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PedsCCM: Evidence-Based Journal Club Sign up for a review

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  • Check off the trial you'd like to review (or provide the citation of one not listed by email, but first be sure its not already under review.)
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  • Please be prepared to submit your first draft of the review within 6 weeks of signing up
    • Each submission is reviewed by two editors and then will be returned to you - you must also respond to the editors' comments/suggested revisions within 2 weeks of receiving it back
    • Do not sign up for a review unless you are prepared to meet these timelines!
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PedsCCM: Evidence-Based Journal Club Sign up for a review





Select only one trial, then scroll down and click on the 'Submit' button. *(Required):
Puri V, Epstein D, Raithel SC, Gandhi SK, Sweet SC, Faro A, Huddleston CB. Extracorporeal membrane oxygenation in pediatric lung transplantation.
J Thorac Cardiovasc Surg 2010 140(2):427-32 [abstract]
Menon K, Ward RE, Lawson ML, Gaboury I, Hutchison JS, HĂ©bert PC, Canadian Critical Care Trials Group. A Prospective Multi-Center Study of Adrenal Function in Critically Ill Children.
Am J Respir Crit Care Med 2010 182:246-251 [abstract]
White M, Barron J, Gornbein J, Lin JA. Are red blood cell transfusions associated with nosocomial infections in pediatric intensive care units?
Pediatr Crit Care Med. 2010 Jul;11(4):464-8. [abstract] [Full-Text]
Eulmesekian PG, PĂ©rez A, Minces PG, Bohn D. Hospital-acquired hyponatremia in postoperative pediatric patients: prospective observational study.
Pediatr Crit Care Med. 2010 2010 Jul;11(4):479-83. [abstract]
Typpo KV, Petersen NJ, Petersen LA, Mariscalco MM. Children with Chronic Illness Return to Their Baseline Functional Status after Organ Dysfunction on the First Day of Admission in the Pediatric Intensive Care Unit
J Pediatr 2010 157(1):108-113.e1. [abstract]
Gauvin F, Spinella PC, Lacroix J, Choker G, Ducruet T, Karam O, HĂ©bert PC, Hutchison JS, Hume HA, Tucci M. Association between length of storage of transfused red blood cells and multiple organ dysfunction syndrome in pediatric intensive care patients.
Transfusion 2010 Apr 30. [Epub ahead of print] [abstract]
del Castillo SL, McCulley ME, Khemani RG, Jeffries HE, Thomas DW, Peregrine J, Wells WJ, Starnes VA, Moromisato DY. Reducing the incidence of necrotizing enterocolitis in neonates with hypoplastic left heart syndrome with the introduction of an enteral feed protocol
Pediatr Crit Care Med. 2010 11(3):373-377. [abstract]
Raymond TT, Cunnyngham CB, Thompson MT, Thomas JA, Dalton HJ, Nadkarni VM; for the American Heart Association National Registry of CPR Investigators. Outcomes among neonates, infants, and children after extracorporeal cardiopulmonary resuscitation for refractory in-hospital pediatric cardiac arrest: A report from the National Registry of CardioPulmonary Resuscitation
Pediatr Crit Care Med. 2010 11:362–371 [abstract] [Full-Text]
Silvestri L, van Saene HK, Zandstra DF, Marshall JC, Gregori D, Gullo A Impact of selective decontamination of the digestive tract on multiple organ dysfunction syndrome: Systematic review of randomized controlled trials
Crit Care Med 2010 38(5):1370-1376 [abstract]
Wert RV, Friedrich JO, Scales DC, Wald R, Adhikari NK; for the University of Toronto Acute Kidney Injury Research Group. High-dose renal replacement therapy for acute kidney injury: Systematic review and meta-analysis
Crit Care Med 2010 38(5):1360-1369 [abstract]
Akre M, Finkelstein M, Erickson M, Liu M, Vanderbilt L, Billman G. Sensitivity of the pediatric early warning score to identify patient deterioration.
Pediatrics 2010 25(4):e763-9 [abstract] [Full-Text]
Srinivasan V, Nadkarni VM, Helfaer MA, Carey SM, Berg RA; American Heart Association National Registry of Cardiopulmonary Resuscitation Investigators. Childhood obesity and survival after in-hospital pediatric cardiopulmonary resuscitation.
Pediatrics 2010 125(3):e481-8. [abstract]
Gaies MG, Gurney JG, Yen AH, Napoli ML, Gajarski RJ, Ohye RG, Charpie JR, Hirsch JC. Vasoactive-inotropic score as a predictor of morbidity and mortality in infants after cardiopulmonary bypass
Pediatr Crit Care Med. 2010 11:234–238 [abstract]
Briel M, Meade M, Mercat A, Brower RG, Talmor D, Walter SD, Slutsky AS, Pullenayegum E, Zhou Q, Cook D, Brochard L, Richard JC, Lamontagne F, Bhatnagar N, Stewart TE, Guyatt G. Higher vs lower positive end-expiratory pressure in patients with acute lung injury and acute respiratory distress syndrome: systematic review and meta-analysis.
