled Iloprost for Severe Pulmonary Hypertension
N Engl J Med 2002 347(5):322-9 [abstract]
Review, by A Arikan
Clinical Diagnosis of Low Cardiac OutputTibby SM, Hatherill M, Murdoch IA, , Capillary refill and core-peripheral temperature gap as indicators of Hemodynamics status in paediatric intensive care patients
Arch Dis Child 1999 109: 1302-1312 [abstract]
Review, by Cray, Steven
Clinical Diagnosis of Low Cardiac OutputRaimer PL, Han YY, Weber MS, Annich GM, Custer JR A normal capillary refill time of ≤ 2 seconds is associated with superior vena cava oxygen saturations of ≥ 70%.
J Pediatr 2011 Jun;158(6):968-72. [abstract]
Review, by Aarti Bavare MD, Baylor College of Medicine and Texas Children's Hospital, Houston TX
Clinical Diagnosis of Low Cardiac OutputKnirsch W, Kretschmar O, Tomaske M, Stutz K, Nagdyman N, Balmer C, Schmitz A, BĂ©ttex D, Berger F, Bauersfeld U, Weiss M. Cardiac output measurement in children: comparison of the Ultrasound Cardiac Output Monitor with thermodilution cardiac output measurement.
Intensive Care Med 2008 34(6):1060-1064 [abstract]
Review, by Jagdish Ambwani MD, Newark Beth Israel Medical Center, New Jersey
Complications following congenital heart surgeryGaies MG, Gurney JG, Yen AH, Napoli ML, Gajarski RJ, Ohye RG, Charpie JR, Hirsch JC. Vasoactive-inotropic score as a predictor of morbidity and mortality in infants after cardiopulmonary bypass
Pediatr Crit Care Med. 2010 11:234–238 [abstract]
Review, by Annie Camerlengo MD, Children's Hospital Los Angeles, Los Angeles, CA
Complications following congenital heart surgeryTabbutt S, Ghanayem N, Ravishankar C, Sleeper LA, Cooper DS, Frank DU, Lu M, Pizarro C, Frommelt P, Goldberg CS, Graham EM, Krawczeski CD, Lai WW, Lewis A, Kirsh JA, Mahony L, Ohye RG, Simsic J, Lodge AJ, Spurrier E, Stylianou M, Laussen P; Pediatric Hear Risk factors for hospital morbidity and mortality after the Norwood procedure: A report from the Pediatric Heart Network Single Ventricle Reconstruction trial
J Thorac Cardiovasc Surg 2012 Oct;144(4):882-95 [abstract]
Review, by Sebastian Tume MD, Catherine Humikowski MD, University of Chicago, Chicago IL
Complications following congenital heart surgeryAndreasen JB, Johnsen SP, Ravn HB. Junctional ectopic tachycardia after surgery for congenital heart disease in children.
Intensive Care Med 2008 34(5):895-902 [abstract]
Review, by Joel A. Reyes DO, USAF MC, University of Texas Health Science Center at San Antonio
Complications following congenital heart surgerySeear MD, Scarfe JC, Leblanc JG. Predicting major adverse events after cardiac surgery in children.
Pediatr Crit Care Med. 2008 9:606-611 [abstract]
Review, by Julie D. Sparks PNP-BC, Adrea L. Leach PNP-BC, West Virginia University Hospital, Morgantown, WV
Complications following congenital heart surgeryMontgomery VL, Strotman JM, Ross MP. Impact of multiple organ system dysfunction and nosocomial infections on survival of children treated with extracorporeal membrane oxygenation after heart surgery
Crit Care Med 2000 ;28:526-31. [abstract]
Review, by Rukmini Komarlu MD, Children’s Hospital of Pittsburgh, Pittsburgh, PA and Varsha Gharpure MD, Advocate Lutheran General Children’s Hospital, Park Ridge, IL
Complications following congenital heart surgeryManrique AM, Arroyo M, Lin Y, El Khoudary SR, Colvin E, Lichtenstein S, Chrysostomou C, Orr R, Jooste E, Davis P, Wearden P, Morell V, Munoz R. Magnesium supplementation during cardiopulmonary bypass to prevent junctional ectopic tachycardia after pediatric cardiac surgery: A randomized controlled study.
J Thorac Cardiovasc Surg 2010 139: 162-9 [abstract]
Review, by Pooja Kulkarni MD, Columbia University, New York, NY
Complications following congenital heart surgeryOhye RG, Sleeper LA, Mahony L, Newburger JW, Pearson GD, Lu M, Goldberg CS, Tabbutt S, Frommelt PC, Ghanayem NS, Laussen PC, Rhodes JF, Lewis AB, Mital S, Ravishankar C, Williams IA, Dunbar-Masterson C, Atz AM, Colan S, Minich LL, Pizarro C, Kanter KR, Ja Comparison of Shunt Types in the Norwood Procedure for Single-Ventricle Lesions.
N Engl J Med 2010 362(21):1980-1992 [abstract]
Review, by Gary Fang MD, Children's Memorial Hospital and Northwestern University, Chicago IL
Complications following congenital heart surgeryBandla HPR, Hopkins RL, Beckerman RC, Gozal D, Pulmonary Risk Factors Compromising Postoperative Recovery After Surgical Repair for Congenital Heart Disease
Chest 1999 116:740-747 [abstract]
Review, by J Geracht J Barron
Complications following congenital heart surgeryClancy RR, McGaurn SA, Wernovsky G, et al., Risk of seizures in survivors of newborn heart surgery using deep hypothermic circulatory arrest
Pediatrics 2003 111(3):592-601 [abstract]
Review, by G Deshpande A Torres
Congestive Heart FailurePrice JF, Mott AR, Dickerson HA, Jefferies JL, Nelson DP, Chang AC, O Worsening renal function in children hospitalized with decompensated heart failure: evidence for a pediatric cardiorenal syndrome?
Pediatr Crit Care Med. 2008 9(3):279-84 [abstract]
Review, by Alvaro Orjuela MD, West Virginia University, Morgantown WV
Corticosteroids in cardiac ICU patientsVerweij EJ, Hogenbirk K, Roest AA, van Brempt R, Hazekamp MG, de Jonge E Serum cortisol concentration with exploratory cut-off values do not predict the effects of hydrocortisone administration in children with low cardiac output after cardiac surgery
Use Other publication-> or leave empty 2012 Oct;15(4):685-9. [abstract]
Review, by Alan Gatward MD, Children's Hospital Los Angeles, Los Angeles CA
Corticosteroids in cardiac ICU patientsMillar KJ, Thiagarajan RR, Laussen PC. Glucocorticoid therapy for hypotension in the cardiac intensive care unit.
Pediatr Cardiol 2007 28(3):176-82 [abstract]
Review, by RE Kirsch MD, L Zorzela MD, D Garros MD, University of Alberta, Stollery Children
CPR methodologyAbella BS, Alvarado JP, Myklebust H, et al. Quality of cardiopulmonary resuscitation during in-hospital cardiac arrest.
JAMA. 2005 Jan 19;293(3):305-10. [abstract]
Review, by Ashlee Smith MD, Stacey Humphreys MD, Pam Hilvers MD, Stephanie Grayson MD, West Virginia University, Morgantown WV
CPR methodologyMaekawa K, Tanno K, Hase M, Mori K, Asai Y Extracorporeal Cardiopulmonary Resuscitation for Patients With Out-of-Hospital Cardiac Arrest of Cardiac Origin: A Propensity-Matched Study and Predictor Analysis
Crit Care Med 2013 May;41(5):1186-96 [abstract]
Review, by Ryan Coleman MD, Baylor College of Medicine, Texas Children's Hospital, Houston TX
CPR methodologyMentzelopoulos SD, Malachias S, Chamos C, Konstantopoulos D, Ntaidou T, Papastylianou A, Kolliantzaki I, Theodoridi M, Ischaki H, Makris D, Zakynthinos E, Zintzaras E, Sourlas S, Aloizos S, Zakynthinos SG. Vasopressin, steroids, and epinephrine and neurologically favorable survival after in-hospital cardiac arrest: a randomized clinical trial
JAMA 2013 310(3):270-9 [abstract]
Review, by Abhishek Patel MD, Janeth Chiaka Ejike MD, Loma Linda University Children’s Hospital, Loma Linda, CA
Diagnostic Technology for Cardiac OutputEgan JR, Festa M, Cole AD, Nunn GR, Gillis J, Winlaw DS. Clinical assessment of cardiac performance in infants and children following cardiac surgery.
Intensive Care Med. 2005 Apr;31(4):568-573 [abstract]
Review, by Jun Sasaki MD, Miami Children's Hospital, Miami FL
Diagnostic Technology for Cardiac OutputCrittendon I 3rd, Dreyer WJ, Decker JA, Kim JJ Ultrasound dilution: An accurate means of determining cardiac output in children.
Pediatric Critical Care Medicine 2012 13:42–46 [abstract]
Review, by Fernando Beltramo MD, Children's Hospital Los Angeles, Los Angeles CA
Diagnostic Technology for Cardiac OutputVarpula M, Karlsson S, Ruokonen E, Pettila V. Mixed venous oxygen saturation cannot be estimated by central venous oxygen saturation in septic shock.
Intensive Care Med 2006 32(9):1336-43 [abstract]
Review, by Reviewed by Gökhan Kalkan MD, University of California San Francisco
Diagnostic Technology for Cardiac OutputTibby SM, Hatherill M, Durward A, Murdoch IA, Are transoesophageal Doppler parameters a reliable guide to paediatric haemodynamic status and fluid management?
Intensive Care Med 2001 27:201-205 [abstract]
Review, by M Duthie O Bagshaw
Diagnostic Technology for Cardiac OutputRichard C, Warszawski J, Angurl N, et al., Early Use of the Pulmonary Artery Catheter and Outcomes in Patients With Shock and Acute Respiratory Distress Syndrome: A Randomized Controlled Trial
JAMA 2003 290 2713-2720 [abstract]
Review, by S. Thammasitboon S. Cortes
Diagnostic Technology for Cardiac OutputLevy RL, Chiavacci RM, Nicolson SC , et al. , An Evaluation of a Noninvasive Cardiac Output Measurement Using Partial Carbon Dioxide Rebreathing in Children
Anesth Analg 2004 99 1642-1647 [abstract]
Review, by M Weber
Dialysis in the ICUSelewski DT, Cornell TT, Blatt NB, Han YY, Mottes T, Kommareddi M, Gaies MG, Annich GM, Kershaw DB, Shanley TP, Heung M. Fluid overload and fluid removal in pediatric patients on extracorporeal membrane oxygenation requiring continuous renal replacement therapy
Crit Care Med 2012 40:2694–2699 [abstract]
Review, by William Sasser MD, University of Alabama at Birmingham, Birmingham AL
Dialysis in the ICUSchiffl H, Lang SM, Fischer R, , Daily hemodialysis and the outcome of acute renal failure
N Engl J Med 2002 346:305-10 [abstract]
Review, by X Garcia
Dialysis in the ICUThe VA/NIH Acute Renal Failure Trial Network. Intensity of Renal Support in Critically Ill Patients with Acute Kidney Injury.
N Engl J Med 2008 359:7-20. [abstract]
Review, by Derek S. Wheeler MD, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH
Dialysis in the ICUHoover NG, Heard M, Reid C, Wagoner S, Rogers K, Foland J, Paden ML, Fortenberry JD. Enhanced fluid management with continuous venovenous hemofiltration in pediatric respiratory failure patients receiving extracorporeal membrane oxygenation support.
Intensive Care Med 2008 34(12):2241-2247 [abstract]
Review, by Kristina R. Krmpotic MD, Children’s Hospital of Eastern Ontario, Ottawa, Canada
Diuretic/renal therapySingh NC, Kissoon N, Mofada SA, Bennett M, Bohn DJ Comparison of continuous versus intermittent furosemide administration in postoperative pediatric cardiac patients
Crit Care Med 1992 27:1974-81 [abstract]
Review, by Patricia Jines Jonathan D. Feldman
Diuretic/renal therapySackner-Bernstein JD, Kowalski M, Fox M, Aaronson K. Short-term risk of death after treatment with nesiritide for decompensated heart failure: a pooled analysis of randomized controlled trials.
JAMA. 2005 Apr 20;293(15):1900-5. [abstract]
Review, by Anne Marie Yered MD, Children's Hospital of Michigan, Detroit MI
Diuretic/renal therapyFriedrich JO, Adhikari N, Herridge MS, Beyene J. Meta-analysis: low-dose dopamine increases urine output but does not prevent renal dysfunction or death.
Ann Intern Med. 2005 Apr 5;142(7):510-24 [abstract]
Review, by Omer Mansoor MD, West Virginia University, Morgantown, WV
Diuretic/renal therapyPretzlaff RK, Vardis RJ, Pollack MM, , Aminophylline in the treatment of fluid overload.
Crit Care Med 1999 342: 1301-1308 [abstract]
Review, by P Jines R Harrison
Diuretic/renal therapyIchai C, Soubielle J, Carles M, Giunti C, Grimaud D Comparison of the renal effects of low to high doses of dopamine and dobutamine in critically ill patients: a single-blind randomized study.
Crit Care Med 2000 283:235-241 [abstract] [Full-Text]
Review, by Narsinghani U.
Diuretic/renal therapyBellomo R, Chapman M, Finfer S, Australian and New Zealand Intensive Care Society (ANZICS) Clinical Trials Group, Low-dose dopamine in patients with early renal dysfunction: a placebo-controlled randomised trial
Lancet 2000 356(9248):2139-43 [abstract]
Review, by J Barron A Madikians
Diuretic/renal therapyKellum JA, M Decker J, , , Use of dopamine in acute renal failure: a meta-analysis
Crit Care Med 2001 1526-31 [abstract]
Review, by C Davison
Diuretic/renal therapyFoland JA, Fortenberry JD, Warshaw BL, et al., Fluid overload before continuous hemofiltration and survival in critically ill children: a retrospective analysis
Crit Care Med 2004 Aug;32(8):1771-6 [abstract]
Review, by L Thompson
ECMO for Cardiac ArrestHuang SC, Wu ET, Chen YS, Chang CI, Chiu IS, Wang SS, Lin FY, Ko WJ. Extracorporeal membrane oxygenation rescue for cardiopulmonary resuscitation in pediatric patients.
Crit Care Med 2008 36(5):1607-13 [abstract]
Review, by Brian Joy MD and Jason M. Kane MD, Northwestern University Feinberg School of Medicine, Children's Memorial Hospital
ECMO for Cardiac ArrestRaymond TT, Cunnyngham CB, Thompson MT, Thomas JA, Dalton HJ, Nadkarni VM; for the American Heart Association National Registry of CPR Investigators. Outcomes among neonates, infants, and children after extracorporeal cardiopulmonary resuscitation for refractory in-hospital pediatric cardiac arrest: A report from the National Registry of CardioPulmonary Resuscitation
Pediatr Crit Care Med. 2010 11:362–371 [abstract] [Full-Text]
Review, by Mihaela Damian MD, Lucile Packard Children’s Hospital, Stanford University, Palo Alto CA
ECMO for Cardiac ArrestBarrett CS, Bratton SL, Salvin JW, Laussen PC, Rycus PT, Thiagarajan RR. Neurological injury after extracorporeal membrane oxygenation use to aid pediatric cardiopulmonary resuscitation.
Pediatr Crit Care Med. 2009 10(4):445-451 [abstract]
Review, by Melissa Atwood DO, Medical College of Wisconsin, Milwaukee WI
ECMO for Cardiac ArrestMorris MC, Wernovsky G, Nadkarni VM, , Survival outcomes after extracorporeal cardiopulmonary resuscitation instituted during active chest compressions following refractory in-hospital pediatric cardiac arrest
Pediatric Critical Care Medicine 2005 Sep;5(5):440-446 [abstract]
Review, by M Frazier A Wratney
ECMO for myocarditisRajagopal SK, Almond CS, Laussen PC, Rycus PT, Wypij D, Thiagarajan RR. Extracorporeal membrane oxygenation for the support of infants, children, and young adults with acute myocarditis: a review of the Extracorporeal Life Support Organization registry.
Crit Care Med 2010 38(2):382-7 [abstract]
Review, by Kevin Madden MD, Childrens Hospital Los Angeles, Los Angeles CA
ECMO in congenital heart diseaseMorris MC, Ittenbach RF, Godinez RI et al. Risk factors for mortality in 137 pediatric cardiac intensive care unit patients managed with extracorporeal membrane oxygenation.
Crit Care Med 2004 ; 32:1061-1069. [abstract]
Review, by Tamika Rozema MD, Kentucky Childrens Hospital/UK Healthcare, Lexington KY
ErythopoietinCorwin HL, Gettinger A, Rodriguez RM, , Efficacy of recombinant human erythropoietin in the critically ill patient: a randomized, double-blind, placebo-controlled trial.
Crit Care Med 1999 27:2346-50 [abstract]
Review, by Prasad
ErythopoietinCorwin HL, Gettinger A, Pearl RG, et al. , Efficacy of recombinant human erythropoietin in critically ill patients: a randomized controlled trial
JAMA 2002 288(22):2827-35 [abstract]
Review, by M Cooper
Fluid management in the PICUMontañana PA, I Alapont VM, OcĂłn AP, LĂłpez PO, Prats JL, Parreño JD. The use of isotonic fluid as maintenance therapy prevents iatrogenic hyponatremia in pediatrics: A randomized, controlled open study.
Pediatr Crit Care Med. 2008 9(6):589-597 [abstract] [Full-Text]
Review, by Rojjanee Lertbunrian MD, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand
Fluid management in the PICUMarik PE, Cavallazzi R Does the central venous pressure predict fluid responsiveness? An updated meta-analysis and a plea for some common sense
Crit Care Med 2013 Jul;41(7):1774-81 [abstract]
Review, by Ronald Wong DO, Children's Hospital Los Angeles, Los Angeles CA
Fluid management in the PICUWang J, Xu E, Xiao Y Isotonic Versus Hypotonic Maintenance IV Fluids in Hospitalized Children: A Meta-Analysis.
Pediatrics 2014 133;105 [abstract]
Review, by Cody Tigges MD, LeBonheur Children's Hospital, Memphis TN
Goal Directed Therapy in Sepsisde Oliveira CF, de Oliveira DS, Gottschald AF, Moura JD, Costa GA, Ventura AC, Fernandes JC, Vaz FA, Carcillo JA, Rivers EP, Troster EJ. ACCM/PALS haemodynamic support guidelines for paediatric septic shock: an outcomes comparison with and without monitoring central venous oxygen saturation.
Intensive Care Med 2008 34(6):1065-75 [abstract]
Review, by Robinder G. Khemani MD MsCI, Childrens Hospital Los Angeles, USC Keck School of Medicine
Goal Directed Therapy in SepsisJansen TC, van Bommel J, Schoonderbeek J, Sleeswijk Visser SJ, van der Klooster JM, Lima AP, Willemsen SP, Bakker J; for the LACTATE Study Group. Early Lactate-Guided Therapy in ICU Patients: A Multicenter, Open-Label, Randomized, Controlled Trial
Am J Respir Crit Care Med 2010 182:752-761 [abstract]
Review, by Amanda Brooks MD, Children's Memorial Hospital, Chicago IL
Hemofiltration for sepsisJoannes-Boyau O, HonorĂ© PM, Perez P, Bagshaw SM, Grand H, Canivet JL, Dewitte A, Flamens C, Pujol W, Grandoulier AS, Fleureau C, Jacobs R, Broux C, Floch H, Branchard O, Franck S, RozĂ© H, Collin V, Boer W, Calderon J, Gauche B, Spapen HD, Janvier G, Oua High-volume versus standard-volume haemofiltration for septic shock patients with acute kidney injury (IVOIRE study): a multicentre randomized controlled trial
Intensive Care Med 2013 Sep;39(9):1535-46 [abstract]
Review, by Eric Peters MD, Children's Hospital Los Angeles, Los Angeles, CA
High-dose epinephrine in the treatment of cardiac arrestPerondi MBM, Reis AG, Paiva EF, Nadkarni VM, Berg RA A Comparison of High-Dose and Standard-Dose Epinephrine in Children with Cardiac Arrest
N Engl J Med 2004 350:1722-1730 [abstract]
Review, by M Sharma
HyponatremiaChoong K, Arora S, Cheng J, Farrokhyar F, Reddy D, Thabane L, Walton JM. Hypotonic Versus Isotonic Maintenance Fluids After Surgery for Children: A Randomized Controlled Trial.
