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PALISI: Pediatric Acute Lung Injury and Sepsis Investigators
MISSION STATEMENT
The Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) are a collaboration of clinical researchers in 39 large pediatric intensive care units across North America. These researchers have joined together to identify optimal supportive, preventive and therapeutic strategies for acute lung injury, sepsis, multi-organ failure, and other acute, life-threatening pulmonary or systemic inflammatory syndromes that affect infants and children. The PALISI Network's goal is to perform multi-center research studies to better describe disease processes and outcomes in pediatric patients and to evaluate interventions in this population. Study designs include prospective cohort studies, case-control studies, genetic epidemiology and gene expression studies, drug dosing and metabolism studies, and Phase I, II, III and IV clinical trials. PALISI network members have the ultimate goal of improving the care and health outcomes of critically ill infants and children.
CURRENT NETWORK SITES (78)
- Brenner Children's Hospital
- Cardinal Glennon Children's Medical Center (St. Louis University)
- Children's and Women's Hospital
- Children's Healthcare of Atlanta
- Children's Hospital and Regional Medical Center
- Children's Hospital and Research Center at Oakland
- Children's Hospital at Dartmouth
- Children's Hospital at Montefiore
- Children's Hospital Boston
- Children's Hospital of Alabama
- Children's Hospital of Austin
- Children's Hospital of Central California
- Children's Hospital of Cincinnati
- Children's Hospital of Denver
- Children's Hospital of Los Angeles
- Children's Hospital of Michigan
- Children's Hospital of Nebraska
- Children's Hospital of Orange County
- Children's Hospital of Philadelphia
- Children's Hospital of Pittsburgh
- Children's Hospital of Wisconsin
- Children's Hospitals and Clinics Minneapolis/St Paul
- Children's Memorial Hospital
- Children's Mercy Hospital
- Children's National Medical Center
- Cincinnati Children's Hospital
- Columbia University
- Connecticut Children's Medical Center
- Cornell Medical Center
- Dana Farber Cancer Institute
- Dell Children's Medical Center of Central Texas
- Denver Children's Hospital
- Discovery Labs
- Doernbecher Children's Hospital
- Duke Children's Hospital
- Duke University Medical Center
- Hackensack University Medical Center
- Hospital Sainte-Justine
- Intermountain Medical Center (LDS Hospital)
- Jackson Children's Hospital
- Johns Hopkins University
- Kentucky Children's Hospital
- Kosair Children's Hospital
- Massachusetts General Hospital
- Mayo Eugenia Litta Children's Hospital
- Medical University of South Carolina
- Miami Children's Hospital
- Monroe Carell Jr. Children's Hospital at Vanderbilt
- Montefiore Medical Center
- Nationwide Children's Hospital
- Penn State Children's Hospital
- Primary Children's Medical Center
- Rainbow Children's Hospital
- Riley Hospital for Children
- Soroka Medical Center
- St. Jude Children's Research Hospital
- St. Louis Children's Hospital
- Stollery Children's Hospital
- Texas Children's Hospital
- The Hospital for Sick Children
- UMASS Memorial Medical Center
- University of Alberta Hospital
- University of Arizonia
- University of California at San Francisco Medical Center
- University of Florida College of Medicine
- University of Florida, Jacksonville
- University of Kentucky Children's Hospital
- University of Louisville
- University of Michigan
- University of Minnesota
- University of North Carolina at Chapel Hill
- University of Pennsylvania
- University of Texas Southwestern Medical Center
- University of Virginia Children's Hospital
- Vanderbilt University Medical Center
- Washington University School of Medicine
- Weill Cornell Medical Center
- Yale University School of Medicine
PUBLISHED WORK
- Randolph AG, Meert KL, O'Neil ME, Hanson JH, Luckett PM, Arnold JH, Gedeit RG, Cox PN, Roberts JS, Venkataraman ST, Forbes PW, Cheifetz IM; Pediatric Acute Lung Injury and Sepsis Investigators Network. The feasibility of conducting clinical trials in infants and children with acute respiratory failure. Am J Respir Crit Care Med. 2003 May 15;167(10):1334-40. [abstract]