JAMA 2010 3;303(9):865-73 [abstract]
O'Brien SM, Clarke DR, Jacobs JP, Jacobs ML, Lacour-Gayet FG, Pizarro C, Welke KF, Maruszewski B, Tobota Z, Miller WJ, Hamilton L, Peterson ED, Mavroudis C, Edwards FH. An empirically based tool for analyzing mortality associated with congenital heart surgery.
J Thorac Cardiovasc Surg 2009 138(5):1139-53 [abstract]
RENAL Replacement Therapy Study Investigators, Bellomo R, Cass A, Cole L, Finfer S, Gallagher M, Lo S, McArthur C, McGuinness S, Myburgh J, Norton R, Scheinkestel C, Su S. Intensity of continuous renal-replacement therapy in critically ill patients
N Engl J Med 2009 22;361(17):1627-38 [abstract]
Taccone P, Pesenti A, Latini R, Polli F, Vagginelli F, Mietto C, Caspani L, Raimondi F, Bordone G, Iapichino G, Mancebo J, GuĂ©rin C, Ayzac L, Blanch L, Fumagalli R, Tognoni G, Gattinoni L; for the Prone-Supine II Study Group Prone Positioning in Patients With Moderate and Severe Acute Respiratory Distress Syndrome: A Randomized Controlled Trial
JAMA 2009 302(18):1977-1984. [abstract]
Alberda C, Gramlich L, Jones N, Jeejeebhoy K, Day AG, Dhaliwal R, Heyland DK. The relationship between nutritional intake and clinical outcomes in critically ill patients: results of an international multicenter observational study.
Intensive Care Med 2009 35(10):1728-37 [abstract]
Carcillo JA, Kuch BA, Han YY, Day S, Greenwald BM, McCloskey KA, Pearson-Shaver AL, Orr RA. Mortality and functional morbidity after use of PALS/APLS by community physicians.
Pediatrics 2009 124(2):500-8 [abstract]
Khemani RG, Conti D, Alonzo TA, Bart RD 3rd, Newth CJ. Effect of tidal volume in children with acute hypoxemic respiratory failure.
Intensive Care Med 2009 35(8):1428-37 [abstract]
Piastra M, De Luca D, Pietrini D, Pulitanò S, D'Arrigo S, Mancino A, Conti G. Noninvasive pressure-support ventilation in immunocompromised children with ARDS: a feasibility study.
Intensive Care Med 2009 35(8):1420-7 [abstract]
Barrett CS, Bratton SL, Salvin JW, Laussen PC, Rycus PT, Thiagarajan RR. Neurological injury after extracorporeal membrane oxygenation use to aid pediatric cardiopulmonary resuscitation.
Pediatr Crit Care Med. 2009 10(4):445-451 [abstract]
Orr RA, Felmet KA, Han Y, McCloskey KA, Dragotta MA, Bills DM, Kuch BA, Watson RS. Pediatric specialized transport teams are associated with improved outcomes.
Pediatrics 2009 124(1):40-8 [abstract]
Siempos II, Kopterides P, Tsangaris I, Dimopoulou I, Armaganidis AE Impact of catheter-related bloodstream infections on the mortality of critically ill patients: a meta-analysis.
Crit Care Med 2009 37(7):2283-9 [abstract]
Marchick MR, Kline JA, Jones AE The significance of non-sustained hypotension in emergency department patients with sepsis
Intensive Care Med 2009 35(7):1261-4 [abstract]
Tibballs J, Kinney S Reduction of hospital mortality and of preventable cardiac arrest and death with increased survival on introduction of a pediatric medical emergency team.
Pediatr Crit Care Med. 2009 10:306–312 [abstract] [Full-Text]
Mikkelsen ME, Miltiades AN, Gaieski DF, Goyal M, Fuchs BD, Shah CV, Bellamy SL, Christie JD. Serum lactate is associated with mortality in severe sepsis independent of organ failure and shock
Crit Care Med 2009 37:1670 –1677 [abstract]
Tang BM, Craig JC, Eslick GD, Seppelt I, McLean AS. Use of corticosteroids in acute lung injury and acute respiratory distress syndrome: A systematic review and meta-analysis
Crit Care Med 2009 37:1594-1603. [abstract]
Srinivasan R, Asselin J, Gildengorin G, Wiener-Kronish J, Flori HR A prospective study of ventilator-associated pneumonia in children.
Pediatrics 2009 123(4):1108-15. [abstract]
Levitt JE, Bedi H, Calfee CS, Gould MK, Matthay MA. Identification of Early Acute Lung Injury at Initial Evaluation in an Acute Care Setting Prior to the Onset of Respiratory Failure.
Chest 2009 135:936-943. [abstract]
Bigham MT, Amato R, Bondurrant P, Fridriksson J, Krawczeski CD, Raake J, Ryckman S, Schwartz S, Shaw J, Wells D, Brilli RJ. Ventilator-Associated Pneumonia in the Pediatric Intensive Care Unit: Characterizing the Problem and Implementing a Sustainable Solution.