Pediatrics 2011 128 857-866
Review, by Candice Olechowski MD, Scottie B. Day MD FAAP, Kentucky Children's Hospital, Lexington KY
HyponatremiaHoorn EJ, Geary D, Robb M, Halperin ML, Bohn D. Acute Hyponatremia Related to Intravenous Fluid Administration in Hospitalized Children: An Observational Study
Pediatrics 2004 ;113 1279-1284 [abstract]
Review, by Paul Veldhouse MD, Jason Kane MD, Children's Memorial Hospital, Chicago IL
HyponatremiaEulmesekian PG, PĂ©rez A, Minces PG, Bohn D. Hospital-acquired hyponatremia in postoperative pediatric patients: prospective observational study.
Pediatr Crit Care Med. 2010 2010 Jul;11(4):479-83. [abstract]
Review, by Sam Lamont MD, Royal Group of Hospitals, Belfast, UK
ICU Outcome by VolumeOster ME, Strickland MJ, Mahle WT. Impact of prior hospital mortality versus surgical volume on mortality following surgery for congenital heart disease
J Thorac Cardiovasc Surg 2011 142:882-6 [abstract]
Review, by Alan Gatward MD, Children’s Hospital Los Angeles, Los Angeles, CA
ICU Outcome by VolumeWelke KF, O The complex relationship between pediatric cardiac surgical case volumes and mortality rates in a national clinical database.
J Thorac Cardiovasc Surg 2009 137(5):1133-40 [abstract]
Review, by Simon Li MD, E. Vincent Faustino MD, Yale University School of Medicine, New Haven CT
Inotropes after Congenital Heart SurgeryDavidson J, Tong S, Hancock H, Hauck A, da Cruz E, Kaufman J. Prospective validation of the vasoactive-inotropic score and correlation to short-term outcomes in neonates and infants after cardiothoracic surgery.
Intensive Care Med 2012 38(7):1184-90 [abstract]
Review, by Harish Bangalore MD, Texas Children's Hospital and Baylor College of Medicine, Houston TX
Inotropes after Congenital Heart SurgeryRicci Z, Garisto C, Favia I, Vitale V, Di Chiara L, Cogo PE. Levosimendan infusion in newborns after corrective surgery for congenital heart disease: randomized controlled trial
Intensive Care Med 2012 38(7):1198-204 [abstract]
Review, by Alberto Orioles MD, Joseph W. Rossano MD, MS, The Children’s Hospital of Philadelphia, Philadelphia PA
Inotropes after Congenital Heart SurgeryHoffman TM, Wernovsky G, Atz AM, et al., Efficacy and safety of milrinone in preventing low cardiac output syndrome in infants and children after corrective surgery for congenital heart disease
Circulation 2003 Feb 25;107(7):996-1002 [abstract]
Review, by A Torres
Inotropes in ShockBarton P, Garcia J, Kouatli A, Kitchen L, Zorka A Hemodynamic effects of i.v. milrinone lactate in pediatric patients with septic shock. A prospective, double-blinded, randomized, placebo-controlled, interventional study.
Chest 1996 27:723-32 [abstract]
Review, by Michael Verive, MD
Inotropes in ShockMarik P. Low-dose dopamine: a systematic review.
Intensive Care Med 2002 ; 28: 877-883. [abstract]
Review, by Shira J. Gertz MD, Texas Children's Hospital and Baylor College of Medicine, Houston TX
Inotropes in ShockKern JW, Shoemaker WC, , , Meta-analysis of hemodynamic optimization in high-risk patients
Crit Care Med 2002 30(8):1686-92 [abstract]
Review, by S Thammasitboon S Thammasitboon
Inotropes in ShockDe Backer D, Biston P, Devriendt J, Madl C, Chochrad D, Aldecoa C, Brasseur A, Defrance P, Gottignies P, Vincent JL; SOAP II Investigators. Comparison of dopamine and norepinephrine in the treatment of shock
N Engl J Med 2010 362(9):779-89 [abstract]
Review, by Kasey Davis MD, Michele Kong MD, University of Alabama, Birmingham, AL
Length of Stay after Cardiopulmonary BypassBrown KL, Ridout DA, Goldman AP, et al., Risk factors for long intensive care unit stay after cardiopulmonary bypass in children
Crit Care Med 2003 31(1):28-33 [abstract]
Review, by A Torres
Mechanical ventilation modesWalsh MA, Merat M, La Rotta G, Joshi P, Joshi V, Tran T, Jarvis S, Caldarone CA, Van Arsdell GS, Redington AN, Kavanagh BP. Airway pressure release ventilation improves pulmonary blood flow in infants after cardiac surgery.
Crit Care Med 2011 39(12):2599-604 [abstract]
Review, by William Sasser MD, Santiago Borasino MD MPH, University of Alabama at Birmingham, Birmingham AL
Near Infrared SpectroscopyBhalala US, Nishisaki A, McQueen D, Bird GL, Morrison WE, Nadkarni VM, Nathan M, Starr JP. Change in regional (somatic) near-infrared spectroscopy is not a useful indictor of clinically detectable low cardiac output in children after surgery for congenital heart defects.
Pediatr Crit Care Med. 2012 13:529–534 [abstract] [Full-Text]
Review, by Matthew Friedman MD, Lurie Children's Hospital, Chicago IL
Neonatal ECMOUK collaborative randomized trial of neonatal extracorporeal membrane oxygenation. , , , , UK collaborative randomized trial of neonatal extracorporeal membrane oxygenation.
Lancet 1996 348: 75-82 [abstract]
Review, by Adrienne Randolph
Neurodevelopmental outcomes after ECMO for cardiac surgeryHamrick SE, Gremmels DB, Keet CA, et al., Neurodevelopmental outcome of infants supported with extracorporeal membrane oxygenation after cardiac surgery
Pediatrics 2003 Jun;111(6 Pt 1):e671-5 [Full-Text]
Review, by S Cooper
Neuroprotection/Neurodevelopmental Outcomes and Congenital Heart SurgeryClancy RR, MCGaurn SA, Goin JE, et al., Allopurinol Neurocardiac Protection Trial in Infants Undergoing Heart Surgery Using Deep Hypothermic Circulatory Arrest
Pediatrics 2001 108 61-70 [abstract] [Full-Text]
Review, by A Shahin
Neuroprotection/Neurodevelopmental Outcomes and Congenital Heart SurgeryLimperopoulos C, Majnemer A, Shevell MI, et al., Predictors of developmental disabilities after open heart surgery in young children with congenital heart defects
J Pediatr 2002 141(1):51-8 [abstract]
Review, by L Elbahlawan
Noninvasive ventilationGray A, Goodacre S, Newby DE, Masson M, Sampson F, Nicholl J; 3CPO Trialists. Noninvasive ventilation in acute cardiogenic pulmonary edema.
N Engl J Med 2008 359(2):142-51 [abstract]
Review, by Kimberly Baker DO and Michael Wilhelm MD, American Family Children’s Hospital at the University of Wisconsin Hospital and Clinics Madison, WI
Nutritional methodologyBraudis NJ, Curley MA, Beaupre K, Thomas KC, Hardiman G, Laussen P, Gauvreau K, Thiagarajan RR. Enteral feeding algorithm for infants with hypoplastic left heart syndrome poststage I palliation
Pediatr Crit Care Med. 2009 10(4):460-466 [abstract]
Review, by Oscar Ingaramo MD, Childrens Hospital Los Angeles, Los Angeles, CA
Outcome after cardiac arrestSrinivasan V, Nadkarni VM, Helfaer MA, Carey SM, Berg RA; American Heart Association National Registry of Cardiopulmonary Resuscitation Investigators. Childhood obesity and survival after in-hospital pediatric cardiopulmonary resuscitation.
Pediatrics 2010 125(3):e481-8. [abstract]
Review, by Manuel Silva MD, Baylor College of Medicine and Texas Children's Hospital, Houston TX
Outcome after cardiac arrestSchindler MB, Bohn D, Cox PN, McCrindle BW, Jarvis A Outcome of out-of-hospital cardiac or respiratory arrest in children.
N Engl J Med 1996 333:1473-9 [abstract]
Review, by Adrienne Randolph
Outcome after cardiac arrestHorisberger T, Fischer JE, Fanconi S. One-year survival and neurological outcome after pediatric cardiopulmonary resuscitation
Intensive Care Med 2002 28: 365-368. [abstract]
Review, by P Prodhan, N Noviski
Outcome after cardiac arrestNitta M, Iwami T, Kitamura T, Nadkarni VM, Berg RA, Shimizu N, Ohta K, Nishiuchi T, Hayashi Y, Hiraide A, Tamai H, Kobayashi M, Morita H; for the Utstein Osaka Project. Age-Specific Differences in Outcomes After Out-of-Hospital Cardiac Arrests.
Pediatrics 2011 128:e812 [abstract]
Review, by Ivie D Esangbedo, MD, MPH, University of Illiniois Chicago, Chicago, IL
Outcome after cardiac arrestMeaney PA, Nadkarni VM, Cook EF, et al. for the American Heart Association National Registry of Cardiopulmonary Resuscitation Investigators. Higher Survival Rates Among Younger Patients After Pediatric Intensive Care Unit Cardiac Arrests.
Pediatrics 2006 118:2424-2433 [abstract]
Review, by Jennifer Matchey MD, Medical College of Wisconsin, Children
Outcome after cardiac arrestMoler FW, Donaldson AE, Meert K, Brilli RJ, Nadkarni V, Shaffner DH, Schleien CL, Clark RS, Dalton HJ, Statler K, Tieves KS, Hackbarth R, Pretzlaff R, van der Jagt EW, Pineda J, Hernan L, Dean JM; for the Pediatric Emergency Care Applied Research Network. Multicenter cohort study of out-of-hospital pediatric cardiac arrest.
Pediatr Crit Care Med. 2011 39:141–149 [abstract]
Review, by Ajay Khilanani MD, Ann & Robert H. Lurie Children’s Hospital of Chicago, Northwestern University Feinberg School of Medicine, Chicago IL
Outcome after cardiac arrestSamson RA, Nadkarni VM, Meaney PA, Carey SM, Berg MD, Berg RA; American Heart Association National Registry of CPR Investigators. Outcomes of in-hospital ventricular fibrillation in children
N Engl J Med 2006 354(22):2328-39 [abstract]
Review, by Downing Lu MD, Children
Outcome after cardiac arrestHagihara A, Hasegawa M, Abe T, Nagata T, Wakata Y, Miyazaki S. Prehospital epinephrine use and survival among patients with out-of-hospital cardiac arrest
JAMA 2012 21;307(11):1161-8 [abstract]
Review, by Katherine Kruse MD, Anthony Olivero MD, Helen DeVos Children's Hosptial, Grand Rapids, MI
Outcome after cardiac arrestParra DA, Totapally BR, Zahn E, , Outcome of cardiopulmonary resuscitation in a pediatric cardiac intensive care unit
Crit Care Med 2000 28(9):296-300 [abstract]
Review, by KP Mistry
Outcome after cardiac arrestLĂłpez-Herce J, Del Castillo J, Matamoros M, Cañadas S, Rodriguez-Calvo A, Cecchetti C, Rodriguez-Núñez A, Alvarez AC; Iberoamerican Pediatric Cardiac Arrest Study Network RIBEPCI. Factors associated with mortality in pediatric in-hospital cardiac arrest: a prospective multicenter multinational observational study.
Intensive Care Med 2013 Feb;39(2):309-18 [abstract]
Review, by Wendy Wong MD, Children's Hospital Los Angeles, Los Angeles CA
Outcome after cardiac arrestBennett KS, Clark AE, Meert KL, Topjian AA, Schleien CL, Shaffner DH, Dean JM, Moler FW; for the Pediatric Emergency Care Medicine Applied Research Network. Early Oxygenation and Ventilation Measurements After Pediatric Cardiac Arrest: Lack of Association With Outcome
Crit Care Med 2013 Jun;41(6):1534-1542 [abstract]
Review, by Sabrina Ann Carrillo MD, University of Texas Health Science Center at San Antonio, San Antonio TX
Outcome after cardiac arrestKilgannon JH, Jones AE, Shapiro NI, Angelos MG, Milcarek B, Hunter K, Parrillo JE, Trzeciak S; Emergency Medicine Shock Research Network (EMShockNet) Investigators. Association between arterial hyperoxia following resuscitation from cardiac arrest and in-hospital mortality.
JAMA 2010 303(21):2165-71. [abstract]
Review, by Manuel Silva MD, Baylor College of Medicine and Texas Children's Hospital, Houston TX
Outcome after cardiac arrestBobrow BJ, Spaite DW, Berg RA, Stolz U, Sanders AB, Kern KB, Vadeboncoeur TF, Clark LL, Gallagher JV, Stapczynski JS, LoVecchio F, Mullins TJ, Humble WO, Ewy GA. Chest compression-only CPR by lay rescuers and survival from out-of-hospital cardiac arrest.
JAMA 2010 304(13):1447-54. [abstract]
Review, by Ryan Stark MD, Baylor College of Medicine and Texas Children's Hospital, Houston TX
Outcome after cardiac arrestSvensson L, Bohm K, Castren M, Pettersson H, Engerstrom L, Herlitz J, Rosenqvist M. Compression-Only CPR or Standard CPR in Out-of-Hospital Cardiac Arrest.
N Engl J Med 2010 363:434-442. [abstract]
Review, by Anoopindar Ghuman MD, Children's Hospital Los Angeles, Los Angeles, CA
Outcome after cardiac arrestRea TD, Fahrenbruch C, Culley L, Donohoe RT, Hambly C, Innes J, Bloomingdale M, Subido C, Romines S, Eisenberg MS. CPR with Chest Compression Alone or with Rescue Breathing
N Engl J Med 2010 363:423-433 [abstract]
Review, by Anoopindar Ghuman MD, Children's Hospital Los Angeles, Los Angeles, CA
Outcomes after congenital heart surgeryBurstein DS, Jacobs JP, Li JS, Sheng S, O Care models and associated outcomes in congenital heart surgery.
Pediatrics 2011 127(6):e1482-9 [abstract]
Review, by Pamela Hilvers MD, West Virginia University School of Medicine, Morgantown WV
Outcomes after congenital heart surgeryCua CL, Thiagarajan RR, Gauvreau K, et al. Early postoperative outcomes in a series of infants with hypoplastic left heart syndrome undergoing stage I palliation operation with either modified Blalock-Taussig shunt or right ventricle to pulmonary artery conduit.
Pediatric Critical Care Medicine 2006 7(3):238-44 [abstract]
Review, by Angela Aramburo MD, University of California San Francisco
Outcomes after congenital heart surgeryDyke PC 2nd, Yates AR, Cua CL, Hoffman TM, Hayes J, Feltes TF, Springer MA, Taeed R. Increased calcium supplementation is associated with morbidity and mortality in the infant postoperative cardiac patient
Pediatr Crit Care Med. 2007 8(3):254-7 [abstract]
Review, by David F. Adams MD; Kshitij Mistry MD MSc, Duke Children’s Hospital, Durham NC
Oxgyen Transport after Cardiac SurgeryRossi AF, Seiden HS, Gross RP, Griepp RB, Oxygen transport in critically ill infants after congenital heart operations
Ann Thorac Surg 1999 67(3):739-44 [abstract] [Full-Text]
Review, by A Shahin
Oxgyen Transport after Cardiac SurgeryHoffman GM, Tweddell JS, Ghanayem NS, et al., Alteration of the critical arteriovenous oxygen saturation relationship by sustained afterload reduction after the Norwood procedure
J Thorac Cardiovasc Surg 2004 Mar;127(3):738-45 [abstract]
Review, by N Lin
Oxygen delivery in shockAlia I, Esteban A, Gordo F, , A randomized and controlled trial of the effect of treatment aimed at maximizing oxygen delivery in patients with severe sepsis or septic shock
Chest 1999 28(4):921-8 [abstract]
Review, by Prabhakaran P. Butler T.
Plasmafiltration in SepsisPiccinni P, Dan M, Barbacini S, et al. Early isovolaemic haemofiltration in oliguric patients with septic shock.
Intensive Care Med. 2006 Jan;32(1):80-6 [abstract]
Review, by Derek S. Wheeler MD, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH
Post-operative analgesiaInoue M, Caldarone CA, Frndova H, Cox PN, Ito S, Taddio A, Guerguerian AM. Safety and efficacy of ketorolac in children after cardiac surgery.
Intensive Care Med 2009 35(9):1584-92 [abstract]
Review, by William E. Gordon MD, Baylor College of Medicine, Texas Children's Hospital, Houston TX
Postoperative Pulmonary Hypertension TreatmentSchulze-Neick I, Hartenstein P, Li J, et al. Intravenous sildenafil is a potent pulmonary vasodilator in children with congenital heart disease.
Circulation. 2003 Sep 9;108 Suppl 1:II167-73. [abstract]
Review, by Jai Udassi MD FAAP, Ikram Haque MD FAAP, Shands Children's Hospital, University of Florida, College of Medicine, Gainesville, FL
Postoperative Pulmonary Hypertension TreatmentFraisse A, Butrous G, Taylor MB, Oakes M, Dilleen M, Wessel DL. Intravenous sildenafil for postoperative pulmonary hypertension in children with congenital heart disease.
Intensive Care Med 2011 37(3):502-9 [abstract]
Review, by O. Kachanov MD, Varsha Gharpure MD, Advocate Lutheran General Children's Hospital, Park Ridge, IL
Postoperative Pulmonary Hypertension TreatmentMiller OI, Tang SF, Keech A, , Inhaled nitric oxide and prevention of pulmonary hypertension after congenital heart surgery: a randomised double-blind study
Lancet 2000 356:1464-1469 [abstract]
Review, by K Daphtary K Meert
Postoperative Pulmonary Hypertension TreatmentMorris K, Beghetti M, Petros A, Adatia I, Bohn D Comparison of hyperventilation and inhaled nitric oxide for pulmonary hypertension after repair of congenital heart disease
Crit Care Med 2000 28(8):2974-8 [abstract]
Review, by R Rao
Prediction tool for sepsisVarpula M, Tallgren M, Saukkonen K, Voipio-Pulkki LM, Pettila V. Hemodynamic variables related to outcome in septic shock.
Intensive Care Med. 2005 Aug;31(8):1066-71. [abstract]
Review, by Stacey Humphreys MD, Pamela Hilvers MD, Stephanie Grayson MD, Ashlee Smith MD, West Virginia University, Morgantown, WV
Prevention of apnea with prostaglandin infusionLim DS, Kulik TJ, Kim DW, Charpie JR, Crowley DC, Maher KO. Aminophylline for the prevention of apnea during prostaglandin E1 infusion
Pediatrics 2003 Jul;112(1 Pt 1):e27-9 [abstract]
Review, by P Alexander
Pulmonary hypertensionBarst RJ, Ivy DD, Gaitan G, Szatmari A, Rudzinski A, Garcia AE, Sastry BK, Pulido T, Layton GR, Serdarevic-Pehar M, Wessel DL. A randomized, double-blind, placebo-controlled, dose-ranging study of oral sildenafil citrate in treatment-naive children with pulmonary arterial hypertension.
Circulation 2013 17;125(2):324-34 [abstract]
Review, by Teresa Bleakly MD, Lucile Packard Children's Hospital, Stanford University, Palo Alto CA
Pulmonary hypertensionYung D, Widlitz AC, Rosenzweig EB, et al. Outcomes in Children With Idiopathic Pulmonary Arterial Hypertension
Circulation 2004 ;110 660-665 [abstract]
Review, by Christoph Hornik MD, David Turner MD, Duke Children’s Hospital, Durham, North Carolina
Pulmonary hypertensionNamachivayam P, Theilen U, Butt WW, Cooper SM, Penny DJ, Shekerdemian LS. Sildenafil prevents rebound pulmonary hypertension after withdrawal of nitric oxide in children.
Am J Respir Crit Care Med 2006 174(9):1042-7 [abstract]
Review, by J. Dayre McNally, MD, PhD, Children’s Hospital of Eastern Ontario, Ottawa, Canada
Resuscitation FluidsDelaney AP, Dan A, McCaffrey J, Finfer S. The role of albumin as a resuscitation fluid for patients with sepsis: A systematic review and meta-analysis.
Crit Care Med 2011 39(2):386-91 [abstract]
Review, by Kasey Davis MD, University of Alabama Birmingham, Birmingham, AL
Resuscitation FluidsChoi PT, Yip G, Quinonez LG, Cook DJ, Crystalloids vs. colloids in fluid resuscitation: a systematic review.
