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PALISI: Pediatric Acute Lung Injury and Sepsis Investigators
MISSION STATEMENT
The Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) are a collaboration of clinical researchers in 39 large pediatric intensive care units across North America. These researchers have joined together to identify optimal supportive, preventive and therapeutic strategies for acute lung injury, sepsis, multi-organ failure, and other acute, life-threatening pulmonary or systemic inflammatory syndromes that affect infants and children. The PALISI Network's goal is to perform multi-center research studies to better describe disease processes and outcomes in pediatric patients and to evaluate interventions in this population. Study designs include prospective cohort studies, case-control studies, genetic epidemiology and gene expression studies, drug dosing and metabolism studies, and Phase I, II, III and IV clinical trials. PALISI network members have the ultimate goal of improving the care and health outcomes of critically ill infants and children.
CURRENT NETWORK SITES (39)
- University of Alabama, Birmingham, Alabama
- Children’s Hospital Los Angeles, Los Angeles, California
- Children's Hospital and Research Center, Oakland, California
- Children's Hospital of Central California, Fresno, California
- Children’s Hospital of Orange County, Orange, California
- University of California at San Francisco, San Francisco, California
- Children’s Hospital of Denver, Denver, Colorado
- Connecticut Children's Medical Center, Hartford, Connecticut
- Yale University School of Medicine, New Haven, Connecticut
- Children's National Medical Center, Washington, DC
- University of Florida College of Medicine, Gainesville, Florida
- Holtz Children's Hospital, Miami, Florida
- Miami Children’s Hospital, Miami, Florida
- University of Kentucky Children’s Hospital, Lexington, Kentucky
- Children's Hospital, Boston, Massachusetts
- UMASS Memorial Medical Center, Worcester, Massachusetts
- University of Minnesota, Minneapolis, Minnesota
- Washington University School of Medicine, St. Louis, Missouri
- Children’s Hospital of Omaha, Omaha, Nebraska
- Children's Hospital at Dartmouth, Lebanon, New Hampshire
- Children's Hospital at Montefiore, Bronx, New York
- Cornell Medical Center, New York, New York
- Duke Children's Hospital, Durham, North Carolina
- Brenner Children’s Hospital, Winston-Salem, North Carolina
- Nationwide Children’s Hospital, Columbus, Ohio
- Doernbecher Children's Hospital, Portland, Oregon
- Penn State Children's Hospital, Hershey, Pennsylvania
- Children's Hospital of Philadelphia, Philadelphia, Pennsylvania
- Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania
- Vanderbilt Children's Hospital, Nashville, Tennessee
- St. Jude Children's Research Hospital, Memphis, Tennessee
- University of Texas Southwestern Medical Center, Dallas, Texas
- Primary Children's Medical Center, Salt Lake City, Utah
- University of Virginia Children's Medical Center, Charlottesville, Virginia
- Seattle Children’s Hospital, Seattle, Washington
- Children's Hospital of Wisconsin, Milwaukee, Wisconsin
- Stollery Children’s Hospital, Edmonton, Alberta, Canada
- The Hospital for Sick Children, Toronto, Ontario, Canada
- HĂ´pital Sainte-Justine, Montreal, Quebec, Canada
PUBLISHED WORK
- Randolph AG, Meert KL, O'Neil ME, Hanson JH, Luckett PM, Arnold JH, Gedeit RG, Cox PN, Roberts JS, Venkataraman ST, Forbes PW, Cheifetz IM; Pediatric Acute Lung Injury and Sepsis Investigators Network. The feasibility of conducting clinical trials in infants and children with acute respiratory failure. Am J Respir Crit Care Med. 2003 May 15;167(10):1334-40. [abstract]
- Randolph AG, Wypij D, Venkataraman ST, Hanson JH, Gedeit RG, Meert KL, Luckett PM, Forbes P, Lilley M, Thompson J, Cheifetz IM, Hibberd P, Wetzel R, Cox PN, Arnold JH; Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network. Effect of mechanical ventilator weaning protocols on respiratory outcomes in infants and children: a randomized controlled trial. JAMA. 2002 Nov 27;288(20):2561-8. [abstract]
- Willson DF, Thomas NJ, Markovitz BP, Bauman LA, DiCarlo JV, Pon S, Jacobs BR, Jefferson LS, Conaway MR, Egan EA; Pediatric Acute Lung Injury and Sepsis Investigators. Effect of exogenous surfactant (calfactant) in pediatric acute lung injury: a randomized controlled trial. JAMA. 2005 Jan 26;293(4):470-6. [abstract]
- Curley MA, Hibberd PL, Fineman LD, Wypij D, Shih MC, Thompson JE, Grant MJ, Barr FE, Cvijanovich NZ, Sorce L, Luckett PM, Matthay MA, Arnold JH. Effect of prone positioning on clinical outcomes in children with acute lung injury: a randomized controlled trial. JAMA. 2005 Jul 13;294(2):229-37. [abstract]
- Randolph AG, Forbes PW, Gedeit RG, Arnold JH, Wetzel RC, Luckett PM, O'neil ME, Venkataraman ST, Meert KL, Cheifetz IM, Cox PN, Hanson JH; for the Pediatric Acute Lung Injury & Sepsis Investigators (PALISI) Network. Cumulative fluid intake minus output is not associated with ventilator weaning duration or extubation outcomes in children. Pediatr Crit Care Med. 2005 Nov;6(6):642-647 [abstract]
- Lacroix J, Hebert PC, Hutchison, et al., for the TRIPICU Investigators, the Canadian Critical Care Trials Group, and the Pediatric Acute Lung Injury and Sepsis Investigators Network. Transfusion Strategies for Patients in Pediatric Intensive Care Units. New Engl J Med 2007; 356:1609-1619. [abstract]
CURRENT STUDIES
Completed
- A randomized clinical trial comparing two protocols (pressure support and volume support) to no protocol for weaning infants and children from mechanical ventilator support. Principal Investigator: Adrienne Randolph, MD, MSc, Children's Hospital, Boston
- A randomized clinical trial of prone positioning for acute lung injury in children. Principal Investigator: Martha Curley, RN, PhD, Children's Hospital, Boston
- A randomized clinical trial of calf-lung surfactant for acute lung injury. Principal Investigator: Doug Willson, MD, University of Virginia Children's Medical Center
- An observational study of blood loss and determinants of transfusion in critically ill children, Scot Bateman, Adrienne Randolph, and Jacques Lacroix, MD
- A randomized trial comparing a liberal versus restrictive transfusion threshold in stable critically ill children.
