| 11 th Annual Pediatric Critical Care Colloquium |
| Session/Time | Neurology/Fri, 10:00 - 12:00 PM |
| Title | Comparison of Neurologic Outcome Following Deep Hypothermic Circulatory Arrest Using Alpha-Stat and Ph-Stat Cardiopulmonary Bypass |
| Author | MA Priestley, MD; CD Kurth, MD; IB O'Hara, MD; J Golden, MD, J McCann, BS |
| Affiliation | Departments of Anesthesiology andICritical Care Medicine and Pathology. The Children's Hospital of Philadelphia, Philadelphia, PA |
| Introduction | Deep hypothermic circulatory arrest (DHCA) for heart surgery poses risk of brain damage. In neonates, pH-stat management during cardiopulmonary bypass (CPB) has been suggested to improve neurologic outcome compared with alpha (a)-stat. This study compared neurologic outcome in newborn pigs after DHCA with a-stat or ph-stat CPB |
| Method | Fourteen piglets aged 5-10 days were randon-Jy assigned to a-stat (n--7) or ph-stat (n=7) CPB management (100 ml/kg/min, hematocrit 21-24%), cooled to 19'C (brain), and arrested for 90 minutes. Then CPB was reinstituted, piglets were rewarmed, separated from CP 3, and survived for 2 days. Neurologic outcome consisted of behavior (performance & functional disability scores) and histologic exam - neuronal cell countina in predetermined brain areas (neocortex: 3"' and 4" gyrus hippocampus: CAI, CA3, dentate gyr-us). Groups were compared with ANOVA and Mann-Whitley tests. |
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