Crit Care Med 1999 134:406-412 [abstract]
Review, by Melchor Sanchez-Mendiola,
Resuscitation FluidsCochrane Injuries Group Albumin Reviewers., , , , Human albumin administration in critically ill patients: systematic review of randomized controlled trials.
Br Med J 1998 150:942-947 [abstract]
Review, by Al Torres, MD, MS
Resuscitation FluidsSchierhout G, Roberts I, , , Fluid resuscitation with colloid or crystalloid solutions in critically ill patients: a systematic review of randomized trials
Br Med J 1998 26: 1265-1270 [abstract]
Review, by Michael J. Verive, MD
Resuscitation FluidsSAFE Study Investigators, Finfer S, McEvoy S, Bellomo R, McArthur C, Myburgh J, Norton R. Impact of albumin compared to saline on organ function and mortality of patients with severe sepsis.
Intensive Care Med 2011 37(1):86-96 [abstract]
Review, by Jean Dozier MD, Children's Hospital Los Angeles, Los Angeles, CA
Resuscitation FluidsNational Heart, Lung, and Blood Institute Acute Respiratory Distress Syndrome (ARDS) Clinical Trials Network. Comparison of two fluid-management strategies in acute lung injury
N Engl J Med 2006 354(24):2564-75 [abstract]
Review, by Mary G. Gaspers MD, Baylor College of Medicine, Texas Children's Hospital, Houson TX
Resuscitation FluidsWilkes MM, Navick RJ, , , Patient Survival after Human Albumin Administration A Meta-Analysis of Randomized, Controlled Trials
Ann Intern Med 2001 135:149-164 [abstract]
Review, by A Torres
Resuscitation FluidsHan YY, Carcillo JA, Dragotta MA, et al., Early Reversal of Pediatric-Neonatal Septic Shock by Community Physicians Is Associated With Improved Outcome
Pediatrics 2003 112 793-799 [abstract]
Review, by N Faqih
Resuscitation FluidsSAFE Study Investigators, , , , A comparison of albumin and saline for fluid resuscitation in the Intensive Care Unit
N Engl J Med 2004 350:2247-2256 [abstract]
Review, by S van Schaik
Role of the pulmonary artery catheter in critical illnessShah MR, Hasselblad V, Stevenson LW, Binanay C, O'Connor CM, Sopko G, Califf RM. Impact of the pulmonary artery catheter in critically ill patients: meta-analysis of randomized clinical trials.
JAMA 2005 Oct 5;294(13):1664-70 [abstract]
Review, by S Gertz
Role of the pulmonary artery catheter in critical illnessNational Heart, Lung, and Blood Institute Acute Respiratory Distress Syndrome (ARDS) Clinical Trials Network. Pulmonary-Artery versus Central Venous Catheter to Guide Treatment of Acute Lung Injury.
N Engl J Med 2006 354:2213-2224 [abstract]
Review, by Pallavi Patwari MD, Children's Memorial Hospital, Chicago, IL
Thrombolytic therapyWan S, Quinlan DJ, Agnelli G, Eikelboom JW. Thrombolysis Compared With Heparin for the Initial Treatment of Pulmonary Embolism: A Meta-Analysis of the Randomized Controlled Trials.
Circulation 2004 ;110 744-749 [abstract]
Review, by Mihaela Damian MD, Stanford University, Lucile Packard Children Hospital, Palo Alto CA
Tri-iodothyronine Therapy after Congenital Heart SurgeryPortman MA, Slee A, Olson AK, Cohen G, Karl T, Tong E, Hastings L, Patel H, Reinhartz O, Mott AR, Mainwaring R, Linam J, Danzi S; TRICC Investigators. Triiodothyronine Supplementation in Infants and Children Undergoing Cardiopulmonary Bypass (TRICC): a multicenter placebo-controlled randomized trial: age analysis.
Circulation 2010 14;122(11 Suppl):S224-33. [abstract]
Review, by Tatiana Sampaio MD and J. Dayre McNally, MD, PhD, Children’s Hospital of Eastern Ontario, Ottawa, Canada
Tri-iodothyronine Therapy after Congenital Heart SurgeryBettendorf M, Schmidt KG, Grulich-Henn J, et al., Tri-iodothyronine treatment in children after cardiac surgery: a double-blind, randomised, placebo-controlled study
Lancet 2000 356(9229):529-34 [abstract]
Review, by L Rajagopalan
Vasopressin in shockTorgersen C, Luckner G, Schröder DC, Schmittinger CA, Rex C, Ulmer H, DĂĽnser MW. Concomitant arginine-vasopressin and hydrocortisone therapy in severe septic shock: association with mortality.
Intensive Care Med 2011 Sep;37(9):1432-7. [abstract]
Review, by Asma Razavi MD, Children's Hospital Los Angleles, Los Angeles, CA
Vasopressin in shockChoong K, Bohn D, Fraser DD, Gaboury I, Hutchison JS, Joffe AR, Litalien C, Menon K, McNamara P, Ward RE Vasopressin in Pediatric Vasodilatory Shock - A Multi-center Randomized Controlled Trial
Am J Respir Crit Care Med 2009 180:632-639 [abstract]
Review, by Elora Hussain MD and Conrad Epting MD, Children’s Memorial Hospital, Northwestern University, Chicago, IL
Vasopressin in the treatment of cardiac arrestGueugniaud PV, David JS, Chanzy E, et al. Vasopressin and Epinephrine vs. Epinephrine Alone in Cardiopulmonary Resuscitation
N Engl J Med 2008 359:21-30 [abstract]
Review, by Varsha Gharpure MD, Children’s Hospital of Pittsburgh
Vasopressin in the treatment of cardiac arrestWenzel V, Krismer AC, Arntz HR, et al., A Comparison of Vasopressin and Epinephrine for Out-of-Hospital Cardiopulmonary Resuscitation
N Engl J Med 2003 350:105-113 [abstract]
Review, by K Denev
Respiratory Infections
Bronchiolitis/RSVKhongphatthanayothin A, Wong PC, Samara Y, , Impact of respiratory syncytial virus infection on surgery for congenital heart disease: postoperative course and outcome.
Crit Care Med 1999 80: 163-166 [abstract] [Full-Text]
Review, by Christopher J. Babbitt MD Jonathan D. Feldman MD
Bronchiolitis/RSVKellner JD, Ohlsson A, Gadomski AM, Wang EE, Efficacy of Bronchodilator Therapy in Bronchiolitis: A Meta-analysis
Arch Pediatr Adolesc Med 1996 23:1294-303 [abstract]
Review, by Margarita Reloza-Macias, MD,
Bronchiolitis/RSVRandolph AG, Wang EE, , , Ribavirin for Respiratory Syncytial Virus Lower Respiratory Tract Infection: A Systematic Overview
Arch Pediatr Adolesc Med 1996 158: 908-916 [abstract] [Full-Text]
Review, by Michael J. Verive, MD
Bronchiolitis/RSVGarrison MM, Christakis DA, Harvey E, Cummings P, Davis RL. Systemic Corticosteroids in Infant Bronchiolitis: A Meta-analysis
Pediatrics 2000 105:e44 [abstract] [Full-Text]
Review, by M. Bonnie Dutta
Bronchiolitis/RSVDobson JV, Stephen-Groff SM, McMahon SR, Stemmler, Brallier SL The Use of Albuterol in Hospitalized Infants With Bronchiolitis
Pediatrics 1998 52: 634-637 [abstract]
Review, by Kshama Daphtary, MD Kathleen Meert, MD,
Bronchiolitis/RSVGuerguerian AM, Gauthier M, Lebel MH, Farrell CA, Lacroix J Ribavirin in ventilated respiratory syncytial virus bronchiolitis. A randomized, placebo-controlled trial.
Am J Respir Crit Care Me 1999 27:2096-104 [abstract]
Review, by P. Chalikonda MD
Bronchiolitis/RSVHollman G, Shen G, Zeng L, , Helium-oxygen improves Clinical Asthma Scores in children with acute bronchiolitis
Crit Care Med 1998 280:159-165 [abstract]
Review, by Kate G. Ackerman, M.D.,
Bronchiolitis/RSVKlassen TP, Sutcliffe TS, Watters LK, Wells Ga, Allen UD Dexamethasone in salbutamol-treated inpatients with acute bronchiolitis: A randomized, controlled trial
J Pediatr 1997 23: 1430-1439 [abstract]
Review, by Barry Markovitz, MD,
Bronchiolitis/RSVCambonie G, Milesi C, Fournier-Favre S, et al. Clinical Effects of Heliox Administration for Acute Bronchiolitis in Young Infants
Chest 2006 ;129 676-682 [abstract]
Review, by Robert Niebler MD, Children
Bronchiolitis/RSVvan Woensel JB, Wolfs TF, van Aalderen WM, Brand PL, Kimpen JL Randomized double blind placebo controlled trial of prednisolone in children admitted to hospital with respiratory syncytial virus bronchiolitis
Thorax 1997 15:579-583 [abstract]
Review, by Al Torres, M.D., M.S.
Bronchiolitis/RSVvan Woensel JB, Vyas H; on behalf of the STAR Trial Group Dexamethasone in children mechanically ventilated for lower respiratory tract infection caused by respiratory syncytial virus: A randomized controlled trial
Crit Care Med 2011 39:1779 –1783 [abstract]
Review, by Jan Hau Lee MD, Duke University Medical Center, Durham NC
Bronchiolitis/RSVDavison C, Ventre KM, Luchetti M, Randolph AG. Efficacy of interventions for bronchiolitis in critically ill infants: A systematic review and meta-analysis.
Pediatr Crit Care Med. 2004 Sep;5(5):482-489. [abstract]
Review, by Omer Mansoor MD, West Virginia University, Morgantown, WV
Bronchiolitis/RSVKim IK, Phrampus E, Sikes K, Pendleton J, Saville A, Corcoran T, Gracely E, Venkataraman S. Helium-oxygen therapy for infants with bronchiolitis: a randomized controlled trial.
Arch Pediatr Adolesc Med 2011 Dec;165(12):1115-22. [abstract]
Review, by Robert Ricketts MD, Texas Children's Hospital, Houston TX
Bronchiolitis/RSVRoosevelt G, Sheehan K, Grupp-Phelan J, , Dexamethasone in bronchiolitis: a randomised controlled trial.
Lancet 1996 348:292-5 [abstract]
Review, by E. Stiles
Bronchiolitis/RSVB?low SM, Nir M, Levin E, , Prednisolone Treatment of Respiratory Syncytial Virus Infection: A Randomized Controlled Trial of 147 Infants.
Pediatrics 1999 104: e77 [abstract] [Full-Text]
Review, by J. Hageman B. Markovitz
Bronchiolitis/RSVGanu SS, Gautam A, Wilkins B, Egan J. Increase in use of non-invasive ventilation for infants with severe bronchiolitis is associated with decline in intubation rates over a decade.
Intensive Care Med 2012 38(7):1177-83 [abstract]
Review, by Rachel Sirignano MD, University of California Irvine and Children's Hospital Orange Country, Irvine CA
Bronchiolitis/RSVKuzik BA, Al-Qadhi SA, Kent S, Flavin MP, Hopman W, Hotte S, Gander S. Nebulized hypertonic saline in the treatment of viral bronchiolitis in infants.
J Pediatr. 2007 151(3):266-70, 270.e1 [abstract]
Review, by Shadi Malaeb MD and Scot Bateman MD, University of Massachusetts Medical School
Bronchiolitis/RSVTibby SM, Hatherill M, Wright SM, , Exogenous Surfactant Supplementation in Infants with Respiratory Syncytial Virus Bronchiolitis
Am J Respir Crit Care Me 2000 162: 1251-1256 [abstract] [Full-Text]
Review, by S Kache
Bronchiolitis/RSVMartinon-Torres F, Rodriguez-Nunez A, Martinon-Sanchez JM, , Heliox Therapy in Infants With Acute Bronchiolitis
Pediatrics 2002 109:68-73 [abstract] [Full-Text]
Review, by H Trivedi K Biagas
Bronchiolitis/RSVLuchetti M, Ferrero F, Gallini C, et al., Multicenter randomized, controlled study of porcine surfactant in severe respiratory syncytial virus-induced respiratory failure
Pediatric Critical Care Medicine 2002 3:261-268 [abstract] [Full-Text]
Review, by M Wilhelm
Bronchiolitis/RSVChowdhury MM, McKenzie SA, Pearson CC, Carr S, Pao C, Shah AR, Reus E, Eliahoo J, Gordon F, Bland H, Habibi P Heliox Therapy in Bronchiolitis: Phase III Multicenter Double-Blind Randomized Controlled Trial
Pediatrics 2013 31:661–669 [abstract]
Review, by Saurabh Chiwane MD, Wayne State University, Detroit MI
Bronchiolitis/RSVKing VJ, Viswanathan M, Bordley WC, et al. Pharmacologic Treatment of Bronchiolitis in Infants and Children: A Systematic Review
Arch Pediatr Adolesc Med 2004 ;158 127-137 [abstract]
Review, by Chloe Johnston MD, Imperial College Healthcare NHS Trust, London, UK
Bronchiolitis/RSVPatel H, Platt RW, Pekeles GS, Ducharme FM, A randomized, controlled trial of the effectiveness of nebulized therapy with epinephrine compared with albuterol and saline in infants hospitalized for acute viral bronchiolitis
J Pediatr 2002 141(6):818-24 [abstract]
Review, by R Lambert R Sanders
Bronchiolitis/RSVPlint AC, Johnson DW, Patel H, Wiebe N, Correll R, Brant R, Mitton C, Gouin S, Bhatt M, Joubert G, Black KJ, Turner T, Whitehouse S, Klassen TP; Pediatric Emergency Research Canada (PERC). Epinephrine and dexamethasone in children with bronchiolitis.
N Engl J Med 2009 360(20):2079-89. [abstract]
Review, by Mary Rose B. Valina MD, West Virginia University, Morgantown, WV
Bronchiolitis/RSVWainwright C, Altamarino L, Medico-Cirujano , et al., A Multicenter, Randomized, Double-Blind, Controlled Trial of Nebulized Epinephrine in Infants with Acute Bronchiolitis.
N Engl J Med 2003 349:27-35 [abstract]
Review, by P Prodhan N Noviski
Bronchiolitis/RSVMcKiernan C, Chua LC, Visintainer PF, Allen H. High Flow Nasal Cannulae Therapy in Infants with Bronchiolitis.
J Pediatr 2010 156(4):634-638 [abstract]
Review, by James McNally MD, Children's Hospital of Eastern Ontario, Ottawa, Ontario, Canada
Diagnosis of Aspergillosis in the ICUMeersseman W, Lagrou K, Maertens J, et al. Galactomannan in bronchoalveolar lavage fluid: a tool for diagnosing aspergillosis in intensive care unit patients.
Am J Respir Crit Care Med 2008 177(1):27-34 [abstract]
Review, by Anglela Mata MD, Children's Hospital of Michigan, Wayne State University, Detroit MI
Diagnosis of empyemaLe Monnier A, Carbonnelle E, Zahar JR, Le Bourgeois M, Abachin E, Quesne G, Varon E, Descamps P, De Blic J, Scheinmann P, Berche P, Ferroni A. Microbiological diagnosis of empyema in children: comparative evaluations by culture, polymerase chain reaction, and pneumococcal antigen detection in pleural fluids.
Clin Infect Dis 2006 15;42(8):1135-40 [abstract]
Review, by Stephanie Grayson MD, West Virginia University, Morgantown, WV
Dialysis in the ICUWert RV, Friedrich JO, Scales DC, Wald R, Adhikari NK; for the University of Toronto Acute Kidney Injury Research Group. High-dose renal replacement therapy for acute kidney injury: Systematic review and meta-analysis
Crit Care Med 2010 38(5):1360-1369 [abstract]
Review, by Joseph Philip MD, Texas Children's Hospital and Baylor College of Medicine, Houston TX
ECMO for Respiratory FailureNoah MA, Peek GJ, Finney SJ, Griffiths MJ, Harrison DA, Grieve R, Sadique MZ, Sekhon JS, McAuley DF, Firmin RK, Harvey C, Cordingley JJ, Price S, Vuylsteke A, Jenkins DP, Noble DW, Bloomfield R, Walsh TS, Perkins GD, Menon D, Taylor BL, Rowan KM. Referral to an Extracorporeal Membrane Oxygenation Center and Mortality Among Patients With Severe 2009 Influenza A(H1N1)
JAMA 2011 306 1659-1668 [abstract]
Review, by Alicia A. DeMarco MD, Helen DeVos Children's Hospital, Grand Rapids MI
Noninvasive ventilationJavouhey E, Barats A, Richard N, Stamm D, Floret D. Non-invasive ventilation as primary ventilatory support for infants with severe bronchiolitis.
Intensive Care Med 2008 34(9):1608-14 [abstract]
Review, by Christopher Page-Goertz MD, Medical College of Wisconsin, Milwaukee, WI
Nosocomial infection preventionLacherade JC, De Jonghe B, Guezennec P, Debbat K, Hayon J, Monsel A, Fangio P, Appere de Vecchi C, Ramaut C, Outin H, Bastuji-Garin S. Intermittent Subglottic Secretion Drainage and Ventilator-associated Pneumonia: A Multicenter Trial.
Am J Respir Crit Care Med 2010 182(7):910-7. [abstract]
Review, by Efren Gutierrez MD, Texas Children's Hospital and Baylor College of Medicine, Houston TX
Nosocomial infection preventionNseir S, Zerimech F, Fournier C, Lubret R, Ramon P, Durocher A, Balduyck M. Continuous Control of Tracheal Cuff Pressure and Microaspiration of Gastric Contents in Critically Ill Patients.
Am J Respir Crit Care Med 2011 184:1041-1047 [abstract]
Review, by Orkun Baloglu MD, Karen Marcdante MD, Medical College of Wisconsin, Children's Hospital of Wisconsin, Milwaukee, WI
Nosocomial infection preventionAfessa B, Shorr AF, Anzueto AR, Craven DE, Schinner R, Kollef MH. Association Between a Silver-Coated Endotracheal Tube and Reduced Mortality in Patients With Ventilator-Associated Pneumonia.
Chest 2010 137;1015-1021 [abstract]
Review, by Fong Lam MD, Baylor College of Medicine, Texas Children's Hospital, Houston TX
PertussisBerger JT, Carcillo JA, Shanley TP, Wessel DL, Clark A, Holubkov R, Meert KL, Newth CJ, Berg RA, Heidemann S, Harrison R, Pollack M, Dalton H, Harvill E, Karanikas A, Liu T, Burr JS, Doctor A, Dean JM, Jenkins TL, Nicholson CE; for the Eunice Kennedy Shri Critical Pertussis Illness in Children: A Multicenter Prospective Cohort Study
Pediatr Crit Care Med. 2013 May;14(4):356-365. [abstract] [Full-Text]
Review, by Jordana Goldman MD, Baylor College of Medicine, Texas Children's Hospital, Houston TX
PertussisRowlands HE, Goldman AP, Harrington K, Karimova A, Brierley J, Cross N, Skellett S, Peters MJ. Impact of Rapid Leukodepletion on the Outcome of Severe Clinical Pertussis in Young Infants
Pediatrics 2010 126;816-827 [abstract]
Review, by Kyle Lemley MD, Children's Mercy Hospital and Clinics, Kansas City MO
Prevention/Diagnosis/Treatment of Ventilator-Associated PneumoniaSterling T, Ho EJ, Brehm WT, Kirkpatrick MB, Diagnosis and treatment of ventilator-associated pneumonia--Impact on survival. A decision analysis.