- Randolph AG, Wypij D, Venkataraman ST, Hanson JH, Gedeit RG, Meert KL, Luckett PM, Forbes P, Lilley M, Thompson J, Cheifetz IM, Hibberd P, Wetzel R, Cox PN, Arnold JH; Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network. Effect of mechanical ventilator weaning protocols on respiratory outcomes in infants and children: a randomized controlled trial. JAMA. 2002 Nov 27;288(20):2561-8. [abstract]
- Willson DF, Thomas NJ, Markovitz BP, Bauman LA, DiCarlo JV, Pon S, Jacobs BR, Jefferson LS, Conaway MR, Egan EA; Pediatric Acute Lung Injury and Sepsis Investigators. Effect of exogenous surfactant (calfactant) in pediatric acute lung injury: a randomized controlled trial. JAMA. 2005 Jan 26;293(4):470-6. [abstract]
- Curley MA, Hibberd PL, Fineman LD, Wypij D, Shih MC, Thompson JE, Grant MJ, Barr FE, Cvijanovich NZ, Sorce L, Luckett PM, Matthay MA, Arnold JH. Effect of prone positioning on clinical outcomes in children with acute lung injury: a randomized controlled trial. JAMA. 2005 Jul 13;294(2):229-37. [abstract]
- Randolph AG, Forbes PW, Gedeit RG, Arnold JH, Wetzel RC, Luckett PM, O'neil ME, Venkataraman ST, Meert KL, Cheifetz IM, Cox PN, Hanson JH; for the Pediatric Acute Lung Injury & Sepsis Investigators (PALISI) Network. Cumulative fluid intake minus output is not associated with ventilator weaning duration or extubation outcomes in children. Pediatr Crit Care Med. 2005 Nov;6(6):642-647 [abstract]
- Lacroix J, Hebert PC, Hutchison, et al., for the TRIPICU Investigators, the Canadian Critical Care Trials Group, and the Pediatric Acute Lung Injury and Sepsis Investigators Network. Transfusion Strategies for Patients in Pediatric Intensive Care Units. New Engl J Med 2007; 356:1609-1619. [abstract]
- Bateman ST, Lacroix J, Boven K, Forbes P, Barton R, Thomas NJ, Jacobs B, Markovitz B, Goldstein B, Hanson JH, Li HA, Randolph AG. Anemia, Blood Loss, and Blood Transfusions in North American Children in the Intensive Care Unit. Am J Respir Crit Care Med. 2008 Apr 17. [Epub ahead of print] [abstract]
- Tamburro RF, Thomas NJ, Pon S, Jacobs BR, Dicarlo JV, Markovitz BP, Jefferson LS, Willson DF; Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network. Post hoc analysis of calfactant use in immunocompromised children with acute lung injury: Impact and feasibility of further clinical trials. Pediatr Crit Care Med. 2008 Sep;9(5):459-64. [abstract]
CURRENT STUDIES
Completed
- A randomized clinical trial comparing two protocols (pressure support and volume support) to no protocol for weaning infants and children from mechanical ventilator support. Principal Investigator: Adrienne Randolph, MD, MSc, Children's Hospital, Boston
- A randomized clinical trial of prone positioning for acute lung injury in children. Principal Investigator: Martha Curley, RN, PhD, Children's Hospital, Boston
- A randomized clinical trial of calf-lung surfactant for acute lung injury. Principal Investigator: Doug Willson, MD, University of Virginia Children's Medical Center
- An observational study of blood loss and determinants of transfusion in critically ill children, Scot Bateman, Adrienne Randolph, and Jacques Lacroix, MD
- A randomized trial comparing a liberal versus restrictive transfusion threshold in stable critically ill children.
Ongoing
- Endotracheal Lucinactant (Surfaxin) for acute hypoxemic respiratory failure in children under 2 years of age
- PALIVE study: An international transversal study capturing data on how ALI patients are managed
- Prospective observational study of critical pertussis (in association with CPCCRN)
- Download the most recent (not finalized) protocol here... (updated July 26, 2007; pdf; 360K)
- If your site is interested in participating, download an "interest" form as pdf (these are indications of interest only and do not imply a guarantee of participation or a commitment on your part at this time...). Applications are still being accepted.
