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Clinical Research
EB Journal Club
PALISI network
Surveys
NIH resources
Clinical Trials
Other grants |
... in this section ...
The National Institute of Child Health and Human Development (NICHD)
- Collaborative Pediatric Critical Care Research Network (CPCCRN)
- Willson DF, Dean JM, Meert KL, Newth CJ, Anand KJ, Berger J, Harrison R, Zimmerman J, Carcillo J, Pollack M, Holubkov R, Jenkins TL, Nicholson C; for the Eunice Kennedy Shriver National Institute of Child Health, and Human Development Collaborative Pediatric Critical Care Research Network. Collaborative Pediatric Critical Care Research Network: Looking back and moving forward. Pediatr Crit Care Med 2010; 11(1):1-6. [abstract]
- Willson DF, Dean JM, Newth C, et al. Collaborative Pediatric Critical Care Research Network (CPCCRN)* Pediatr Crit Care Med. 2006 Jul;7(4):301-307. [abstract]
- The Pediatric Critical Care Scientist Development Program (PCCSDP) has been successfully reissued by the NICHD.
The Pediatric Critical Care Scientist Development Program (PCCSDP) is a K12 program funded by the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD). The program began in 2004, and is entering its eighth year of funding. There have been 24 PCCSDP Scholars since the program began, and of these 24, ten have obtained independent K08 or K23 NIH grants. The program has two components. The first component, Phase I, is generally 2 years in length, and provides K-type funding to the Scholar's institution. The second component, Phase II, is the remainder of a five year total period, and is generally funded either by the institution or by the Scholar's own K award. It is a requirement for admission to the program that the institution makes a commitment to protect the Scholar for research development for the entire five year period.
One of the benefits of applying for the PCCSDP is participation in the annual research retreat, which will be held November 15 to 18, 2012, in Deer Valley, Utah. Applicant interviews are conducted during this retreat, so attendance at this retreat is mandatory for applicants. In addition to the interview process, applicants devote time listening to Scholar scientific presentations and discussions of scientific mentorship and faculty development. Please mark these dates on your calendar!
We anticipate having one to two available positions for funding beginning January 2013. The application deadline for the program is October 1, 2012. Applications are submitted in the current NIH K award format, and instructions are available on the NIH website. The entire application should be submitted to Dr. J. Michael Dean, the PCCSDP program director, at the University of Utah. Applications should be submitted electronically by email directly to Dr. Dean at mike.dean@hsc.utah.edu and should also be mailed. Detailed current instructions for the application procedure, including the mailing address, are available at the website: www.pccsdp.org.
Questions about the PCCSDP should be directed to Dr. Dean at the previously mentioned email address, with the subject heading "PCCSDP Applicant"; this subject heading avoids the dreaded Dr. Dean spam machine and will assure a prompt response. Dr. Dean does not participate in the selection of Scholars and can provide advice and feedback throughout the application process.
The PCCSDP is committed to the principles of diversity in academic pediatric critical care medicine and is introducing an innovative new program for PICU fellows who might be interested in research. As such, funding is now available for potential candidates from a diverse background who have an early interest in pediatric critical care research to participate in the annual retreat held in Deer Valley, Utah (November 15 – 18, 2012). Applications are now open to all fellows in PCCM who meet these criteria. It is not a requirement to have a fully developed research project or a faculty mentor. Retreat participants will be allowed to view the application process, and will benefit from exposure to the National Advisory Committee of the PCCSDP. Further, these fellows will undergo a focused development session, lead by senior PCCSDP faculty, exploring and expanding research ideas.
We anticipate three to five positions will be awarded to diverse, PCCM fellows to fund the cost of attending this year’s retreat, including transportation, hotel and dining expenses. An application to the retreat may be downloaded from the Diversity page of the website: www.pccsdp.org. Submission deadline is October 1, 2012. Applications should be submitted electronically by email directly to Dr. J. Michael Dean, the PCCSDP program director, at the University of Utah at mike.dean@hsc.utah.edu. Further information is available at the Website: www.pccsdp.org. Fellows who are accepted to attend the retreat will be notified by October 10, 2012 so that travel arrangements can be made.