Chest 1996 110: 1025-34 [abstract]
Review, by Adrienne Randolph
Prevention/Diagnosis/Treatment of Ventilator-Associated PneumoniaWu CL, le Yang D, Wang NY, Kuo HT, Chen PZ. Quantitative Culture of Endotracheal Aspirates in the Diagnosis of Ventilator-Associated Pneumonia in Patients With Treatment Failure
Chest 2002 ;122 662-668. [abstract]
Review, by SA Grayson MD, PS Hilvers MD, A Smith MD, West Virginia University Children's Hospital, Morgantown WV
Prevention/Diagnosis/Treatment of Ventilator-Associated PneumoniaHolzapfel L, Chastang C, Demingeon G, , A randomized study assessing the systematic search for maxillary sinusitis in nasotracheally mechanically ventilated patients. Influence of nosocomial maxillary sinusitis on the occurrence of ventilator-associated pneumonia
Am J Respir Crit Care Me 1999 26:645-650 [abstract]
Review, by Kshama Daphtary, MD Kathleen Meert, MD
Prevention/Diagnosis/Treatment of Ventilator-Associated PneumoniaSanchez Garcia MS, Cambronero Galache JA, Diaz JL, , Effectiveness and Cost of Selective Decontamination of the Digestive Tract in Critically Ill Intubated Patients. A randomized, double-blind, placebo-controlled, multicenter trial
Am J Respir Crit Care Me 1998 130:191-6 [abstract]
Review, by Paulette Johnson, MD Barry Markovitz, MD
Prevention/Diagnosis/Treatment of Ventilator-Associated PneumoniaKrueger WA, Lenhart FP, Neeser G et al. Influence of Combined Intravenous and Topical Antibiotic Prophylaxis on the Incidence of Infections, Organ Dysfunctions, and Mortality in Critically Ill Surgical Patients: A Prospective, Stratified, Randomized, Double-Blind, Placebo-controlled Clinica
Am J Respir Crit Care Med 2002 ;166 1029-1037 [abstract]
Review, by Luna Sharma MD, West Virginia University
Prevention/Diagnosis/Treatment of Ventilator-Associated PneumoniaKoeman M, van der Ven AJ, Hak E, et al. Oral Decontamination with Chlorhexidine Reduces the Incidence of Ventilator-associated Pneumonia.
Am J Respir Crit Care Med. 2006 173(12):1348-5 [abstract]
Review, by Kelby G. Maher DO, Scot T. Bateman MD, University of Massachusetts Medical Center, Worcester, MA
Prevention/Diagnosis/Treatment of Ventilator-Associated PneumoniaLabenne M, Poyart C, Rambaud C, , Blind protected specimen brush and bronchoalveolar lavage in ventilated children
Crit Care Med 1999 1999 ;27:2537-43 [abstract]
Review, by R Sanders AL Graciano
Prevention/Diagnosis/Treatment of Ventilator-Associated PneumoniaSrinivasan R, Asselin J, Gildengorin G, Wiener-Kronish J, Flori HR A prospective study of ventilator-associated pneumonia in children.
Pediatrics 2009 123(4):1108-15. [abstract]
Review, by Julia D. Ruiz MD, University of Texas Health Science Center at San Antonio, TX
Prevention/Diagnosis/Treatment of Ventilator-Associated PneumoniaKollef MH, Afessa B, Anzueto A, et al. for the NASCENT Investigation Group Silver-Coated Endotracheal Tubes and Incidence of Ventilator-Associated Pneumonia: The NASCENT Randomized Trial
JAMA 2008 300(7):805-813 [abstract]
Review, by Guruprasad T. Mahadevaiah MD and Sameer Gupta MD, University of Minnesota Children’s Hospital, Fairview MN
Prevention/Diagnosis/Treatment of Ventilator-Associated PneumoniaBergmans DCJJ, Bonten MJM, Gaillard CA, et al., Prevention of Ventilator-associated Pneumonia by Oral Decontamination A Prospective, Randomized, Double-blind, Placebo-controlled Study
Am J Respir Crit Care Me 2001 164:382-388 [abstract]
Review, by P Kamat J Stockwell
Prevention/Diagnosis/Treatment of Ventilator-Associated PneumoniaNtoumenopoulos G, Presneill JJ, McElholum M, Cade JF, Chest physiotherapy for the prevention of ventilator-associated pneumonia
Intensive Care Med 2002 28: 850-856 [abstract]
Review, by N Hoover J Stockwell
Prevention/Diagnosis/Treatment of Ventilator-Associated PneumoniaLopriore , Markhorst D, Gemke RJBJ, , Ventilator-associated pneumonia and upper airway colonisation with Gram negative bacilli: the role of stress ulcer prophylaxis in children
Intensive Care Med 2002 28: 763-767 [abstract]
Review, by D Godorov
Prevention/Diagnosis/Treatment of Ventilator-Associated PneumoniaGauvin F, Dassa C, Chaibou M, Proulx F, Farrell CA, Lacroix J. Ventilator-associated pneumonia in intubated children: comparison of different diagnostic methods.
Pediatr Crit Care Med. 2003 Oct;4(4):437-43. [abstract]
Review, by Kathryn Young MD, Medical College of Wisconsin and Children's Hospital of Wisconsin, Milwaukee, WI
Prevention/Diagnosis/Treatment of Ventilator-Associated PneumoniaZack JE, Garrison T, Trovillion E, Clinkscale D, Coopersmith CM, Fraser VJ, Kollef MH. Effect of an education program aimed at reducing the occurrence of ventilator-associated pneumonia
Crit Care Med. 2002 ;30(11):2407-12. [abstract]
Review, by William Cutrer MD, Baylor College of Medicine, Texas Children's Hospital, Houston TX
Prevention/Diagnosis/Treatment of Ventilator-Associated PneumoniaSirvent JM, Vidaur L, Gonzalez S, et al., Microscopic examination of intracellular organisms in protected bronchoalveolar mini-lavage fluid for the diagnosis of ventilator-associated pneumonia
Chest 2003 123(2):518-23 [abstract]
Review, by C Kennedy
Prevention/Diagnosis/Treatment of Ventilator-Associated PneumoniaSingh N, Rogers P, Atwood CW, Wagener MM, Yu VL. Short-course Empiric Antibiotic Therapy for Patients with Pulmonary Infiltrates in the Intensive Care Unit. A proposed solution for indiscriminate antibiotic prescription
Am J Respir Crit Care Med. 2000 ;162(2):505-511. [abstract] [Full-Text]
Review, by Christine Vohwinkel MD, Ryan Carroll MD, Children’s Memorial Hospital, Chicago IL
Prevention/Diagnosis/Treatment of Ventilator-Associated PneumoniaSmulders K, van der Hoeven H, Weers-Pothoff I, Vandenbroucke-Grauls C, A Randomized Clinical Trial of Intermittent Subglottic Secretion Drainage in Patients Receiving Mechanical Ventilation
Chest 2002 121: 858-862 [abstract]
Review, by M Sehgal
Prevention/Diagnosis/Treatment of Ventilator-Associated PneumoniaBarret JP, Ramzy PI, Wolf SE, Herndon DN, Sensitivity and Specificity of Bronchoalveolar Lavage and Protected Bronchial Brush in the Diagnosis of Pneumonia in Pediatric Burn Patients
Arch Surg 1999 134:1243-1247 [abstract]
Review, by A Vohra
Prevention/Diagnosis/Treatment of Ventilator-Associated PneumoniaChastre J, Wolff M, Fagon J-Y, et al., Comparison of 8 vs 15 Days of Antibiotic Therapy for Ventilator-Associated Pneumonia in Adults: A Randomized Trial
JAMA 2003 290 2588-2598 [abstract]
Review, by J Cortes
Prevention/Diagnosis/Treatment of Ventilator-Associated PneumoniaSachdev A, Chugh K, Sethi M, Gupta D, Wattal C, Menon G. Diagnosis of ventilator-associated pneumonia in children in resource-limited setting: A comparative study of bronchoscopic and nonbronchoscopic methods
Pediatr Crit Care Med. 2010 11: 258-266 [abstract]
Review, by Joseph Philip MD, Baylor College of Medicine and Texas Children's Hospital, Houston TX
Prevention/Diagnosis/Treatment of Ventilator-Associated PneumoniaJung YJ, Koh Y, Hong SB, Chung JW, Ho Choi S, Kim NJ, Kim MN, Choi IS, Han SY, Kim WD, Yun SC, Lim CM Effect of vancomycin plus rifampicin in the treatment of nosocomial methicillin-resistant Staphylococcus aureus pneumonia.
Crit Care Med 2010 38(1):175-80 [abstract]
Review, by Neeraj Srivastava MD, Baylor College of Medicine and Texas Children's Hospital, Houston TX
Prevention/Diagnosis/Treatment of Ventilator-Associated PneumoniaHeyland DK, Dodek P, Muscedere J, Day A, Cook D; for the Canadian Critical Care Trials Group. Randomized trial of combination versus monotherapy for the empiric treatment of suspected ventilator-associated pneumonia
Crit Care Med. 2008 36:737-744 [abstract]
Review, by Debra Davey MD, Primary Children's Hospital, University of Utah, Salt Lake City, UT
Prevention/Diagnosis/Treatment of Ventilator-Associated PneumoniaMentec H, May-Michelangeli L, Rabbat A, et al., Blind and bronchoscopic sampling methods in suspected ventilator-associated pneumonia: A multicentre prospective study
Intensive Care Med 2004 30-1319-1326. [abstract]
Review, by M Weber
Prevention/Diagnosis/Treatment of Ventilator-Associated PneumoniaJongerden IP, Rovers MM, Grypdonck MH, Bonten MJ. Open and closed endotracheal suction systems in mechanically ventilated intensive care patients: A meta-analysis.
Crit Care Med 2007 35:260-270 [abstract]
Review, by Stephen Tomek MD, University of Rochester Medical Center, Rochester NY
Therapy for AtelectasisRaoof S, Chowdhrey N, Raoof S, et al., Effect of Combined Kinetic Therapy and Percussion Therapy on the Resolution of Atelectasis in Critically Ill Patients
Chest 1999 115:1658-1666 [abstract]
Review, by O Borisenko
Tracheostomy in the ICUTerragni PP, Antonelli M, Fumagalli R, et al. Early vs Late Tracheotomy for Prevention of Pneumonia in Mechanically Ventilated Adult ICU Patients. A Randomized Controlled Trial
JAMA 2010 303(15):1483-1489 [abstract]
Review, by Neeraj Srivastava MD, Baylor College of Medicine and Texas Children's Hospital, Houston TX
Treatment of CroupAusejo M, Saenz, Pham, , The effectiveness of glucocorticoids in treating croup: meta-analysis.
Br Med J 1999 8:491-9 [abstract]
Review, by Melchor Sanchez-Mendiola
Treatment of CroupWeber JE, Chudnofsky CR, Younger JG, et al., A randomized comparison of helium-oxygen mixture (heliox) and racemic epinephrine for the treatment of moderate to severe croup
Pediatrics 2001 Jun;107(6):E96 [abstract] [Full-Text]
Review, by M Cooper
Treatment of CroupScolnik D, Coates AL, Stephens D, et al. Controlled Delivery of High vs Low Humidity vs Mist Therapy for Croup in Emergency Departments: A Randomized Controlled Trial.
JAMA 2006 ;295 1274-1280 [abstract]
Review, by Eddie Gordon MD, Baylor College of Medicine, Texas Children's Hospital, Houston TX
Respiratory
Albumin and Lasix for ARDSMartin GS, Moss M, Wheeler AP, Mealer M, Morris JA, Bernard GR. A randomized, controlled trial of furosemide with or without albumin in hypoproteinemic patients with acute lung injury.
Crit Care Med. 2005 Aug;33(8):1681-1687. [abstract]
Review, by Robert B. Kelly MD, Irwin K. Weiss MD, Mattel Children’s Hospital at UCLA, Los Angeles, CA
Albumin and Lasix for ARDSMartin GS, Mangialardi RJ, Wheeler AP, et al, Albumin and furosemide therapy in hypoproteinemic patients with acute lung injury
Crit Care Med 2002 30(10):2175-82 [abstract]
Review, by D Godorov
ALI/ARDS alternative therapiesCraig TR, Duffy MJ, Shyamsundar M, McDowell C, O A Randomized Clinical Trial of Hydroxymethylglutaryl-CoA reductase Inhibition for Acute Lung Injury (The HARP study).
Am J Respir Crit Care Med 2011 183:620-626. [abstract]
Review, by Gitanjali Indramohan MD, James Lin MD, UCLA Mattel Children's Hospital, Los Angeles, CA
ALI/ARDS alternative therapiesMatthay MA, Brower RG, Carson S, Douglas IS, Eisner M, Hite D, Holets S, Kallet RH, Liu KD, Macintyre N, Moss M, Schoenfeld D, Steingrub J, Thompson BT; The National Heart, Lung, and Blood Institute ARDS Clinical Trials Network. Randomized, Placebo-Controlled Clinical Trial of an Aerosolized Beta-2 Agonist for Treatment of Acute Lung Injury.
Am J Respir Crit Care Med 2011 184: 561-568. [abstract]
Review, by Priyanka Naik MBBS MS, Varsha Gharpure MD, Advocate Lutheran General Children’s Hospital, Park Ridge, IL
ALI/ARDS alternative therapiesRice TW, Wheeler AP, Thompson BT, Deboisblanc BP, Steingrub J, Rock P; for the NHLBI ARDS Clinical Trials Network. Enteral Omega-3 Fatty Acid, {gamma}-Linolenic Acid, and Antioxidant Supplementation in Acute Lung Injury.
JAMA 2011 JAMA. 2011;306 1574-1581 [abstract]
Review, by Vinod Havalad MD, Columbia University, New York City, NY
ALI/ARDS alternative therapiesPerkins GD, McAuley DF, Thickett DR, Gao F. The Beta Agonist Lung Injury Trial (BALTI) a randomised placebo controlled clinical trial.
Am J Respir Crit Care Med. 2006 ;173 281-287 [abstract]
Review, by Matei Petrescu, MD, Baylor College of Medicine, Texas Children's Hospital, Houston TX
ALI/ARDS alternative therapiesMercat A, Richard J-C M, Vielle B, et al. for the Expiratory Pressure (Express) Study Group Positive End-Expiratory Pressure Setting in Adults With Acute Lung Injury and Acute Respiratory Distress Syndrome: A Randomized Controlled Trial.
JAMA 2008 299 646-655 [abstract]
Review, by Aveek Jayant, Postdoctoral student, Dept of Anaesthesiology, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Medical College PO, Thiruvananthapuram, India
ALI/ARDS alternative therapiesFan E, Wilcox ME, Brower RG, Stewart TE, Mehta S, Lapinsky SE, Meade MO, Ferguson ND. Recruitment Maneuvers for Acute Lung Injury: A Systematic Review.
Am J Respir Crit Care Med 2008 178 1156-1163 [abstract]
Review, by Ivie D Esangbedo MD MPH, Baylor College of Medicine and Texas Children’s Hospital, Houston TX
Asthma treatmentWheeler DS, Jacobs BR, Kenreigh CA, et al., Theophylline versus terbutaline in treating critically ill children with status asthmaticus: A prospective, randomized, controlled trial
Pediatric Critical Care Medicine 2005 Mar;6(2):142-147 [abstract]
Review, by A Sharangpani J Natale
Asthma treatmentKim IK, Phrampus E, Venkataraman S, et al. , Helium/oxygen-driven albuterol nebulization in the treatment of children with moderate to severe asthma exacerbations: a randomized, controlled trial.
Pediatrics 2005 Nov;116(5):1127-33 [abstract]
Review, by N Dean
Asthma treatmentOsmond MH, Klassen TP, , , Efficacy of ipratropium bromide in acute childhood asthma: a meta-analysis
Acad Emergency Med 1995 339:429-435 [abstract]
Review, by Al Torres, MD, MS
Asthma treatmentCiarallo, L, Sauer AH, Shannon NW, , Intravenous magnesium therapy for moderate to severe pediatric asthma: Results of a randomized, placebo-controlled trial.
J Pediatr 1996 129: 809-14 [abstract]
Review, by Barry Markovitz
Asthma treatmentQureshi F, Pestian J, Davis P, Zaritsky A, Effect of nebulized ipratropium bromide on the hospitalization rates of children with asthma.
N Engl J Med 1998 26:1164-1172 [abstract]
Review, by Al Torres, MD, MS G. Kris Bysani, MD
Asthma treatmentYung M, South M, , , Randomized controlled trial of aminophylline for severe acute asthma.
Arch Dis Child 1998 336: 597-604 [abstract]
Review, by Girish Deshpande, MD Kathleen Meert, MD
Asthma treatmentSchuh S, Reisman J, Alshehri M, Annie Dupuis, Mary Corey A comparison of inhaled fluticasone and oral prednisone for children with severe acute asthma.
N Engl J Med 2000 343(10):689-94 [abstract]
Review, by A. Torres
Asthma treatmentCiarallo L, Brousseau D, Reinert S, , Higher-Dose Intravenous Magnesium Therapy for Children With Moderate to Severe Acute Asthma
Arch Pediatr Adolesc Med 2000 154:979-983 [abstract] [Full-Text]
Review, by M Chavolla
Asthma treatmentReam RS, Loftis LL, Albers GM, , Efficacy of IV Theophylline in Children With Severe Status Asthmaticus
Chest 2001 119:1480-1488 [abstract] [Full-Text]
Review, by M Chavolla
Asthma treatmentWilliams AM, Abramo TJ, Shah MV, Miller RA, Burney-Jones C, Rooks S, Estrada C, Arnold DH. Safety and clinical findings of BiPAP utilization in children 20 kg or less for asthma exacerbations.
Intensive Care Med 2011 37(8):1338-43 [abstract]
Review, by Eunice Torres MD, Downing Lu MD, Walter Reed National Military Medical Center, Bethesda MD
Asthma treatmentQureshi F, Zaritsky A, Poirier MP, , Comparative efficacy of oral dexamethasone versus oral prednisone in acute pediatric asthma
J Pediatr 2001 139(1):20-6 [abstract]
Review, by A Torres
Asthma treatmentHo AMH, Lee A, Karmakar MK , et al., Heliox vs Air-Oxygen Mixtures for the Treatment of Patients With Acute Asthma: A Systematic Overview
Chest 2003 123 882-890 [abstract]
Review, by G Wolf
Asthma treatmentSoroksky A, Stav D, Shpirer I, , A Pilot Prospective, Randomized, Placebo-Controlled Trial of Bilevel Positive Airway Pressure in Acute Asthmatic Attack
Chest 2003 123 1018-1025 [abstract]
Review, by K Lewis
Asthma treatmentThill PJ, McGuire JK, Baden HP, et al., Noninvasive positive-pressure ventilation in children with lower airway obstruction
Pediatric Critical Care Medicine 2004 Jul;5(4):337-342 [abstract]
Review, by S Rishmawi
Detection of intrinsic PEEPKress JP, O'Connor MF, Schmidt GA, , Clinical Examination Reliably Detects Intrinsic Positive End-Expiratory Pressure in Critically Ill, Mechanically Ventilated Patients
Am J Respir Crit Care Me 1999 159: 290-294 [abstract]
Review, by R. Orellana M. McPherson
Diagnosis of ALI/ARDSKhemani RG, Patel NR, Bart RD 3rd, Newth CJ. Comparison of the Pulse Oximetric Saturation/Fraction of Inspired Oxygen Ratio and the PaO2/Fraction of Inspired Oxygen Ratio in Children
Chest 2009 135(3):662-8 [abstract]
Review, by Margaret Scheffler MD, Baylor College of Medicine and Texas Children's Hospital, Houston, TX
ECMO for Respiratory FailureZabrocki LA, Brogan TV, Statler KD, Poss WB, Rollins MD, Bratton SL. Extracorporeal membrane oxygenation for pediatric respiratory failure: Survival and predictors of mortality
Crit Care Med 2011 39(2):364-70. [abstract]
Review, by Matthew Musick MD, Baylor College of Medicine, Texas Children's Hospital, Houston TX
ECMO for Respiratory FailureDomico MB, Ridout DA, Bronicki R, Anas NG, Cleary JP, Cappon J, Goldman AP, Brown KL. The impact of mechanical ventilation time before initiation of extracorporeal life support on survival in pediatric respiratory failure: A review of the extracorporeal life support registry
Pediatr Crit Care Med. 2012 Jan;13(1):16-21. [abstract] [Full-Text]
Review, by Michael Keenaghan MD, New York Presbyterian-Columbia University Medical Center, New York, NY
ECMO for Respiratory FailureBrogan TV, Zabrocki L, Thiagarajan RR, Rycus PT, Bratton SL Prolonged extracorporeal membrane oxygenation for children with respiratory failure
Pediatr Crit Care Med. 2012 13:e249–e254 [abstract] [Full-Text]
Review, by Rajat Pareek MD, Le Bonheur Children’s Hospital, University of Tennessee Health Science Center, Memphis TN
ECMO for Respiratory FailurePeek GJ, Mugford M, Tiruvoipati R, Wilson A, Allen E, Thalanany MM, Hibbert CL, Truesdale A, Clemens F, Cooper N, Firmin RK, Elbourne D; for the CESAR trial collaboration. Efficacy and economic assessment of conventional ventilatory support versus extracorporeal membrane oxygenation for severe adult respiratory failure (CESAR): a multicentre randomised controlled trial.