J Pediatr. 2009 154:582-7. [abstract]
Timsit JF, Schwebel C, Bouadma L, Geffroy A, Garrouste-Orgeas M, Pease S, Herault MC, Haouache H, Calvino-Gunther S, Gestin B, Armand-Lefevre L, Leflon V, Chaplain C, Benali A, Francais A, Adrie C, Zahar JR, Thuong M, Arrault X, Croize J, Lucet JC; Dressi Chlorhexidine-impregnated sponges and less frequent dressing changes for prevention of catheter-related infections in critically ill adults: a randomized controlled trial.
JAMA 2009 301(12):1231-41. [abstract]
Czaja AS, Zimmerman JJ, Nathens AB. Readmission and late mortality after pediatric severe sepsis.
Pediatrics 2009 123(3):849-57 [abstract]
Anton N, Cox PN, Massicotte MP, Chait P, Yasui Y, Dinyari PM, Marzinotto V, Mitchell LG. Heparin-bonded central venous catheters do not reduce thrombosis in infants with congenital heart disease: a blinded randomized, controlled trial.
Pediatrics 2009 123(3):e453-8. [abstract]
Mayordomo-Colunga J, Medina A, Rey C, DĂ­az JJ, Concha A, Los Arcos M, MenĂ©ndez S. Predictive factors of non invasive ventilation failure in critically ill children: a prospective epidemiological study.
Intensive Care Med 2009 35(3):527-536 [abstract]
Neufeld RE, Clark BG, Robertson CM, Moddemann DM, Dinu IA, Joffe AR, Sauve RS, Creighton DE, Zwaigenbaum L, Ross DB, Rebeyka IM; Western Canadian Complex Pediatric Therapies Follow-up Group. Five-year neurocognitive and health outcomes after the neonatal arterial switch operation.
J Thorac Cardiovasc Surg 2008 136(6):1413-1421.e2 [abstract]
de Smet AM, Kluytmans JA, Cooper BS, et al. Decontamination of the Digestive Tract and Oropharynx in ICU Patients.
N Engl J Med 2009 360(1):20-31 [abstract]
Domi T, Edgell DS, McCrindle BW, et al. Frequency, Predictors, and Neurologic Outcomes of Vaso-occlusive Strokes Associated With Cardiac Surgery in Children
Pediatrics 2008 122: 1292-1298 [abstract]
Hoover NG, Heard M, Reid C, Wagoner S, Rogers K, Foland J, Paden ML, Fortenberry JD. Enhanced fluid management with continuous venovenous hemofiltration in pediatric respiratory failure patients receiving extracorporeal membrane oxygenation support.
Intensive Care Med 2008 34(12):2241-2247 [abstract]
Trzeciak S, McCoy JV, Phillip Dellinger R, Arnold RC, Rizzuto M, Abate NL, Shapiro NI, Parrillo JE, Hollenberg SM; on behalf of the Microcirculatory Alterations in Resuscitation and Shock (MARS) investigators. Early increases in microcirculatory perfusion during protocol-directed resuscitation are associated with reduced multi-organ failure at 24 h in patients with sepsis.
Intensive Care Med 2008 34(12):2210-221 [abstract]
Arabi YM, Dabbagh OC, Tamim HM, Al-Shimemeri AA, Memish ZA, Haddad SH, Syed SJ, Giridhar HR, Rishu AH, Al-Daker MO, Kahoul SH, Britts RJ, Sakkijha MH. Intensive versus conventional insulin therapy: A randomized controlled trial in medical and surgical critically ill patients
Crit Care Med 2008 36(12):3190-3197 [abstract]
Rafaat KT, Spear RM, Kuelbs C, Parsapour K, Peterson B. Cranial computed tomographic findings in a large group of children with drowning: Diagnostic, prognostic, and forensic implications.
Pediatr Crit Care Med. 2008 9(6):567-572 [abstract]
Miller MP, Sagy M. Pressure Characteristics of Mechanical Ventilation and Incidence of Pneumothorax Before and After the Implementation of Protective Lung Strategy (PLS) in the Management of Pediatric Patients with Severe ARDS.
Chest 2008 134 969-973. [abstract]
Zarychanski R, Doucette S, Fergusson D, Roberts D, Houston DS, Sharma S, Gulati H, Kumar A. Early intravenous unfractionated heparin and mortality in septic shock.
Crit Care Med 2008 36(11):2973-2979 [abstract]
Curley MA, Harrison CH, Craig N, Lillehei CW, Micheli A, Laussen PC. Pediatric staff perspectives on organ donation after cardiac death in children
Pediatr Crit Care Med. 2007 8(3):212-9. [abstract]
Montagnino BA, Ethier AM. The experiences of pediatric nurses caring for children in a persistent vegetative state
Pediatr Crit Care Med. 2007 8(5):440-6 [abstract]
Liu KD, Levitt J, Zhuo H, Kallet RH, Brady S, Steingrub J, Tidswell M, Siegel MD, Soto G, Peterson MW, Chesnutt MS, Phillips C, Weinacker A, Thompson BT, Eisner MD, Matthay MA. Randomized Clinical Trial of Activated Protein C for the Treatment of Acute Lung Injury.