The PCCSDP Research Retreat has been a positive experience for nearly 80 junior faculty since 2004, and the Diversity Program instituted in 2011 was well received by the critical care fellows who attended. The PCCSDP is now providing the opportunity for mid-career critical care faculty to participate in the annual retreat held in Deer Valley, Utah (November 15 - 18, 2012). Applications are now open to faculty in PCCM who are attempting to transition into research-focused activities after a substantial number of years primarily devoted to clinical care. We are nick-naming those considering this change “ Mid Career Research Travelers.” We do not require a fully developed research protocol or mentor. Retreat participants will be allowed to view the application process used for PCCSDP Scholars, will benefit from exposure to the National Advisory Committee of the PCCSDP. Mid Career travelers have the opportunity to interact with young critical care physician scientists who are presenting their research, and to thoughtfully consider the review process. Further, the mid-career faculty participants will undergo a focused development session, led by senior faculty and NIH program staff. This will be a good time to present research ideas and discuss obstacles to success.
We anticipate three to five positions being available for this year’s retreat. We cannot support travel costs (usually about $500 for lodging and food). Roundtrip airfare from your location to Salt Lake City will need to be provided by you or your institution as well. Some meals will be provided. An application for the Mid-Career Transition to Research Program may be downloaded on the website. In addition, submit a current curriculum vitae. Submission deadline is October 1, 2012. Applications should be submitted electronically by email directly to Dr. J. Michael Dean, the PCCSDP program director, at the University of Utah at mike.dean@hsc.utah.edu.
- Announced changes regarding the NIH peer review process:
- Multidisciplinary Translational Research in Critical Care: The National Institutes of Health (NIH) announce the availability of funds to promote multidisciplinary translational research that will improve the treatment, diagnosis, and outcome of patients with critical illness and increase the understanding of fundamental processes causing critical illness in humans of all ages. Read the full announcement: http://grants.nih.gov/grants/guide/pa-files/PA-07-233.html
- NIH Program Announcement for EMSC research: "This multi-agency program announcement is designed to improve the quality and quantity of research related to emergency medical services for children (EMSC), with the goal of reducing morbidity and mortality in children through improved care delivery." Read the full text here...
- PA-04-059: Technologies for Monitoring and Performing Resuscitation (SBIR [R43/R44])
This funding opportunity will fostering development of better systems and methods for out-of-hospital and basic resuscitation research that:
- enables monitoring of genetic, molecular, biochemical, physical or metabolic derangements associated with circulatory, hypoxemic, or traumatic arrest; and
- elucidates the unique pathophysiology of irreversible injury following multiple organ or whole-body ischemia and reperfusion.
- "Seeking Support From the NIH for Pediatric Critical Care Research" is an invaluable Powerpoint presentation by Carol Nicholson, MD, MS from the NIH/NICHD/NCMRR to anyone interested in seeking NIH funding. She has presented this at recent meetings and has now graciously made it publicly available. (Powerpoint file, 3.2 MB)
- Khemani RG, Newth CJ. The design of future pediatric mechanical ventilation trials for acute lung injury. Am J Respir Crit Care Med. 2010 Dec 15;182(12):1465-74. [abstract]
- CDC funding opportunities of interest to Pediatric Critical Care:
- Research Grants to Describe Traumatic Brain Injury Consequences
- The funding announcement for Research Grants to Describe Traumatic Brain Injury Consequences (CE06-003) can be accessed at www.cdc.gov/od/pgo/funding/CE06-003.htm .
- Approximately $650,000 is expected to be available.
- One award will be funded.
- Funding level will not exceed $650,000 (including both direct and indirect costs) per year.
- Project period is up to five years.
- The award mechanism is a R49 grant.