Lancet 2009 Sep 15. [Epub ahead of print] [abstract]
Review, by Sabrina Derrington MD, Childrens Hospital Los Angeles, Los Angeles CA
ECMO for Respiratory FailurePettignano R, Fortenberry JD, Heard ML, et al., Primary use of the venovenous approach for extracorporeal membrane oxygenation in pediatric acute respiratory failure
Pediatric Critical Care Medicine 2003 4(3):291-8 [abstract]
Review, by M Sharma
Enteral feedingThe National Heart, Lung, and Blood Institute Acute Respiratory Distress Syndrome (ARDS) Clinical Trials Network Initial Trophic vs Full Enteral Feeding in Patients With Acute Lung Injury: The EDEN Randomized Trial.
JAMA 2012 307:832-842 [abstract]
Review, by Natasha Afonso MD, Texas Children's Hospital and Baylor College of Medicine, Houston TX
Fluid management in the PICUValentine SL, Sapru A, Higgerson RA, Spinella PC, Flori HR, Graham DA, Brett M, Convery M, Christie LM, Karamessinis L, Randolph AG Fluid balance in critically ill children with acute lung injury
Crit Care Med 2012 40:2883–2889 [abstract]
Review, by Fernando Beltramo MD, Children's Hospital Los Angeles, Los Angeles CA
Fluid management in the PICUArikan AA, Zappitelli M, Goldstein SL, Naipaul A, Jefferson LS, Loftis LL. Fluid overload is associated with impaired oxygenation and morbidity in critically ill children
Pediatr Crit Care Med. 2012 May;13(3):253-8 [abstract] [Full-Text]
Review, by William Bortcosh MD, University of Massachusetts Medical Center, Worcester MA
Goal Directed Therapy in SepsisIscimen R, Cartin-Ceba R, Yilmaz M, Khan H, Hubmayr RD, Afessa B, Gajic O. Risk factors for the development of acute lung injury in patients with septic shock: an observational cohort study.
Crit Care Med 2008 36(5):1518-22 [abstract]
Review, by Daniel J. Adams MD, Christopher M. Watson MD MPH, Walter Reed Army Medical Center, Washington, DC
High Frequency Ventilation for Respiratory FailureDavid M, Weiler N, Heinrichs W, et al, High-frequency oscillatory ventilation in adult acute respiratory distress syndrome
Intensive Care Med 2003 Oct;29(10):1656-65 [abstract]
Review, by J O'Rourke N Mehta
High Frequency Ventilation for Respiratory FailureConti G, Montini L, Pennisi MA, et al., A prospective, blinded evaluation of indexes proposed to predict weaning from mechanical ventilation
Intensive Care Med 2004 May;30(5):830-6 [abstract]
Review, by A Wratney
High Frequency Ventilation for Respiratory FailureArnold JH, Hanson JH, Toro-Figuero LO, , Prospective, randomized comparison of high-frequency oscillatory ventilation and conventional mechanical ventilation in pediatric respiratory failure
Crit Care Med 1994 22(10):1530-9 [abstract]
Review, by X Garcia
High Frequency Ventilation for Respiratory FailureFerguson ND, Cook DJ, Guyatt GH, Mehta S, Hand L, Austin P, Zhou Q, Matte A, Walter SD, Lamontagne F, Granton JT, Arabi YM, Arroliga AC, Stewart TE, Slutsky AS, Meade MO; the OSCILLATE Trial Investigators and the Canadian Critical Care Trials Group. High-Frequency Oscillation in Early Acute Respiratory Distress Syndrome.
N Engl J Med 2013 368:795-805 [abstract]
Review, by Matthew Pesek MD, Texas Children's Hospital and Baylor College of Medicine, Houston TX
High Frequency Ventilation for Respiratory FailureYoung D, Lamb S, Shah S, Mackenzie I, Tunnicliffe W, Lall R, Rowan K, Cuthbertson BH; the OSCAR Study Group. High-Frequency Oscillation for Acute Respiratory Distress Syndrome
N Engl J Med 2013 368:806-813 [abstract]
Review, by Sara Aghamohammadi MD, Elena Chung MD, Children's Hospital Los Angeles, Los Angeles CA
High Frequency Ventilation for Respiratory FailureDerdak S, Mehta S, Stewart TE, et al., High-Frequency Oscillatory Ventilation for Acute Respiratory Distress Syndrome in Adults
Am J Respir Crit Care Me 2002 166:801-808 [abstract]
Review, by K Ventre
Lung protection for organ recoveryMascia L, Pasero D, Slutsky AS, Arguis MJ, Berardino M, Grasso S, Munari M, Boifava S, Cornara G, Della Corte F, Vivaldi N, Malacarne P, Del Gaudio P, Livigni S, Zavala E, Filippini C, Martin EL, Donadio PP, Mastromauro I, Ranieri VM. Effect of a lung protective strategy for organ donors on eligibility and availability of lungs for transplantation: a randomized controlled trial
JAMA 2010 304(23):2620-7 [abstract]
Review, by Ryan Stark MD, Texas Children's Hospital and Baylor College of Medicine, Houston, TX
Macrolides and ALIWalkey AJ, Wiener RS Macrolide Antibiotics and Survival in Patients with Acute Lung Injury.
Chest 2012 141:1153-1159 [abstract]
Review, by Matthew Pesek MD, Texas Children's Hospital and Baylor College of Medicine, Houston TX
Mechanical ventilation durationPayen V, Jouvet P, Lacroix J, Ducruet T, Gauvin F. Risk factors associated with increased length of mechanical ventilation in children
Pediatr Crit Care Med. 2012 13:152–157 [abstract]
Review, by Jennifer Flint MD and Kelly Tieves DO, Children's Mercy Hospital, University of Missouri, Kansas City MO
Mechanical Ventilation WeaningThiagarajan RR, Bratton SL, Martin LD, et al., Predictors of Successful Extubation in Children
Am J Respir Crit Care Me 1999 160:1562-1566 [abstract]
Review, by K Yen
Mechanical Ventilation WeaningKhamiees M, Raju P, DeGirolamo A, Amoateng-Adjepong Y, Manthous CA. Predictors of Extubation Outcome in Patients Who Have Successfully Completed a Spontaneous Breathing Trial
Chest 2001 120 1262-1270 [abstract]
Review, by J Barron
Mechanical Ventilation WeaningHuang CJ, Lin HC. Association between adrenal insufficiency and ventilator weaning.
Am J Respir Crit Care Med. 2006 Feb 1;173(3):276-80. [abstract]
Review, by Christine Agee, CPNP-AC/PC, Duke University Medical Center, Durham, NC
Mechanical Ventilation WeaningForonda FA, Troster EJ, Farias JA, Barbas CS, Ferraro AA, Faria LS, Bousso A, Panico FF, Delgado AF. The impact of daily evaluation and spontaneous breathing test on the duration of pediatric mechanical ventilation: A randomized controlled trial.
Crit Care Med 2011 39:2526–2533 [abstract]
Review, by Lindsay Blackmon MD and Scottie B. Day MD, University of Kentucky, Lexington KY
Mechanical Ventilation WeaningButler R, Keenan SP, Inman KJ, Sibbald WJ, Block G. Is there a preferred technique for weaning the difficult-to-wean patient? A systematic review of the literature.
Crit Care Med 1999 319:595-600 [abstract] [Full-Text]
Review, by A. Torres J. Wohrley
Mechanical Ventilation WeaningFerguson LP, Walsh BK, Munhall D, Arnold JH A spontaneous breathing trial with pressure support overestimates readiness for extubation in children.
Pediatr Crit Care Med. 2011 12:e330 – e335 [abstract] [Full-Text]
Review, by Katherine Cashen MD, Lurie Children's Hospital and Northwestern University School of Medicine, Chicago, IL
Mechanical Ventilation WeaningChavez A, Cruz RD, Zaritsky A. Spontaneous breathing trial predicts successful extubation in infants and children
Pediatric Critical Care Medicine 2006 7(4):324-8 [abstract] [Full-Text]
Review, by Karl Yen MD, Children
Mechanical Ventilation WeaningFarias JA, Alia I, Esteban A, Golubicki, Olazarri FA Weaning from mechanical ventilation in pediatric intensive care patients.
Intensive Care Med 1998 24: 1070-1075 [abstract]
Review, by P. Jines A. Madikians
Mechanical Ventilation WeaningBaumeister BL, el-Khatib M, Smith PG, Blumer JL, Evaluation of predictors of weaning from mechanical ventilation in pediatric patients.
Pediatr Pulmonol 1997 24:344-52 [abstract]
Review, by S. Venkataraman
Mechanical Ventilation WeaningVenkataraman ST, Khan N, Brown A, , Validation of predictors of extubation success and failure in mechanically ventilated infants and children.
Crit Care Med 2000 28(8):2991-6 [abstract]
Review, by D. Epstein R. Bart
Mechanical Ventilation WeaningHubble CL, Gentile MA, Tripp DS, Craig DM, Meliones JN Deadspace to tidal volume ratio predicts successful extubation in infants and children.
Crit Care Med 2000 28(6):2034-40 [abstract]
Review, by A. Torres
Mechanical Ventilation WeaningManczur TI, Greenough A, Pryor D, Rafferty GF, Comparison of predictors of extubation from mechanical ventilation in children.
Pediatric Critical Care Medicine 2000 1:28-32
Review, by S Venkataraman
Mechanical Ventilation WeaningPutensen C, Zech S, Wrigge H , , Long-Term Effects of Spontaneous Breathing During Ventilatory Support in Patients with Acute Lung Injury
Am J Respir Crit Care Me 2001 27: 1511-1517; DOI 10.1007/s001340101039 [abstract]
Review, by S Kache V Kesavulu
Mechanical Ventilation WeaningBanner MJ, Euliano NR, Martin AD, Al-Rawas N, Layon AJ, Gabrielli A. Noninvasive work of breathing improves prediction of post-extubation outcome
Intensive Care Med 2012 38(2):248-55. [abstract]
Review, by Tessy Thomas DO, Texas Chiildren's Hospital and Baylor College of Medicine, Houston TX
Mechanical Ventilation WeaningFontela PS, Piva JP, Garcia PC, Bered PL, Zilles K. Risk factors for extubation failure in mechanically ventilated pediatric patients.
Pediatr Crit Care Med. 2005 Mar;6(2):166-170. [abstract]
Review, by Julianne Harrison DO, Myke Federman MD, Mattel Children’s Hospital UCLA, Los Angeles CA
Mechanical Ventilation WeaningMekontso Dessap A, Roche-Campo F, Kouatchet A, Tomicic V, Beduneau G, Sonneville R, Cabello B, Jaber S, Azoulay E, Castanares-Zapatero D, Devaquet J, Lellouche F, Katsahian S, Brochard L. Natriuretic Peptide-driven Fluid Management during Ventilator Weaning: A Randomized Controlled Trial
Am J Respir Crit Care Med 2012 15;186(12):1256-63 [abstract]
Review, by Harish Bangalore MD, Baylor College of Medicine and Texas Children's Hospital, Houston TX
Mechanical Ventilation WeaningTanios MA, Nevins ML, Hendra KP, et al. A randomized, controlled trial of the role of weaning predictors in clinical decision making.
Crit Care Med 2006 34(10):2530-5 [abstract]
Review, by Amy S. Arrington MD PhD, Baylor College of Medicine and Texas Children's Hospital, Houston TX
Mechanical Ventilation WeaningFarias JA, Retta A, et al., , A comparison of two methods to perform a breathing trial before extubation in pediatric intensive care patients
Intensive Care Med 2001 27:1649-1654 [abstract]
Review, by A Arikan M McPherson
Mechanical Ventilation WeaningJouvet PA, Payen V, Gauvin F, Emeriaud G, Lacroix J. Weaning children from mechanical ventilation with a computer-driven protocol: a pilot trial.
Intensive Care Med 2013 May;39(5):919-25 [abstract]
Review, by L. Nelson Sanchez-Pinto MD and Claudia Moreno MD, Children’s Hospital Los Angeles, Los Angeles CA
Mechanical Ventilation WeaningSmyrnios NA, Connolly A, Wilson MM, , Effects of a multifaceted, multidisciplinary, hospital-wide quality improvement program on weaning from mechanical ventilation
Crit Care Med 2002 30(6):1224-30 [abstract]
Review, by S Thammasitboon S Thammasitboon
Mechanical Ventilation WeaningUusaro A, Chittock DR, Russell JA, , Stress test and gastric-arterial PCO2 measurement improve prediction of successful extubation
Crit Care Med 2000 28(7):2313-9 [abstract]
Review, by N Hoover A Vats
Mechanical Ventilation WeaningEsteban A, Alia I, Tobin MJ, et al. Effect of Spontaneous Breathing Trial Duration on Outcome of Attempts to Discontinue Mechanical Ventilation
Am J Respir Crit Care Med 1999 ;159:512-518. [abstract]
Review, by M. Fares Albitar MD, Ikram Haque MD, Shands Hospital at the University of Florida, Gainesville, Florida
Mechanical Ventilation WeaningFoster CB, Spaeder MC, McCarter RJ, Cheng YI, Berger JT. The use of near-infrared spectroscopy during an extubation readiness trial as a predictor of extubation outcome.
Pediatr Crit Care Med. 2013 Jul;14(6):587-92 [abstract] [Full-Text]
Review, by Binod Balakrishnan MD, Medical College of Wisconsin, Milwaukee WI
Mechanical Ventilation WeaningRandolph AG, Wypij D, Venkataraman ST, et al., for PALISI network Effect of Mechanical Ventilator Weaning Protocols on Respiratory Outcomes in Infants and Children: A Randomized Controlled Trial
JAMA 2002 288:2561-2568 [abstract]
Review, by M Twite
Mechanical Ventilation WeaningMarelich GP, Murin S, Battistella F, Inciardi J, Vierra T, Roby M. Protocol Weaning of Mechanical Ventilation in Medical and Surgical Patients by Respiratory Care Practitioners and Nurses : Effect on Weaning Time and Incidence of Ventilator-Associated Pneumonia.
Chest. 2000 ;118(2):459-467. [abstract]
Review, by Julia Mercer Niebauer MD, University of Alabama at Birmingham, AL
Mechanical Ventilation WeaningFerrer M, Esquinas A, Arancibia F, et al., Non-invasive ventilation during persistent weaning failure. A randomized controlled trial
Am J Respir Crit Care Me 2003 168(1):70-6 [abstract]
Review, by L Smith
Mechanical Ventilation WeaningBreatnach C, Conlon NP, Stack M, Healy M, O A prospective crossover comparison of neurally adjusted ventilatory assist and pressure-support ventilation in a pediatric and neonatal intensive care unit population
Pediatr Crit Care Med. 2010 11(1):7-11 [abstract] [Full-Text]
Review, by Bria Coates MD, Kelly Michelson MD, Children's Memorial Hospital, Northwestern University School of Medicine, Chicago IL
Mechanical Ventilation WeaningHarikumar G, Egberongbe Y, Nadel S, Wheatley E, Moxham J, Greenough A, Rafferty GF. Tension Time Index as a Predictor of Extubation Outcome in Ventilated Children.
Am J Respir Crit Care Med 2009 180: 982-988 [abstract]
Review, by Julianne Harrison DO, Robert B. Kelly MD, University of California Los Angeles and Mattel Children's Hospital, Los Angeles CA
Mechanical Ventilation WeaningKrishnan JA, Moore D, Robeson C, et al., A Prospective, Controlled Trial of a Protocol-based Strategy to Discontinue Mechanical Ventilation
Am J Respir Crit Care Me 2004 169 673-678 [abstract]
Review, by A Lee M Nilufer
Mechanical Ventilation WeaningEsteban A, Frutos-Vivar F, Ferguson ND, et al., Noninvasive Positive-Pressure Ventilation for Respiratory Failure after Extubation
N Engl J Med 2004 350:2452-2460 [abstract]
Review, by T Cholis
Mechanical Ventilation WeaningFarias JA, Alía I, Retta A, et al., An evaluation of extubation failure predictors in mechanically ventilated infants and children
Intensive Care Med 2002 28:752-757 [abstract]
Review, by A Wratney DK Benjamin
Mechanical Ventilation WeaningKurachek SC, Newth CJ, Quasney MW, et al., Extubation failure in pediatric intensive care: A multiple-center study of risk factors and outcomes
Crit Care Med 2003 Nov;31(11):2657-64 [abstract]
Review, by S Primis A Wratney
Neuromuscular blockade in ARDSPapazian L, Forel JM, Gacouin A, Penot-Ragon C, Perrin G, Loundou A, Jaber S, Arnal JM, Perez D, Seghboyan JM, Constantin JM, Courant P, Lefrant JY, GuĂ©rin C, Prat G, Morange S, Roch A. Neuromuscular Blockers in Early Acute Respiratory Distress Syndrome.
N Engl J Med 2010 363(12):1107-1116 [abstract]
Review, by Jenna MIller MD, Baylor College of Medicine and Texas Children's Hospital, Houston TX
Nitric Oxide and Almitrine for ARDSGallart L, Lu Q, Puybasset L, , Intravenous Almitrine Combined with Inhaled Nitric Oxide for Acute Respiratory Distress Syndrome
Am J Respir Crit Care Me 1998 27:807-14 [abstract]
Review, by Steven Cray
Nitric Oxide for respiratory failureFioretto JR, De Moraes MA, Bonatto RC, et al., Acute and sustained effects of early administration of inhaled nitric oxide to children with acute respiratory distress syndrome
Pediatric Critical Care Medicine 2004 Sep;5(5):469-74 [abstract]
Review, by J Matchey
Nitric Oxide for respiratory failure Inhaled Nitric Oxide and Hypoxic Respiratory Failure in Infants With Congenital Diaphragmatic Hernia
Pediatrics 1997 99: 838-845 [abstract]
Review, by The Neonatal Inhaled Nitric Oxide Study Group (NINOS)
Nitric Oxide for respiratory failureDellinger RP, Zimmerman JL, Taylor RW, Straube RC, Hauser DL Effects of inhaled nitric oxide in patients with acute respiratory distress syndrome: results of a randomized phase II trial
Crit Care Med 1998 127:267-274 [abstract]
Review, by Scot Bateman, MD
Nitric Oxide for respiratory failureDobyns EL, Cornfield DN, Anas NG, Fortenberry JD, Tasker RC Multicenter randomized controlled trial of the effects of inhaled nitric oxide on gas exchange in children with acute hypoxemic respiratory failure.
J Pediatr 1999 159: 695-701 [abstract]
Review, by Al Torres, MD, MS,
Nitric Oxide for respiratory failureMicheal JR, Barton RG, Saffle JR, , Inhaled Nitric Oxide Versus Conventional Therapy: Effect on Oxygenation in ARDS
Am J Respir Crit Care Me 1998 338: 355-361 [abstract]
Review, by Gerardo Reyes, M.D.
Nitric Oxide for respiratory failureThe Neonatal Inhaled Nitric Oxide Group , , , , Inhaled nitric oxide in full term and nearly full term infants with hypoxic respiratory failure.
N Engl J Med 1997 1731-1736 [abstract]
Review, by P. Chhangani, MD J. Hupert, MD
Nitric Oxide for respiratory failureReam RS, Hauver JF, Lynch RE, Kountzman B, Gale GB Low-dose inhaled nitric oxide improves the oxygenation and ventilation of infants and children with acute, hypoxemic respiratory failure
Crit Care Med 1999 158: 1831-1838 [abstract] [Full-Text]
Review, by Ron Sanders Jr., MD
Nitric Oxide for respiratory failureTroncy E, Collet JP, Shapiro S, Guimond JG, Blair L Inhaled Nitric Oxide in Acute Respiratory Distress Syndrome: A Pilot Randomized Controlled Study.
Am J Respir Crit Care Me 1998 339: 1030-35 [abstract]
Review, by Maher Eldadah MD
Nitric Oxide for respiratory failureInhaled Nitric Oxide Study Group. Inhaled Nitric Oxide and Persistent Pulmonary Hypertension of the Newborn.
N Engl J Med 1997 ; 336: 605-610. [abstract]
Review, by Jessica Oldfield, MBChB MRCPCH, Leeds General Infirmary, LEEDS, United Kingdom
Nitric Oxide for respiratory failureSokol J, Jacobs SE, Bohn D, , Inhaled nitric oxide for acute hypoxemic respiratory failure in children and adults
Cochrane Review 2002 Issue 4 2002. Oxford: Update Software [abstract]
Review, by S Thammasitboon S Thammasitboon
Nitric Oxide for respiratory failureAdhikari NK, Dellinger RP, Lundin S, Payen D, Vallet B, Gerlach H, Joo Park K, Mehta S, Slutsky AS, Friedrich JO. Inhaled Nitric Oxide Does Not Reduce Mortality in Patients With Acute Respiratory Distress Syndrome Regardless of Severity: Systematic Review and Meta-Analysis.