Am J Respir Crit Care Med 2008 178:618-623 [abstract]
Marik PE, Corwin HL. Efficacy of red blood cell transfusion in the critically ill: A systematic review of the literature.
Crit Care Med 2008 36:2667-2674 [abstract]
Wiener Soylemez R, Wiener DC, Larson RJ. Benefits and Risks of Tight Glucose Control in Critically Ill Adults: A Meta-analysis.
JAMA 2008 300:933-944. [abstract]
Klein GW, Hojsak JM, Schmeidler J, Rapaport R. Hyperglycemia and Outcome in the Pediatric Intensive Care Unit.
J Pediatr 2008 153:379-384 [abstract]
Javouhey E, Barats A, Richard N, Stamm D, Floret D. Non-invasive ventilation as primary ventilatory support for infants with severe bronchiolitis.
Intensive Care Med 2008 34(9):1608-14 [abstract]
Hirshberg E, Larsen G, Van Duker H. Alterations in glucose homeostasis in the pediatric intensive care unit: Hyperglycemia and glucose variability are associated with increased mortality and morbidity
Pediatr Crit Care Med. 2008 9:361-366 [abstract]
Abroug F, Ouanes-Besbes L, Elatrous S, Brochard L. The effect of prone positioning in acute respiratory distress syndrome or acute lung injury: a meta-analysis. Areas of uncertainty and recommendations for research.
Intensive Care Med 2008 34(6):1002-11 [abstract]
Kalyanaraman M, DeCampli WM, Campbell AI, Bhalala U, Harmon TG, Sandiford P, McMahon CK, Shore S, Yeh TS. Serial blood lactate levels as a predictor of mortality in children after cardiopulmonary bypass surgery.
Pediatr Crit Care Med. 2008 9(3):285-8. [abstract]
Iscimen R, Cartin-Ceba R, Yilmaz M, Khan H, Hubmayr RD, Afessa B, Gajic O. Risk factors for the development of acute lung injury in patients with septic shock: an observational cohort study.
Crit Care Med 2008 36(5):1518-22 [abstract]
Sarani B, Dunkman WJ, Dean L, Sonnad S, Rohrbach JI, Gracias VH. Transfusion of fresh frozen plasma in critically ill surgical patients is associated with an increased risk of infection.
Crit Care Med. 2008 36(4):1114-8. [abstract]
Mekontso-Dessap A, Leon R, Habibi A, et al. Pulmonary Hypertension and Cor Pulmonale during Severe Acute Chest Syndrome in Sickle Cell Disease.
Am J Respir Crit Care Med 2008 177:646-653 [abstract]
Numa A, Williams G, Awad J, Duffy B. After-hours admissions are not associated with increased risk-adjusted mortality in pediatric intensive care.
Intensive Care Med 2008 34(1):148-151 [abstract]
Meersseman W, Lagrou K, Maertens J, et al. Galactomannan in bronchoalveolar lavage fluid: a tool for diagnosing aspergillosis in intensive care unit patients.
Am J Respir Crit Care Med 2008 177(1):27-34 [abstract]
NiĂ«l-Weise BS, Stijnen T, van den Broek PJ. Anti-infective-treated central venous catheters: a systematic review of randomized controlled trials.
Intensive Care Med 2007 33(12):2058-68 [abstract]
Laupland KB, Kirkpatrick AW, Delaney A. Polyclonal intravenous immunoglobulin for the treatment of severe sepsis and septic shock in critically ill adults: A systematic review and meta-analysis.
Crit Care Med. 2007 35:2686-2692 [abstract]
Lorente L, Lecuona M, Jimenez A, Mora ML, Sierra A. Influence of an Endotracheal Tube with Polyurethane Cuff and Subglottic Drainage on Pneumonia.
Am J Respir Crit Care Med 2007 176: 1079-1083 [abstract]
Stevens RD, Dowdy DW, Michaels RK, Mendez-Tellez PA, Pronovost PJ, Needham DM. Neuromuscular dysfunction acquired in critical illness: a systematic review
Intensive Care Med 2007 33(11):1876-91 [abstract]
Villar J, Perez-Mendez L, Lopez J, Belda J, Blanco J, Saralegui I, Suarez-Sipmann F, Lopez J, Lubillo S, Kacmarek RM; on behalf of the HELP Network. An Early PEEP/FIO2 Trial Identifies Different Degrees of Lung Injury in Patients with Acute Respiratory Distress Syndrome.