- Research Grants for the Care of the Acutely Injured
- The funding announcement for Research Grants for the Care of the Acutely Injured (CE06-005) can be accessed at www.cdc.gov/od/pgo/funding/CE06-005.htm .
- Approximately $1,800,000 is expected to be available.
- Three to five awards will be funded.
- Funding level will not exceed $450,000 (including both direct and indirect costs) per year.
- Project period is up to three years.
- The award mechanism is a R49 grant.
- Grants.gov is "a single, comprehensive Web site that will contain information about finding and applying for all federal grant programs."
- Pediatric critical care research training fellowships:
Be sure to scan the list of fellowships available for those with NIH Training Grant funding for pediatric scientist training...
- Children & Clinical Studies: an NIH-developed website to explain clinical research to children and families - why it is needed, what to expect, how to identify additional reliable resources.
Important announcements
The Robert Wood Johnson Clinical Scholars Program
The Robert Wood Johnson Clinical Scholars Program is a two-year fellowship for physicians interested in clinical research and healthcare leadership. The fellowship provides rigorous training in clinical and health services research, health policy, and community-based health research. Under the guidance of mentors, Scholars will conduct two or more independent clinical research projects during the fellowship. The fellowship is offered at four sites: the University of California, the University of Michigan, the University of Pennsylvania, and Yale University. Physicians typically apply in their second year of residency, for a start date after the end of their third year of residency. Surgeons can apply in their first year of residency. Application deadline: February 29, 2008.
For more detailed information and to obtain an application, please visit the Program website at http://rwjcsp.unc.edu/.
PALISI; Pediatric Acute Lung Injury and Sepsis Investigators. ![[updated]](images/updated.gif)
- A focused network of PICUs "to perform multicenter clinical studies to discover evidence that can improve the clinical management of critically ill children suffering from acute lung injury and sepsis." And now PALISI has a new and independent website here...
Clinical Trial Registration: Required
Want to publish your clinical trial in JAMA, The New England Journal, or other member journals of the International Committee of Medical Journal Editors? Starting July 2005 (for trials beginning enrollment after this date), your trial will need be registered in advance. Read DeAngelis CD, Drazen JM, Frizelle FA et al. Clinical Trial Registration: A Statement From the International Committee of Medical Journal Editors. JAMA 8 September 2004 (10.1001/jama.292.11.1363) [full-text].
Go to www.clinicaltrials.gov to register a trial.
An update: Laine C, et al. Clinical Trial Registration: Looking Back and Moving Ahead. New Engl J Med 2007; 10.1056/NEJMe078110 [full-text]
The National Data Archive on Child Abuse and Neglect
The National Data Archive on Child Abuse and Neglect is accepting applications for the 2005 Summer Research Institute (SRI). This message contains the Summer Research Institute 2005 Announcement and the Application questions.
A full description is available as a Word file (52K) or pdf document (60K).
The application is here: http://www.ndacan.cornell.edu/NDACAN/Workshops/SRI2005Application.html
From the Centers for Disease Control and Prevention (CDC):
Guillain Barre following Meningococcal Conjugate Vaccine
The Food and Drug Administration (FDA) and Centers for Disease Control and Prevention (CDC) are alerting consumers and health care providers to five reports of Guillain Barre Syndrome (GBS) following administration of Meningococcal Conjugate Vaccine A, C, Y, and W135 (trade name Menactra), manufactured by Sanofi Pasteur. It is not known yet whether these cases were caused by the vaccine or are coincidental. FDA and CDC are sharing this information with the public now and actively investigating the situation because of its potentially serious nature.
Because of the potentially serious nature of this matter, FDA and CDC are asking any persons with knowledge of any possible cases of GBS occurring after Menactra to report them to the Vaccine Adverse Event Reporting System (VAERS) to help the agencies further evaluate the matter. Individuals can report to VAERS on the web at www.vaers.hhs.gov or by phone at 1-800-822-7967. Read the complete alert: www.fda.gov/bbs/topics/NEWS/2005/NEW01238.html
Acute Encephalopathy Cases in U.S. Children Associated with Influenza Virus Infection
Since the mid-1990's, several hundreds of cases of acute encephalopathy have been reported in Japanese children with influenza. These cases have been characterized by fever and rapid onset of encephalopathy, resulting in a high frequency of neurological sequelae and mortality. Most of the children have had laboratory-confirmed evidence of influenza virus infection.