Crit Care Med 2014 42:404–412 [abstract]
Review, by Asavari Kamerkar MD, Children's Hospital Los Angeles, Los Angeles CA
Nitric Oxide for respiratory failureTaylor RW, Zimmerman JL, Dellinger RP, et al., Low-dose inhaled nitric oxide in patients with acute lung injury: a randomized controlled trial
JAMA 2004 Apr 7;291(13):1603-9 [abstract]
Review, by R Orellana
Noninvasive ventilationSquadrone V, Massaia M, Bruno B, Marmont F, Falda M, Bagna C, Bertone S, Filippini C, Slutsky AS, Vitolo U, Boccadoro M, Ranieri VM. Early CPAP prevents evolution of acute lung injury in patients with hematologic malignancy.
Intensive Care Med 2010 36(10):1666-74 [abstract]
Review, by Aarti Bavare MD, Baylor College of Medicine, Texas Children's Hospital, Houston TX
Noninvasive ventilationKeenan SP, Sinuff T, Cook DJ, Hill NS. Does noninvasive positive pressure ventilation improve outcome in acute hypoxemic respiratory failure? A systematic review.
Crit Care Med 2004 Dec;32(12):2516-23 [abstract]
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Noninvasive ventilationAntonelli M, Conti G,, Rocco M, , Bufi M, De Blasi RA A comparison of noninvasive positive-pressure ventilation and conventional mechanical ventilation in patients with acute respiratory failure.
N Engl J Med 1998 157: 1372-1380 [abstract] [Full-Text]
Review, by Girish Deshpande, MD Kathleen Meert, MD
Noninvasive ventilationFerrer M, Esquinas A, Leon M, Gonzalez G, Alarcon A, Torres A. Noninvasive ventilation in severe hypoxemic respiratory failure: a randomized clinical trial
Am J Respir Crit Care Med. 2003 Dec 15;168(12):1438-44 [abstract]
Review, by H Sahhar
Noninvasive ventilationAntonelli M, Conti G, Bufi M, et al. Noninvasive Ventilation for Treatment of Acute Respiratory Failure in Patients Undergoing Solid Organ Transplantation; A Randomized Trial.
JAMA 2000 27:2799-805 [abstract]
Review, by P. Prabhakaran, M. Mariscalco
Noninvasive ventilationSchibler A, Pham TM, Dunster KR, Foster K, Barlow A, Gibbons K, Hough JL. Reduced intubation rates for infants after introduction of high-flow nasal prong oxygen delivery.
Intensive Care Med 2011 37(5):847-52 [abstract]
Review, by Shivanand Medar MD and Sandeep Tripathi MD, The Children’s Hospital at Montefiore, Bronx NY
Noninvasive ventilationFerrer M, Valencia M, Nicolas JM, Bernadich O, Badia JR, Torres A. Early noninvasive ventilation averts extubation failure in patients at risk: a randomized trial
Am J Respir Crit Care Med. 2006 Jan 15;173(2):164-70. [abstract]
Review, by Punkaj Gupta MD, Natan Noviski MD, Massachusetts General Hospital, Boston MA
Noninvasive ventilationHonrubia T, Garcia Lopez FJ, et al. Noninvasive vs conventional mechanical ventilation in acute respiratory failure: a multicenter, randomized controlled trial.
Chest. 2005 Dec;128(6):3916-24. [abstract]
Review, by Matei Petrescu MD, Baylor College of Medicine, Texas Children's Hospital, Houston TX
Noninvasive ventilationPiastra M, De Luca D, Marzano L, Stival E, Genovese O, Pietrini D, Conti G. The number of failing organs predicts non-invasive ventilation failure in children with ALI/ARDS.
Intensive Care Med 2011 Sep;37(9):1510-6. [abstract]
Review, by Tara Benton MD, Craig M Smith MD, Lurie Children's Hospital, Chicago IL
Noninvasive ventilationZhan Q, Sun B, Liang L, Yan X, Zhang L, Yang J, Wang L, Ma Z, Shi L, Wei L, Li G, Yang L, Shi Z, Chen Y, Xu Q, Li W, Zhu X, Wang Z, Sun Y, Zhuo J, Liu Y, Li X, Wang C. Early use of noninvasive positive pressure ventilation for acute lung injury: A multicenter randomized controlled trial
Crit Care Med 2012 40(2):455-460 [abstract]
Review, by Mona Karimullah MD, Texas Children's Hospital and Baylor College of Medicine, Houston TX
Noninvasive ventilationJames CS, Hallewell CP, James DP, Wade A, Mok QQ. Predicting the success of non-invasive ventilation in preventing intubation and re-intubation in the paediatric intensive care unit.
Intensive Care Med 2011 Dec;37(12):1994-2001 [abstract]
Review, by Laura Haws MD, Children's Mercy Hospital, Kansas City MO
Noninvasive ventilationDelclaux C, L'Her E, Alberti C, , Treatment of Acute Hypoxemic Nonhypercapnic Respiratory Insufficiency With Continuous Positive Airway Pressure Delivered by a Face Mask: A Randomized Controlled Trial
JAMA 2000 284(18):2352-2360 [abstract] [Full-Text]
Review, by C. Davison
Noninvasive ventilationHilbert G, Gruson D, Vargas F , , Noninvasive ventilation in immunosuppressed patients with pulmonary infiltrates, fever, and acute respiratory failure
N Engl J Med 2001 344(7):481-7 [abstract]
Review, by J Barron
Noninvasive ventilationNava S, Gregoretti C, Fanfulla F, et al. Noninvasive ventilation to prevent respiratory failure after extubation in high-risk patients
Crit Care Med. 2005 Nov;33(11):2465-2470. [abstract]
Review, by Pamela Hilvers MD, Robyn Schultz MD, WVU Children’s Hospital, Morgantown, WV
Noninvasive ventilationYañez LJ, Yunge M, Emilfork M, Lapadula M, Alcántara A, Fernández C, Lozano J, Contreras M, Conto L, Arevalo C, Gayan A, Hernández F, Pedraza M, Feddersen M, Bejares M, Morales M, Mallea F, Glasinovic M, Cavada G. A prospective, randomized, controlled trial of noninvasive ventilation in pediatric acute respiratory failure.
Pediatr Crit Care Med. 2008 9(5):484-9 [abstract]
Review, by Zainab Abdurrahman MD MMath, McMaster University, Hamilton, Ontario, Canada
Noninvasive ventilationNava S, Carbone G, DiBattista N, et al., Noninvasive ventilation in cardiogenic pulmonary edema: a multicenter randomized trial
Am J Respir Crit Care Me 2003 Dec 15;168(12):1432-7 [abstract]
Review, by L Thompson
Noninvasive ventilationMayordomo-Colunga J, Medina A, Rey C, DĂ­az JJ, Concha A, Los Arcos M, MenĂ©ndez S. Predictive factors of non invasive ventilation failure in critically ill children: a prospective epidemiological study.
Intensive Care Med 2009 35(3):527-536 [abstract]
Review, by by Jennifer L York MD, St. Louis Children’s Hospital and Washington University in St. Louis, MO
Noninvasive ventilationPark M, Sangean MC, de S Volpe M, et al., Randomized, prospective trial of oxygen, continuous positive airway pressure, and bilevel positive airway pressure by face mask in acute cardiogenic pulmonary edema.
Crit Care Med 2004 Dec;32(12):2407-15 [abstract]
Review, by J Kane MD, Medical College Wisconsin, Milwaukee, WI
Oxgyen Transport after Cardiac SurgeryDobyns EL, Cornfield DN, Anas NG, Fortenberry JD, Tasker RC Multicenter randomized controlled trial of the effects of inhaled nitric oxide therapy on gas exchange in children with acute hypoxemic respiratory failure.
J Pediatr 1999 79: 405-410 [abstract]
Review, by Faberowski L.
Pediatric ARDS epidemiologyLĂłpez-Fernández Y, Azagra AM, de la Oliva P, Modesto V, Sánchez JI, Parrilla J, Arroyo MJ, Reyes SB, Pons-Ă“dena M, LĂłpez-Herce J, Fernández RL, Kacmarek RM, Villar J Pediatric Acute Lung Injury Epidemiology and Natural History Study: Incidence and outcome of the acute respiratory distress syndrome in children
Crit Care Med 2012 Dec;40(12):3238-3245 [abstract]
Review, by Lorena Maria Fernandez-Restrepo MD, University of Texas San Antonio, San Antonio TX
PEEP in ARDSTalmor D, Sarge T, Malhotra A, O Mechanical Ventilation Guided by Esophageal Pressure in Acute Lung Injury.
N Engl J Med 2008 359:2095-104 [abstract]
Review, by Jane L. Di Gennaro MD, Seattle Children’s Hospital
PEEP in ARDSVillar J, Kacmarek RM, Perez-Mendez L, Aguirre-Jaime A; for the ARIES Network. A high positive end-expiratory pressure, low tidal volume ventilatory strategy improves outcome in persistent acute respiratory distress syndrome: A randomized, controlled trial.
Crit Care Med. 2006 ; 34:1311-1318. [abstract]
Review, by Aline M Bernard MD, University of Colorado, Denver CO
PEEP in ARDSNHLBI ARDS Clinical Trials Network, , , , Higher versus Lower Positive End-Expiratory Pressures in Patients with the Acute Respiratory Distress Syndrome
N Engl J Med 2004 351:327-336 [abstract]
Review, by M White
Prognosis in ARDSTrachsel D, McCrindle BW, Nakagawa S, Bohn DJ, Oxygenation Index Predicts Outcome in Children with Acute Hypoxemic Respiratory Failure
Am J Respir Crit Care Me 2005 172:206-211 [abstract]
Review, by C Froehlich J Fortenberry
Prognosis in ARDSFlori HR, Glidden DV, Rutherford GW, Matthay MA. Pediatric Acute Lung Injury: Prospective Evaluation of Risk Factors Associated with Mortality
Am J Respir Crit Care Med. 2005 171(9):995-1001 [abstract]
Review, by Jeffrey J. Fanning MD, Medical College of Wisconsin, Milwaukee, WI
Prognosis in ARDSHerridge MS, Cheung AM, Tansey CM, et al. One-year outcomes in survivors of the acute respiratory distress syndrome.
N Engl J Med 2003 Feb 20;348(8):683-93 [abstract]
Review, by G Wolf
Prognosis in ARDSGhuman AK, Newth CJ, Khemani RG. The association between the end tidal alveolar dead space fraction and mortality in pediatric acute hypoxemic respiratory failure
Pediatric Critical Care Medicine 2012 13:11–15 [abstract]
Review, by Anne Camerlengo MD, Children's Hospital Los Angeles, Los Angeles CA
Prognosis in ARDSMangialardi RJ, Martin GS, Bernard GR, et al., Hypoproteinemia predicts acute respiratory distress syndrome development, weight gain, and death in patients with sepsis
Crit Care Med 2000 28(9):3137-45 [abstract]
Review, by N Faqih
Prognosis in ARDSNuckton TJ, Alonso JA, Kallet RH, et a;/, Pulmonary dead-space fraction as a risk factor for death in the acute respiratory distress syndrome
N Engl J Med 2002 346(17):1281-6 [abstract]
Review, by S Kannan K Meert
Prognosis in ARDSBersten AD, Hunt T, Nicholas TE, et al., Elevated Plasma Surfactant Protein-B Predicts Development of Acute Respiratory Distress Syndrome in Patients with Acute Respiratory Failure
Am J Respir Crit Care Me 2001 164 648-652 [abstract]
Review, by S Huntoon Vitali
Prone positioning in respiratory failureAbroug F, Ouanes-Besbes L, Elatrous S, Brochard L. The effect of prone positioning in acute respiratory distress syndrome or acute lung injury: a meta-analysis. Areas of uncertainty and recommendations for research.
Intensive Care Med 2008 34(6):1002-11 [abstract]
Review, by Alan Gatward MD, Children's Hospital Los Angeles, Los Angeles, CA
Prone positioning in respiratory failureCurley MA, Hibberd PL, Fineman LD, et al., Effect of prone positioning on clinical outcomes in children with acute lung injury: a randomized controlled trial
JAMA 2005 Jul 13;294(2):229-37 [abstract]
Review, by M Paden
Prone positioning in respiratory failureGuerin C, Gaillard S, Lemasson S, et al., Effects of Systematic Prone Positioning in Hypoxemic Acute Respiratory Failure: A Randomized Controlled Trial
JAMA 2004 292 2379-2387 [abstract]
Review, by AS Jeyapalan
Prone positioning in respiratory failureJolliet P, Bulpa P , Chevrolet JC, , Effects of the prone position on gas exchange and hemodynamics in severe acute respiratory distress syndrome.
Crit Care Med 1998 99:e11 [abstract] [Full-Text]
Review, by Varsha Gharpure, MD Kathleen Meert, MD
Prone positioning in respiratory failureMancebo J, Fernandez R, Blanch L, et al. A multicenter trial of prolonged prone ventilation in severe acute respiratory distress syndrome.
Am J Respir Crit Care Med. 2006 173(11):1233-9. [abstract]
Review, by Moreshwar S. Desai MD, Pediatric Critical Care, Baylor College of Medicine, Houston, TX
Prone positioning in respiratory failureKornecki A, Frndova H, , Coates AL, Shemie SD A Randomized Trial of Prolonged Prone Positioning in Children With Acute Respiratory Failure.
Chest 2001 119: 211-218 [abstract] [Full-Text]
Review, by L. Wise-Faberowski
Prone positioning in respiratory failureGattinoni L, Tognoni G, Pesenti A, et al., Effect of Prone Positioning on the Survival of Patients with Acute Respiratory Failure
N Engl J Med 2001 345:568-573 [abstract]
Review, by P Kamat
Prone positioning in respiratory failurePapazian L, Gainnier M, Marin V, et al. Comparison of prone positioning and high-frequency oscillatory ventilation in patients with acute respiratory distress syndrome.
Crit Care Med. 2005 Oct;33(10):2162-71. [abstract]
Review, by Jonna Clark MD, Seattle Children's Hospital, Seattle WA
Prone positioning in respiratory failureGuĂ©rin C, Reignier J, Richard JC, Beuret P, Gacouin A, Boulain T, Mercier E, Badet M, Mercat A, Baudin O, Clavel M, Chatellier D, Jaber S, Rosselli S, Mancebo J, Sirodot M, Hilbert G, Bengler C, Richecoeur J, Gainnier M, Bayle F, Bourdin G, Leray V, Gira Prone Positioning in Severe Acute Respiratory Distress Syndrome.
N Engl J Med 2013 2013 May 20. DOI: 10.1056/NEJMoa1214103 [abstract]
Review, by Sangita Trivedi MD, Rahul Kashyap MBBS, Yves Ouellette MD, Mayo Clinic Children's Center, Rochester MN
Prone positioning in respiratory failureAlsaghir AH, Martin CM. Effect of prone positioning in patients with acute respiratory distress syndrome: a meta-analysis.
Crit Care Med. 2008 36(2):603-9 [abstract]
Review, by Anoop Ghuman MD, Childrens Hospital Los Angeles, Los Angeles CA
Prone positioning in respiratory failureTaccone P, Pesenti A, Latini R, Polli F, Vagginelli F, Mietto C, Caspani L, Raimondi F, Bordone G, Iapichino G, Mancebo J, GuĂ©rin C, Ayzac L, Blanch L, Fumagalli R, Tognoni G, Gattinoni L; for the Prone-Supine II Study Group Prone Positioning in Patients With Moderate and Severe Acute Respiratory Distress Syndrome: A Randomized Controlled Trial
JAMA 2009 302(18):1977-1984. [abstract]
Review, by Sandeep Tripathi MD, Sara Ross MD, Children's Hospital at Montefiore, New York, NY
Prostacyclin for acute lung injuryDahlem P, van Aalderen WMC, de Neef M, Dijkgraaf MGW, Bos AP Randomized controlled trial of aerosolized prostacyclin therapy in children with acute lung injury
Crit Care Med 2004 32:1055-1060 [abstract]
Review, by AA Arikan
Respiratory Failure and Bone Marrow TransplantRossi R, Shemie SD, Calderwood S, , Prognosis of pediatric bone marrow transplant recipients requiring mechanical ventilation.
Crit Care Med 1999 27:1181-6 [abstract]
Review, by J. Heggen J. Fortenberry
Respiratory Failure and Bone Marrow TransplantKeenan HT, Bratton SL, Martin LD, Crawford SW, Weiss NS Outcome of children who require mechanical ventilatory support after bone marrow transplantation.
Crit Care Med 2000 28(3):830-5 [abstract]
Review, by X. Garcia H. Tcharmtchi
Respiratory Failure and Bone Marrow TransplantRowan CM, Hege KM, Speicher RH, Goodman M, Perkins SM, Slaven JE, Westenkirchner DF, Haut PR, Nitu ME. Oxygenation index predicts mortality in pediatric stem cell transplant recipients requiring mechanical ventilation
Pediatr Transplant 2012 Sep;16(6):645-50 [abstract]
Review, by Rajat Pareek MD, Le Bonheur Children’s Hospital, University of Tennessee Health Science Center, Memphis TN
Respiratory Failure and Bone Marrow TransplantTamburro RF, Barfield RC, Shaffer ML, Rajasekaran S, Woodard P, Morrison RR, Howard SC, Fiser RT, Schmidt JE, Sillos EM. Changes in outcomes (1996-2004) for pediatric oncology and hematopoietic stem cell transplant patients requiring invasive mechanical ventilation.
Pediatr Crit Care Med. 2008 9(3):270-7. [abstract]
Review, by Christine Vohwinkel MD, Denise Goodman MD, Children’s Memorial Hospital, Northwestern University, Chicago IL
Respiratory Failure and Bone Marrow TransplantDiCarlo JV, Alexander SR, Agarwal R, Schiffman JD, Continuous veno-venous hemofiltration may improve survival from acute respiratory distress syndrome after bone marrow transplantation or chemotherapy
J Pediatr Hematol Oncol 2003 Oct;25(10):801-5 [abstract]
Review, by E Cullen
SpO2 vs. PaO2 in diagnosing ARDSKhemani RG, Thomas NJ, Venkatachalam V, Scimeme JP, Berutti T, Schneider JB, Ross PA, Willson DF, Hall MW, Newth CJ; Pediatric Acute Lung Injury and Sepsis Network Investigators (PALISI). Comparison of SpO2 to PaO2 based markers of lung disease severity for children with acute lung injury.
Crit Care Med 2012 40(4):1309-1316 [abstract]
Review, by Shelley N. Hancock MD, University of Texas Health Science Center at San Antonio, San Antonio TX
Steroids for ARDSSteinberg KP, Hudson LD, Goodman RB for the Acute Respiratory Distress Syndrome (ARDS) Clinical Trials Network. Efficacy and safety of corticosteroids for persistent acute respiratory distress syndrome.
N Engl J Med. 2006 Apr 20;354(16):1671-84 [abstract]
Review, by Shaghig Kouyoumjian MD, Children's Hospital Los Angeles, Los Angeles, CA
Steroids for ARDSMeduri GU, Headley AS, Golden E, Carson SJ, Umberger RA Effect of prolonged methylprednisolone therapy in unresolving acute respiratory distress syndrome: a randomized controlled trial
JAMA 1998 317: 235-240 [Full-Text]
Review, by MIcheal Kelly MD Steven Pon, MD
Steroids for ARDS Varpula T, Pettila, Rintala E, Takkunen O, Valtonen Late steroid therapy in primary acute lung injury.
Intensive Care Med 2000 26:526-531 [abstract]
Review, by Narsinghani U. Heulitt M.
Steroids for ARDSMeduri GU, Golden E, Freire AX, Taylor E, Zaman M, Carson SJ, Gibson M, Umberger R. Methylprednisolone infusion in early severe ARDS: results of a randomized controlled trial.
Chest 2007 131(4):954-63. [abstract]
Review, by Jennifer R Foster MD FRCPC, Children’s Hospital of Eastern Ontario
Steroids for ARDSMeduri GU, Marik PE, Chrousos GP, Pastores SM, Arlt W, Beishuizen A, Bokhari F, Zaloga G, Annane D. Steroid treatment in ARDS: a critical appraisal of the ARDS network trial and the recent literature.
