Session/Time	Neurology/Fri, 10:00 - 12:00 PM
Title	Validation of Frequency-Domain Near Infrared Spectroscopy with Cerebral Oxygen Saturation Measurements in Children
Author	HM Watzinan, CD Kurth, J Rome, SC Nicolson, JM Steven, LM Montenegro
Affiliation	Department of Anesthesia and Pediatrics. The Children's Hospital of Philadelphia, University of Pennsylvania, Philadelphia, PA
Introduction	Near infrared spectroscopy (NIRS) is a non-invasive method to monitor cerebral 0, saturation. NIRS has lacked absolute quantification related to uncertainties in optical pathlength and light scattering. Recently, frequency-domain NIRS (fdNTIRS) was developed to measure optical pathiength and absorption, permitting absolute quantitation of saturation. This study compared cerebral 02 saturation measured by fdNIRS with co-oximetry.
Method	We studied 15 children, (newbom to 6 years) with congenital heart disease during cardiac catheterization. Blood was withdrawn from catheters- in the jugular bulb and ascending aorta to measure cerebral-venous saturation (SvO,) and arterial saturation (SaO,). N92 S cerebral saturation (nirsSO,) was measured with fdNIRS probe on the forehead. SvO2, SaO2, and nirsSO2 were recorded during 3 conditions: 21% FiO2-normoventilation, 100% FiO2-normov entilation, and 21% FiO2 - hyperventilation. nirsSO2 was compared with SaO2 and SvO2 by multi-linear regression analysis.
Result
Conclusion	fdNIRS accuracy was excellent between 35% - 92% cerebral 02 saturation. Its bias and precision meet clinical instrument standards (-10%), similar to pulse oximetry. From the regr ession, fdNMS measures saturation between artery and vein, weighted toward venous saturation, consistent with the concept that NIRS monitors a mixed vascular saturation.Figure: multilinear regressoin between NIRS(nirSO2) vs. arterial (SaO2) and jugular bulb (SvO2)saturation.

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Document created April 12, 1999