Am J Respir Crit Care Med 2007 176(8):795-804 [abstract]
Shah PS, Ohlsson A, Perlman M. Hypothermia to Treat Neonatal Hypoxic Ischemic Encephalopathy: Systematic Review
Arch Pediatr Adolesc Med 2007 161 951-958 [abstract]
Corwin HL, Gettinger A, Fabian TC, May A, Pearl RG, Heard S, An R, Bowers PJ, Burton P, Klausner MA, Corwin MJ; EPO Critical Care Trials Group. Efficacy and safety of epoetin alfa in critically ill patients.
N Engl J Med. 2007 357(10):965-76. [abstract]
Mascia L, Zavala E, Bosma K, et al. High tidal volume is associated with the development of acute lung injury after severe brain injury: An international observational study.
Crit Care Med. 2007 35(8):1815-1820. [abstract]
Quenot JP, Ladoire S, Devoucoux F, Doise JM, Cailliod R, Cunin N, Aube H, Blettery B, Charles PE. Effect of a nurse-implemented sedation protocol on the incidence of ventilator-associated pneumonia
Crit Care Med. 2007 35(9):2031-2036 [abstract]
Rivers EP, Kruse JA, Jacobsen G, Shah K, Loomba M, Otero R, Childs EW. The influence of early hemodynamic optimization on biomarker patterns of severe sepsis and septic shock
Crit Care Med. 2007 35(9):2016-2024 [abstract]
Jones AE, Focht A, Horton JM, Kline JA. Prospective external validation of the clinical effectiveness of an emergency department-based early goal-directed therapy protocol for severe sepsis and septic shock.
Chest 2007 132(2):425-32 [abstract]
Phipps LM, Thomas NJ, Gilmore RK, et al. Prospective assessment of guidelines for determining appropriate depth of endotracheal tube placement in children.
Pediatr Crit Care Med. 2005 6: 519-22 [abstract]
Ramelet AS, Abu-Saad HH, Bulsara MK, et al. Capturing postoperative pain responses in critically ill infants aged 0 to 9 months.
Pediatr Crit Care Med. 2006 7: 19-26 [abstract]
Curley MA, Harris SK, Fraser KA, et al. State Behavioral Scale: A sedation assessment instrument for infants and young children supported on mechanical ventilation
Pediatr Crit Care Med. 2006 7: 107-114 [abstract]
Hesselgard K, Larson S, Romner B. Validity and reliability of the behavioural observational pain scale for postoperative pain measurement in children 1-7 years of age.
Pediatr Crit Care Med. 2007 8: 102-108 [abstract]
Donkin M, Kolovos N, Checchia PA Effects of a specialized pediatric institutional setting on organ recovery from potential donors.
Am J Crit Care 2006 15: 497-501 [abstract]
Larson EL, Quiros D, Giblin T, et al . Relationship of antimicrobial control policies and hospital and infection control characteristics to antimicrobial resistance rates.
Am J Crit Care 2007 16: 110-120 [abstract]
Ahrens T, Kollef M, Stewart J, et al . Effect of kinetic therapy on pulmonary complications.
Am J Crit Care 2004 13: 376-83 [abstract]
Bear LA, Ward-Smith P Interrater reliability of the COMFORT Scale.
Pediatr Nurs 2006 32: 427- 34 [abstract]
McCord S, McElvain V, Sachdeva R, et al Risk factors associated with pressure ulcers in the pediatric intensive care unit.
J Wound Ostomy Continence Nurs. 2004 31: 179-83 [abstract]
Kato Y, Shime N, Hashimoto S, et al. Effects of controlled perioperative antimicrobial prophylaxis on infectious outcomes in pediatric cardiac surgery.
Crit Care Med 2007 35:1763-1768. [abstract]
Vilmaz M, Keegan MT, Iscimen R, et al. Toward the prevention of acute lung injury: Protocol-guided limitation of large tidal volume ventilation and inappropriate transfusion.
Crit Care Med 2007 35:1660-1666 [abstract]
Varpula M, Pulkki K, Karlsson S, Ruokonen E, Pettila V; FINNSEPSIS Study Group. Predictive value of N-terminal pro-brain natriuretic peptide in severe sepsis and septic shock.
Crit Care Med 2007 35(5):1277-83 [abstract]
Lacherade JC, Jabre P, Bastuji-Garin S, Grimaldi D, Fangio P, Theron V, Outin H, De Jonghe B. Failure to achieve glycemic control despite intensive insulin therapy in a medical ICU: incidence and influence on ICU mortality.
Intensive Care Med 2007 33(5):814-21 [abstract]
Lipiner D, Sprung CL, Laterre PF, et al. Adrenal function in sepsis: The retrospective Corticus cohort study.
Crit Care Med 2007 35:1012-1018. [abstract]
Garcia-Teresa MA, Casado-Flores J, Delgado Dominguez MA, et al. Infectious complications of percutaneous central venous catheterization in pediatric patients : A Spanish multicenter study.
Intensive Care Med 2007 33(3):466-76. [abstract]
Hermans G, Wilmer A, Meersseman W, et al. Impact of intensive insulin therapy on neuromuscular complications and ventilator dependency in the medical intensive care unit.