Intensive Care Med 2008 34(1):61-9 [abstract]
Review, by Bonny Bardhan MD, Tom Spentzas MD, University of Tennessee at Memphis, LeBonheur Children's Hospital, Memphis TN
Stridor/airway injury after extubationGomes Cordeiro AM, Fernandes JC, Troster EJ., , Possible risk factors associated with moderate or severe airway injuries in children who underwent endotracheal intubation
Crit Care Med 2004 Jul;5(4):364-8 [abstract]
Review, by A Wratney
Stridor/airway injury after extubationAnene O , Meert KL, Uy H, Simpson P, Sarmiak AP Dexamethasone for the prevention of postextubation airway obstruction: a prospective, randomized, double-blind, placebo-controlled trial.
Crit Care Med 1996 24: 1666-1669 [abstract]
Review, by Adrienne Randolph
Stridor/airway injury after extubationHarel Y, Vardi A, Quigley, B rink, Manning SC Extubation failure due to post-extubation stridor is better correlated with neurologic impairment than with upper airway lesions in critically ill pediatric patients
Int J Pediatr Otorhynolaryngal 1997 39: 147-158 [abstract]
Review, by Barry P. Markovitz
Stridor/airway injury after extubationCheng KC, Hou CC, Huang HC, Lin SC, Zhang H. Intravenous injection of methylprednisolone reduces the incidence of postextubation stridor in intensive care unit patients.
Crit Care Med. 2006 ; 34(5):1345-1350. [abstract]
Review, by Julianne Harrison DO, Myke Federman MD, Mattel Children’s Hospital at UCLA, Los Angeles CA
Stridor/airway injury after extubationTellez DW, Galvis AG, Storgion SA, Amer HN, Hoseyni M Dexamethasone in the prevention of postextubation stridor in children.
J Pediatr 1991 118:289-294 [abstract]
Review, by Adrienne Randolph
Stridor/airway injury after extubationWratney AT, Benjamin DK Jr, Slonim AD, He J, Hamel DS, Cheifetz IM. The endotracheal tube air leak test does not predict extubation outcome in critically ill pediatric patients.
Pediatr Crit Care Med. 2008 9:490-496 [abstract] [Full-Text]
Review, by Erin Reade MD MPH, Children's Hospital of Philadelphia, Philadelphia PA
Stridor/airway injury after extubationMarkovitz BP, Randolph AG, , , Corticosteroids for the Prevention of Reintubation and Postextubation Stridor in Pediatric Patients: A Meta-Analysis
Pediatric Critical Care Medicine 2002 3:223-226 [abstract] [Full-Text]
Review, by K Brinkman
Stridor/airway injury after extubationMhanna MJ, Zamel YB, Tichy CM, Super DM. The "air leak" test around the endotracheal tube, as a predictor of postextubation stridor, is age dependent in children
Crit Care Med. 2002 ;30(12):2639-43. [abstract]
Review, by Mary G. Gaspers MD, Baylor College of Medicine, Houston TX
Stridor/airway injury after extubationMcCaffrey J, Farrell C, Whiting P, Dan A, Bagshaw SM, Delaney AP. Corticosteroids to prevent extubation failure: a systematic review and meta-analysis.
Intensive Care Med 2009 Jun;35(6):977-86 [abstract]
Review, by Enrico Opocher MD, University Hospital of Padua, Italy
Stridor/airway injury after extubationDe Bast Y, De Backer D, Moraine JJ, et al., The cuff leak test to predict failure of tracheal extubation for laryngeal edema
Intensive Care Med 2002 28: 1267-1272 [abstract]
Review, by A Wratney DK Benjamin Jr
Surfactant for Respiratory FailureSpragg RG, Lewis JF, Walmrath HD, et al., Effect of recombinant surfactant protein C-based surfactant on the acute respiratory distress syndrome
N Engl J Med 2004 351:884-892 [abstract]
Review, by F Norozian
Surfactant for Respiratory FailureLópez-Herce J, de Lucas N, Carrillo A, Bustinza A, Moral R. Surfactant treatment for acute respiratory distress syndrome
Arch Dis Child 1999 80:248-252 [abstract]
Review, by J. Barron, A. Madikians
Surfactant for Respiratory FailureThomas NJ, Hollenbeak CS, Lucking SE, Willson DF. Cost-effectiveness of exogenous surfactant therapy in pediatric patients with acute hypoxemic respiratory failure.
Pediatr Crit Care Med. 2005 Mar;6(2):160-165. [abstract]
Review, by Mahesh Sharman MD, Paula Silva MD, Hurley Medical Center and Michigan State University, Flint, MI
Surfactant for Respiratory FailureWillson DF, Zaritsky A, Bauman LA, , Instillation of calf lung surfactant extract (calfactant) is beneficial in pediatric acute hypoxemic respiratory failure
Crit Care Med 1999 316: 961-5 [abstract]
Review, by Poyyapakkam Srivaths M.D. Kathleen Meert, M.D.
Surfactant for Respiratory FailureThomas NJ, Guardia CG, Moya FR, Cheifetz IM, Markovitz B, Cruces P, Barton P, Segal R, Simmons P, Randolph AG, for the PALISI Network. A pilot, randomized, controlled clinical trial of lucinactant, a peptide-containing synthetic surfactant, in infants with acute hypoxemic respiratory failure.
Pediatr Crit Care Med. 2012 13(6):646-653 [abstract]
Review, by Nirmal Kavalloor Visruthan, MBBS, DCH, MRCPCH; Zhi Min Ng, MBBS, MRCPCH; Jan Hau Lee, MBBS, MRCPCH; KK Women's and Children's Hospital, Singapore
Surfactant for Respiratory FailureDuffett M, Choong K, Ng V, Randolph A, Cook DJ. Surfactant therapy for acute respiratory failure in children: a systematic review and meta-analysis.
Critical Care 2007 15;11(3):R66 [abstract]
Review, by Matei Petrescu MD, Tulane School of Medicine, New Orleans LA
Surfactant for Respiratory FailureMoller JC, Schaible T, Roll C, et al., Treatment with bovine surfactant in severe acute respiratory distress syndrome in children: a randomized multicenter study
Intensive Care Med 2003 29(3):437-46 [abstract]
Review, by N Mehta
Surfactant for Respiratory FailureKesecioglu J, Beale R, Stewart TE, Findlay GP, Rouby JJ, Holzapfel L, Bruins P, Steenken EJ, Jeppesen OK, Lachmann B. Exogenous Natural Surfactant for Treatment of Acute Lung Injury and the Acute Respiratory Distress Syndrome.
Am J Respir Crit Care Med 2009 180: 989-994. [abstract]
Review, by Matthew Musick MD, Baylor College of Medicine, Texas Children's Hospital, Houston TX
Surfactant for Respiratory FailureWillson DF, Thomas NJ, Markovitz BP,, et al. , Effect of Exogenous Surfactant (Calfactant) in Pediatric Acute Lung Injury: A Randomized Controlled Trial
JAMA 2005 293 470-476 [abstract]
Review, by A Shieh Czaja
Tidal volume reduction in ARDS/Prevention of barotraumaAmato MBP, Barbas CSV, Medeiros DM, , Effect of a Protective-Ventilation Strategy on Mortality in the Acute Respiratory Distress Syndrome.
N Engl J Med 1998 101: 361-368 [abstract]
Review, by Kazuo Obata MD
Tidal volume reduction in ARDS/Prevention of barotraumaBrochard L, Roudot-Thoraval F, Roupie E, , Tidal Volume Reduction for Prevention of Ventilator-induced Lung Injury in Acute Respiratory Distress Syndrome.
Am J Respir Crit Care Me 1998 150: 1166-1172 [abstract]
Review, by Graham Tse, MD,
Tidal volume reduction in ARDS/Prevention of barotraumaRanieri VM, Suter PM, Tortorella C, et al. Effect of Mechanical Ventilation on Inflammatory Mediators in Patients with Acute Respiratory Distress Syndrome: A Randomized Controlled Trial
JAMA 1999 282:54-61 [abstract] [Full-Text]
Review, by S Kache, R Harrison
Tidal volume reduction in ARDS/Prevention of barotraumaStewart TE, Meade MO, Cook DJ, , Evaluation of a Ventilation Strategy to Prevent Barotrauma in Patients at High Risk for Acute Respiratory Distress Syndrome
N Engl J Med 1998 26: 15-23 [abstract]
Review, by Mona McPherson MD Michele Mariscalo MD
Tidal volume reduction in ARDS/Prevention of barotraumaAcute Respiratory Distress Syndrome Network, , , , Ventilation with Lower Tidal Volumes as Compared with Traditional Tidal Volumes for Acute Lung Injury and the Acute Respiratory Distress Syndrome.
N Engl J Med 2000 27:2331-6 [abstract]
Review, by Steven Cray
Tidal volume reduction in ARDS/Prevention of barotraumaBrower RG, Shanholtz CB, Fessler HE, , Prospective, randomized, controlled clinical trial comparing traditional versus reduced tidal volume ventilation in acute respiratory distress syndrome patients.
Crit Care Med 1999 27:1492-8 [abstract]
Review, by P. Prabhakaran
Tidal volume reduction in ARDS/Prevention of barotraumaMeade MO, Cook Dj, Guyatt GH, et al. for the Lung Open Ventilation Study Investigators. Ventilation Strategy Using Low Tidal Volumes, Recruitment Maneuvers, and High Positive End-Expiratory Pressure for Acute Lung Injury and Acute Respiratory Distress Syndrome: A Randomized Controlled Trial
JAMA 2008 299 637-645 [abstract]
Review, by Carlos Acuna MD, Antonio Cabrera MD, Le Bonheur Children’s Medical Center, University of Tennessee, Memphis, TN
Tidal volume reduction in ARDS/Prevention of barotraumaEsteban A, Alia I, Gordo F, et al. , Prospective Randomized Trial Comparing Pressure-Controlled Ventilation and Volume-Controlled Ventilation in ARDS
Chest 2000 117(6):1690-1696 [abstract] [Full-Text]
Review, by A Pelaez
Tracheal intubation issuesSanders RC Jr, Giuliano JS Jr, Sullivan JE, Brown CA 3rd, Walls RM, Nadkarni V, Nishisaki A; for the National Emergency Airway Registry for Children Investigators and Pediatric Acute Lung Injury and Sepsis Investigators Network Level of Trainee and Tracheal Intubation Outcomes.
Pediatrics 2013 131;e821. [abstract]
Review, by Cornelius A. James, MD, Paras Khandhar, MD, William Beaumont Hospital, Royal Oak MI
Tracheostomy in the ICURumbak MJ, Newton M, Truncale T, Schwartz SW, Adams JW, Hazard PB. A prospective, randomized, study comparing early percutaneous dilational tracheotomy to prolonged translaryngeal intubation (delayed tracheotomy) in critically ill medical patients
Crit Care Med. 2004 Aug;32(8):1689-94. [abstract]
Review, by Muzamil Noorani MD, Baylor College of Medicine, Houston TX
Unplanned extubation predictorsMarcin JP, Rutan E, Rapetti PM, Brown JP, Rahnamayi R, Pretzlaff RK. Nurse staffing and unplanned extubation in the pediatric intensive care unit.
Pediatr Crit Care Med. 2005 May;6(3):254-257. [abstract]
Review, by Corey Philpot MD, Medical College of Wisconsin and Children's Hospital of Wisconsin, Milwaukee, WI
Ventilator-induced lung injuryGajic O, Dara SI, Mendez JL, et al. Ventilator-associated lung injury in patients without acute lung injury at the onset of mechanical ventilation.
Crit Care Med. 2004 Sep;32(9):1817-24 [abstract]
Review, by Ronald Wong MD, Children's Hospital Los Angeles, Los Angeles CA
Ventilator-induced lung injurySerpa Neto A, Cardoso SO, Manetta JA, Pereira VG, EspĂłsito DC, Pasqualucci Mde O, Damasceno MC, Schultz MJ. Association between use of lung-protective ventilation with lower tidal volumes and clinical outcomes among patients without acute respiratory distress syndrome: a meta-analysis.
JAMA 2012 308(16):1651-9 [abstract]
Review, by Mary Lihinie deAlmeida MD, Weill Cornell Medical Center, New York, NY
Outcomes/Other
Acidosis/Lactate as Mortality PredictorCharpie JR, Dekeon MK, Goldberg CS, Mosca RS, Bove EL, Kulik TJ. Serial blood lactate measurements predict early outcome after neonatal repair or palliation for complex congenital heart disease.
J Thorac Cardiovasc Surg. 2000 Jul;120(1):73-80 [abstract]
Review, by A Gazit
Acidosis/Lactate as Mortality PredictorHatherill M, McIntyre AG, Wattie M, Murdoch IA, Early hyperlactataemia in critically ill children
Intensive Care Med 2000 26:314-318 [abstract]
Review, by R Graham
Acidosis/Lactate as Mortality PredictorMorris KP, McShane P, Stickley J, Parslow RC. The relationship between blood lactate concentration, the Paediatric Index of Mortality 2 (PIM2) and mortality in paediatric intensive care.
Intensive Care Med 2012 Dec;38(12):2042-6 [abstract]
Review, by Joseph Treister MD, University of California Irvine and Children's Hospital Orange Country, Irvine CA
Acidosis/Lactate as Mortality PredictorHatherill M, Waggie Z, Purves L, et al, Mortality and the nature of metabolic acidosis in children with shock
Intensive Care Med 2003 Feb;29(2):286-91 [abstract]
Review, by R Lambert A Zaritsky
Acidosis/Lactate as Mortality PredictorBernal W, Donaldson N, Wyncoll D, Wendon J, Blood lactate as an early predictor of outcome in paracetamol-induced acute liver failure: a cohort study
Lancet 2002 Feb 16;359(9306):558-63 [abstract]
Review, by P Prodhan N Noviski
Acidosis/Lactate as Mortality PredictorRossi AF, Khan DM, Hannan R, et al, Goal-directed medical therapy and point-of-care testing improve outcomes after congenital heart surgery
Intensive Care Med 2005 Jan;31(1):98-104 [abstract]
Review, by M Drayer R Harrison
Adrenal insufficiency/Steroids in sepsis/septic shockMcPhee LC, Badawi O, Fraser GL, Lerwick PA, Riker RR, Zuckerman IH, Franey C, Seder DB. Single-Dose Etomidate Is Not Associated With Increased Mortality in ICU Patients With Sepsis: Analysis of a Large Electronic ICU Database.
Crit Care Med 2013 41:774-783 [abstract]
Review, by Prashant Purohit MD, Nathan Luna MD, Lucile Packard Children’s Hospital at Stanford, Palo Alto, CA
Albumin as outcome predictorDurward A, Mayer A, Skellett S, et al., Hypoalbuminaemia in critically ill children: incidence, prognosis, and influence on the anion gap
Arch Dis Child 2003 May;88(5):419-22 [abstract]
Review, by R Lambert
Blood transfusionsKneyber MC, Hersi MI, Twisk JW, Markhorst DG, Plotz FB. Red blood cell transfusion in critically ill children is independently associated with increased mortality
Intensive Care Med 2007 33(8):1414-22 [abstract]
Review, by LM Zorzela MD, R Kirsh MD, G Guerra MD, AR Joffe MD; Stollery Children
Care models in the PICUPeeters B, Jansen NJ, Bollen CW, van Vught AJ, van der Heide D, Albers MJ. Off-hours admission and mortality in two pediatric intensive care units without 24-h in-house senior staff attendance.
Intensive Care Med 2010 36(11):1923-7 [abstract]
Review, by Paras Khandhar MD, Martin Wakeham MD, Medical College of Wisconsin and Milwaukee Children's Hospital, Milwaukee WI
Care models in the PICUNishisaki A, Pines JM, Lin R, Helfaer MA, Berg RA, Tenhave T, Nadkarni VM. The impact of 24-hr, in-hospital pediatric critical care attending physician presence on process of care and patient outcomes
Crit Care Med 2012 40(7):2190-5 [abstract]
Review, by Scott Wheatley MD, Baylor College of Medicine and Texas Children's Hospital, Houston TX
Care models in the PICUWallace DJ, Angus DC, Barnato AE, Kramer AA, Kahn JM. Nighttime Intensivist Staffing and Mortality among Critically Ill Patients.
N Engl J Med 2012 366:2093-101 [abstract]
Review, by Paras Khandhar MD, Martin Wakeham MD, Medical College of Wisconsin, Milwaukee WI
Care models in the PICUKerlin MP, Small DS, Cooney E, Fuchs BD, Bellini LM, Mikkelsen ME, Schweickert WD, Bakhru RN, Gabler NB, Harhay MO, Hansen-Flaschen J, Halpern SD. A Randomized Trial of Nighttime Physician Staffing in an Intensive Care Unit
N Engl J Med 2013 DOI: 10.1056/NEJMoa1302854 [abstract]
Review, by Brian M Jackson MD, Children's Hospital Colorado, Aurora CO
Catheter insertion techniquesFragou M, Gravvanis A, Dimitriou V, Papalois A, Kouraklis G, Karabinis A, Saranteas T, Poularas J, Papanikolaou J, Davlouros P, Labropoulos N, Karakitsos D. Real-time ultrasound-guided subclavian vein cannulation versus the landmark method in critical care patients: A prospective randomized study.
Crit Care Med 2011 39(7):1607-1612 [abstract]
Review, by Jennifer York MD, Washington University, St. Louis Children's Hospital, St. Louis MO
Catheter insertion techniquesAlten JA, Borasino S, Gurley WQ, Law MA, Toms R, Dabal RJ. Ultrasound-guided femoral vein catheterization in neonates with cardiac disease
Pediatr Crit Care Med. 2012 Nov;13(6):654-9 [abstract]
Review, by Shaghig Kouyoumjian MD, Kristin Richards MD, Children's Hospital Los Angeles, Los Angeles CA
Central line infection/complication preventionAnton N, Cox PN, Massicotte MP, Chait P, Yasui Y, Dinyari PM, Marzinotto V, Mitchell LG. Heparin-bonded central venous catheters do not reduce thrombosis in infants with congenital heart disease: a blinded randomized, controlled trial.
Pediatrics 2009 123(3):e453-8. [abstract]
Review, by Laura Haws MD, Children’s Mercy Hospital, Kansas City MO
Central line infection/complication preventionFroehlich CD, Rigby MR, Rosenberg ES, Li R, Roerig PL, Easley KA, Stockwell JA. Ultrasound-guided central venous catheter placement decreases complications and decreases placement attempts compared with the landmark technique in patients in a pediatric intensive care unit.
Crit Care Med 2009 Mar;37(3):1090-6. [abstract]
Review, by Amanda M. Madden DO, Children’s Mercy Hospital, University of Missouri-Kansas City, Kansas City, MO
Checklists in the ICUWeiss CH, Moazed F, McEvoy CA, Singer BD, Szleifer I, Amaral LA, Kwasny M, Watts CM, Persell SD, Baker DW, Sznajder JI, Wunderink RG. Prompting Physicians to Address a Daily Checklist and Process of Care and Clinical Outcomes: A Single-Site Study
Am J Respir Crit Care Med 2011 184:680–686. [abstract]
Review, by L. Nelson Sanchez-Pinto MD, Children's Hospital Los Angeles, Los Angeles CA
Death after life support withdrawalShore PM, Huang R, Roy L, Darnell C, Grein H, Robertson T, Thompson L. Development of a bedside tool to predict time to death after withdrawal of life-sustaining therapies in infants and children
Pediatr Crit Care Med. 2012 13:415–422 [abstract]
Review, by Natasha Afonso MD, Texas Childrens Hospital/Baylor College of Medicine, Houston TX
Diagnosis of Pulmonary EmbolismWells PS, Anderson DR, Rodger M, , Excluding Pulmonary Embolism at the Bedside without Diagnostic Imaging: Management of Patients with Suspected Pulmonary Embolism Presenting to the Emergency Department by Using a Simple Clinical Model and D-dimer
Ann Intern Med 2001 135:98-107 [abstract] [Full-Text]
Review, by D Mackey
Diagnosis of Pulmonary EmbolismQuiroz R, Kucher N, Zou KH, et al., Clinical Validity of a Negative Computed Tomography Scan in Patients With Suspected Pulmonary Embolism: A Systematic Review
JAMA 2005 Apr 27;293(16):2012-2017 [abstract]
Review, by S Hanson
Diagnostic Technology AssessmentMilling TJ Jr, Rose J, Briggs WM, Birkhahn R, Gaeta TJ, Bove JJ, Melniker LA. Randomized, controlled clinical trial of point-of-care limited ultrasonography assistance of central venous cannulation: The Third Sonography Outcomes Assessment Program (SOAP-3) Trial.
