Is hyperglycemia detrimental?
Hyperglycemia is associated with high brain lactate levels and possibly greater cerebral cellular injury, particularly in the early phases of brain injury (animal research / not conclusive / older studies)
- Recommendation: Avoid hyperglycemia, particularly during the early stages of brain injury. Consider the use of intravenous solutions that do not contain dextrose for early fluid and electrolyte management
Chopp et al., (1988). Stroke, 19.
Lanier et al., (1987). Anesthesiology, 66.
Ljunggren et al. (1974). Brain Research, 77.
Myers et al., (1976). Journal of Neuropathology and Experiemental Neurology, 35.
Smith et al. (1986). Journal of Cerebral Blood Flow and Metabolism, 6.
Natale et al. (1990). Resuscitation, 19.