Am J Respir Crit Care Med 2007 175(5):480-9 [abstract]
Pronovost P, Needham D, Berenholtz S, et al. An intervention to decrease catheter-related bloodstream infections in the ICU.
N Engl J Med 2006 28;355(26):2725-32. [abstract]
Jongerden IP, Rovers MM, Grypdonck MH, Bonten MJ. Open and closed endotracheal suction systems in mechanically ventilated intensive care patients: A meta-analysis.
Crit Care Med 2007 35:260-270 [abstract]
Silver M, Corwin MJ, Bazan A, Gettinger A, Enny C, Corwin HL. Efficacy of recombinant human erythropoietin in critically ill patients admitted to a long-term acute care facility: a randomized, double-blind, placebo-controlled trial.
Crit Care Med 2006 34(9):2310-6. [abstract]
Segers P, Speekenbrink RG, Ubbink DT, van Ogtrop ML, de Mol BA Prevention of Nosocomial Infection in Cardiac Surgery by Decontamination of the Nasopharynx and Oropharynx With Chlorhexidine Gluconate: A Randomized Controlled Trial.
JAMA 2006 22;296(20):2460-2466 [abstract]
Demoule A, Girou E, Richard JC, Taille S, Brochard L Benefits and risks of success or failure of noninvasive ventilation.
Intensive Care Med 2006 32(11):1756-65 [abstract]
Elliott R, McKinley S, Aitken LM, Hendrikz J. The effect of an algorithm-based sedation guideline on the duration of mechanical ventilation in an Australian intensive care unit.
Intensive Care Med 2006 32(10):1506-14 [Full-Text]
Tanios MA, Nevins ML, Hendra KP, et al. A randomized, controlled trial of the role of weaning predictors in clinical decision making.
Crit Care Med 2006 34(10):2530-5 [abstract]
Kahn JM, Goss CH, Heagerty PJ, et al. Hospital volume and the outcomes of mechanical ventilation.
N Engl J Med 2006 355(1):41-50 [abstract]
Metnitz PG, Reiter A, Jordan B, Lang T. More interventions do not necessarily improve outcome in critically ill patients.
Intensive Care Med. 2004 ; 30: 1586 - 1593 [abstract]
Holzer M, Bernard SA, Hachimi-Idrissi S, et al. Hypothermia for neuroprotection after cardiac arrest: systematic review and individual patient data meta-analysis.
Crit Care Med. 2005 Feb;33(2):414-8. [abstract]
Warren DK, Zack JE, Mayfield JL, et al. The effect of an education program on the incidence of central venous catheter-associated bloodstream infection in a medical ICU.
Chest. 2004 Nov;126(5):1612-8. [abstract]
Egan JR, Festa M, Cole AD, Nunn GR, Gillis J, Winlaw DS. Clinical assessment of cardiac performance in infants and children following cardiac surgery.
Intensive Care Med. 2005 Apr;31(4):568-573 [abstract]
Girou E, Schortgen F, Delclaux C, et al. Association of noninvasive ventilation with nosocomial infections and survival in critically ill patients.
JAMA. 2000 Nov 8;284(18):2361-7. [abstract]
Gong MN, Thompson BT, Williams P, et al. Clinical predictors of and mortality in acute respiratory distress syndrome: Potential role of red cell transfusion.
Crit Care Med. 2005 Jun;33(6):1191-1198. [abstract]
Abella BS, Alvarado JP, Myklebust H, et al. Quality of cardiopulmonary resuscitation during in-hospital cardiac arrest.