- Cluster RCT on Sedation Management in children with acute respiratory failure (funded by NIH, NHLBI)
- RCT of Calfactant for ALI in oncology patients
- Phase II Pediatric RCT on Glucose Control using an electronic protocol for insulin management
CURRENT HEMATOPOIETIC STEM CELL TRANSPLANTATION (HSCT) ONCOLOGY SUBGROUP STUDIES
Ongoing Studies
- Survey of current practice variation in management of HSCT patients across centers
Proposed Studies
- Observational study of the outcomes of HSCT patients in the ICU
- Calfactant for ALI in HSCT
NETWORK LEADERSHIP
Chair: Adrienne G. Randolph, MD, MSc (2002-present), Children's Hospital, Boston, MA, USA
Executive Committee:
- Dan Levin, MD (2008-present), Dartmouth Medical Center, Hanover, NH, USA
- Jacques Lacroix, MD (2002-present), Hopital St. Justine, Montreal, Quebec, Canada
- Ann Thompson, MD (2002-present), Children’s Hospital of Pittsburgh, Pittsburgh, PA, USA
- Doug Willson, MD (2002-present), University of Virginia Children’s Medical Center, Charlottesville, VA, USA
Scientific-Steering Committee:
- Ira Cheifetz, MD (2002-present), Duke Children’s Hospital, Durham, NC, USA
- Heidi Flori, MD, (2002-present), Children’s Hospital Oakland, CA, USA
- Barry Markovitz, MD MPH (2002-present), Children’s Hospital of Los Angeles, CA, USA
- Vinay Nadkarni, MD (2004-present), Children’s Hospital of Philadelphia, PA, USA
- Neal Thomas, MD (2004-present), Penn State Children’s Hospital, Hershey, PA, USA
- Scott Watson, MD, MPH (2004-present), Children’s Hospital of Pittsburgh, Pittsburgh, PA, USA
Past members:
- Executive Committee: Jerry Zimmerman, MD, PhD, Children’s Hospital Seattle, WA (2002-2004), Arno Zaritsky MD, Shand's Children's Hospital, Gainesvilled, FL USA (2007-2007)
- Scientific Steering Committee: Brahm Goldstein, MD (2002-2004); Martha Curley, RN, PhD (2002-2004); Arno Zaritsky, MD (2002-2004); Christopher Newth, MD (2002-2004)
CONTACT INFORMATION:
For additional information about PALISI, please contact:
Laura Clark
PALISI Network Coordinator
Children’s Hospital Boston
300 Longwood Avenue
Bader 634
Boston, MA 02115
Laura.Clark2@childrens.harvard.edu
Phone: 617-355-6143
Fax: 617-730-0453
PALISI: MEETINGS
Upcoming Meetings
13th International PALISI Meeting
March 4-7, 2009
Snowbird Resort & Conference Center, Cliff Lodge
Snowbird, Utah
Please make reservations by February 2, 2009 to receive the discounted rate.
Reservations: 1-800-453-3000
Specify you are attending the PALISI Network International Meeting (Children’s Hospital Boston)
Past Meetings
First International PALISI Meeting
October 17-20th, 2002
Topnotch Resort
Stowe, Vermont
Second International PALISI Meeting
June 5-7th, 2003
Boston Park Plaza Hotel
Boston, Massachusetts
Third International PALISI Meeting
January 15-17th, 2004
Shadow Ridge Resort and Conference Center
Park City, Utah
Fourth International PALISI Meeting
October 2-4th, 2004
Park Central Hotel
New York, New York
5th International PALISI Meeting
March 16th-19th 2005
Snowbird Resort & Conference Center, Cliff Lodge
Snowbird, Utah
6th International PALISI Meeting
September 22-24, 2005
Montreal, Quebec, Canada
7th International PALISI Meeting
March 8-11
Snowbird Resort & Conference Center, Cliff Lodge
Snowbird, Utah
8th International PALISI Meeting
September 17-20, 2006
Hotel Viking
Newport, RI
9th International PALISI Meeting
March 21-24, 2007
Snowbird Resort and Conference Center, Cliff Lodge
10th International PALISI Meeting
October 4-7, 2007
Williamsburg Lodge
Williamsburg, Virginia
11th International PALISI Meeting
March 5-8, 2008
Snowbird Resort & Conference Center, Cliff Lodge
Snowbird, Utah
12th International PALISI Meeting
September 24-27, 2008
Intercontinental Montreal Hotel, Montreal, Quebec
Last Updated: 2008-12-10 15:25:05
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