To determine if a similar pattern of influenza-associated encephalopathy cases is occurring in the U.S., the Centers for Disease Control and Prevention (CDC) is requesting information from health care providers on any case meeting the following criteria:
- < 18 years old;
- Altered mental status, or personality change, lasting > 24 hours, occurring within 5 days of the onset of an acute febrile respiratory illness;
- Laboratory or rapid diagnostic test evidence of acute influenza virus infection
- Diagnosed in the U.S.
Please report any suspected cases to either Dr. Tim Uyeki (404-639-0277; tmu0@cdc.gov) or Dr. Niranjan Bhat (404-639-2893; nib9@cdc.gov) at CDC.
The CDC Study of Pulmonary Hemorrhage in Infants: a call for cases.
Also see:
Information about the Pediatric Critical Care Study Group
- The premiere organization for multicenter clinical research in pediatric critical care is now part of The Virtual PICU
Network ARDS in Children
- A prospective Internet-based data collection project studying ARDS in children.
- Contact Dr. Lutz Bindl for more information on how to participate.
Clinical Research Trials:
Descriptions of studies available for additional collaborators
- Invitation to participate in SAFE EPIC: Saline vs. Albumin Resuscitation - Extrapolation to Paediatric Intensive Care, an international single day cross sectional observational study. Organized and sponsored by the Paediatric Study Group of the Australia and New Zealand Intensive Care Society (ANZICS PSG)The invitation is here...
- Seeking sites interested in participating in a NICHD funded study of the effects of sodium nitroprusside:
Study: A PHASE II, MULTICENTER, RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED, PARALLEL GROUP STUDY TO DETERMINE THE PHARMACODYNAMICS OF SODIUM NITROPRUSSIDE DURING PROLONGED INFUSION IN PEDIATRIC SUBJECTS (Protocol Number: NICHD-2003-09-LT)
Requirements: ≥12 bed PICU caring for infants and children with hypertension for which sodium nitroprusside may be administered for at least 12 hours. Sites should have the infrastructure to conduct relatively complex clinical trials.
Interested investigators should contact Dr. Greg Hammer, Professor of Anesthesia and Pediatrics, Stanford University School of Medicine at ham@stanford.edu.
- From Dr. Goldstein at Oregon Health & Sciences University: Traumatic Brain Injury Research Project: additional sites interested in participating in our physiologic waveform analysis and dynamic ICP modeling research project. Read more here...
- The Genomics of Pediatric Sepsis Database is now entering its 9th year of funding by the NIH. The goals of the database have now matured from the initial discovery and exploratory phase, to a translational and clinical application phase. Extensive details regarding the progress and achievements of the database can found at this website. Or read more here here (pdf file, 58K)...
- A Pilot Study of Abnormal Acquired and Genetic Coagulation Factors in Children with Porencephaly and Stroke
- Consider adding an outline of your trial to attract other interested investigators
- National and International Databases of Clinical Research Trials
Surveys of the pediatric critical care community?
- The CDC is interested in cases of severe pertussis in PICU's in the United States. Please download and complete this very brief survey (Word file, 24K) and return to Dr. Karen Broder at kbroder@cdc.gov.
- Have a survey idea? Would you like it posted on PedsCCM? Email us for details.
- Survey results:
- Where are acuity lines drawn between PICU's and Transitional Care Units? Survey results from C. Adams, Kosair Children's Hospital, Louisville KY. (Powerpoint presentation 208K)
Rare Diseases Clinical Research;
Grant resources on the Internet
Last Updated: 2013-01-28 20:32:25
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