JAMA. 2005 Jan 19;293(3):305-10. [abstract]
Sloan EP, Koenigsberg M, Gens D, et al. Diaspirin Cross-Linked Hemoglobin (DCLHb) in the Treatment of Severe Traumatic Hemorrhagic Shock: A Randomized Controlled Efficacy Trial
JAMA. 1999 ;282:1857-1864. [abstract] [Full-Text]
White B, Livingstone W, Murphy C, et al. An open-label study of the role of adjuvant hemostatic support with protein C replacement therapy in purpura fulminans-associated meningococcemia
Blood. 2000 ;96(12):3719-24. [abstract]
Ryan CM, Schoenfeld DA, Thorpe WP, et al. Objective Estimates of the Probability of Death from Burn Injuries
N Engl J Med . 1998 ; 338: 362-6. [abstract]
Fagon JY, Chastre J, Wolff M, et al. Invasive and noninvasive strategies for management of suspected ventilator-associated pneumonia. A randomized trial
Ann Intern Med. 2000 ;132:621-30. [abstract] [Full-Text]
Timsit JF, Cheval C, Gachot B et al. Usefulness of a strategy based on bronchoscopy with direct examination of bronchoalveolar lavage fluid in the initial antibiotic therapy of suspected ventilator-associated pneumonia
Intensive Care Med 2001 Apr;27(4):640-7. [abstract]
Dezfulian C, Lavelle J, Nallamothu BK, Kaufman SR, Saint S. Rates of infection for single-lumen versus multilumen central venous catheters: a meta-analysis
Crit Care Med. 2003 Sep;31(9):2385-90. [abstract]
Cooper AB, Ferguson ND, Hanly PJ, Meade MO, Kachura JR, Granton JT, Slutsky AS, Stewart TE. Long-term follow-up of survivors of acute lung injury: Lack of effect of a ventilation strategy to prevent barotrauma
Crit Care Med 1999 ; 27: 2616-2621. [abstract]
Fischer JE, Benn A, Harbarth S, Nadal D, Fanconi S. Diagnostic accuracy of G-CSF, IL-8, and IL-1ra in critically ill children with suspected infection
Intensive Care Med 2002 ; 28: 1324-1331. [abstract]
Kollef MH, Skubas NJ, Sundt TM. A Randomized Clinical Trial of Continuous Aspiration of Subglottic Secretions in Cardiac Surgery Patients
Chest 1999 116: 1339-1346. [abstract] [Full-Text]
McIntyre RC Jr, Pulido EJ, Bensard DD, Shames BD, Abraham E. Thirty years of clinical trials in acute respiratory distress syndrome
Crit Care Med. 2000 ;28(9):3314-31. [abstract]
Elatrous S, Boukef R, Ouanes Besbes L, Marghli S, Nooman S, Nouira S, Abroug F. Diagnosis of ventilator-associated pneumonia: agreement between quantitative cultures of endotracheal aspiration and plugged telescoping catheter
Intensive Care Med. 2004 May;30(5):853-8. [abstract]
Brook AD, Ahrens TS, Schaiff R, Prentice D, Sherman G, Shannon W, Kollef MH. Effect of a nursing-implemented sedation protocol on the duration of mechanical ventilation
Crit Care Med 1999 ; 27: 2609-2615. [abstract]
Tenner PA, Dibrell H, Taylor RP. Improved survival with hospitalists in a pediatric intensive care unit.
Crit Care Med 2003 ; 31(3):847-852 [abstract]
Carrasco MN, Bueno A, De Las Cuevas C, et al. Evaluation of a triple-lumen central venous heparin-coated catheter versus a catheter coated with chlorhexidine and silver sulfadiazine in critically ill patients
Intensive Care Med. 2004 Apr;30(4):633-8 [abstract]
Combes P, Fauvage B, Oleyer C. Nosocomial pneumonia in mechanically ventilated patients, a prospective randomised evaluation of the Stericath closed suctioning system
Intensive Care Med 2000 ; 26: 878-882. [abstract]
Singh-Naz N, Sprague BM, Patel KM, Pollack MM. Risk assessment and standardized nosocomial infection rate in critically ill children
Crit Care Med. 2000 ;28(6):2069-75. [abstract]
Kollef MH, Ward S. The influence of access to a private attending physician on the withdrawal of life-sustaining therapies in the intensive care unit
Crit Care Med. 1999 ;27:2125-32. [abstract]
Arnold JH, Anas NG, Luckett P, et al. High-frequency oscillatory ventilation in pediatric respiratory failure: a multicenter experience
Crit Care Med. 2000 ;28(12):3913-9. [abstract]
Petrucci N, Iacovelli W. Ventilation with Smaller Tidal Volumes: A Quantitative Systematic Review of Randomized Controlled Trials.
Anesth Analg 2004 ;99 193-200. [abstract]
Phu NH, Hien TT, Mai NTH, et al. Hemofiltration and Peritoneal Dialysis in Infection-Associated Acute Renal Failure in Vietnam
N Engl J Med 2002 ;347:895-902. [abstract]
Flori HR, Ware LB, Glidden D, Matthay MA. Early elevation of plasma soluble intercellular adhesion molecule-1 in pediatric acute lung injury identifies patients at increased risk of death and prolonged mechanical ventilation
Pediatr Crit Care Med. 2003 Jul;4(3):315-321. [abstract]
Ibrahim EH, Ward S, Sherman G, Schaiff R, Fraser VJ, Kollef MH. Experience with a clinical guideline for the treatment of ventilator-associated pneumonia
Crit Care Med. 2001 ;29(6):1109-15. [abstract]
Sheridan RL, Remensnyder JP, Schnitzer JJ, et al. Current Expectations for Survival in Pediatric Burns
Arch Pediatr Adolesc Med 2000 ;154:245-249. [abstract] [Full-Text]
Wu CL, le Yang D, Wang NY, Kuo HT, Chen PZ. Quantitative Culture of Endotracheal Aspirates in the Diagnosis of Ventilator-Associated Pneumonia in Patients With Treatment Failure
Chest 2002 ;122 662-668. [abstract]
Ikle L, Hale K, Fashaw L, Boucek M, Rosenberg AA. Developmental outcome of patients with hypoplastic left heart syndrome treated with heart transplantation
J Pediatr. 2003 ;142(1):20-5. [abstract]
Eichacker PQ, Gerstenberger EP, Banks SM, Cui X, Natanson C. Meta-Analysis of Acute Lung Injury and Acute Respiratory Distress Syndrome Trials Testing Low Tidal Volumes
Am J Respir Crit Care Med 2002 ; 166: 1510-1514. [abstract] [Full-Text]
Brun-Buisson C, Doyon F, Sollet JP, Cochard JF, Cohen Y, Nitenberg G. Prevention of intravascular catheter-related infection with newer chlorhexidine-silver sulfadiazine-coated catheters: a randomized controlled trial
Intensive Care Med. 2004 May;30(5):837-43 [abstract]
Barr J, Hecht M, Flavin KE, Khorana A, Gould MK. Outcomes in critically ill patients before and after the implementation of an evidence-based nutritional management protocol
Chest. 2004 Apr;125(4):1446-57 [abstract]
Rello J, Ollendorf DA, Oster G, Vera-Llonch M, Bellm L, Redman R, Kollef MH. Epidemiology and Outcomes of Ventilator-Associated Pneumonia in a Large US Database
Chest. 2002 ;122(6):2115-21. [abstract]
Gajic O, Dara SI, Mendez JL, et al. Ventilator-associated lung injury in patients without acute lung injury at the onset of mechanical ventilation.