Crit Care Med 2005 171:348-353 [abstract]
Review, by Matthew Christopherson MB ChB MRCPCH, Leeds General Infirmary, UK
Diagnostic Technology AssessmentCoule LW, Truemper EJ, Steinhart CM, Lutin WA, Accuracy and utility of a continuous intra-arterial blood gas monitoring system in pediatric patients
Crit Care Med 2001 29(2):420-6 [abstract]
Review, by J Tuladhar
Economic Analysis of ED Analgesia ManagementRainer TH, Jacobs P, Ng YC , et al, Cost effectiveness analysis of intravenous ketorolac and morphine for treating pain after limb injury: double blind randomised controlled trial
Br Med J 2000 321:1247-1252 [abstract] [Full-Text]
Review, by A Torres
Effect of time/day of admission and PICU outcomesHixson ED, Davis S, Morris S, Harrison AM. Do weekends or evenings matter in a pediatric intensive care unit?
Pediatr Crit Care Med. 2005 Sep;6(5):523-530. [abstract]
Review, by W. Eddie Gordon MD, Texas Children's Hospital, Baylor College of Medicine, Houston TX
Effect of time/day of admission and PICU outcomesCavallazzi R, Marik PE, Hirani A, Pachinburavan M, Vasu TS, Leiby BE. Association between time of admission to the ICU and mortality: a systematic review and metaanalysis.
Chest 2010 138(1):68-75 [abstract]
Review, by K Kruse MD and J Krishnan MD, Helen DeVos Children's Hospital, Grand Rapids MI
Endotracheal tube placementPhipps LM, Thomas NJ, Gilmore RK, et al. Prospective assessment of guidelines for determining appropriate depth of endotracheal tube placement in children.
Pediatr Crit Care Med. 2005 6: 519-22 [abstract]
Review, by Danika Alexander MD, Downing Lu MD MPH, Walter Reed National Military Medical Center, Bethesda MD
ICU Outcome by VolumeMarcin JP, Song J, Leigh JP. The impact of pediatric intensive care unit volume on mortality: A hierarchical instrumental variable analysis.
Pediatr Crit Care Med. 2005 Mar;6(2):136-141 [abstract]
Review, by Al Torres MD FCCM, Nemours Children’s Hospital, Orlando FL
ICU Outcome by VolumeTilford JM, Simpson PM, Green JW, Lensing S, Fiser DH Volume-Outcome Relationships in Pediatric Intensive Care Units
Pediatrics 2000 106(2):289-294 [abstract]
Review, by J White
ICU Outcome by VolumeNathens AB, Jurkovich GJ, Maier RV , et al., Relationship between trauma center volume and outcomes
JAMA 2001 285(9):1164-71 [abstract] [Full-Text]
Review, by K Hardart
ICU Working EnvironmentAfessa B, Gajic O, Morales IJ, Keegan MT, Peters SG, Hubmayr RD. Association between ICU admission during morning rounds and mortality.
Chest 2009 136(6):1489-95 [abstract]
Review, by Aarti Bavare MD, Baylor College of Medicine, Texas Children's Hospital, Houston TX
ICU Working EnvironmentGajic O, Afessa B, Hanson AC, et al. Effect of 24-hour mandatory versus on-demand critical care specialist presence on quality of care and family and provider satisfaction in the intensive care unit of a teaching hospital.
Crit Care Med. 2008 36:26-44. [abstract]
Review, by Paras Khandhar MD, Martin Wakeham MD, Medical College of Wisconsin, Madison Wi
ICU Working EnvironmentLandrigan CP, Rothschild JM, Cronin JW, et al., Effect of reducing interns' work hours on serious medical errors in intensive care units
N Engl J Med 2004 Oct 28;351(18):1838-48 [abstract]
Review, by L Huang J Lajoie
MODS Prediction ModelsLeclerc F, Leteurtre S, Duhamel A, et al., Cumulative Influence of Organ Dysfunctions and Septic State on Mortality of Critically Ill Children
Am J Respir Crit Care Me 2005 171:348-353 [abstract]
Review, by K Typpo
MODS Prediction ModelsGraciano AL, Balko JA, Rahn DS, Ahmad N, Giroir BP. The Pediatric Multiple Organ Dysfunction Score (P-MODS): Development and validation of an objective scale to measure the severity of multiple organ dysfunction in critically ill children.
Crit Care Med 2005 Jul;33(7):1484-1491 [abstract]
Review, by K Hebbar, T Petrillo
MODS Prediction ModelsLeteurtre S, Martinot A, Duhamel A, et al. Validation of the paediatric logistic organ dysfunction (PELOD) score: prospective, observational, multicentre study
Lancet. 2003 Jul 19;362(9379):192-7 [abstract]
Review, by J. Davre McNally MD PhD, Children's Hospital of Eastern Ontario, Ottawa, Canada
Organ donation issuesWind J, Snoeijs MG, Brugman CA, Vervelde J, Zwaveling J, van Mook WN, van Heurn EL. Prediction of time of death after withdrawal of life-sustaining treatment in potential donors after cardiac death*
Crit Care Med 2012 40(3):766-9. [abstract]
Review, by Anna Gunz MD, Children’s Hospital of Eastern Ontario, Ottawa Canada
Outcome after cardiac arrestSharek PJ, Parast LM, Long K, Coombs J, Earnest K, Sullivan J, Frankel LR, Roth SJ. Effect of a Rapid Response Team on Hospital-wide Mortality and Code Rates Outside the ICU in a Children
JAMA 2007 298 2267-2274 [abstract]
Review, by Jennifer Plant MD, University of California San Francisco and Children’s Hospital and Research Center Oakland
Outcomes and head injury managementBulger EM, Nathens AB, Rivara FP, et al., Management of severe head injury: institutional variations in care and effect on outcome
Crit Care Med 2002 30(8):1870-6 [abstract]
Review, by J Adler
Oxygen delivery in shockDavison DL, Chawla LS, Selassie L, Jones EM, McHone KC, Vota AR, Junker C, Sateri S, Seneff MG. Femoral-based central venous oxygen saturation is not a reliable substitute for subclavian/internal jugular-based central venous oxygen saturation in patients who are critically ill
Chest 2010 138(1):76-83. [abstract]
Review, by Ivie D Esangbedo MD, Baylor College of Medicine, Texas Children's Hospital, Houston TX
Parental presence on roundsPhipps LM, Bartke CN, Spear DA, et al. Assessment of parental presence during bedside pediatric intensive care unit rounds: Effect on duration, teaching, and privacy
Pediatr Crit Care Med. 2007 8: 220-224 [abstract]
Review, by Julianne Harrison DO, Myke Federman MD, UCLA Mattel Children's Hospital, Los Angeles CA
Pediatric Early Warning Scoring systemsAkre M, Finkelstein M, Erickson M, Liu M, Vanderbilt L, Billman G. Sensitivity of the pediatric early warning score to identify patient deterioration.
Pediatrics 2010 25(4):e763-9 [abstract] [Full-Text]
Review, by Sanju Susan Samuel MD, Baylor College of Medicine and Texas Children's Hospital, Houston TX
Pediatric Organ Dysfunction PredictionLeteurtre S, Duhamel A, Salleron J, Grandbastien B, Lacroix J, Leclerc F; on behalf of the Groupe Francophone de RĂ©animation et d’Urgences PĂ©diatriques (GFRUP) PELOD-2: An Update of the PEdiatric Logistic Organ Dysfunction Score
Crit Care Med 2013 41(7):1761-1773 [abstract]
Review, by L. Nelson Sanchez-Pinto MD, Children's Hospital Los Angeles, Los Angeles CA
Post-operative analgesiaCeelie I, de Wildt SN, van Dijk M, van den Berg MM, van den Bosch GE, Duivenvoorden HJ, de Leeuw TG, MathĂ´t R, Knibbe CA, Tibboel D. Effect of intravenous paracetamol on postoperative morphine requirements in neonates and infants undergoing major noncardiac surgery: a randomized controlled trial.
JAMA 2013 9;309(2):149-54 [abstract]
Review, by Priyank Yagnik MD, University of Texas Southwestern Medical Center, Dallas TX
Pre-hospital patient management/access to careGausche M, Lewis RJ, Stratton SJ, , Effect of Out-of-Hospital Pediatric Endotracheal Intubation on Survival and Neurological Outcome: A Controlled Clinical Trial.
JAMA 2000 283:783-790 [abstract] [Full-Text]
Review, by J. Gregory K. Tegtmeyer
Pre-hospital patient management/access to careGoh AYT,, Abdel-Latif MEA, Lum LCS, Abu-Bakar MN, Outcome of children with different accessibility to tertiary pediatric intensive care in a developing country - a prospective cohort study
Intensive Care Med 2003 29: 97-102 [abstract]
Review, by J Cortes
Prevention of stress ulcerationCook D, Guyatt G, Marshall J, , A Comparison of Sucralfate and Ranitidine for the Prevention of Upper Gastrointestinal Bleeding in Patients Requiring Mechanical Ventilation
N Engl J Med 1998 25:346-351 [abstract]
Review, by Scot T. Bateman, M.D
Prevention of stress ulcerationMessori A, Trippoli S, Vaiani M, Gorini M, Corrado A. Bleeding and pneumonia in intensive care patients given ranitidine and sucralfate for prevention of stress ulcer: meta-analysis of randomised controlled trials
Br Med J 1999 321:1103-1106 [abstract] [Full-Text]
Review, by S Cray
Prevention of stress ulcerationKuusela AL, Ruuska T, Karikoski R, Laippala P, Ilonen S A randomized controlled study of prophylactic Ranitidine in preventing stress-induced gastric mucosal lesions in neonatal intensive care unit patients.
Crit Care Med 1997 127:257-266 [abstract]
Review, by Girish Deshpande, MD Kathleen Meert, MD
Prognosis Following Bone Marrow TransplantLamas A, Otheo E, Ros P, et al., Prognosis of child recipients of hematopoietic stem cell transplantation requiring intensive care
Intensive Care Med 2003 29: 91-96 [abstract]
Review, by L Hite
Prognosis Following Bone Marrow TransplantJacobe SJ, Hassan A, Veys P, Mok Q, Outcome of children requiring admission to an intensive care unit after bone marrow transplantation.
Crit Care Med 2003 31(5):1299-305 [abstract]
Review, by E Harry
Propofol infusion syndromeFong JJ, Sylvia L, Ruthazer R, Schumaker G, Kcomt M, Devlin JW. Predictors of mortality in patients with suspected propofol infusion syndrome
Crit Care Med 2008 36(8):2281-7 [abstract]
Review, by Mihaela Damian MD, Lucile Packard Children's Hospital, Stanford University School of Medicine, Palo Alto, CA
Quality of Life after BurnsSheridan RL, Hinson MI, Liang MH, , Long-term Outcome of Children Surviving Massive Burns
JAMA 2000 283:69-73 [abstract] [Full-Text]
Review, by R Graham
Quality of life after congenital heart surgeryCulbert EL, Ashburn DA, Cullen-Dean G, et al., Quality of Life of Children After Repair of Transposition of the Great Arteries
Circulation 2003 108 857-862 [abstract]
Review, by D Stockwell J Natale
Quality of life after PICUJones S, Rantell K, Stevens K et al. on behalf of the United Kingdom Pediatric Intensive Care Outcome Study Group. Outcome at 6 Months After Admission for Pediatric Intensive Care: A Report of a National Study of Pediatric Intensive Care Units in the United Kingdom.
Pediatrics 2006 118 2101-2108 [abstract]
Review, by Katri Typpo MD MPH, Baylor College of Medicine, Texas Children
Quality of life after PICUMorrison AL, Gillis J, O'Connell AJ, , Quality of life of survivors of pediatric intensive care
Pediatric Critical Care Medicine 2002 3:1-5 [abstract]
Review, by K Ventre
Quality of life after PICUKnoester H, Bronner MB, Bos AP. Surviving pediatric intensive care: physical outcome after 3 months.
Intensive Care Med 2008 34(6):1076-1082 [abstract]
Review, by Simon Li, MD and E. Vincent S. Faustino, MD, Yale University School of Medicine, New Haven, CT
Rapid response teamsAl-Qahtani S, Al-Dorzi HM, Tamim HM, Hussain S, Fong L, Taher S, Al-Knawy BA, Arabi Y. Impact of an Intensivist-Led Multidisciplinary Extended Rapid Response Team on Hospital-Wide Cardiopulmonary Arrests and Mortality
Crit Care Med 2013 41:506–517 [abstract]
Review, by Priti Jani MD, Julie Fitzgerald MD, University of Chicago, Chicago IL
Sedation issuesDeeter KH, King MA, Ridling D, Irby GL, Lynn AM, Zimmerman JJ. Successful implementation of a pediatric sedation protocol for mechanically ventilated patients.
Crit Care Med 2011 39:683–688 [abstract]
Review, by Manish Dhar Bajracharya MD, UTSW Medical Center/Dallas Children's Hospital, Dallas TX
Sedation issuesLe KN, Moffett BS, Ocampo EC, Zaki J, Mossad EB Impact of dexmedetomidine on early extubation in pediatric cardiac surgical patients
Intensive Care Med 2011 37(4):686-90 [abstract]
Review, by Manuel Silva MD, Baylor College of Medicine and Texas Children's Hospital, Houston, TX
Sedation issuesJakob SM, Ruokonen E, Grounds RM, Sarapohja T, Garratt C, Pocock SJ, Bratty JR, Takala J; Dexmedetomidine for Long-Term Sedation Investigators Dexmedetomidine vs midazolam or propofol for sedation during prolonged mechanical ventilation: two randomized controlled trials
JAMA 2012 21;307(11):1151-60 [abstract]
Review, by Scott Wheatley MD, Texas Children's Hospital and Baylor Medical College, Houston TX
Sedation issuesSrinivasan M, Turmelle M, Depalma LM, Mao J, Carlson DW. Procedural Sedation for Diagnostic Imaging in Children by Pediatric Hospitalists using Propofol: Analysis of the Nature, Frequency, and Predictors of Adverse Events and Interventions.
J Pediatr 2012 160:801-6. [abstract]
Review, by Keshava Murthy Narayana Gowda M.D., Children’s Hospital of Michigan, Detroit MI
Sedation issuesCourtman SP, Wardurgh A, Petros AJ. Comparison of the bispectral index monitor with the Comfort score in assessing level of sedation of critically ill children
Intensive Care Med. 2003 Dec;29(12):2239-46 [abstract]
Review, by Asavari Kamerkar DO, Children's Hospital Los Angeles, Los Angeles CA
Sedation issuesRiker RR, Shehabi Y, Bokesch PM, Ceraso D, Wisemandle W, Koura F, Whitten P, Margolis BD, Byrne DW, Ely EW, Rocha MG; for the SEDCOM (Safety and Efficacy of Dexmedetomidine Compared With Midazolam) Study Group Dexmedetomidine vs Midazolam for Sedation of Critically Ill Patients: A Randomized Trial.
JAMA 2009 301(5):489-499 [abstract]
Review, by Samuel Umaru MD, Baylor College of Medicine, Texas Children's Hospital, Houston TX
SIRS/sepsis predictorsFiser RT, West NK, Bush AJ, Sillos EM, Schmidt JE, Tamburro RF. Outcome of severe sepsis in pediatric oncology patients.
Pediatr Crit Care Med. 2005 Sep;6(5):531-536. [abstract] [Full-Text]
Review, by Danny Castro DO, Baylor College of Medicine, Texas Children
Telemedicine in the ICULilly CM, Cody S, Zhao H, Landry K, Baker SP, McIlwaine J, Chandler MW, Irwin RS; for the University of Massachusetts Memorial Critical Care Operations Group. Hospital Mortality, Length of Stay, and Preventable Complications Among Critically Ill Patients Before and After Tele-ICU Reengineering of Critical Care Processes.
JAMA 2011 2011;305 2175-2183 [abstract]
Review, by Thomas Conlon MD, The Children’s Hospital of Philadelphia, Philadelphia PA
Telemedicine in the ICUThomas EJ, Lucke JF, Wueste L, Weavind L, Patel B. Association of telemedicine for remote monitoring of intensive care patients with mortality, complications, and length of stay.
JAMA 2009 23;302(24):2671-8. [abstract]
Review, by Francis R. Carandang MD, Stanford University, Palo Alto CA
Transport issuesOrr RA, Felmet KA, Han Y, McCloskey KA, Dragotta MA, Bills DM, Kuch BA, Watson RS. Pediatric specialized transport teams are associated with improved outcomes.
Pediatrics 2009 124(1):40-8 [abstract]
Review, by Efren Gutierrez MD, Texas Children's Hospital and Baylor College of Medicine, Houston TX
Transport issuesStroud MH, Prodhan P, Moss M, Fiser R, Schexnayder S, Anand K Enhanced Monitoring Improves Pediatric Transport Outcomes: A Randomized Controlled Trial.
Pediatrics 2011 127: 42-48 [abstract]
Review, by Lance C. Peeples EMT-P, St. Louis Children's Hospital, St. Louis MO
Trisomy patients in the PICUTibby SM, Durward A, Goh CT, Thorburn K, Morris K, Broadhead M, Peters MJ. Clinical course and outcome for critically ill children with Down syndrome: a retrospective cohort study.
Intensive Care Med 2012 38(8):1365-71 [abstract]
Review, by Teck Wah Ting, MBBS MRCPCH and Jan Hau Lee, MBBS MRCPCH, KK Hospital, Singapore
Nursing Research
Nutritional methodologyOctober TW, Hardart GE. Successful placement of postpyloric enteral tubes using electromagnetic guidance in critically ill children.
Pediatr Crit Care Med. 2009 10(2):196-200. [abstract]
Review, by Cara Connolly MD, Beaumont Hospital, Dublin, Ireland
Organ donation issuesCurley MA, Harrison CH, Craig N, Lillehei CW, Micheli A, Laussen PC. Pediatric staff perspectives on organ donation after cardiac death in children
Pediatr Crit Care Med. 2007 8(3):212-9. [abstract]
Review, by Tessy A. Thomas DO, Baylor College of Medicine, Texas Children's Hospital, Houston TX
Post-operative analgesiaRamelet AS, Abu-Saad HH, Bulsara MK, et al. Capturing postoperative pain responses in critically ill infants aged 0 to 9 months.
Pediatr Crit Care Med. 2006 7: 19-26 [abstract]
Review, by Pamela Hilvers MD, Stacey Humphreys MD, Ashlee Smith DO, West Virginia University, Morgantown, WV
Prevention of corneal abrasionsSorce LR, Hamilton SM, Gauvreau K, Mets MB, Hunter DG, Rahmani B, Wu C, Curley MA. Preventing corneal abrasions in critically ill children receiving neuromuscular blockade: A randomized, controlled trial.
Pediatr Crit Care Med. 2009 10(2):171-175. [abstract]
Review, by Muzamil Noorani MD, Baylor College of Medicine, Texas Children's Hospital, Houston TX
Prone positioning in respiratory failureFineman LD, LaBrecque M, Shih M-C, Curley MA Prone positioning can be safely performed in critically ill infants and children
Pediatr Crit Care Med. 2006 7: 413-22 [abstract]
Review, by Mark D Weber RN PCCNP, Duke University Medical Center, Durham, NC
Risk factors for pressure ulcersMcCord S, McElvain V, Sachdeva R, et al Risk factors associated with pressure ulcers in the pediatric intensive care unit.
J Wound Ostomy Continence Nurs. 2004 31: 179-83 [abstract]
Review, by Jun Sasaki MD, Miami Children's Hospital, Miami FL
Sedation issuesCurley MA, Harris SK, Fraser KA, et al. State Behavioral Scale: A sedation assessment instrument for infants and young children supported on mechanical ventilation
Pediatr Crit Care Med. 2006 7: 107-114 [abstract]
Review, by Jun Sasaki MD, Miami Children's Hospital, Miami FL
Sedation issuesFranck LS, Harris SK, Soetenga DJ, Amling JK, Curley MA. The Withdrawal Assessment Tool-1 (WAT-1): an assessment instrument for monitoring opioid and benzodiazepine withdrawal symptoms in pediatric patients.
Pediatr Crit Care Med. 2008 9(6):573-80 [abstract]
Review, by Rebekah Shappley MD, Thomas Spentzas MD, University of Tennessee Health Science Center, Memphis TN
Therapy for AtelectasisAhrens T, Kollef M, Stewart J, et al . Effect of kinetic therapy on pulmonary complications.
Am J Crit Care 2004 13: 376-83 [abstract]
Review, by Aarti Gaglani MD, Phoenix Children's Hospital, Phoenix AZ
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