Ongoing
- Endotracheal Lucinactant (Surfaxin) for acute hypoxemic respiratory failure in children under 2 years of age
- PALIVE study: An international transversal study capturing data on how ALI patients are managed
- Prospective observational study of critical pertussis (in association with CPCCRN)
- Download the most recent (not finalized) protocol here... (updated July 26, 2007; pdf; 360K)
- If your site is interested in participating, download an "interest" form as pdf (these are indications of interest only and do not imply a guarantee of participation or a commitment on your part at this time...). Applications are still being accepted.
- Cluster RCT on Sedation Management in children with acute respiratory failure (funded by NIH, NHLBI)
- RCT of Calfactant for ALI in oncology patients
- Phase II Pediatric RCT on Glucose Control using an electronic protocol for insulin management
CURRENT HEMATOPOIETIC STEM CELL TRANSPLANTATION (HSCT) ONCOLOGY SUBGROUP STUDIES
Ongoing Studies
- Survey of current practice variation in management of HSCT patients across centers
Proposed Studies
- Observational study of the outcomes of HSCT patients in the ICU
- Calfactant for ALI in HSCT
NETWORK LEADERSHIP
Chair: Adrienne G. Randolph, MD, MSc (2002-present), Children's Hospital, Boston, MA, USA
Executive Committee:
- Jacques Lacroix, MD (2002-present), Hopital St. Justine, Montreal, Quebec, Canada
- Ann Thompson, MD (2002-present), Children’s Hospital of Pittsburgh, Pittsburgh, PA, USA
- Doug Willson, MD (2002-present), University of Virginia Children’s Medical Center, Charlottesville, VA, USA
- Arno Zaritsky, MD (2004-present), Shand’s Children’s Hospital, Gainesville, FL, USA
Scientific-Steering Committee:
- Ira Cheifetz, MD (2002-present), Duke Children’s Hospital, Durham, NC, USA
- Heidi Flori, MD, (2002-present), Children’s Hospital Oakland, CA, USA
- Barry Markovitz, MD MPH (2002-present), Children’s Hospital of Los Angeles, CA, USA
- Vinay Nadkarni, MD (2004-present), Children’s Hospital of Philadelphia, PA, USA
- Neal Thomas, MD (2004-present), Penn State Children’s Hospital, Hershey, PA, USA
- Scott Watson, MD, MPH (2004-present), Children’s Hospital of Pittsburgh, Pittsburgh, PA, USA
Past members:
- Executive Committee: Jerry Zimmerman, MD, PhD, Children’s Hospital Seattle, WA (2002-2004), Arno Zaritsky MD, Shand's Children's Hospital, Gainesvilled, FL USA (2007-2007)
- Scientific Steering Committee: Brahm Goldstein, MD (2002-2004); Martha Curley, RN, PhD (2002-2004); Arno Zaritsky, MD (2002-2004); Christopher Newth, MD (2002-2004)
CONTACT INFORMATION:
For additional information about PALISI, please contact:
Laura Clark
PALISI Network Coordinator
Children’s Hospital Boston
300 Longwood Avenue
Bader 634
Boston, MA 02115
Laura.Clark2@childrens.harvard.edu
Phone: 617-355-6143
Fax: 617-730-0453
PALISI: MEETINGS
Upcoming Meetings
12th International PALISI Meeting
Fall, 2008
Montreal, Canada
Past Meetings
First International PALISI Meeting
October 17-20th, 2002
Topnotch Resort
Stowe, Vermont
Second International PALISI Meeting
June 5-7th, 2003
Boston Park Plaza Hotel
Boston, Massachusetts
Third International PALISI Meeting
January 15-17th, 2004
Shadow Ridge Resort and Conference Center
Park City, Utah
Fourth International PALISI Meeting
October 2-4th, 2004
Park Central Hotel
New York, New York
5th International PALISI Meeting
March 16th-19th 2005
Snowbird Resort & Conference Center, Cliff Lodge
Snowbird, Utah
6th International PALISI Meeting
September 22-24, 2005
Montreal, Quebec, Canada
7th International PALISI Meeting
March 8-11
Snowbird Resort & Conference Center, Cliff Lodge
Snowbird, Utah
8th International PALISI Meeting
September 17-20, 2006
Hotel Viking
Newport, RI
9th International PALISI Meeting
March 21-24, 2007
Snowbird Resort and Conference Center, Cliff Lodge
10th International PALISI Meeting
October 4-7, 2007
Williamsburg Lodge
Williamsburg, Virginia
11th International PALISI Meeting
March 5-8, 2008
Snowbird Resort & Conference Center, Cliff Lodge
Snowbird, Utah
Last Updated: 2008-04-09 08:52:52
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