Crit Care Med. 2004 Sep;32(9):1817-24 [abstract]
Moran JL, Bersten AD, Solomon PJ. Meta-analysis of controlled trials of ventilator therapy in acute lung injury and acute respiratory distress syndrome: an alternative perspective
Intensive Care Med. 2005 Feb;31(2):227-35 [abstract]
Morris MC, Ittenbach RF, Godinez RI et al. Risk factors for mortality in 137 pediatric cardiac intensive care unit patients managed with extracorporeal membrane oxygenation.
Crit Care Med 2004 ; 32:1061-1069. [abstract]
Marcin JP, Song J, Leigh JP. The impact of pediatric intensive care unit volume on mortality: A hierarchical instrumental variable analysis.
Pediatr Crit Care Med. 2005 Mar;6(2):136-141 [abstract]
Courtman SP, Wardurgh A, Petros AJ. Comparison of the bispectral index monitor with the Comfort score in assessing level of sedation of critically ill children
Intensive Care Med. 2003 Dec;29(12):2239-46 [abstract]
Jubran A, Grant BJ, Laghi F, Parthasarathy S, Tobin MJ. Weaning Prediction: Esophageal Pressure Monitoring Complements Readiness Testing
Am J Respir Crit Care Med. 2005 ; 171 1252-1259. [abstract]
Larsen GY, Parker HB, Cash J, O Standard Drug Concentrations and Smart-Pump Technology Reduce Continuous-Medication-Infusion Errors in Pediatric Patients.
Pediatrics. 2005 Jul;116(1):e21-e25. [abstract]
Uchino S, Kellum JA, Bellomo R, et al. Acute renal failure in critically ill patients: a multinational, multicenter study.
JAMA. 2005 Aug 17;294(7):813-8. [abstract]
Kieft H, Roos AN, van Drunen JD, Bindels AJ, Bindels JG, Hofman Z. Clinical outcome of immunonutrition in a heterogeneous intensive care population
Intensive Care Med. 2005 Apr;31(4):524-532. [abstract]
Abraham E, Laterre PF, Garg R, et al. for the Administration of Drotrecogin Alfa (Activated) in Early Stage Severe Sepsis (ADDRESS) Study Group. Drotrecogin alfa (activated) for adults with severe sepsis and a low risk of death.
N Engl J Med. 2005 Sep 29;353(13):1332-41. [abstract]
Varpula M, Tallgren M, Saukkonen K, Voipio-Pulkki LM, Pettila V. Hemodynamic variables related to outcome in septic shock.
Intensive Care Med. 2005 Aug;31(8):1066-71. [abstract]
Sakr Y, Vincent JL, Reinhart K, et al. High tidal volume and positive fluid balance are associated with worse outcome in acute lung injury.
Chest. 2005 Nov;128(5):3098-108. [abstract]
Villar J, Kacmarek RM, Perez-Mendez L, Aguirre-Jaime A; for the ARIES Network. A high positive end-expiratory pressure, low tidal volume ventilatory strategy improves outcome in persistent acute respiratory distress syndrome: A randomized, controlled trial.
Crit Care Med. 2006 ; 34:1311-1318. [abstract]
Steinberg KP, Hudson LD, Goodman RB for the Acute Respiratory Distress Syndrome (ARDS) Clinical Trials Network. Efficacy and safety of corticosteroids for persistent acute respiratory distress syndrome.
N Engl J Med. 2006 Apr 20;354(16):1671-84 [abstract]
Kola A, Eckmanns T, Gastmeier P. Efficacy of heat and moisture exchangers in preventing ventilator-associated pneumonia: meta-analysis of randomized controlled trials.
Intensive Care Med. 2005 Jan;31(1):5-11 [abstract]
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